CN1842335A - 用于治疗高眼压的眼用组合物 - Google Patents
用于治疗高眼压的眼用组合物 Download PDFInfo
- Publication number
- CN1842335A CN1842335A CNA2004800243370A CN200480024337A CN1842335A CN 1842335 A CN1842335 A CN 1842335A CN A2004800243370 A CNA2004800243370 A CN A2004800243370A CN 200480024337 A CN200480024337 A CN 200480024337A CN 1842335 A CN1842335 A CN 1842335A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- chemical compound
- heterocyclic radical
- aryl
- randomly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50009003P | 2003-09-04 | 2003-09-04 | |
US60/500,090 | 2003-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1842335A true CN1842335A (zh) | 2006-10-04 |
Family
ID=34312180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2004800243370A Pending CN1842335A (zh) | 2003-09-04 | 2004-08-31 | 用于治疗高眼压的眼用组合物 |
Country Status (7)
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7528163B2 (en) | 2002-11-08 | 2009-05-05 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
EP1663987B1 (en) * | 2003-09-04 | 2009-03-18 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534580A1 (fr) | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
US5151444B1 (en) | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
AU3693789A (en) | 1988-05-10 | 1989-11-29 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | New ophthalmic preparation for treating glaucoma |
ATE101342T1 (de) | 1988-09-06 | 1994-02-15 | Kabi Pharmacia Ab | Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension. |
US5296504A (en) | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
US5352708A (en) | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5922773A (en) | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
JPH08511024A (ja) | 1993-06-08 | 1996-11-19 | バイディ ファーマシューティカルズ | 眼内圧を低下させる方法および組成物 |
US5510383A (en) | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US5573758A (en) | 1995-04-28 | 1996-11-12 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
US5925342A (en) | 1996-11-13 | 1999-07-20 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
EP1114816A4 (en) | 1998-09-14 | 2002-09-04 | Ono Pharmaceutical Co | SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES- $ g (V) AND MEDICINAL PRODUCTS CONTAINING THEM AS ACTIVE INGREDIENT |
PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
AU1293101A (en) | 1999-12-22 | 2001-07-03 | Pfizer Products Inc. | Ep4 receptor selective agonists in the treatment of osteoporosis |
AU1918001A (en) * | 2000-03-17 | 2001-10-03 | Alcon Universal Ltd | 5-hydroxy indazole derivatives for treating glaucoma |
EP1268438A1 (en) | 2000-03-17 | 2003-01-02 | Alcon, Inc | 6-hydroxy-indazole derivatives for treating glaucoma |
EP1186287A1 (en) | 2000-03-31 | 2002-03-13 | Toray Industries, Inc. | Hair growth or hair formation controlling agents |
AU2001290250A1 (en) | 2000-09-21 | 2002-04-02 | Ono Pharmaceutical Co. Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
CA2429850C (en) | 2000-11-27 | 2008-12-30 | Pfizer Products Inc. | Ep4 receptor selective agonists in the treatment of osteoporosis |
BR0210241A (pt) * | 2001-06-01 | 2004-08-10 | Alcon Inc | Piranoindazóis e seu uso no tratamento de glaucoma |
US7528163B2 (en) * | 2002-11-08 | 2009-05-05 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
EP1479675A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Indazole-derivatives as factor Xa inhibitors |
-
2004
- 2004-08-31 CA CA002537430A patent/CA2537430A1/en not_active Abandoned
- 2004-08-31 US US10/570,231 patent/US7494983B2/en not_active Expired - Fee Related
- 2004-08-31 AU AU2004271978A patent/AU2004271978B2/en not_active Ceased
- 2004-08-31 CN CNA2004800243370A patent/CN1842335A/zh active Pending
- 2004-08-31 WO PCT/US2004/028351 patent/WO2005025568A1/en active Application Filing
- 2004-08-31 EP EP04782774A patent/EP1663221A4/en not_active Withdrawn
- 2004-08-31 JP JP2006525401A patent/JP2007504236A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2004271978A1 (en) | 2005-03-24 |
EP1663221A4 (en) | 2009-04-22 |
US20070027188A1 (en) | 2007-02-01 |
AU2004271978B2 (en) | 2009-02-05 |
US7494983B2 (en) | 2009-02-24 |
JP2007504236A (ja) | 2007-03-01 |
CA2537430A1 (en) | 2005-03-24 |
WO2005025568A1 (en) | 2005-03-24 |
EP1663221A1 (en) | 2006-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1266138C (zh) | 促旋酶抑制剂和其用途 | |
CN1025999C (zh) | 咪唑并[4,5-b]喹啉氧烷酰胺的制备方法 | |
CN1061041C (zh) | 哌啶类衍生物 | |
CN1206228C (zh) | 作为nos抑制剂的n-杂环衍生物 | |
CN1816530A (zh) | 用于治疗高眼压症的眼用组合物 | |
CN1100534C (zh) | 2-(1h-4(5)-咪唑基环丙基衍生物及含该衍生物的药物组合物和其制备方法 | |
CN1745077A (zh) | 促旋酶抑制剂及其用途 | |
CN1294577A (zh) | 钾通道抑制剂 | |
CN1329599A (zh) | 作为钾通道调节剂的3-取代-4-芳基喹啉-2-酮衍生物 | |
CN1344257A (zh) | cGMP磷酸二酯酶的稠合吡啶并哒嗪抑制剂 | |
CN1934083A (zh) | 作为肾素抑制剂用于治疗高血压的5-氨基-4-羟基-7-(1h-吲哚基甲基)-8-甲基壬酰胺衍生物 | |
CN1102648A (zh) | 取代的单-和双-吡啶基甲基吡啶酮类化合物 | |
CN1871242A (zh) | 作为mch r1拮抗剂用于治疗肥胖症、糖尿病、抑郁症和焦虑的3-(4-(氨基苯基)噻吩并嘧啶-4-酮衍生物 | |
CN1455769A (zh) | 用作β-3肾上腺素能受体激动剂的环胺磺酰胺 | |
CN1681789A (zh) | 1-吡啶-4-基-脲衍生物 | |
CN1819846A (zh) | 包含毒蕈碱性受体激动剂的经皮肤吸收的眼用制剂 | |
CN1206407A (zh) | 取代的乙烯基吡啶衍生物和含有它们的药物 | |
CN101035537A (zh) | 治疗眼部疾病的组合物和方法 | |
US7279490B2 (en) | Ophthalmic compositions for treating ocular hypertension | |
CN1863773A (zh) | 四氢吡啶衍生物 | |
CN1329613A (zh) | 新的化合物 | |
CN1780836A (zh) | 作为血管紧张肽原酶抑制剂的新型二氮杂双环壬烯和四氢吡啶衍生物 | |
CN1845914A (zh) | 用于治疗眼压过高的眼用组合物 | |
CN1042632C (zh) | 吡啶酮羧酸衍生物、制备它们的中间体及药物组合物 | |
CN1856305A (zh) | 吡啶衍生物及其作为尾加压素ⅱ拮抗剂的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Open date: 20061004 |