CN111514132A - Composition with effect of preventing and treating furuncle and carbuncle - Google Patents
Composition with effect of preventing and treating furuncle and carbuncle Download PDFInfo
- Publication number
- CN111514132A CN111514132A CN202010058336.9A CN202010058336A CN111514132A CN 111514132 A CN111514132 A CN 111514132A CN 202010058336 A CN202010058336 A CN 202010058336A CN 111514132 A CN111514132 A CN 111514132A
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- China
- Prior art keywords
- cosmetic
- carbuncle
- furuncle
- composition
- arctigenin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The invention belongs to the field of medicines, and particularly relates to a composition with a function of preventing and treating furuncle and carbuncle. The composition provided by the invention not only has a remarkable treatment effect on local symptoms of furuncle and carbuncle, but also can quickly relieve general symptoms caused by the furuncle and the carbuncle, can effectively reduce the use of antibiotic medicines, has a special curative effect, also has a remarkable treatment effect on repeatedly-occurring and unhealed furunculosis, and has a very good development and application value.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a composition with a function of preventing and treating furuncle and carbuncle.
Background
Furuncle and carbuncle are acute bacterial suppurative inflammation of one or more adjacent hair follicles and surrounding tissues, lesions usually involve deep subcutaneous connective tissues and can be found in any part, and the clinical manifestations of the furuncle have red, swollen, hot and painful symptoms, the course of disease is short, and the furuncle and carbuncle have the characteristics of easy pus discharge, easy ulcer and easy astringency, such as no treatment and wrong treatment, persistent and untreatable disease, easy yellowing or invagination and life threatening.
Most of furuncle carbuncle does not have obvious systemic symptoms at the initial stage, but if the resistance level of a diseased receptor is low and the blood is relatively rich, various toxic and bloody symptoms including chilly, fever, anorexia and dizziness can be induced in a short time, particularly, for the furuncle carbuncle at the periphery of the upper lip and the position of the nasal wing, if the furuncle carbuncle is extruded or punctured by external force, infection diffusion can be caused to cause intracranial suppurative cavernous phlebitis, and the progressive red swelling symptom of peripheral tissues is generated, at the moment, antibiotics are needed to be used for systemic treatment, and certain mortality rate is caused if the treatment is not timely. Therefore, how to timely perform treatment intervention on a patient suffering from furuncle and carbuncle and adopt reasonable nursing measures has important values for treating and intervening the disease and improving the cure rate of the disease.
The fructus Arctii is dried mature fruit of two-year-old plant of Compositae, and is traditional Chinese medicine of China. Arctigenin is a main active ingredient extracted from fructus arctii, and is a plant-derived lignan compound. Research shows that the compound has biological activities of anti-inflammation, immunoregulation, antivirus, antitumor, neuroprotection and the like.
Disclosure of Invention
The invention provides a composition with a remarkable treatment effect on furuncle and carbuncle, which takes arctigenin as a main active ingredient.
The invention provides a pharmaceutical preparation containing the composition.
Preferably, the pharmaceutical preparation may be an oral preparation or an external preparation.
More preferably, the oral preparation can be tablets, capsules, granules, pills, powder or oral liquid; the external preparation is liniment, cream or gel.
The preparation contains arctigenin as main active ingredient, and pharmaceutically acceptable adjuvants.
The invention provides cosmetics containing the composition, and the composition can be prepared into cosmetics with a function of preventing and treating furuncle and carbuncle together with auxiliary materials which are allowed to be added into the cosmetics.
The cosmetic is astringent, cosmetic lotion, essence, facial mask, face cleaning lotion or skin cream.
Preferably, the cosmetic is a skin cream.
The cosmetic contains arctigenin as main active ingredient, and adjuvants which can be added into cosmetic.
The content of arctigenin in the cosmetic provided by the invention is 0.01-10 wt%.
The cosmetic provided by the invention not only has a remarkable treatment effect on furuncle and carbuncle, but also can be used as a daily skin care product, has the effects of increasing cell activity, improving skin color and maintaining and moistening skin, can also have a prevention effect on furuncle and carbuncle, and is particularly suitable for being used as a daily skin care product for patients with diabetes and severe systemic skin diseases.
The pharmaceutical preparation and the cosmetics provided by the invention can be used together, and can play a role in enhancing the curative effect under the condition of two ducts.
The invention tests the curative effect of the pharmaceutical preparation and the cosmetics through clinical tests and typical cases. The results of clinical trials show that: when the cosmetic provided by the invention is used for treating furuncle and carbuncle, the cosmetic not only has the characteristics of obvious curative effect and quick response, but also can reduce the incidence rate of adverse reactions, reduce the occurrence of general symptoms and obviously improve skin pigmentation caused by furuncle and carbuncle. Typical case results show that: when the oral medicine provided by the invention is combined with the skin cream to treat furuncle and carbuncle, the local symptoms can be quickly relieved through detumescence and analgesic treatment, the general symptoms such as chilliness and fever can be remarkably relieved, and the application of antibiotics medicines is reduced.
