CN1836509A - Use of N,N-diethylphenylacetamide compound in mite-resistance and bacteria-suppression - Google Patents
Use of N,N-diethylphenylacetamide compound in mite-resistance and bacteria-suppression Download PDFInfo
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Abstract
The present invention belongs to the field of fine chemical technology, and is the miticidal and bacteriostasis application of N, N-diethylphenyl acetylamine compound. Serial tests show that the miticidal and bacteriostatic agent prepared with N, N-diethylphenyl acetylamine compound has excellent miticidal, bacterium inhibiting and fungus inhibiting effect and may find its wide application in daily life.
Description
Technical field
The invention belongs to the fine chemical technology field.Be specifically related to a kind of N, N diethylbenzene yl acetamide compound is used for the antibacterial application of anti-mite.
Background technology
The acarid naked eyes be cannot see, the small pest of an impalpable class Arthropoda arachnids, generally in the 0.1-0.5 millimeter, become mite to have four pairs of foots (eight leg).To pass through acarid throughout one's life ovum, young mite, as if mite with become 4 stages of mite, about 1 thoughtful 4 weeks of 1 generation.Become mite can live 60-100 days.In the household, in straw mat, bamboo mat, pillow, bedding, simmons, clothing, sofa, carpet and dust, multiplying thousands of acarids close and numerously.Common acarid has dirt mite, flour mite, the mite that wriggles, itch mite, gamasid, trombiculid, Pu mite etc., acarid brings out various diseases, itch mite causes scabies, the mite that wriggles causes acne rosacea, the skin mite causes pruitus, flour mite causes dermatitis, pulmonary acariasis, intestinal acariasis, the dirt mite causes facial wet disease, allergic asthma, chronic bronchitis and rhinitis, acarid also carries pathogene such as bacterium, virus, Richettsia, Chlamydia, become all means of infection, the health that is endangering the people is with health, and is particularly serious to old man and children especially.
N, N diethylbenzene yl acetamide be as repellant, is used for the protectant of the mosquito, sand fly, buffalo gnat, Lian, Qiang mite etc. of anti-system HAEMATOPHAGOUS ARTHROPODS vector, is used for individual protection, and anti-system mosquito sandfly and biting of buffalo gnat are sucked blood.Be used for anti-system roach mite, can drive a kind of blattaria (Brownbandtl cockroal supella longipalpa (F)) of the Groton bug of going out, American cockroach and India.Be used for anti-system mosquito, but repellent yellow-fever mosquito (aedes albopictus and Aedes aegypti), culex and anopheles.Also being used for anti-system white mosquito, buffalo gnat and Qiang mite etc. has the harm of insect thing.Its place comprises between indoor food storing, beverage room, kitchen, shop, household etc., the outdoor field work places such as construction site, sentry post, harbour that comprise.
Summary of the invention
Technical problem to be solved by this invention is that research relates to N, and N diethylbenzene yl acetamide compound is in the application of anti-mite aspect effect.
The invention provides N, N diethylbenzene yl acetamide compound is used for the antibacterial application of anti-mite.
The inventor has researched and developed N, and N diethylbenzene yl acetamide compound presses down the mite agent as the sterilization of active ingredient, and by campaign proof N, N diethylbenzene yl acetamide compound has anti-mite bacteriostasis.
The effect detection result that the miticide (the bacterium mite is clean) of inventor's development drives the acarid that goes out through Prevention ﹠ Control Station of Parasitic Disease, China Diseases Prevention ﹠ C is as follows:
One, four kinds are killed mite liquid and drive the acarid effect detection of going out
Test item: kill mite liquid and drive the acarid effect detection of going out
Detect foundation: detect by No. (2003) 45, agricultural chemicals inspection (giving birth to survey) letter " mite of going out, drive full test method and evaluation criterion ".
Sample presentation unit: Shanghai Baimao Co., Ltd
Date landed: 2004.10.22
Date of test: 2004.10.24
Reporting date: 2004.10.29
Submitted sample: kill mite liquid 1#, 2#, 3# and 4#, white is moulded each 1 bottle of bottled 20ml.
Sample title and purposes: kill mite liquid 1#, 2#, 3# and 4#, have the acarid effect of going out of driving
Testing conditions: 25 ± 1 ℃ of laboratory's temperature, relative moisture are 70 ± 2%.
For trying insect: the sensitive strain acarid that adopts this to raise:
Acarid: method is had a liking for skin mite (Dermatophagoides farinae), female male imago.
Detection method: kill mite liquid 1#, 2#, 3# and 4#, with 20mg/cm
2Dosage evenly spread upon on the filter paper to be detected.
1. the mite effect detection of going out
Get filter paper to be tested, placing straight warp respectively is the 9.0cm culture dish, and the culture dish inner rim is smeared white oil and vaseline (1: 1) mixture, in case acarid climbs out of, the acarid of some is respectively put at the culture dish center, allows it freely creep.Timing immediately places and supports the indoor acarid death toll on 24h, 48h, 72h observed and recorded filter paper of mite.
