CN1875028B - 基于 Seneca Valley 病毒的组合物以及疾病的治疗方法 - Google Patents

基于 Seneca Valley 病毒的组合物以及疾病的治疗方法 Download PDF

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CN1875028B
CN1875028B CN200480030443XA CN200480030443A CN1875028B CN 1875028 B CN1875028 B CN 1875028B CN 200480030443X A CN200480030443X A CN 200480030443XA CN 200480030443 A CN200480030443 A CN 200480030443A CN 1875028 B CN1875028 B CN 1875028B
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tumor
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CN1875028A (zh
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保罗·L·哈伦贝克
卡尔·M·哈伊
尚西·加内什
塞希达·雷迪·波利斯
徐玲
杨敬平
程诚
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Novartis AG
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CN200480030443XA 2003-09-26 2004-09-23 基于 Seneca Valley 病毒的组合物以及疾病的治疗方法 Expired - Lifetime CN1875028B (zh)

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US50618203P 2003-09-26 2003-09-26
US60/506,182 2003-09-26
PCT/US2004/031504 WO2005030139A2 (en) 2003-09-26 2004-09-23 Seneca valley virus based compositions and methods for treating disease

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CN1875028A CN1875028A (zh) 2006-12-06
CN1875028B true CN1875028B (zh) 2012-07-04

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EP (1) EP1668025B1 (https=)
JP (1) JP2007506434A (https=)
KR (1) KR20060103890A (https=)
CN (1) CN1875028B (https=)
AU (1) AU2004275832A1 (https=)
BR (1) BRPI0414810A (https=)
CA (1) CA2540177A1 (https=)
DK (1) DK1668025T3 (https=)
IL (1) IL174430A0 (https=)
MX (1) MXPA06003318A (https=)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
US7638318B2 (en) * 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
WO2007047256A2 (en) * 2005-10-13 2007-04-26 Neotropix, Inc. Svv-based animal vaccines and uses thereof
CN108601802A (zh) 2015-12-02 2018-09-28 纪念斯隆-凯特林癌症中心 塞尼卡谷病毒（svv）细胞受体靶向的肿瘤治疗
CN105925728B (zh) * 2016-06-01 2019-09-20 华南农业大学 一种塞内加谷病毒实时荧光定量pcr检测引物及试剂盒
US10323069B2 (en) * 2016-08-23 2019-06-18 Regents Of The University Of Minnesota Senecavirus A antigens and methods of use
AU2018301701A1 (en) * 2017-07-14 2020-02-27 Elevatebio Technologies, Inc. Encapsulated polynucleotides and methods of use
CN109627293B (zh) * 2017-08-13 2021-02-09 中牧实业股份有限公司 塞尼卡谷病毒结构蛋白抗原表位多肽及其应用
CN107513524B (zh) * 2017-09-30 2021-02-09 中牧实业股份有限公司 一株猪塞内加谷病毒毒株及其应用
CN108467904B (zh) * 2018-05-24 2021-11-19 华南农业大学 检测塞尼卡谷病毒的rt-lamp引物组、试剂盒及应用
CN109182278B (zh) * 2018-10-12 2021-08-06 河南省动物疫病预防控制中心 塞尼卡谷病毒毒株及其应用
EP3880812A4 (en) * 2018-11-13 2022-09-07 Oncorus, Inc. ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE
CN109234464A (zh) * 2018-11-23 2019-01-18 山东新希望六和集团有限公司 用于检测塞尼卡谷病毒的引物及探针、荧光定量pcr试剂盒及方法和应用
CN111733144A (zh) * 2019-03-25 2020-10-02 金宇保灵生物药品有限公司 一种塞内卡病毒的纯化方法及病毒液的浓缩纯化方法
CN112433049B (zh) * 2019-06-24 2023-08-18 中国动物疫病预防控制中心(农业农村部屠宰技术中心) 检测塞内卡病毒抗体的试剂及其应用
AU2020315800A1 (en) 2019-07-19 2022-03-03 Seneca Therapeutics, Inc. Second generation seneca valley virus oncolytic therapy: compositions and methods thereof
CN110923211A (zh) * 2019-12-25 2020-03-27 哈药集团生物疫苗有限公司 塞内卡病毒分离株、塞内卡病毒病灭活疫苗及其制备方法
CN111286491A (zh) * 2020-02-03 2020-06-16 河南省动物疫病预防控制中心 猪塞内卡病毒核酸标准物及其应用
CN111849925B (zh) * 2020-07-06 2022-06-03 马忠仁 一种抗结肠癌疫苗及其制法
CN111798712B (zh) * 2020-07-15 2021-10-29 周晓庆 噬菌体侵染细菌3d智能模拟方法
CN111944764A (zh) * 2020-08-31 2020-11-17 信阳农林学院 一种表达猪塞内加谷病毒蛋白的细胞系、构建方法和应用
CN112390861A (zh) * 2020-09-30 2021-02-23 信阳农林学院 表达猪塞内加谷病毒vp1蛋白的细胞系、构建方法和应用
CN117281824B (zh) * 2023-08-11 2025-10-21 华南农业大学 Trim基因的过表达剂在制备抑制猪塞内卡病毒复制的产品中的应用
CN117487006B (zh) * 2023-12-29 2024-04-12 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种抗a型塞内卡病毒的单克隆抗体以及抗原表位及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008692A1 (en) * 1997-08-13 1999-02-25 Oncolytics Biotech, Inc. Reovirus for the treatment of neoplasia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008692A1 (en) * 1997-08-13 1999-02-25 Oncolytics Biotech, Inc. Reovirus for the treatment of neoplasia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Russell S.J..RNA viruses as virotherapy agents.《Cancer Gene Therapy》.2002,第9卷961-966. *

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KR20060103890A (ko) 2006-10-04
IL174430A0 (en) 2006-08-01
SG149069A1 (en) 2009-01-29
HK1094583A1 (en) 2007-04-04
EP1668025B1 (en) 2014-06-25
BRPI0414810A (pt) 2006-11-14
WO2005030139A3 (en) 2005-10-20
WO2005030139A2 (en) 2005-04-07
DK1668025T3 (da) 2014-08-25
MXPA06003318A (es) 2006-06-08
CN1875028A (zh) 2006-12-06
EP1668025A2 (en) 2006-06-14
CA2540177A1 (en) 2005-04-07
EP1668025A4 (en) 2007-05-16
JP2007506434A (ja) 2007-03-22
AU2004275832A1 (en) 2005-04-07

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