Compared with the prior art, the composition provided by the invention has the following advantages when used for treating furuncle and carbuncle:
1. has obvious effect and quick response
When the composition provided by the invention is used for treating furuncle and carbuncle, the composition not only has the characteristics of obvious curative effect and quick response, but also can reduce the incidence rate of adverse reactions and reduce the occurrence of general symptoms; when the general symptoms occur due to improper treatment, the general symptoms can be relieved, so that the use of antibiotics is reduced.
2. Special effects
The composition provided by the invention not only has a remarkable treatment effect on the repeated furunculosis, but also has a function of preventing relapse of the furunculosis.
3. Is safe and nontoxic
The arctigenin serving as a main active substance in the composition provided by the invention is a natural product extracted from traditional Chinese medicines, and has the characteristics of safety and no toxicity compared with the existing antibiotic medicines.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The present invention is further illustrated below by specific examples in order to provide those skilled in the art with a full understanding of the present invention, but it should be understood by those skilled in the art that the examples of the present invention are not to be construed as limiting the present invention in any way.
Formulation examples
Example 1 arctigenin tablet
The preparation process comprises the following steps: arctigenin is dissolved in diethylene glycol monoethyl ether, hydroxypropyl cellulose is added, stirring is carried out to dissolve, then diatomite with the amount according to the prescription is added for adsorption, and then the mixture is uniformly mixed with lactose, sodium carboxymethyl starch and magnesium stearate and is pressed by adopting a direct tabletting process to prepare the tablet.
Example 2 arctigenin capsule preparation
The preparation process comprises the following steps: mixing 100g of arctigenin, 120g of lactose and 130g of corn starch in a mixer for 10-15 minutes, adding 5g of magnesium stearate, mixing for 1-3 minutes, and filling into 1000-grain capsule shells.
Example 3 Arctiin oral liquid
The preparation process comprises the following steps: putting the nipagin methyl ester and the ethanol with the prescription amount into a proper container, adding the arctigenin with the prescription amount, heating in water bath to dissolve the arctigenin, dissolving the sodium benzoate, the essence and the cane sugar with a small amount of water with the prescription amount, adding the dissolved solution into the medicine-containing mixed solution, adding water to full amount, stirring uniformly, filtering, subpackaging and sterilizing to obtain the medicine.
Example 4 arctigenin liniment
Distilled water was added to 1000ml while adjusting the pH to 6.5 with an appropriate amount of 10% sodium hydroxide solution.
The preparation process comprises the following steps: at normal temperature and pressure, 10g of arctigenin is weighed, dissolved in a proper amount of distilled water, and added according to the mixture ratio of each component in the prescription, namely 350g of glycerol, 10g of urea, 16ml of 5% benzalkonium bromide solution (or 0.8g of benzalkonium bromide) and 5g of sodium chloride. Finally, a proper amount of distilled water is added to 1000ml, the mixture is fully mixed, and meanwhile, a proper amount of 10% sodium hydroxide solution is used for adjusting the pH value to 6.5.
Example 5 Arctiin cream
The preparation process comprises the following steps: weighing arctigenin and the above adjuvants according to the prescription amount, mixing, stirring, sterilizing, and packaging.
Example 6 arctigenin gel
The preparation process comprises the following steps: weighing arctigenin and the above adjuvants according to the prescription amount, mixing, stirring, sterilizing, and packaging.
Cosmetic examples
Skin cream examples
Mixing the above components in a certain order and by a certain preparation process.
In addition, the skin cream with different contents and the same function can be prepared by adjusting the content of the arctigenin.
The other cosmetics such as astringent, cosmetic emulsion, essence, facial mask, facial cleanser and the like are prepared by taking arctigenin as a main active ingredient and auxiliary materials allowed to be added into the cosmetics according to a certain proportion.
Report of clinical trials
1. General data
During the period from 1 month to 2 months in 2017, 50 patients with furuncle and carbuncle are selected as study objects, and all the patients are diagnosed as furuncle and carbuncle. The groups were divided according to the digital random table method, and 25 cases were used for the control group and 25 cases were used for the treatment group. In 25 patients in the control group, 13 men and 12 women have the ages of 20-53 years, and the diameters of the red and swollen areas of furuncle and carbuncle are 4.0-10.0 cm; in 25 patients in the treatment group, 12 men and 13 women have the age of 22-56 years old, and the range of red and swollen furuncle and carbuncle is 3.0-10.0 cm in diameter. The comparison between the two groups of patients' basic data has no statistical significance (P >0.05) and is comparable.
