CN1879736A - Antibacterial Chinese medicinal composition for birds and preparation method thereof - Google Patents
Antibacterial Chinese medicinal composition for birds and preparation method thereof Download PDFInfo
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- CN1879736A CN1879736A CN 200610013714 CN200610013714A CN1879736A CN 1879736 A CN1879736 A CN 1879736A CN 200610013714 CN200610013714 CN 200610013714 CN 200610013714 A CN200610013714 A CN 200610013714A CN 1879736 A CN1879736 A CN 1879736A
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Abstract
The invention relates to an antibacterial composition for fowl and process for preparation, wherein the composition is prepared from white peony root 5-18 parts, Chinese angelica root 3-12 parts, pulsatilla root 3-22 parts, yellow corktree bark 5-20 parts, banksia rose 5-17 parts through the steps of disintegrating, sieving, weighing, ethanol immersing, filtering the supernatant fluid, merging the extracts, finally concentrating.
Description
Technical field
The present invention relates to a kind of birds medication, in particular, relate to a kind ofly be used for antimicrobial pharmaceutical composition and preparation method thereof by what Chinese herbal medicine was prepared from.
Background technology
At present, the aviculture of China is raised scattered based on peasant household mostly, and it is uneven that the raiser cultures level, lacks relevant feeding and management and epidemic prevention and control knowledge, causes the sickness rate of some diseases and relapse rate to significantly improve, especially some conditionality pathogenic bacterium such as colibacillosis, salmonellosis, these diseases are used western medicine mostly, and in taking the process of Western medicine, Western medicine and many bacterial strains are easy to generate drug resistance especially, influenced the therapeutical effect of medicine, treatment time is long.And western medicine composition remains in the birds body easily, and the edible back of people produces harm to human body.
In addition, existing Chinese medicine is when the treatment disease, and edible with mixing in the feedstuff after the Chinese herbal medicine pulverizing, effective ingredient is difficult to stripping, and treatment time is long.And spice is wasted time and energy, and takes inconvenience.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of enteritis, diarrhea that can effectively treat the common bacterial disease of birds and cause because of feeding and management is improper is provided, and noresidue in the birds body, Chinese medicine antibacterial combination that does not develop immunity to drugs and abundant effective component extracting are with the preparation method of the Chinese medicine antibacterial combination that shortens treatment time.
The present invention is achieved through the following technical solutions:
A kind of birds Chinese medicine antibacterial combination is characterized in that: made by following raw material by weight: Radix Paeoniae Alba 5-18 part, Radix Angelicae Sinensis 3-12 part, Radix Pulsatillae 3-22 part, Cortex Phellodendri 5-20 part, Radix Aucklandiae 5-17 part.
A kind of preparation method of birds Chinese medicine antibacterial combination comprises the steps
(1) Radix Paeoniae Alba, Radix Angelicae Sinensis, the Radix Pulsatillae, Cortex Phellodendri, the Radix Aucklandiae are pulverized, crossed the 20-80 mesh sieve;
(2) accurately weighing by weight: Radix Paeoniae Alba 5-18 part, Radix Angelicae Sinensis 3-12 part, Radix Pulsatillae 3-22 part, Cortex Phellodendri 5-20 part, Radix Aucklandiae 5-17 part;
(3) extracted 12-48 hour with the soak with ethanol of above composition weight 3-10 20-80% doubly earlier, cross the leaching supernatant, obtain extracting solution one time;
(4) carry out second extraction with the ethanol of composition weight 1-5 10-60% doubly then, the time crossed the leaching supernatant at 12-48 hour, obtained secondary raffinate;
(5) merge extracted twice liquid, promptly make Chinese medicine antibacterial combination of the present invention.
Use for convenience, reduce the dosage that uses, after merging extracted twice liquid, extracting solution can be concentrated into density is 1.0-2.0.
The present invention has following technique effect:
1. the present invention is a pure Chinese medicinal preparation, the Radix Paeoniae Alba and Radix Angelicae Sinensis in the prescription have inhibitory action to various bacteria, cooperate the Radix Pulsatillae, Cortex Phellodendri, the Radix Aucklandiae simultaneously, but heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain, stomach function regulating antidiarrheal cause bacterial diarrhoea, watery diarrhea that the obvious treatment effect is arranged to the escherichia coli of fowl with because of feeding and management is improper.Clinical trial shows that this product can reach more than 90% colibacillary control rate, and wherein the diseases such as flu diarrhoea that chicken is caused owing to catching cold have better curative effect, and cure rate is up to 96.0%.
2. pharmaceutical composition of the present invention is after birds is edible, and noresidue in the body is not developed immunity to drugs.
3. drug regimen article toxicity of the present invention is little, and cost is lower, can directly be added in the animal drinking-water, and is easy to use, can play the preventive effect to bacterial disease, but the anti-adversity ability of enhancing body also simultaneously.
