CN1840045A - Rare earth-containing medicinal ointment for treating scald and injury - Google Patents
Rare earth-containing medicinal ointment for treating scald and injury Download PDFInfo
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- CN1840045A CN1840045A CNA2006100422278A CN200610042227A CN1840045A CN 1840045 A CN1840045 A CN 1840045A CN A2006100422278 A CNA2006100422278 A CN A2006100422278A CN 200610042227 A CN200610042227 A CN 200610042227A CN 1840045 A CN1840045 A CN 1840045A
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Abstract
The invention relates to a rare earth-containing medicinal ointment for treating scald and injury, wherein the medical ointment is prepared from the following raw materials (by weight parts): boracic acid rare earth 1.5-3, aloe powder 0.5-2, root of large-flowered skullcap 3-6, coptis root 3-6, phellodendron bark 3-6, methyl glycol 12-20, and beeswax 14-20 and vegetable oil 50-60.
Description
Affiliated technical field
The invention belongs to a kind of treatment burn medicine and preparation method thereof.
Background technology
Burn, wound are human unexpected accident calamities, general therapeutic is hindered when scalding often will live for several weeks in sterilizing room with the dried therapy burn patient of sour jujube, the expense of every day is very expensive, when debridement and when binding up a wound, the capital is cried out patient's pain unbearably and is screamed, and, still have every year thousands of patients to die from infection, embarrassed cicatrix makes many survivor feel that life is dim.
CN86108951A discloses the processing technology of a kind of many low melting points ointment dosage form and moist expose burn ointment, it is characterized in that moist expose burn ointment by Radix Scutellariae, Cortex Phellodendri, and Rhizoma Coptidis, Plantula Papaveris, Pheretima and Oleum Sesami, Cera Flava are made.This ointment and wet exposing therapy are the improvement to traditional burn and scald Therapeutic Method, have the wound surface of making and air insulated, avoiding dry stimulates, in time discharge metabolite by the lax arrectores pilorum adequate drainage of medicine, improve the immunity of local organization, avoid the wound surface drying and dehydrating to cause tissue necrosis preferably, control cellulose hypertypic regeneration and the regeneration of promotion epithelial cell, reduce advantages such as cicatrix, but the sterilizing ability of medicine is relatively poor, remain the problem at the wound face bacterial infection, this medicine is relatively poor to the wound curative effect in addition.
Summary of the invention
The purpose of this invention is to provide a kind of advantage that keeps moist expose burn ointment and have again the technical scheme that the novel therapeutic of high-strength sterilizing ability burns the ointment of wound, another object of the present invention provides the preparation method of this medicine.
Technical scheme of the present invention is that the ointment of wound is burnt in a kind of treatment that contains rare earth, is the medicine of being made by the raw material of following portions by weight ratio:
Boric acid rare earth 1.5-3, Aloe powder 0.5-2, Radix Scutellariae 3-6, Rhizoma Coptidis 3-6, Cortex Phellodendri 3-6, propylene glycol 12-20, Cera Flava 14-20, vegetable oil 50-60.
The raw material weight umber ratio of optimizing is:
Boric acid rare earth 2-2.5, Aloe powder 0.5-1.5, Radix Scutellariae 4-5, Rhizoma Coptidis 3-5, Cortex Phellodendri 3-5, propylene glycol 15-20, Cera Flava 14-20, vegetable oil 50-55.
The Borneolum Syntheticum that also has the 2-5 weight portion in the raw material.
Described vegetable oil is Oleum Sesami or vegetable oil
Contain the preparation method that the ointment of wound is burnt in the treatment of rare earth:
A. extraction: vegetable oil is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 3-6 hour, and cooling to 75-85 ℃, to get supernatant standby,
B. make rare earth, mixed with propylene glycol liquid: will react 1 hour under rare earth, the mixed with propylene glycol room temperature, clarification,
C. the edible vegetable oil that the A step is produced mixes with the mixed liquor that the B step is made to heat to 75-85 ℃ and adds after Cera Flava stirs, and is cooled to 45-55 ℃, packing.
The preparation method of optimizing:
A. extraction: vegetable oil is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 4 hours, and cooling to 80 ℃, to get supernatant standby,
B. make rare earth, Borneolum Syntheticum, mixed with propylene glycol liquid: will react 1 hour under rare earth, Borneolum Syntheticum, the mixed with propylene glycol room temperature, clarification,
C. with A step system edible vegetable oil mixes with the mixed liquor that the B step is made to heat to 80 ℃ and adds after Cera Flavas stir, be cooled to 50 ℃, pack.
