CN1863791B - {2-[1-(3,5-双-三氟甲基-苄基)-5-吡啶-4-基-1h-[1,2,3]三唑-4-基]-吡啶-3-基}-(2-氯苯基)-甲酮的新晶形 - Google Patents
{2-[1-(3,5-双-三氟甲基-苄基)-5-吡啶-4-基-1h-[1,2,3]三唑-4-基]-吡啶-3-基}-(2-氯苯基)-甲酮的新晶形 Download PDFInfo
- Publication number
- CN1863791B CN1863791B CN2004800291393A CN200480029139A CN1863791B CN 1863791 B CN1863791 B CN 1863791B CN 2004800291393 A CN2004800291393 A CN 2004800291393A CN 200480029139 A CN200480029139 A CN 200480029139A CN 1863791 B CN1863791 B CN 1863791B
- Authority
- CN
- China
- Prior art keywords
- pyridin
- crystalline form
- chlorophenyl
- methanone
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GMNRLJOAZMNQMK-PDGQHHTCSA-N O/C(/c1ccncc1)=C\c1ncccc1C(c1ccccc1Cl)=O Chemical compound O/C(/c1ccncc1)=C\c1ncccc1C(c1ccccc1Cl)=O GMNRLJOAZMNQMK-PDGQHHTCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51430003P | 2003-10-24 | 2003-10-24 | |
| US60/514,300 | 2003-10-24 | ||
| PCT/US2004/030914 WO2005042515A1 (en) | 2003-10-24 | 2004-10-12 | Novel crystalline forms of {2-[1-(3,5-bis-trifluoromethylbenzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1863791A CN1863791A (zh) | 2006-11-15 |
| CN1863791B true CN1863791B (zh) | 2011-12-07 |
Family
ID=34549327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800291393A Expired - Lifetime CN1863791B (zh) | 2003-10-24 | 2004-10-12 | {2-[1-(3,5-双-三氟甲基-苄基)-5-吡啶-4-基-1h-[1,2,3]三唑-4-基]-吡啶-3-基}-(2-氯苯基)-甲酮的新晶形 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7381826B2 (enExample) |
| JP (1) | JP4959336B2 (enExample) |
| KR (1) | KR100848407B1 (enExample) |
| CN (1) | CN1863791B (enExample) |
| AR (1) | AR046131A1 (enExample) |
| AT (1) | ATE462700T1 (enExample) |
| AU (1) | AU2004285855B8 (enExample) |
| BR (1) | BRPI0415010B8 (enExample) |
| CA (1) | CA2542140C (enExample) |
| CL (2) | CL2009001310A1 (enExample) |
| CR (1) | CR8353A (enExample) |
| DE (1) | DE602004026333D1 (enExample) |
| DK (1) | DK1675846T3 (enExample) |
| EA (1) | EA008881B1 (enExample) |
| EC (1) | ECSP066517A (enExample) |
| ES (1) | ES2340772T3 (enExample) |
| HR (1) | HRP20100207T1 (enExample) |
| IL (1) | IL174926A0 (enExample) |
| MA (1) | MA28329A1 (enExample) |
| MY (1) | MY157375A (enExample) |
| NO (1) | NO335090B1 (enExample) |
| NZ (2) | NZ545917A (enExample) |
| PE (1) | PE20050481A1 (enExample) |
| PT (1) | PT1675846E (enExample) |
| TW (1) | TW200524906A (enExample) |
| UA (1) | UA82901C2 (enExample) |
| WO (1) | WO2005042515A1 (enExample) |
| ZA (1) | ZA200603234B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2121610T3 (pl) | 2006-12-20 | 2014-09-30 | Lilly Co Eli | Nowy półprodukt oraz sposób przydatny w wytwarzaniu {2-[1-(3,5-bistrifluorometylo-benzylo)-5-pirydyn-4-ylo-1H-[1,2,3]triazol-4-ilo]-pirydyn-3-ylo}-(2-chlorofenylo)-metanonu |
| WO2009075778A2 (en) * | 2007-12-06 | 2009-06-18 | The Regents Of The University Of California | Nonpeptidic inhibitors of cruzain |
| US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| CA3213864A1 (en) * | 2015-03-04 | 2016-09-09 | Vanda Pharmaceuticals Inc. | Dosing regimen of tradipitant |
| WO2017031215A1 (en) * | 2015-08-17 | 2017-02-23 | Eli Lilly And Company | Process development of a pyridine-containing nk-1 receptor antagonist |
