CN1840034A - Medicine for treating acute hematogenous osteomyelitis and preparation method thereof - Google Patents

Abstract

The invention relates to a medicament for treating acute hematogenous osteomyelitis and preparation method, wherein the medicament is prepared mainly from haw, toad venoms, pangolin scales, antelope's horn and natural indigo by a predetermined proportion. The medicament can be made into any one of the oral administration dosage forms.

Description

A kind of medicine for the treatment of acute hematogenous osteomyelitis and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of acute hematogenous osteomyelitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Acute hematogenous osteomyelitis is one of infant commonly encountered diseases, and clinical is extremity limbs pain, coma, tic, hyperpyrexia, can not walk, body temperature 38.5-41 ℃ is not waited, red and swollen position skin temperature is higher, at first is that lymph infects, and bone is worn and is Hemolytic streptococcus, Diplococcus pneumoniae, the infection of golden Portugal bacterium.At present the Chinese medicine of this disease of treatment comprises two kinds of medicine for external use and oral medicine, but these medicines also all are that this disease is alleviated or topical therapeutic, can't solve myelitic recurrence problem.The treatment of Western medicine also can't reach radical cure for the moment, and frequent further consultation and treatment bring heavy financial burden to the patient.

Summary of the invention:

Therefore, people have great demand to the better efficacy Chinese medicine preparation, also do not find the report of any relevant pharmaceutical composition of the present invention at present.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has found the oral medicinal herb medicine that the treatment of better curative effect acute hematogenous osteomyelitis is arranged finally, thereby has finished the present invention.

Purpose of the present invention just provides a kind of a kind of compositions of more effectively treating acute hematogenous osteomyelitis.

Another object of the present invention has provided the preparation method of this Chinese medicine composition.

