CN1879644A - Use of actiin in preparation of anti-inflammatory drug - Google Patents
Use of actiin in preparation of anti-inflammatory drug Download PDFInfo
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- CN1879644A CN1879644A CN 200510035169 CN200510035169A CN1879644A CN 1879644 A CN1879644 A CN 1879644A CN 200510035169 CN200510035169 CN 200510035169 CN 200510035169 A CN200510035169 A CN 200510035169A CN 1879644 A CN1879644 A CN 1879644A
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- arctiin
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- inflammatory drug
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Abstract
The invention relates to the use of arctiin in preparing anti-inflammatory medicament, more specifically to the use in preparing medicament for the treatment or prevention of infectious or non-infectious inflammations caused by various reasons. The preferred administration mode is oral administration.
Description
Technical field
The present invention relates to medical technical field, exactly is the purposes of arctiin aspect the preparation anti-inflammatory drug.
Background technology
Fructus Arctii is the fruit of feverfew Fructus Arctii (Arctium lappa L.), and head is stated from " Bencao Tujing ".Fructus Arctii is cool in nature, acrid in the mouth is bitter, has dispelling wind and heat pathogens, the lung qi dispersing rash, and effects such as subduing swelling and detoxicating, with controlling the cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule is not saturating, and rubella is had an itch, diseases such as carbuncle sore tumefacting virus.Wherein arctiin is one of Main Ingredients and Appearance, and the arctiin hydrolyzable is an arctigenin, about both activity report following several respects is arranged: 1, antitumor action; 2) immunoregulation effect; 3) hypoglycemic activity.This three aspects pharmacological action is the result show: arctigenin is main active ingredient.Then do not appear in the newspapers for the arctiin antiinflammatory action.
Summary of the invention
The invention provides the application of arctiin in the preparation anti-inflammatory drug.Infectivity that causes at preparation treatment or prevention a variety of causes and the application in the non-infectious inflammation medicine particularly.
Arctiin using dosage of the present invention is 600mg～1800mg/ day, and preferred dose is 1200mg～1800mg/ day.
The present invention has proved the purposes of arctiin by following embodiment, but is not limited thereto.
The specific embodiment:
Test example 1: the influence of arctiin xylol induced mice auricle edema
1. divide into groups and method
Get 50 of Kunming kind white mice, be divided into 5 groups at random.Normal control group (waiting the normal saline of capacity), arctiin high dose group (iv, 300mg/kg), middle dosage group (iv, 200mg/kg), low dose group (iv, 100mg/kg), the indomethacin positive controls (iv, 20mg/kg).Behind the administration 1h, evenly be coated with dimethylbenzene 30 μ l in the wide both sides of auris dextra, left ear contrast is put to death after causing scorching 2h, cuts two auricles, gets the auricle weighing with the 8mm card punch, and of poor quality with two auricles is the swelling degree.
2. result
All can significantly suppress the auricle edema that dimethylbenzene causes by the visible arctiin (100mg/kg, 200mg/kg, 300mg/kg) of table 1, indomethacin.
Table 1 arctiin xylol cause mice auricle swelling influence (x ± s, n=10)
| Group | Dosage (mg/kg) | Swelling degree (mg) |
| Normal control group arctiin indomethacin group | - 100 200 300 20 | 9.58±2.80 4.78±2.71* 4.13±2.85* 3.38±1.09** 5.75±2.89* |
Annotate: compare * P＜0.05 with matched group, * * P＜0.01,
Test example 2: the arctiin Dichlorodiphenyl Acetate brings out the influence of mice capillary permeability
1. divide into groups and method
It is the same to divide into groups.Behind the administration 1h, the tail vein injects 0.5% according to civilian blue 5ml/kg, 5min pneumoretroperitoneum injection (ip) 0.7% acetic acid 10ml/kg, taking off cervical vertebra behind the 30min puts to death, cut open the belly and repeatedly wash the abdominal cavity with distilled water, it is centrifugal that flushing liquor is diluted to 10.0ml, gets supernatant in 721 spectrophotometer 610nm place's photometry density (D), in D value permeability.
3 results
The result shows: middle and high dosage group of arctiin and indomethacin can significantly suppress the increase that acetic acid causes the mouse peritoneal capillary permeability.
Table 2 arctiin salt Dichlorodiphenyl Acetate cause the mice capillary permeability influence (x ± s, n=10)
| Group | Dosage (mg/kg) | Comply with civilian blue concentration (μ g/ml) in the eluent |
| Normal control group arctiin indomethacin group | - 100 200 300 20 | 5.50±1.34 4.99±1.71 3.14±1.66* 2.59±1.18* 1.90±0.89* |
Annotate: compare * P＜0.05 with matched group.
Claims (5)
1. the invention provides the application of arctiin in the preparation anti-inflammatory drug.Infectivity that causes at preparation treatment or prevention a variety of causes and the application in the non-infectious inflammation medicine particularly.
2. application according to claim 1, its dosage are 500mg～2000mg.
3. application according to claim 2, its dosage range are preferably 1000mg～1800mg/ day.
4. according to the described application of claim 1-3, its administering mode is oral administration, intramuscular injection or intravenously administrable (comprising intravenous injection and intravenous drip).
5. application according to claim 4, route of administration is preferably oral administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510035169 CN1879644A (en) | 2005-06-13 | 2005-06-13 | Use of actiin in preparation of anti-inflammatory drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510035169 CN1879644A (en) | 2005-06-13 | 2005-06-13 | Use of actiin in preparation of anti-inflammatory drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1879644A true CN1879644A (en) | 2006-12-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510035169 Pending CN1879644A (en) | 2005-06-13 | 2005-06-13 | Use of actiin in preparation of anti-inflammatory drug |
Country Status (1)
| Country | Link |
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| CN (1) | CN1879644A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859804A (en) * | 2016-04-27 | 2016-08-17 | 江西普正制药有限公司 | Eucommia ulmoides extract as well as preparation method and application thereof |
| CN108601762A (en) * | 2016-02-08 | 2018-09-28 | 客乐谐控股株式会社 | Inflammatory body activates inhibitor |
| CN111514132A (en) * | 2019-02-01 | 2020-08-11 | 鲁南制药集团股份有限公司 | Composition with effect of preventing and treating furuncle and carbuncle |
-
2005
- 2005-06-13 CN CN 200510035169 patent/CN1879644A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601762A (en) * | 2016-02-08 | 2018-09-28 | 客乐谐控股株式会社 | Inflammatory body activates inhibitor |
| CN105859804A (en) * | 2016-04-27 | 2016-08-17 | 江西普正制药有限公司 | Eucommia ulmoides extract as well as preparation method and application thereof |
| CN111514132A (en) * | 2019-02-01 | 2020-08-11 | 鲁南制药集团股份有限公司 | Composition with effect of preventing and treating furuncle and carbuncle |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20061220 |