CN1875004B - 那维啶酰胺衍生物的拆分 - Google Patents

那维啶酰胺衍生物的拆分 Download PDF

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Publication number
CN1875004B
CN1875004B CN2004800276266A CN200480027626A CN1875004B CN 1875004 B CN1875004 B CN 1875004B CN 2004800276266 A CN2004800276266 A CN 2004800276266A CN 200480027626 A CN200480027626 A CN 200480027626A CN 1875004 B CN1875004 B CN 1875004B
Authority
CN
China
Prior art keywords
bromoamide
mixed solution
galantamine
formula
racemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800276266A
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English (en)
Chinese (zh)
Other versions
CN1875004A (zh
Inventor
乔治·施勒默
萧宗育
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scinopharm Taiwan Ltd
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34393160&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1875004(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of CN1875004A publication Critical patent/CN1875004A/zh
Application granted granted Critical
Publication of CN1875004B publication Critical patent/CN1875004B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2004800276266A 2003-09-26 2004-09-27 那维啶酰胺衍生物的拆分 Expired - Fee Related CN1875004B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50646903P 2003-09-26 2003-09-26
US60/506,469 2003-09-26
PCT/US2004/031936 WO2005030713A2 (en) 2003-09-26 2004-09-27 Resolution of a narwedine amide derivative

Publications (2)

Publication Number Publication Date
CN1875004A CN1875004A (zh) 2006-12-06
CN1875004B true CN1875004B (zh) 2010-06-23

Family

ID=34393160

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800276266A Expired - Fee Related CN1875004B (zh) 2003-09-26 2004-09-27 那维啶酰胺衍生物的拆分

Country Status (9)

Country Link
US (1) US7307162B2 (enExample)
EP (1) EP1670767B2 (enExample)
JP (1) JP5020633B2 (enExample)
CN (1) CN1875004B (enExample)
AU (1) AU2004276354B2 (enExample)
CA (1) CA2540248C (enExample)
IL (1) IL174551A0 (enExample)
NZ (1) NZ546768A (enExample)
WO (1) WO2005030713A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US7985879B2 (en) * 2007-04-12 2011-07-26 Scinopharm Taiwan Ltd. Process for making galantamine
ES2463715T3 (es) 2008-04-14 2014-05-29 Neurodyn Life Sciences Inc. Derivados de galantamina como profármacos para el tratamiento de enfermedades del cerebro humano
WO2011151359A1 (en) 2010-06-02 2011-12-08 Noscira, S.A. Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
BG66818B1 (bg) 2013-03-07 2019-01-31 Berbee Beheer B. V. Състав на екстракт от hippeastrum papilio за производство на лекарствени средства и хранителни добавки

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018043A (en) * 1995-04-06 2000-01-25 Janssen Pharmaceutica, N.V. Process for preparing galanthamine derivatives by asymmetric reduction
US6084094A (en) * 1995-04-03 2000-07-04 Janssen Pharmaceutica, N.V. Oxidative process for preparing narwedine derivatives
US6369238B1 (en) * 1994-10-21 2002-04-09 Sanochemia Pharmazeutica Processes for the preparation of derivatives of 4a, 5, 9, 10, 11, 12-hexahydro-6H-benzofuro-[3a, 3, 2-ef][2]benzazepine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BG28325A1 (en) * 1978-11-21 1980-04-15 Vlakhov Method of obtaining of enons navedine type and their derivatives
US4290862A (en) * 1979-11-14 1981-09-22 Edinen Centar P Chimia Method for the preparation of narwedine-type enones
US5428159A (en) 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
GB9707413D0 (en) * 1997-04-11 1997-05-28 Chiroscience Ltd Process

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369238B1 (en) * 1994-10-21 2002-04-09 Sanochemia Pharmazeutica Processes for the preparation of derivatives of 4a, 5, 9, 10, 11, 12-hexahydro-6H-benzofuro-[3a, 3, 2-ef][2]benzazepine
US6084094A (en) * 1995-04-03 2000-07-04 Janssen Pharmaceutica, N.V. Oxidative process for preparing narwedine derivatives
US6018043A (en) * 1995-04-06 2000-01-25 Janssen Pharmaceutica, N.V. Process for preparing galanthamine derivatives by asymmetric reduction

Also Published As

Publication number Publication date
EP1670767A4 (en) 2007-08-29
NZ546768A (en) 2009-07-31
CN1875004A (zh) 2006-12-06
WO2005030713A3 (en) 2006-01-26
WO2005030713A2 (en) 2005-04-07
US20050070522A1 (en) 2005-03-31
CA2540248A1 (en) 2005-04-07
EP1670767B2 (en) 2014-10-29
EP1670767A2 (en) 2006-06-21
JP5020633B2 (ja) 2012-09-05
AU2004276354B2 (en) 2009-07-09
AU2004276354A1 (en) 2005-04-07
US7307162B2 (en) 2007-12-11
EP1670767B1 (en) 2011-08-24
IL174551A0 (en) 2006-08-20
JP2007506794A (ja) 2007-03-22
CA2540248C (en) 2010-12-07

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: SCINOPHARM TAIWAN LTD.

Free format text: FORMER OWNER: SCHLOEMER GEORGE

Effective date: 20070803

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20070803

Address after: Tainan City, Taiwan, China

Applicant after: Scinopharm Taiwan, Ltd.

Address before: American Colorado

Applicant before: Scinopharm Taiwan Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100623

Termination date: 20200927

CF01 Termination of patent right due to non-payment of annual fee