| EP4487912A3 (en) | 2017-09-13 | 2025-03-26 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| FI3710000T3 (fi) * | 2017-11-17 | 2025-07-03 | Vanda Pharmaceuticals Inc | Tradipitantti käytettäväksi gastropareesin hoidossa |
| JP7410137B2 (ja) | 2018-06-08 | 2024-01-09 | バンダ・ファーマシューティカルズ・インコーポレイテッド | トラジピタントを用いる処置方法 |
| EP4450126A3 (en) * | 2018-09-28 | 2025-02-19 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| US20220096449A1 (en) | 2018-12-03 | 2022-03-31 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| US20230226046A1 (en) | 2020-02-25 | 2023-07-20 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| WO2021195205A1 (en) | 2020-03-26 | 2021-09-30 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| WO2023019084A1 (en) | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
| US20240350469A1 (en) | 2021-08-31 | 2024-10-24 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| KR20250123807A (ko) | 2022-12-21 | 2025-08-18 | 반다 파마슈티칼즈, 인코퍼레이티드. | 트라디피탄트를 이용한 치료 방법 |
| EP4599831A1 (en) | 2024-02-09 | 2025-08-13 | Vanda Pharmaceuticals Inc. | Treatment of gastroparesis with tradipitant |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432952B1 (en) * | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | Polymorphic form of a tachykinin receptor antagonist |
| CN1378541A (zh) * | 1999-08-12 | 2002-11-06 | 沃泰克斯药物股份有限公司 | c－JUN N－末端激酶(JNK)和其它蛋白激酶的抑制剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
| GB9505492D0 (en) * | 1995-03-18 | 1995-05-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9525296D0 (en) * | 1995-12-11 | 1996-02-07 | Merck Sharp & Dohme | Therapeutic agents |
| EP0929303B1 (en) * | 1996-10-07 | 2006-07-26 | Merck Sharp & Dohme Ltd. | Cns-penetrant nk-1 receptor antagonists as antidepressant and/or an anti-anxiety agent |
| US20020044971A1 (en) * | 2000-07-07 | 2002-04-18 | Amidon Gordon L. | Dissolution rate of poorly soluble drugs |
| US7320994B2 (en) * | 2002-04-26 | 2008-01-22 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
-
2004
- 2004-10-12 NZ NZ545917A patent/NZ545917A/en unknown
- 2004-10-12 US US10/574,712 patent/US7381826B2/en not_active Expired - Lifetime
- 2004-10-12 DK DK04793893.1T patent/DK1675846T3/da active
- 2004-10-12 NZ NZ580480A patent/NZ580480A/en unknown
- 2004-10-12 CA CA2542140A patent/CA2542140C/en not_active Expired - Lifetime
- 2004-10-12 ES ES04793893T patent/ES2340772T3/es not_active Expired - Lifetime
- 2004-10-12 PT PT04793893T patent/PT1675846E/pt unknown
- 2004-10-12 BR BRPI0415010A patent/BRPI0415010B8/pt active IP Right Grant
- 2004-10-12 AU AU2004285855A patent/AU2004285855B8/en not_active Expired
- 2004-10-12 KR KR1020067007751A patent/KR100848407B1/ko not_active Expired - Lifetime
- 2004-10-12 WO PCT/US2004/030914 patent/WO2005042515A1/en not_active Ceased
- 2004-10-12 EA EA200600829A patent/EA008881B1/ru not_active IP Right Cessation
- 2004-10-12 CN CN2004800291393A patent/CN1863791B/zh not_active Expired - Lifetime
- 2004-10-12 DE DE602004026333T patent/DE602004026333D1/de not_active Expired - Lifetime
- 2004-10-12 AT AT04793893T patent/ATE462700T1/de active
- 2004-10-12 HR HR20100207T patent/HRP20100207T1/hr unknown