4. preparation method of the present invention adopts second extraction, select the solvent of suitable concentration for use according to the dissolubility of effective monomer in the different medical materials, can make the abundant stripping of effective ingredient of medicine, fully effective component extracting can directly contact with pathological tissues, suppress the breeding of antibacterial, bring down a fever, cold expelling, induce sweat, but the anti-adversity ability of enhancing body is better brought into play diseases prevention, the resistant effect of medicine, evident in efficacy, Time of Administration is short.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Before preparation, earlier the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Radix Pulsatillae, Cortex Phellodendri, the Radix Aucklandiae are pulverized after the assay was approved, it is standby to cross the 20-80 mesh sieve.
Embodiment 1
Accurately the Radix Paeoniae Alba 9 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 11 grams, the Radix Pulsatillae 17 grams, Cortex Phellodendri 18 grams, the Radix Aucklandiae 12 grams.Extracted 24 hours with 40% soak with ethanol of 4 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.20% ethanol with 1.5 times of composition weights carries out second extraction then, and the time crossed the leaching supernatant at 24 hours, obtained secondary raffinate, and merging extracted twice liquid and being concentrated into density is 1.0, promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyethylene material, and bottleneck carries out heat seal.
Embodiment 2
Accurately the Radix Paeoniae Alba 12 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 9 grams, the Radix Pulsatillae 15 grams, Cortex Phellodendri 13 grams, the Radix Aucklandiae 11 grams.Extracted 24 hours with 60% soak with ethanol of 4 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.50% ethanol with 3 times of composition weights carries out second extraction then, 36 hours time, cross the leaching supernatant, and obtain secondary raffinate, merging extracted twice liquid and being concentrated into density is 1.7 promptly to make Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyester material, and bottleneck carries out heat seal.
Embodiment 3
Accurately the Radix Paeoniae Alba 10 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 8 grams, the Radix Pulsatillae 17 grams, Cortex Phellodendri 13 grams, the Radix Aucklandiae 15 grams.Extracted 24 hours with 60% soak with ethanol of 8 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.40% ethanol with 3 times of composition weights carries out second extraction then, and the time is 28 hours, crosses the leaching supernatant, obtains secondary raffinate, and merging extracted twice liquid and being concentrated into density is 1.3, promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyester material, and bottleneck carries out heat seal.
Embodiment 4
Accurately the Radix Paeoniae Alba 13 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 8 grams, the Radix Pulsatillae 18 grams, Cortex Phellodendri 18 grams, the Radix Aucklandiae 9 grams.Extracted 48 hours with 40% soak with ethanol of 7 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.20% ethanol with 1.5 times of composition weights carries out second extraction then, and the time is 24 hours, crosses the leaching supernatant, obtains secondary raffinate, and merging extracted twice liquid and being concentrated into density is 1.5, promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyester material, and bottleneck carries out heat seal.
Embodiment 5
Accurately the Radix Paeoniae Alba 12 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 11 grams, the Radix Pulsatillae 9 grams, Cortex Phellodendri 9 grams, the Radix Aucklandiae 12 grams.Extracted 36 hours with 60% soak with ethanol of 5 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.40% ethanol with 2 times of composition weights carries out second extraction then, and the time crossed the leaching supernatant at 36 hours, obtained secondary raffinate, merges extracted twice liquid and promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyethylene material, and bottleneck carries out heat seal.
Embodiment 6
Accurately the Radix Paeoniae Alba 13 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 8 grams, the Radix Pulsatillae 18 grams, Cortex Phellodendri 15 grams, the Radix Aucklandiae 13 grams.Extracted 24 hours with 40% soak with ethanol of 8 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.30% ethanol with 3 times of composition weights carries out second extraction then, 12 hours time, cross the leaching supernatant, and obtain secondary raffinate, merge extracted twice liquid promptly and to be concentrated into density be 2.0, make Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyethylene material, and bottleneck carries out heat seal.
Embodiment 7
Accurately the Radix Paeoniae Alba 13 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 12 grams, the Radix Pulsatillae 18 grams, Cortex Phellodendri 18 grams, the Radix Aucklandiae 15 grams.Extracted 36 hours with 60% soak with ethanol of 4 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.40% ethanol with 1.5 times of composition weights carries out second extraction then, and the time is 28 hours, crosses the leaching supernatant, obtains secondary raffinate, and merging extracted twice liquid and being concentrated into density is 1.5, promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyethylene material, and bottleneck carries out heat seal.