The medicament selection Radix Astragali of the present invention, Fructus Crataegi, Massa Medicata Fermentata, wine breast do not have, Wine Toad, Borneolum Syntheticum, Cornu Bubali, Squama Manis, Realgar, Margarita, Calculus Bovis, Fructus Gardeniae, Herba Taraxaci, Herba Violae, Radix Scutellariae, Radix Et Rhizoma Rhei, Cornu Saigae Tataricae, Indigo Naturalis, Radix Trichosanthis, Radix Rehmanniae and Cortex Moutan make up.The alternative Semen Coicis (parched) is used as dietetic therapy is auxilliary with 200g system medicated porridge.Make each efficacy of drugs produce synergism above-mentioned these drug regimens, thereby can effectively treat myelitic recurrence.Wherein select for use the Radix Astragali to be because Radix Astragali nature and flavor are sweet, tepor is returned lung, spleen channel.Useful consolidating superficial resistance, the inducing diuresis to remove edema defended, poison holding, life function are held concurrently and are treated night sweat, arthralgia due to stagnation of blood, edema, treat carbuncle again and do not burst or routed not holding back.Select for use Fructus Crataegi to be because the acid of Fructus Crataegi nature and flavor is sweet, tepor is returned spleen, stomach, Liver Channel.Have help digestion long-pending, dissipating blood stasis blood, the expelling tenia function cures mainly that meat is long-pending, lump in the abdomen, phlegm retention, feeling of fullness, dysentery, hemorrhoidal hamorrhage, hernia.Select that Massa Medicata Fermentata, wine breast do not have for use, Wine Toad, Borneolum Syntheticum, Cornu Bubali, Squama Manis, Realgar, be because the sweet suffering of Massa Medicata Fermentata nature and flavor, temperature is returned spleen, stomach warp, invigorating the spleen and regulating the stomach helps digestion and transfers, and controls feeling of stuffiness in chest abdominal distention, vomiting dysentery.The wine breast does not have, and nature and flavor are arduous, temperature, and GUIXIN, liver, stomach warp, regulating qi and activating blood, chases after poison at analgesic therapy, controls coagulation of QI-blood, and trusted subordinate's pain is treated the edema due to wind pathogen toxic swelling, traumatic injury.Wine Toad, the sweet suffering of nature and flavor, temperature is included into bright, the shaoyin channel of foot sun, detoxifcation, detumescence, heart tonifying, skin ulcer is treated in pain relieving, the carbuncle carbuncle on the back, scrofula, chronic osteomyelitis is treated heart failure, wind, worm, toothache again.Borneolum Syntheticum nature and flavor suffering, temperature, GUIXIN, lung meridian, logical all keys, the stagnated fire of loosing, reducing swelling and alleviating pain is controlled the apoplexy locked mouth, calentura coma, convulsions expectorant fan, conjunctivitis.Cornu Bubali nature and flavor hardship is salty, and is cold, heat clearing away, and removing heat from blood, the calentura headache is controlled in detoxifcation, the high fever coma, speckle is examined, and tells nosebleed.Liver, stomach warp are returned in the salty cold of Squama Manis nature and flavor, the routed carbuncle of detumescence, and it is active to search wind, the stimulating milk secretion of stimulating the menstrual flow, it is swollen to control the carbuncle skin ulcer, and anemofrigid-damp arthralgia is treated malignant boil, anal fistula, scabies again.Realgar nature and flavor suffering, hardship, temperature, GUIXIN, liver, stomach warp dispel the wind, parasite killing, detoxifcation, control tinea alba, carbuncle, tetanus is fainted from fear, hemorrhoid complicated by anal fistula.Select Margarita, cattle, Fructus Gardeniae, Herba Taraxaci, Herba Violae, Radix Scutellariae, Radix Et Rhizoma Rhei, Cornu Saigae Tataricae, Indigo Naturalis, Radix Trichosanthis, Radix Rehmanniae and Cortex Moutan, be because Margarita property sweet-salty, cold, be included into the heart, Liver Channel, tranquilizing mind, yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., expectorant is weighed down in heat clearing away, and removing toxic substances and promoting granulation is controlled palpitation with fear, epilepsy, infantile convulsion is twitched, the sore throat aphtha.Calculus Bovis nature and flavor hardship, sweet, cold, GUIXIN, Liver Channel clear away heart-fire, reduce phlegm, function of gallbladder promoting, relieving convulsion, control the calentura coma, epilepsy is gone mad, convulsion with spasms, aphtha of the mouth and tongue.Fructus Gardeniae, the nature and flavor hardship, cold, GUIXIN, liver, stomach, lung meridian, resolving heat and reducing pathogenic fire, removing pathogenic heat from blood and toxic substance from the body, the treatment calentura of holding concurrently is vexed, and jaundice, stranguria with blood are treated again and are told nosebleed hematochezia, heat-virulence in a sore.Herba Taraxaci, the property bitter but sweet flavor, cold, return liver, stomach warp, heat-clearing and toxic substances removing, the diuresis eliminating stagnation is controlled acute mastitis, lymphadenitis, scrofula, the furuncle poison is swollen, acute conjunctivitis, tonsillitis, bronchitis, gastritis, hepatitis, cholecystitis.Herba Violae has another name called Herba Violae, Herba Corydalis Bungeanae, the nature and flavor hardship, and suffering, cold, GUIXIN, Liver Channel, clearing heat secreting bile, removing toxic substances and promoting subsidence of swelling, treatment carbuncle carbuncle on the back, furuncle swelling toxin, measles pyretic toxicity.Radix Scutellariae nature and flavor bitter cold is included into the heart, lung, gallbladder, large intestine channel, and cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, metrorrhagia are controlled in the hemostasis dehumidifying, the swollen furuncle of pain.Radix Et Rhizoma Rhei, the nature and flavor hardship, cold, return taste, large intestine, Liver Channel, the poison that purges heat, removing mass stagnates, clots absorbing blood is controlled the excess-heat constipation, delirium is gone mad, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, furuncle swelling toxin.Cornu Saigae Tataricae, nature and flavor are salty, and are cold, return liver, heart channel, suppressing the hyperactive liver to relieve the wind syndrome, heat clearing away is relieving convulsion, and detoxifcation is controlled calentura coma convulsion and is fainted, and infantile convulsion is twitched, conjunctivitis.Indigo Naturalis is salty, and is cold, returns liver, stomach, lung meridian, heat clearing away, and removing heat from blood, detoxifcation controls that epidemic febrile disease intenseness of heat, macule, skin ulcer are swollen, erysipelas, snake bite and insect sting.Radix Trichosanthis, nature and flavor sweetness and bitterness, acid is cool, attaches to the lung and stomach meridians, and promotes the production of body fluid, and only drinks, and pathogenic fire reducing is moisturized, and the evacuation of pus detumescence is used for the calentura mouth and drinks, dryness of the lung hemoptysis, carbuncle, anal fistula.Radix Rehmanniae, another name Radix Rehmanniae, dry Radix Rehmanniae, marrow, be the Scrophulariaceae herbaceos perennial, the dry rhizome of bosom celebrating Radix Rehmanniae, nature and flavor sweetness and bitterness, cold, GUIXIN, liver, kidney channel, the effect that YIN nourishing is arranged, nourishes blood is controlled fever due to yin deficiency, epistaxis, metrorrhagia, the moon is hindered constipation.Cortex Moutan, nature and flavor are arduous, cold, GUIXIN, liver, kidney channel, heat clearing away, removing heat from blood, and blood, the clear stasis of blood,, treat infantile convulsion, have blood in stool hectic fever due to YIN-deficiency consumptive fever, lump in the abdomen carbuncle and ulcer.In order to obtain optimum curative effect, medicine of the present invention can be selected else and use the Semen Coicis dietetic therapy on the basis of said medicine, is because of the Semen Coicis slightly sweet flavor, cold, return spleen, kidney, lung meridian, the sharp lung of spleen invigorating, clearing away heat-damp and promoting diuresis, control have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi." herbal classic " record, main muscular contracture contracture, unable to flex and stretch the extremities, " not record " day: except that the muscles and bones pathogen meciless, sharp the intestines and stomach, consumer edema makes us and can eat.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and amounts of components is for all having curative effect preferably in the following weight parts scope:

Radix Astragali 80-120 Keshan short, bristly hair or beard 80-120 gram Massa Medicata Fermentata 80-120 gram

The wine breast does not have 15-25 gram Wine Toad 1.5-2.5 gram Borneolum Syntheticum 1.5-2.5 gram

Cornu Bubali 15-25 gram Squama Manis 35-45 gram Realgar 5-10 gram

Margarita powder 15-25 gram Calculus Bovis 15-25 gram Fructus Gardeniae 5-10 gram

Herba Taraxaci 80-120 gram Herba Violae 80-125 gram Radix Scutellariae 3.5-4.5 gram

Radix Et Rhizoma Rhei 5-6 gram Cornu Saigae Tataricae 15-25 gram Indigo Naturalis 5-15 gram

Radix Trichosanthis 5-15 gram Radix Rehmanniae 5-15 gram Cortex Moutan 15-25 gram

Be preferably: the Radix Astragali 100 grams, Fructus Crataegi 100 grams, Massa Medicata Fermentata 100 grams, the wine breast does not have 20 grams; Wine Toad 2 grams, Borneolum Syntheticum 2 grams, Cornu Bubali 20 grams, Squama Manis 40 grams; Realgar 6 grams, Margarita powder 20 grams, Calculus Bovis 20 grams, Fructus Gardeniae 6 grams; Herba Taraxaci 100 grams, Herba Violae 100 grams, Radix Scutellariae 4 grams; Radix Et Rhizoma Rhei 4 grams, Cornu Saigae Tataricae 20 grams, Indigo Naturalis 10 grams; Radix Trichosanthis 10 grams, Radix Rehmanniae 10 grams, Cortex Moutan 20 grams.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the oral preparations of any routine.