- 2004-10-12 JP JP2006536635A patent/JP4959336B2/ja not_active Expired - Lifetime
- 2004-10-20 PE PE2004001008A patent/PE20050481A1/es not_active Application Discontinuation
- 2004-10-20 AR ARP040103801A patent/AR046131A1/es not_active Application Discontinuation
- 2004-10-21 MY MYPI20044338A patent/MY157375A/en unknown
- 2004-10-22 TW TW093132097A patent/TW200524906A/zh unknown
- 2004-12-10 UA UAA200604473A patent/UA82901C2/uk unknown
-
2006
- 2006-04-11 IL IL174926A patent/IL174926A0/en unknown
- 2006-04-21 ZA ZA200603234A patent/ZA200603234B/en unknown
- 2006-04-21 EC EC2006006517A patent/ECSP066517A/es unknown
- 2006-04-21 CR CR8353A patent/CR8353A/es not_active Application Discontinuation
- 2006-05-22 MA MA29043A patent/MA28329A1/fr unknown
- 2006-05-24 NO NO20062371A patent/NO335090B1/no unknown
-
2009
- 2009-05-29 CL CL2009001310A patent/CL2009001310A1/es unknown
- 2009-05-29 CL CL2009001311A patent/CL2009001311A1/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1378541A (zh) * | 1999-08-12 | 2002-11-06 | 沃泰克斯药物股份有限公司 | c－JUN N－末端激酶(JNK)和其它蛋白激酶的抑制剂 |
| US6432952B1 (en) * | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | Polymorphic form of a tachykinin receptor antagonist |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1863791B (zh) | {2-[1-(3,5-双-三氟甲基-苄基)-5-吡啶-4-基-1h-[1,2,3]三唑-4-基]-吡啶-3-基}-(2-氯苯基)-甲酮的新晶形 | |
| CN114096542B (zh) | 作为α-1抗胰蛋白酶调节剂的缩合三环吡咯 | |
| JP4025200B2 (ja) | ピペリジンｍｃｈアンタゴニストおよび肥満の処置におけるそれらの使用 | |
| RU2577541C2 (ru) | КРИСТАЛЛИЧЕСКАЯ ФОРМА СОЕДИНЕНИЯ ПИРИМИДО [6, 1-а]ИЗОХИНОЛИН-4-ОНА | |
| TWI473613B (zh) | 用作肥大細胞類胰蛋白酶抑制劑之〔４－（５－胺基甲基－２－氟－苯基）－六氫吡啶－１－基〕－〔７－氟－１－（２－甲氧基－乙基）－４－三氟甲氧基－１ｈ－吲哚－３－基〕－甲酮 | |
| EA011087B1 (ru) | Соединения и фармацевтические композиции для лечения воспалительных заболеваний | |
| TW200911245A (en) | Pyridone derivatives | |
| WO2009158315A1 (en) | Prolyl hydroxylase inhibitors | |
| JP6619503B2 (ja) | Ｃｇｒｐ受容体アンタゴニスト | |
| TWI445697B (zh) | 塔適那偉（ａｔａｚａｎａｖｉｒ）硫酸氫鹽之製法及其新穎的形式 | |
| CA2518999A1 (en) | Crystalline and amorphous solids of pantoprazole and processes for their preparation | |
| JP2008543820A (ja) | Ｎ−（２，２−ジメチルプロピル）−６−（３−フルオロ−５−（（３−イソオキサゾリルアミノ）カルボニル）−２−メチルフェニル）−３−ピリジンカルボキサミド | |
| EP3849977B1 (en) | Improved method for the manufacture of 3-[(1s)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof | |
| CN1980666B (zh) | 制备阿扎那韦硫酸氢盐的方法和新的形式 | |
| TW202428285A (zh) | 含磷類化合物及其製備方法和醫藥應用 | |
| EP1675846B1 (en) | Novel crystalline forms of {2-[1-(3,5-bis-trifluoromethylbenzyl)-5-pyridin-4-yl-1h- [1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone | |
| JPH0778040B2 (ja) | アミノピリジン類及びピコリルアミン類から得られるベンジルセレノベンズアミド類、及びその製造方法 | |
| CN120817955A (zh) | 苯并二氢呋喃类化合物及其医药用途 | |
| MXPA06004444A (en) | Novel crystalline forms of {2-[1-(3, 5-bis-trifluoromethylbenzyl) -5-pyridin-4-yl -1h-[1, 2, 3]triazol -4-yl]- pyridin-3-yl}- (2-chlorophenyl) -methanone | |
| HK40053049A (en) | Improved method for the manufacture of 3-[(1s)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof | |
| HK40053049B (en) | Improved method for the manufacture of 3-[(1s)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof | |
| JPH01175966A (ja) | ブタジエン化合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20111207 |