Embodiment 8
Accurately the Radix Paeoniae Alba 5 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 3 grams, the Radix Pulsatillae 22 grams, Cortex Phellodendri 5 grams, the Radix Aucklandiae 17 grams.Extracted 12 hours with 80% soak with ethanol of 10 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.60% ethanol with 1 times of composition weight carries out second extraction then, and the time crossed the leaching supernatant at 48 hours, obtained secondary raffinate, and merging extracted twice liquid and being concentrated into density is 1.4, promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyethylene material, and bottleneck carries out heat seal.
Embodiment 9
Accurately the Radix Paeoniae Alba 18 of the above-mentioned pulverizing of weighing restrains, Radix Angelicae Sinensis 11 grams, the Radix Pulsatillae 3 grams, Cortex Phellodendri 20 grams, the Radix Aucklandiae 5 grams.Extracted 24 hours with 20% soak with ethanol of 3 times of above composition weights earlier, mistake leaching supernatant obtains extracting solution one time.10% ethanol with 5 times of composition weights carries out second extraction then, and the time crossed the leaching supernatant at 24 hours, obtained secondary raffinate, and merging extracted twice liquid and being concentrated into density is 1.7, promptly makes Chinese medicine antibacterial combination of the present invention.Final finished is packaged in the bottle of polyester material, and bottleneck carries out heat seal.
Chinese medicine antibacterial combination of the present invention is used for the enteritis, diarrhea of effectively treating the common bacterial disease of fowl and causing because of feeding and management is improper.
Clinical trial:
1. to the test of chicken colibacillosis:
Application example:
The address: the Xiao Wang village, Jinghai County, Tianjin honest and just certain
Kind: AA broiler chicken
Age in days: 37 ages in days
Incidence: chicken group spirit is depressed, and the feather pine is disorderly drawn HUANGBAI(sic), yellow green loose stool, and feed intake descends, and mortality rate 7% cuts open visible slight fibrinous pericarditis and the perihepatitis of inspection, and intestinal mucosa thickens or comes off, and the intestinal diffuse hemorrhage.Take pathological material of disease to diagnose, be judged to escherichia coli, add in the drinking-water, freely drink for fowl in 0.5% ratio through test chamber, this bactericidal composition, logotype 3 days, mortality rate reduces, and feed intake obviously rises, and it is normal that feces recovers, and obtains good result.
Concrete condition sees the following form:
| Group | Mortality rate/% | Inefficiency % | Effective percentage % | Cure rate % | Experiment has symptom chicken number when finishing |
| Infect contrast | 19.1 (21/110) | 28.2 | 71.8 | 63.6 | 19 |
| Antibacterial combination high dose group (1.0%) | 2.7 (3/110) | 4.5 | 95.5 | 90.9 | 2 |
| Dosage group (0.5%) in the antibacterial combination | 4.5 (5/110) | 4.5 | 95.5 | 90.9 | 5 |
| Antibacterial combination low dose group (0.1%) | 5.4 (6/110) | 5.5 | 94.5 | 90.0 | 5 |
| Polygynax soluble powder matched group | 3.6 (4/110) | 5.5 | 94.5 | 92.7 | 4 |
2. application example
Address: Shao of Zaozhuang City, Shandong Province
Kind: AA broiler chicken
Age in days: 7 ages in days
Incidence: improper because of the brood time feeding and management, temperature is lower than normal requirement, causes the chicken group flu of catching cold, 50% appearance Hakuri, diarrhoea and feces adhesion anus phenomenon, and spirit is depressed, and the decline of searching for food uses this pharmaceutical composition to add in the entry in 0.5% ratio, logotype 3 days, the increase of searching for food, the obvious minimizing of Hakuri is used 2 days again, transference cure, the course of disease is controlled.Concrete condition sees the following form:
| Group | Mortality rate/% | Inefficiency % | Effective percentage % | Cure rate % | Experiment has symptom chicken number when finishing |
| Infect contrast | 22.3 (67/300) | / | / | / | 72 |
| Antibacterial combination high dose group (1.0%) | 1.3 (4/300) | 1.3 | 98.7 | 98 | 2 |
| Dosage group (0.5%) in the antibacterial combination | 1.6 (5/300) | 1.6 | 98.4 | 97.0 | 4 |
| Antibacterial combination low dose group (0.1%) | 2.3 (7/300) | 2.3 | 97.7 | 96.0 | 5 |
| The florfenicol powder matched group | 1.3 (4/300) | 1.3 | 98.7 | 97.3 | 4 |
Laboratory test:
This antibacterials has a broad antifungal spectrum suppresses and killing action various bacteria is had during plantation dosage,
Concrete condition sees the following form:
| Group | Mortality rate/% | Inefficiency % | Effective percentage % | Cure rate % | Experiment has symptom chicken number when finishing |
| The staphylococcus group | 3(9/300) | 3.0 | 97.0 | 94.7 | 7 |
| The dysentery bacterium group | 2.3 (7/300) | 2.3 | 97.7 | 95.7 | 6 |
| The vibrio cholera group | 2.3 (7/300) | 2.3 | 97.7 | 94.7 | 9 |
| The pasteurellosis bacillus group | 2.7 (8/300) | 2.7 | 97.3 | 95.7 | 5 |
Although the disclosed a kind of birds Chinese medicine antibacterial combination and preparation method thereof that relates to has been carried out special description with reference to embodiment, embodiment described above is illustrative and not restrictive, under the situation that does not break away from the spirit and scope of the present invention, all variations and modification are all within the scope of the present invention.