The preparation method of medicine activity component of the present invention is as follows:

One, Chinese medicine processing

The Radix Astragali is chosen clean impurity, removes residual root head and hollow the greater, is soaked in water and pulls out, runs through back section in time and dries, and pulverizes.Fructus Crataegi is got the Fructus Crataegi that chooses clean and puts in the pot to fry with slow fire and be faint yellow taking-up to the outside and cool, and pulverizes.Massa Medicata Fermentata, Borneolum Syntheticum are pulverized.Realgar is ground into powder.The wine breast does not have, and gets Olibanum, Myrrha half and half, grinds as mud with few wine, flies over water, shines dry grinding.Wine Toad is got the Venenum Bufonis piece and is smashed to pieces, puts to add the Chinese liquor dipping in the magnetic basin, stirs constantly, becomes the thick paste shape to off-bottom, takes out and puts in the basin, puts the clean place that ventilates and dries and be ground into fine powder.Every Venenum Bufonis is joined 20 jin of Chinese liquor for 10 jin.Cornu Bubali is rived, and uses hot-water soak, pulls out, and the pound sheet shines dry grinding.Squama Manis is got the Squama Manis sheet size separately of choosing clean, sand is put to fry in the pot in addition to add the Squama Manis sheet to easily the time, fries to heaving when being golden yellow, takes out sieve shakeout, cools pulverizing.Margarita is got Margarita and cleans, and wraps with cloth, boils altogether about 2 hours with bean curd and water, takes out and cleans, and smashs to pieces, and a little is ground into superfine powder to add water, dry.Calculus Bovis grinds and is smalls.Fructus Gardeniae, sieve dedust bits are chosen decontamination, pulverize and sieve.Herba Taraxaci is chosen decontamination, cleans earth, and section is dried, and pulverizes.Herba Violae is chosen clean impurity, flush away earth, and dry grinding is shone in section.Radix Scutellariae is chosen decontamination, removes residual stem, soaks into or puts to soak slightly in the boiled water and pull out with cold water, running through the back section and drying, and pulverizes.Radix Et Rhizoma Rhei, it is yellow good to have another name called living army, and former medicine is chosen clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, and dry grinding is shone in section.Cornu Saigae Tataricae removes the plug of boning, and files brokenly, is ground into fine powder.Indigo Naturalis, the sieve decontamination is put in the mortar, adds proper amount of clear water, mixes porphyrize, injects clear water again, stirs gently fine powder is suspended, and treats that post precipitation removes clear water in another container of impouring, then with sedimentary powder, is poured in the sieve of spreading blank sheet of paper, dries porphyrize.Radix Trichosanthis is chosen decontamination, and size block is separated, and water soaks 6 one-tenth thoroughly, and it is even to inside and outside humidity to pull stewing profit out, and the solarization sheet of cutting into slices is pulverized.Radix Rehmanniae, another name Radix Rehmanniae, dry Radix Rehmanniae, water steeps slightly, cleans silt impurity, pulls stewing profit out, and section is dried, and pulverizes.Cortex Moutan is chosen decontamination, removes core, cleans to run through, and section is dried, and pulverizes.Semen Coicis is got the Semen Coicis of choosing clean and is put pot interior slow fire stir-fry to little yellow, takes out to cool to get final product.Optional Semen Coicis 50 grams of dietetic therapy with enduring, make Oryza glutinosa ripe with Oryza glutinosa 100 grams, go Oryza glutinosa to get food a meal every day.

Two, medication preparation

1, the medicine powder with above-mentioned weight proportion is a smalls, by measuring foot;

2, Mel is placed refine in the container to 100-120 ℃, then medicated powder is added that Mel is mixed to stick together, pill is made in rubbing again, every ball crude drug in whole 4.5 grams, and the ratio of medicated powder and Mel is 1: 1-1: 2;

3, join in the production process in order to prevent that pill from adhering to, and can smear a small amount of Cera Flava outside pill in system;

4, mellisic preparation, can add Mel in vegetable oil is 4: 1-5: 1 ratio preparation.

The active component of medicine of the present invention can add preparation required various conventional adjuvant during different dosage form, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as powder, tablet, capsule.

Medicine waking up the patient from unconsciousness by clearing away heat of the present invention, detoxicating, killing bacteria, blood circulation promoting and blood stasis dispelling, detumescence and apocenosis has antitumor, protects the liver, and kills the leukaemia, improves immunologic function, is used for the treatment of hematogenous osteomyelitis.

The specific embodiment:

Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested the routine pharmacodynamics test of medicine of the present invention and the clinical observation on the therapeutic effect of having comprised and test.