2. Method of producing a composite material
Control group 25 patients in the control group were treated by compound purslane ointment administration according to the conventional application method. During application, attention is required: the area of the second dressing change is required to be larger than that of the previous dressing, and the dressing can be applied for the second time after the previous dressing is completely cleaned.
Treatment group 25 patients were treated with the skin cream of the cosmetic example of the present invention. The specific scheme is as follows: firstly, ethanol solution with the concentration of 75.0 percent is used for thoroughly disinfecting a furuncle and carbuncle area and a red and swollen part around the furuncle and carbuncle area, and then the cosmetics provided by the invention are applied. The coating amount needs to ensure that the coating thickness reaches more than 1.0 mm. For the patients with red swelling diameter of furuncle and carbuncle of more than 6.0cm, the treatment of applying medicine is not carried out within 1.6cm of the central area. Aiming at the patients with the coarse furuncle, carbuncle and red swelling diameter within 6.0cm, a certain area is reserved in the central area properly according to the furuncle and carbuncle conditions without medicine application treatment. For patients with pus head ulceration, the external pus and the pus suppository are thoroughly removed before applying the medicine. The frequency of application was 1 time/d. The secondary smearing area needs to be larger than the previous area, and the secondary smearing area needs to be carried out after the previous complete cleaning.
3. Observation index
The time of recovery and the occurrence of complications during the period of drug application treatment of two groups of patients are compared and observed.
After the healing, the ointment is continuously used, and the ulcer scabbing after the discharge of the pustule and the improvement condition of the pigmentation after the scabbing are observed.
The same person, the same camera, the same light source, the same distance and the photographing parameters are adopted. In the double-blind situation, the pre-and post-treatment photographs of the patient were compared by 3 experienced plastic surgeons. Evaluation was carried out according to 4-grade standard established by the pigment pathology group of the national association of Chinese and western medicine in 1998: (1) the basic cure is as follows: the fading area of the color spot is more than 90 percent through naked eye observation, and the color of the color spot basically disappears; (2) the effect is shown: the area of fading of the color spot is more than 60 percent through naked eye observation, and the color of the color spot is obviously lightened; (3) the method has the following advantages: the area of fading of the color spot is more than 30 percent through naked eye observation, and the color of the color spot is lightened; (4) and (4) invalidation: the area of the fading of the color spot was observed with naked eyes to be less than 30%, and the color change was not obvious.
4. Statistical treatment
Statistical analysis is carried out on the obtained data by adopting SPSS 17.0 software, the measured data is expressed by mean +/-standard deviation (x +/-s), and t test is adopted for comparison; the count data is expressed in terms of rate (%) and the confidence comparison is carried out in terms of χ2Test, interval 95%, P<A difference of 0.05 is statistically significant.
5. Results
By using the cosmetic provided by the invention, the healing time of patients in a treatment group is obviously shorter than that of a control group, the incidence rate of adverse reactions in the treatment period is obviously lower than that of the control group, and the differences have statistical significance (P <0.05), and are detailed in tables 1 and 2.
TABLE 1 comparison of the time between application and recovery (d) for two groups of patients
Group of | n | The diameter is less than or equal to 6.0cm | Diameter of>6.0cm |
Control group | 25 | 5.7±0.3 | 7.0±0.6 |
Treatment group | 25 | 3.9±0.5 | 5.4±0.8 |
TABLE 2 adverse reaction during the drug application treatment period of two groups of patients
Group of | n | Aversion to cold and fever (example) | Dizziness (example) | Total example (%) |
Control group | 25 | 2(8%) | 1(4%) | 3(12%) |
Treatment group | 25 | 0 | 0 | 0 |
As can be seen from the results in tables 1 and 2, when the cosmetic provided by the invention is used for treating furuncle and carbuncle, the cosmetic not only has the characteristics of obvious curative effect and quick response, but also can reduce the incidence rate of adverse reactions and reduce the occurrence of systemic symptoms, thereby reducing the use of antibiotics.
After recovery, the pigmentation of the treatment group is obviously improved by continuously using the cosmetic provided by the invention, and the result is obviously different from that of the control group (P <0.05), and the specific result is shown in table 3.
TABLE 3 comparison of pigmentation in two groups of patients
Group of | n | Cure of disease | Show effect | Is effective | Invalidation | Total effective |
Control group | 25 | 0 | 5(20%) | 8(32%) | 12(48%) | 31(52%) |
Treatment group | 25 | 16(64%) | 6(24%) | 2(8%) | 1(4%) | 37(96%) |
Table 3 the results show that: the cosmetic disclosed by the invention has a remarkable treatment effect on furuncle and carbuncle and can remarkably improve skin pigmentation caused by the occurrence of the furuncle and the carbuncle.