In medicine of the present invention, Oleum Sesami, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Cera Flava are that the raw material of former moist expose burn ointment uses them can make the invention medicine keep the advantage of former ointment, in the raw material of medicine of the present invention, increased rare earth, antibiotic, the antiinflammatory of rare earth compound according to the study, treatment dermatosis truly have distinctive feature, its effect to skin roughly has the following aspects: one, rare earth does not have element and enters after the stratum basale, has activated some enzyme, has quickened the division and the hypertrophy of cell.Rare earth can strengthen cell to the absorbing of nutrient substance, and has strengthened the cell people's physiologically active, and this helps the healing of wound; Its two, many researchs are verified, the rare earth in the zooblast does not have the immunocompetence that element can improve animal, strengthens the influence resist outside poor environment, pair cell has repair function; Its three, it is very low that microorganism does not have plain tolerance dose to rare earth, rare earth can kill the microorganism of wound surface, has stopped secondary infection.Effects such as Aloe plays in this medicine and preserves moisture, sterilization, the serious dehydration reparation of protection wound.Borneolum Syntheticum can play analgesic effect in this medicine.The combination of each medicine in this ointment, the relevant expert's who passes through analysis, research consistently thinks that formula combination is reasonable, the traditional Chinese medical science also is familiar with not to gram, opposite medicine coexistence one.
The clinical experiment report:
Physical data is selected 100 routine patients, male 62 people, women 38 people, age 6-62 year.The sick kind has burn, chemical burn, wound.Wherein area 15-20% shallow two spends wound surface 25 examples, the dark two degree wound surface of area 10-15% 10 examples, wound face infects 30 examples in addition, area is less than 20 square centimeters of burn scar 35 examples, wherein do not select for use phosphorus to hinder the patient, because this medicine can dissolved phosphorus, promote the absorption of wound surface to phosphorus, cause the harm of phosphorus easily to human body.
Therapeutic Method: with medicine of the present invention and on spatula, be applied to wound surface gently, the about 1mm of thickness is until wound healing.With mode reuse medicine 15 days on the healing wound surface of the oil of rubbing hands, with Palmitoleic Acid, medication will be avoided the wound surface that rubs then, and the thing that will liquefy again after the medicine melting layer absorbs is stained with, coating again, and the maintenance wound surface is covered by medicine.Medication in per 4 hours once.As the blister type, blister cut off discharge water, coating is wiped out root bubble skin again after the pain relieving of band wound surface then.
The result: medicine of the present invention is evident in efficacy for burn, chemical burn, wound, traumatic infection, and pigmentation is not stayed in equal epidermis healing in 7-10 days behind the shallow two degree topical agents of clinical improvements 100%, 25 example; The equal epidermis healing in 15-20 days after wound of the dark two degree wound surface of 10 examples, preventing from scar, traumatic infection takes place in none example; Former wound face infected patient 30 examples infect and disappear, and transfer normal healing to; 25 routine cicatrixes are softening in the 35 routine small-area burn cicatrixes disappears, and the clinical improvements rate is more than 70%.Use the moist expose burn ointment wound infection rate to reduce more than 70%.
Medicine of the present invention has easy to use, and antimicrbial power is strong, and anti-the infection healed soon, and advantages such as preventing from scar are applicable to the treatment of various burns, chemical burn, wounded patient.
The specific embodiment
The specific embodiment of the present invention is:
Embodiment 1, gets boric acid rare earth 2.2kg, Aloe powder 1kg, Radix Scutellariae 4kg, Rhizoma Coptidis 4kg, Cortex Phellodendri 4kg, propylene glycol 15kg, Cera Flava 15.6kg, Oleum Sesami 54.2kg prepare ointment according to following step,
A. extraction: Oleum Sesami is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 4 hours, and cooling to 80 ℃, to get supernatant standby,
B. make rare earth, mixed with propylene glycol liquid: will react 1 hour under rare earth, the mixed with propylene glycol room temperature, clarification,
C. the edible vegetable oil that the A step is produced mix with the mixed liquor that the B step is made heat stir to 80 ℃ after, be cooled to 50 ℃, packing.
Embodiment 2 boric acid rare earth 2.5kg, Aloe powder 0.7kg, Radix Scutellariae 4kg, Rhizoma Coptidis 4kg, Cortex Phellodendri 3kg, propylene glycol 15kg, Borneolum Syntheticum 2kg, Cera Flava 15kg, vegetable oil 44.8kg.
A. extraction: vegetable oil is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 4 hours, and cooling to 80 ℃, to get supernatant standby,
B. make rare earth, Borneolum Syntheticum, mixed with propylene glycol liquid: will react 1 hour under rare earth, Borneolum Syntheticum, the mixed with propylene glycol room temperature, clarification,
C. the edible vegetable oil that the A step is produced mix with the mixed liquor that the B step is made heat stir to 80 ℃ after, be cooled to 50 ℃, packing.
Embodiment 3: boric acid rare earth 2.5kg, Aloe powder 1kg, Radix Scutellariae 4kg, Rhizoma Coptidis 4kg, Cortex Phellodendri 3kg, propylene glycol 16kg, Borneolum Syntheticum 1.5kg, Cera Flava 15kg, Oleum Sesami 43kg.