The specific embodiment:

[test example 1] animal toxicity test data

Select 20 of new zealand rabbits, male and female dual-purpose, body weight 2-2.5 kilogram, be divided into two groups, 10 every group, wherein one group is the normal amount group, another group is mixed with medicine of the present invention for the super quantity group with distilled water, 100 gram crude drug/100ml suspensions, for rabbit space toxicity test, the administration of normal amount group is per kilogram of body weight 0.1 gram, and the super quantity group is per kilogram of body weight 0.5 gram, adopt the administration by gavage administration, every day, secondary serve on 7, observe medication reaction every day, activity normally had no adverse reaction after normal group was taken medicine.Performance was dispirited in the super quantity group was taken medicine in back two hours, reposed and do not look for food, and recovered normal after four hours.

The clinical data of [test example 2] Drug therapy acute hematogenous osteomyelitis of the present invention

1, physical data

Accept out-patient's 60 examples for medical treatment, wherein male 42 examples, women 18 examples, age 7-20 year, 32 examples, 21-30 year 11 examples, 31-40 year 7 examples, 41-50 year 6 examples, 51-60 year 4 examples.Three phases by clinical manifestation is divided into three groups, every group 20 example.

2, diagnostic criteria

Haematogenous marrow inflammation is by the body local focal infection, spread to periosteum through the blood circulation as skin ulcer, furuncle, abscess, pharyngitis, tonsillitis, otitis media or soft tissue diffusion, periosteum is separated with surface of bone, form periosteum abscess inflammation, when the abscess inflammation increases increased pressure gradually, promptly invade pulp cavity by the bone canaliculus system.As in the pulp cavity during pus increased pressure, then outwards spread to subperiosteum through the bone canaliculus system, form subperiosteal abscess.The dope that immerses in medullary cavity and the bone canaliculus corrodes the vascularization thrombosis then, makes the backbone because of ischemic necrosis, or pathologisch Bruch takes place.Patient morbidity has two kinds of General Symptoms and local symptoms: General Symptoms: patient's sudden onset, general malaise is arranged earlier, and loss of appetite is shivered, then the hyperpyrexia of having a headache, the whole body arthralgia, weight person's coma, the dehydration of fainting from fear, cause acidosis, septicemia as untimely treatment, will cause fatal serious consequence.Local symptom: limbs are stiff in morbidity back 1-2 day, are afraid of to touch, and the performance of child's General Symptoms is lighter, and adult's performance also is not true to type, and state of an illness duration is longer.Clinical manifestation is divided into subperiosteal abscess in earlier stage, subperiosteal abscess mid-term and soft tissue deep abscess phase three phases.

(1) subperiosteal abscess in earlier stage: the patient fell ill 1-2 days, and a small amount of pus and blood is only arranged in the medullary cavity, and the medullary cavity internal pressure does not increase as yet, and limbs do not have obvious swelling, and dark tenderness is arranged, and body temperature obviously raises.

(2) subperiosteal abscess mid-term: the patient fell ill 3-5 days, and pus increases in the medullary cavity, increased pressure, and pus passes cortical bone by the bone canaliculus system periosteum is started, and forms subperiosteal abscess, the sick lower limb vein tissue edema, rubescent, burning pain is violent, and refusal is pushed touch.

(3) the soft tissue deep abscess phase: the patient falls ill 7-8 after day, and the egilops periosteum is invaded in the soft tissue, forms the soft tissue abscess, and subperiosteum pressure descends suddenly, so the local symptom pain relief, soft tissue is local red and swollen, and the burning pain symptom is obvious, and checking has fluctuation.

3, Therapeutic Method

(1) subperiosteal abscess early stage: the each clothes of adult 1 ball, child's per kilogram of body weight 0.1 gram, every 6 hours once, two weeks is a course of treatment, logotype 1-3 course of treatment.

(2) subperiosteal abscess mid-term: each oral 1 ball of adult, child's per kilogram of body weight 0.1 gram, every 6 hours once, two weeks is a course of treatment, logotype 1-3 course of treatment.