Typical cases
1. Wangzhi, Man, 32 years old, Shandong Linyi. The red and swollen plaque is found at the eyebrow tip part of the right face, the eyebrow tip part is accompanied with heat and pain, the surface is smooth, the edge is limited and gradually enlarged, the eyebrow tip part starts to be suppurated at the 5 th day, the eyebrow tip part is extruded as acne by mistake, the eyelid and the right face appear red and swollen at the next day, and general symptoms such as chill, fever, nausea and the like appear.
2. Du Chi, male, 22 years old, Shandong Jinan. Conical inflammatory papules appear on the top of the head, the base is hard and is accompanied with red, swelling, heat and pain, 3-5 different parts appear successively on the next day, the centers of nodules become soft after several days, yellow and white punctate pustules appear on the tops, the pustules are removed carelessly due to the squeezing effect when clothes are taken off on a certain day, the red swelling is aggravated, mupirocin ointment is used for smearing, the inflammation disappears after several days, but similar papules with different sizes appear successively on adjacent parts, the work and the interaction of the papules are seriously influenced, then the ointment provided by the invention is used for the second day, the pain is relieved, the inflammation disappears after the 3 rd day, the pustules are well healed after being discharged, pigment precipitation is avoided, new papules are not recurred, and the treatment effect of a patient is very satisfactory.
Claims (10)
1. A composition with the function of preventing and treating furuncle and carbuncle is characterized in that the composition takes arctigenin as a main active ingredient.
2. A pharmaceutical formulation comprising the composition of claim 1.
3. The pharmaceutical formulation of claim 2, wherein the pharmaceutical formulation is an oral formulation or an external formulation.
4. The pharmaceutical preparation according to claim 3, wherein the oral preparation is a tablet, capsule, granule, pill, powder or oral liquid; the external preparation is liniment, cream or gel.
5. The pharmaceutical formulation of claim 4, further comprising pharmaceutically acceptable excipients.
6. A cosmetic comprising the composition of claim 1.
7. The cosmetic according to claim 6, wherein the cosmetic is a lotion, a milky lotion, a essence, a pack, a face wash or a skin cream.
8. The cosmetic of claim 7, wherein the cosmetic is a skin cream.
9. The cosmetic of claim 6, wherein the cosmetic further comprises auxiliary materials which are acceptable for addition to the cosmetic.
10. The cosmetic according to any one of claims 6 to 8, wherein the arctigenin is contained in an amount of 0.01 to 10 wt%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201910105037 | 2019-02-01 | ||
CN2019101050373 | 2019-02-01 |
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CN111514132A true CN111514132A (en) | 2020-08-11 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1879644A (en) * | 2005-06-13 | 2006-12-20 | 海口绿科南药研究开发有限公司 | Use of actiin in preparation of anti-inflammatory drug |
US20070166255A1 (en) * | 2004-11-22 | 2007-07-19 | Gupta Shyam K | Treatment of Topical Discomforts Including Acne, Sunburn, Diaper Rash, Wound, Wrinkles and Dandruff/Hair Loss by Natural Lignans via Fatty Acid Desaturase Inhibition |
CN101578092A (en) * | 2007-02-28 | 2009-11-11 | 高丽雅娜化妆品股份有限公司 | Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient |
CN103622952A (en) * | 2012-08-26 | 2014-03-12 | 鲁南制药集团股份有限公司 | Application of arctigenin in preparation of anti-infectious immunity drugs |
CN104220041A (en) * | 2012-03-30 | 2014-12-17 | 乐敦制药株式会社 | Anti-aging agent containing arctigenin derivative |
CN108601762A (en) * | 2016-02-08 | 2018-09-28 | 客乐谐控股株式会社 | Inflammatory body activates inhibitor |
-
2020
- 2020-01-19 CN CN202010058336.9A patent/CN111514132A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070166255A1 (en) * | 2004-11-22 | 2007-07-19 | Gupta Shyam K | Treatment of Topical Discomforts Including Acne, Sunburn, Diaper Rash, Wound, Wrinkles and Dandruff/Hair Loss by Natural Lignans via Fatty Acid Desaturase Inhibition |
CN1879644A (en) * | 2005-06-13 | 2006-12-20 | 海口绿科南药研究开发有限公司 | Use of actiin in preparation of anti-inflammatory drug |
CN101578092A (en) * | 2007-02-28 | 2009-11-11 | 高丽雅娜化妆品股份有限公司 | Cosmetic composition for skin whitening comprising arctiin, arctigenin or the mixture thereof as active ingredient |
CN104220041A (en) * | 2012-03-30 | 2014-12-17 | 乐敦制药株式会社 | Anti-aging agent containing arctigenin derivative |
CN103622952A (en) * | 2012-08-26 | 2014-03-12 | 鲁南制药集团股份有限公司 | Application of arctigenin in preparation of anti-infectious immunity drugs |
CN108601762A (en) * | 2016-02-08 | 2018-09-28 | 客乐谐控股株式会社 | Inflammatory body activates inhibitor |
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