Claims (3)
1, a kind of birds Chinese medicine antibacterial combination is characterized in that: made by following raw material by weight: Radix Paeoniae Alba 5-18 part, Radix Angelicae Sinensis 3-12 part, Radix Pulsatillae 3-22 part, Cortex Phellodendri 5-20 part, Radix Aucklandiae 5-17 part.
2, a kind of preparation method of birds Chinese medicine antibacterial combination is characterized in that comprising the steps:
(1) Radix Paeoniae Alba, Radix Angelicae Sinensis, the Radix Pulsatillae, Cortex Phellodendri, the Radix Aucklandiae are pulverized, crossed the 10-80 mesh sieve;
(2) accurately weighing by weight: Radix Paeoniae Alba 5-18 part, Radix Angelicae Sinensis 3-12 part, Radix Pulsatillae 3-22 part, Cortex Phellodendri 5-20 part, Radix Aucklandiae 5-17 part;
(3) extract more than 12-48 hour with the soak with ethanol of above composition weight 3-10 20-80% doubly earlier, cross the leaching supernatant, obtain extracting solution one time;
(4) then with composition weight 1-5 doubly the ethanol of above 10-60% carry out second extraction, the time crossed the leaching supernatant at 12-48 hour, obtained secondary raffinate;
(5) merge extracted twice liquid and promptly make Chinese medicine antibacterial combination of the present invention.
3, the preparation method of birds Chinese medicine antibacterial combination according to claim 2, it is characterized in that merging extracted twice liquid after, it is 1.0-2.0 that extracting solution is concentrated into density.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100137141A CN1879736B (en) | 2006-05-16 | 2006-05-16 | Antibacterial Chinese medicinal composition for birds and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100137141A CN1879736B (en) | 2006-05-16 | 2006-05-16 | Antibacterial Chinese medicinal composition for birds and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1879736A true CN1879736A (en) | 2006-12-20 |
| CN1879736B CN1879736B (en) | 2010-11-03 |
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| CN2006100137141A Expired - Fee Related CN1879736B (en) | 2006-05-16 | 2006-05-16 | Antibacterial Chinese medicinal composition for birds and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102716240A (en) * | 2012-06-15 | 2012-10-10 | 李良 | Pulsatilla traditional Chinese medicine decoction for treating dysentery and preparation method of decoction |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321472A (en) * | 2000-04-29 | 2001-11-14 | 陈江辉 | Medicinal tea for curing bacillary dysentery and its preparation method |
| CN1176684C (en) * | 2002-01-30 | 2004-11-24 | 王福田 | 'Jiwenning' for treating chicken pest and its preparing process |
| CN1218654C (en) * | 2002-09-19 | 2005-09-14 | 田洪沛 | Natural nutrient for egg-laying poultry and use method thereof |
| CN1217690C (en) * | 2003-05-08 | 2005-09-07 | 林少彬 | Chinese medicine for treating bacillary dysentery and producing method thereof |
-
2006
- 2006-05-16 CN CN2006100137141A patent/CN1879736B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102688305B (en) * | 2012-06-11 | 2013-12-25 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102716240A (en) * | 2012-06-15 | 2012-10-10 | 李良 | Pulsatilla traditional Chinese medicine decoction for treating dysentery and preparation method of decoction |
| CN102716240B (en) * | 2012-06-15 | 2013-09-18 | 李良 | Pulsatilla traditional Chinese medicine decoction for treating dysentery and preparation method of decoction |
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| Publication number | Publication date |
|---|---|
| CN1879736B (en) | 2010-11-03 |
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Owner name: TIANJIN CITY VIGOR BIOENGINEERING CO., LTD. Free format text: FORMER OWNER: TIANJIN SHENGJI GROUP CO., LTD. Effective date: 20120921 |
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Effective date of registration: 20120921 Address after: 301609, Tianjin County, Dafeng County, Jinghai province historians Village Patentee after: Tianjin Vigor Bio-Engineering Co., Ltd. Address before: 301609. 2, Tianyu Science Park, Jinghai, Tianjin Patentee before: Tianjin Shengji Group Co., Ltd. |
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Granted publication date: 20101103 Termination date: 20140516 |