(3) the soft tissue deep abscess phase: each oral 1 ball of adult, child's per kilogram of body weight 0.1 gram every 8 hours clothes once, is obeyed a week; Change 12 hours after one week into once, obey a week again; Change 24 hours clothes after one week into once, be to obey during 10-12 night medicine time; Take continuously and change 48 hours clothes two weeks into once, be night during 10-12 medicine time, serve on 3-4 week.

Can not drug withdrawal during the acute osteomyelitis treatment, must obey to reach and consolidate curative effect the course of treatment, in order to avoid residual poison is unclear, secondary infection transfers chronic osteomyelitis disease to.

Points for attention: anemia of pregnant woman's forbidding; Deficiency and coldness of spleen and stomach person forbidding; Hypertension, the careful usefulness of chronic disease person.

4, efficacy evaluation method

Produce effects: various periosteum abscess are after treatment, and General Symptoms disappears, and the limbs soft tissue swelling is eliminated, and abscess is discharged in the medullary cavity, and limbs joint activity and antisecosis are normal.Observe 6 months no recidivists.

Take a turn for the better: healing time is accelerated, and abscess disappears, and the intermission prolongs, and pain degree alleviates, and body temperature is normal.

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

Group	Produce effects		Take a turn for the better		Invalid		Total effective rate %
								The example number	Obvious effective rate %	The example number	Obvious effective rate %	The example number	Obvious effective rate %
	Subperiosteal abscess in earlier stage	16	80	2	10	2								10	90
Subperiosteal abscess mid-term							14	70	3	15	3	15	85
	The soft tissue deep abscess phase	13	65	4	20	3								15	85

Evidence with medicine of the present invention to the patient treatment result of three different phases is respectively: periosteum abscess patient's 20 examples in early stage, and produce effects 16 examples, 2 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 80%, and improvement rate is 10%, and total effective rate is 90%.Periosteum abscess patient in mid-term 20 examples, produce effects 14 examples, 3 examples that take a turn for the better, invalid 3 examples, obvious effective rate is 70%, and improvement rate is 15%, and total effective rate is 85%.Soft tissue deep abscess phase patient 20 examples, produce effects 13 examples, 4 examples that take a turn for the better, invalid 3 examples, obvious effective rate is 65%, improvement rate 20%, total effective rate are 85%.

Claims (3)

1, a kind of medicine for the treatment of acute hematogenous osteomyelitis is characterized in that: it mainly is to be made by following bulk drugs:

Radix Astragali 80-120 Keshan short, bristly hair or beard 80-120 gram Massa Medicata Fermentata 80-120 gram

The wine breast does not have 15-25 gram Wine Toad 1.5-2.5 gram Borneolum Syntheticum 1.5-2.5 gram

Cornu Bubali 15-25 gram Squama Manis 35-45 gram Realgar 5-10 gram

Margarita powder 15-25 gram Calculus Bovis 15-25 gram Fructus Gardeniae 5-10 gram

Herba Taraxaci 80-120 gram Herba Violae 80-125 gram Radix Scutellariae 3.5-4.5 gram

Radix Et Rhizoma Rhei 5-6 gram Cornu Saigae Tataricae 15-25 gram Indigo Naturalis 5-15 gram

Radix Trichosanthis 5-15 gram Radix Rehmanniae 5-15 gram Cortex Moutan 15-25 gram.

2, the medicine of treatment acute hematogenous osteomyelitis according to claim 1, wherein the consumption of crude drug is: the Radix Astragali 100 grams, Fructus Crataegi 100 grams, Massa Medicata Fermentata 100 grams; the wine breast does not have 20 grams, Wine Toad 2 grams, Borneolum Syntheticum 2 grams, Cornu Bubali 20 grams; Squama Manis 40 grams, Realgar 6 grams, Margarita powder 20 grams, Calculus Bovis 20 grams; Fructus Gardeniae 6 grams, Herba Taraxaci 100 grams, Herba Violae 100 grams, Radix Scutellariae 4 grams; Radix Et Rhizoma Rhei 4 grams, Cornu Saigae Tataricae 20 grams, Indigo Naturalis 10 grams; Radix Trichosanthis 10 grams, Radix Rehmanniae 10 grams, Cortex Moutan 20 grams.