A. extraction: with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, stirring, heating rises to 140-160 ℃, extracts 4 hours with Oleum Sesami, and cooling to 80 ℃, to get supernatant standby,
B. make rare earth, Borneolum Syntheticum, mixed with propylene glycol liquid: will react 1 hour under rare earth, Borneolum Syntheticum, the mixed with propylene glycol room temperature, clarification,
C. the edible vegetable oil that the A step is produced mix with the mixed liquor that the B step is made heat stir to 80 ℃ after, be cooled to 50 ℃, packing.
Claims (7)
1. the ointment of wound is burnt in a treatment that contains rare earth, it is characterized in that: mainly be the medicine of being made by the raw material of following portions by weight ratio:
Boric acid rare earth 1.53, Aloe powder 0.5-2, Radix Scutellariae 3-6, Rhizoma Coptidis 3-6, Cortex Phellodendri 3-6, propylene glycol 12-20, Cera Flava 14-20, vegetable oil 50-60.
2. the ointment of wound is burnt in a kind of treatment that contains rare earth according to claim 1, and it is characterized in that: each raw materials in part by weight ratio is:
Boric acid rare earth 2-2.5, Aloe powder 0.5-1.5, Radix Scutellariae 4-5, Rhizoma Coptidis 3-5, Cortex Phellodendri 3-5, propylene glycol 15-20, Cera Flava 14-20, vegetable oil 50-55.
3. the ointment of wound is burnt in a kind of treatment that contains rare earth according to claim 1 and 2, and it is characterized in that: described vegetable oil is Oleum Sesami or vegetable oil.
4. the preparation method that the ointment of wound is burnt in a kind of treatment that contains rare earth according to claim 1 is characterized in that:
A. extraction: Oleum Sesami is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 3-6 hour, and cooling to 75-85 ℃, to get supernatant standby,
B. make rare earth, mixed with propylene glycol liquid: will react 1 hour under rare earth, the mixed with propylene glycol room temperature, clarification,
C. the edible vegetable oil that the A step is produced mixes with the mixed liquor that the B step is made to heat to 75-85 ℃ and adds after Cera Flava stirs, and is cooled to 45-55 ℃, packing.
5. the ointment of wound is burnt in a kind of treatment that contains rare earth according to claim 1 and 2, it is characterized in that: the Borneolum Syntheticum that also has the 2-5 weight portion in the raw material.
6. the preparation method that the ointment of wound is burnt in a kind of treatment that contains rare earth according to claim 5 is characterized in that:
A. extraction: vegetable oil is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 3-6 hour, and cooling to 75-85 ℃, to get supernatant standby,
B. make rare earth, Borneolum Syntheticum, mixed with propylene glycol liquid: will react 1 hour under rare earth, Borneolum Syntheticum, the mixed with propylene glycol room temperature, clarification,
C. with A step system edible vegetable oil mixes with the mixed liquor that the B step is made to heat to 75-85 ℃ and adds after Cera Flava stirs, be cooled to 45-55 ℃, pack.
7. the preparation method that the ointment of wound is burnt in a kind of treatment that contains rare earth according to claim 6 is characterized in that:
A. extraction: vegetable oil is stirred with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Aloe powder, and heating rises to 140-160 ℃, extracts 4 hours, and cooling to 80 ℃, to get supernatant standby,
B. make rare earth, Borneolum Syntheticum, mixed with propylene glycol liquid: will react 1 hour under rare earth, Borneolum Syntheticum, the mixed with propylene glycol room temperature, clarification,
C. with A step system edible vegetable oil mixes with the mixed liquor that the B step is made to heat to 80 ℃ and adds after Cera Flavas stir, be cooled to 50 ℃, pack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100422278A CN100430078C (en) | 2006-01-24 | 2006-01-24 | Rare earth-containing medicinal ointment for treating scald and injury |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100422278A CN100430078C (en) | 2006-01-24 | 2006-01-24 | Rare earth-containing medicinal ointment for treating scald and injury |
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| CN1840045A true CN1840045A (en) | 2006-10-04 |
| CN100430078C CN100430078C (en) | 2008-11-05 |
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| CNB2006100422278A Expired - Fee Related CN100430078C (en) | 2006-01-24 | 2006-01-24 | Rare earth-containing medicinal ointment for treating scald and injury |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020091699A1 (en) * | 2018-10-31 | 2020-05-07 | Yeditepe Universitesi | Use of nano-sized lanthanide borate (dysprosium borate and erbium borate) compounds for wound healing purposes and production method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1201771C (en) * | 2002-07-17 | 2005-05-18 | 单正安 | Burn paste and its preparing method |
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- 2006-01-24 CN CNB2006100422278A patent/CN100430078C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020091699A1 (en) * | 2018-10-31 | 2020-05-07 | Yeditepe Universitesi | Use of nano-sized lanthanide borate (dysprosium borate and erbium borate) compounds for wound healing purposes and production method thereof |
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| CN100430078C (en) | 2008-11-05 |
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