CN1872038A - 一种滴丸型氯霉素滴眼液及其制作方法 - Google Patents
一种滴丸型氯霉素滴眼液及其制作方法 Download PDFInfo
- Publication number
- CN1872038A CN1872038A CNA2006100780244A CN200610078024A CN1872038A CN 1872038 A CN1872038 A CN 1872038A CN A2006100780244 A CNA2006100780244 A CN A2006100780244A CN 200610078024 A CN200610078024 A CN 200610078024A CN 1872038 A CN1872038 A CN 1872038A
- Authority
- CN
- China
- Prior art keywords
- drop pill
- buffer
- drop
- chloromycetin
- chloramphenicol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 title claims abstract description 53
- 239000006187 pill Substances 0.000 title claims abstract description 51
- 229960005091 chloramphenicol Drugs 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000012530 fluid Substances 0.000 title claims description 9
- 229940097572 chloromycetin Drugs 0.000 claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 28
- 239000003889 eye drop Substances 0.000 claims abstract description 21
- 239000008215 water for injection Substances 0.000 claims abstract description 19
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229910021538 borax Inorganic materials 0.000 claims abstract description 16
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 16
- 239000004327 boric acid Substances 0.000 claims abstract description 15
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000006196 drop Substances 0.000 claims description 53
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 239000002202 Polyethylene glycol Substances 0.000 claims description 19
- 229920001223 polyethylene glycol Polymers 0.000 claims description 19
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 12
- 238000007789 sealing Methods 0.000 claims description 12
- 238000011049 filling Methods 0.000 claims description 11
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 10
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 9
- 238000005303 weighing Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 6
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 238000004382 potting Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- 235000006485 Platanus occidentalis Nutrition 0.000 claims description 3
- 244000268528 Platanus occidentalis Species 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 3
- 206010010741 Conjunctivitis Diseases 0.000 abstract description 2
- 208000010217 blepharitis Diseases 0.000 abstract description 2
- 206010023332 keratitis Diseases 0.000 abstract description 2
- MOEFFSWKSMRFRQ-UHFFFAOYSA-N 2-ethoxyphenol Chemical compound CCOC1=CC=CC=C1O MOEFFSWKSMRFRQ-UHFFFAOYSA-N 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 150000001336 alkenes Chemical class 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 208000022873 Ocular disease Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000003885 eye ointment Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 201000001371 inclusion conjunctivitis Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
Images
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100780244A CN100369604C (zh) | 2006-04-30 | 2006-04-30 | 一种滴丸型氯霉素滴眼液及其制作方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100780244A CN100369604C (zh) | 2006-04-30 | 2006-04-30 | 一种滴丸型氯霉素滴眼液及其制作方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1872038A true CN1872038A (zh) | 2006-12-06 |
CN100369604C CN100369604C (zh) | 2008-02-20 |
Family
ID=37482749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006100780244A Expired - Fee Related CN100369604C (zh) | 2006-04-30 | 2006-04-30 | 一种滴丸型氯霉素滴眼液及其制作方法 |
Country Status (1)
Country | Link |
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CN (1) | CN100369604C (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101167710B (zh) * | 2007-10-26 | 2010-04-21 | 张咏梅 | 保质期长的氯霉素滴眼液及其制备方法 |
CN103550145A (zh) * | 2013-10-29 | 2014-02-05 | 沈阳神龙药业有限公司 | 一种氯霉素滴眼液及其制备方法 |
CN106268388A (zh) * | 2015-05-11 | 2017-01-04 | 江西科伦药业有限公司 | 一种滴眼液配液真空均质乳化机组及使用方法 |
CN110585126A (zh) * | 2019-11-05 | 2019-12-20 | 河北医科大学 | 一种滴眼制剂及其制备方法与应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1045382C (zh) * | 1993-06-17 | 1999-10-06 | 凌沛学 | 含玻璃酸钠的氯霉素滴眼液及其制备方法 |
JPH0930966A (ja) * | 1995-07-24 | 1997-02-04 | Gakuzo Tamura | 眼科用新規製剤 |
-
2006
- 2006-04-30 CN CNB2006100780244A patent/CN100369604C/zh not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101167710B (zh) * | 2007-10-26 | 2010-04-21 | 张咏梅 | 保质期长的氯霉素滴眼液及其制备方法 |
CN103550145A (zh) * | 2013-10-29 | 2014-02-05 | 沈阳神龙药业有限公司 | 一种氯霉素滴眼液及其制备方法 |
CN106268388A (zh) * | 2015-05-11 | 2017-01-04 | 江西科伦药业有限公司 | 一种滴眼液配液真空均质乳化机组及使用方法 |
CN110585126A (zh) * | 2019-11-05 | 2019-12-20 | 河北医科大学 | 一种滴眼制剂及其制备方法与应用 |
Also Published As
Publication number | Publication date |
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CN100369604C (zh) | 2008-02-20 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: CANGZHOU GUANGMING PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: DUAN YUXIN Effective date: 20091002 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20091002 Address after: Hebei province Cangzhou City Beihuan Road No. 8 Patentee after: Cangzhou Guangming Pharmaceutical Co., Ltd. Address before: No. 134 Traffic Street, Hebei, Cangzhou province Cangzhou food and Drug Administration Patentee before: Duan Yuxin |
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C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080220 Termination date: 20130430 |