3, according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:

(1) Chinese medicine processing

The Radix Astragali is chosen clean impurity, removes residual root head and hollow the greater, is soaked in water and pulls out, runs through back section in time and dries, and pulverizes; Fructus Crataegi is got the Fructus Crataegi that chooses clean and puts in the pot to fry with slow fire and be faint yellow taking-up to the outside and cool, and pulverizes; Massa Medicata Fermentata, Borneolum Syntheticum are pulverized; Realgar is ground into powder; The wine breast does not have, and gets Olibanum, Myrrha half and half, grinds as mud with few wine, flies over water, shines dry grinding; Wine Toad is got the Venenum Bufonis piece and is smashed to pieces, puts to add the Chinese liquor dipping in the magnetic basin, stirs constantly, becomes the thick paste shape to off-bottom, takes out and puts in the basin, puts the clean place that ventilates and dries and be ground into fine powder, and Venenum Bufonis is joined 20 jin of Chinese liquor for 10 jin; Cornu Bubali is rived, and uses hot-water soak, pulls out, and the pound sheet shines dry grinding; Squama Manis is got the Squama Manis sheet size separately of choosing clean, sand is put to fry in the pot in addition to add the Squama Manis sheet to easily the time, fries to heaving when being golden yellow, takes out sieve shakeout, cools pulverizing; Margarita is got Margarita and cleans, and wraps with cloth, boils altogether about 2 hours with bean curd and water, takes out and cleans, and smashs to pieces, and a little is ground into superfine powder to add water, dry; Calculus Bovis grinds and is smalls; Fructus Gardeniae, sieve dedust bits are chosen decontamination, pulverize and sieve; Herba Taraxaci is chosen decontamination, cleans earth, and section is dried, and pulverizes; Herba Violae is chosen clean impurity, flush away earth, and dry grinding is shone in section; Radix Scutellariae is chosen decontamination, removes residual stem, soaks into or puts to soak slightly in the boiled water and pull out with cold water, running through the back section and drying, and pulverizes; Radix Et Rhizoma Rhei, former medicine is chosen clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, and dry grinding is shone in section; Cornu Saigae Tataricae removes the plug of boning, and files brokenly, is ground into fine powder; Indigo Naturalis, the sieve decontamination is put in the mortar, adds proper amount of clear water, mixes porphyrize, injects clear water again, stirs gently fine powder is suspended, and treats that post precipitation removes clear water in another container of impouring, then with sedimentary powder, is poured in the sieve of spreading blank sheet of paper, dries porphyrize; Radix Trichosanthis is chosen decontamination, and size block is separated, and water soaks 6 one-tenth thoroughly, and it is even to inside and outside humidity to pull stewing profit out, and the solarization sheet of cutting into slices is pulverized; Radix Rehmanniae, water steeps slightly, cleans silt impurity, pulls stewing profit out, and section is dried, and pulverizes; Cortex Moutan is chosen decontamination, removes core, cleans to run through, and section is dried, and pulverizes; Semen Coicis is got the Semen Coicis of choosing clean and is put pot interior slow fire stir-fry to little yellow, takes out to cool to get final product; Optional Semen Coicis 50 grams of dietetic therapy with enduring, make Oryza glutinosa ripe with Oryza glutinosa 100 grams, go Oryza glutinosa to get food a meal every day;

(2) medication preparation

(1), be smalls with the medicine powder of above-mentioned weight proportion, by measuring foot;

(2), Mel placed refines in the container to 100-120 ℃, then medicated powder is added that Mel is mixed to stick together, pill is made in rubbing again, every ball crude drug in whole 4.5 grams, the ratio of medicated powder and Mel is 1: 1-1: 2;

(3) join in the production process in order to prevent that pill from adhering to, and can smear a small amount of Cera Flava outside pill in system;

(4) mellisic preparation, can add Mel in vegetable oil is 4: 1-5: 1 ratio preparation;

The active component of medicine of the present invention can add preparation required various conventional adjuvant during different dosage form, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as powder, tablet, capsule.