With the data of testing three times, calculate the rate of going out of driving.Be calculated as follows the rate of going out of driving.
2. drive the mite effect detection
Get 7 little culture dishes (directly through 6cm, high 1.5cm), wherein 1 is the center culture dish, and all the other 6 training wares are put around the center culture dish, and have place's culture dish wall to contact with the center culture dish, be placed on after 7 culture dishes are set its position is fixed.In the culture dish of center, put into 1000 of acarids, place test filter paper and contrast filter paper, the area of filter paper and culture dish floor space basically identical at interval in 6 culture dishes around.On filter paper, respectively put acarid feed 0.05g.Be fixed on this cover experimental rig on the viscose glue cardboard put into one (30 * 20 * 5cm) cover porcelain dish, add saturated common salt solution and make that humidity remains on about 75% in the porcelain dish, (25 ℃ ± 1 ℃) was cultivated 24 hours in insulating box.Acarid in the feed is separated and collect with floatation, the method that washes with water collects the acarid on each culture dish and the filter paper.Write down the acarid number on the filter paper respectively, be calculated as follows scattering ratio:
Testing result: kill mite liquid 1#, 2#, 3# and 4# killing and repellent effect (table 1, table 2) to acarid.
Table 1 kills mite liquid 1#, 2#, 3# and the 4# killing effect to acarid
| Detect perfumed soap | Acarid number (only) | 30min knocks down number (only) | 30min rate of knockdown (%) | The 24h mite rate (%) of going out | The 48h mite rate (%) of going out | The 72h mite rate (%) of going out |
| 1234 contrasts | 367 378 306 314 113 | 353 364 291 273 0 | 96.19 96.30 95.10 89.94 0 | 99.12 98.25 98.04 90.76 0 | 100 100 100 94.59 0 | - - - 97.77 0 |
Table 2 kills mite liquid 1#, 2#, 3# and the 4# repellent effect to acarid
| Detect perfumed soap | Sample acarid number (only) | Contrast acarid number (only) | Drive mite rate (%) |
| 1 2 3 4 | 0 0 0 3 | 109 213 157 126 | 100 100 100 97.62 |
Evaluation of result:
By 3.1 driving the mite evaluating drug effect that goes out in No. (2003) 45, medicine inspection (the give birth to survey) letter " mite of going out, drive full test method and evaluation criterion ", kill mite liquid 1#, 2#, 3# and 4# acarid 30min rate of knockdown is respectively 96.19%, 96.30%, 95.10% and 89.94%.The 24h mite rate of going out is respectively 99.1 2%, 98.25%, 98.04%, 90.76%, the 48h mite rate of going out is respectively 100%, 100%, 100%, 94.59%, the 72h mite rate of going out is respectively 100%, 100%, 100% and 97.77%, kills mite liquid 1#, 2#, 3# and 4#24h the mite rate of driving of acarid is respectively 100%, 100%, 100% and 97.62%.Kill that mite liquid 1#, 2#, 3# drive mite, the mite drug effect of going out belongs to the A group, kill that mite liquid 4# drives mite, the mite drug effect of going out is the B group.
Two, remove the mite laundry soap and drive the acarid measure of merit that goes out
Test item: remove the mite laundry soap and drive the acarid measure of merit that goes out
Detect foundation: test by No. (2003) 45, agricultural chemicals inspection (giving birth to survey) letter " mite of going out, drive full test method and evaluation criterion "
Sample presentation unit: Shanghai Soap Making Co., Ltd.
Date landed: 2004.10.7
Date of test: 2004.10.9
Reporting date: 2004.10.15
Submitted sample: remove mite laundry soap * 4 piece
Sample title and purposes: remove the mite laundry soap, have the acarid effect of going out of driving
Testing conditions: 25 ± 1 ℃ of laboratory's temperature, relative moisture are 75 ± 2%
For trying insect: the sensitive strain acarid that adopts this to raise
Acarid: method is had a liking for skin mite (Dermatophagoides farinae), female male imago
Detection method: the tested mite laundry soap water that removes is pressed 1: 10 concentration dilution, with 20mg/cm
2Dosage evenly spread upon on the filter paper to be detected.
1. the mite effect detection of going out
Get the filter paper that scribbles except that the mite laundry soap, placing straight warp respectively is the 9.0cm culture dish, and the culture dish inner rim is smeared white oil and vaseline (1: 1) mixture, in case acarid climbs out of, the acarid of some is respectively put at the culture dish center, allows it freely creep.Timing immediately places and supports the indoor acarid death toll on 24h, 48h, 72h observed and recorded filter paper of mite.
With the data of testing three times, calculate the mite rate of going out.Be calculated as follows the mite rate of going out.
2. drive the mite effect detection
Get 7 little culture dishes (directly through 6cm, high 1.5cm), wherein 1 is the center culture dish, and all the other 6 training wares are put around the center culture dish, and have place's culture dish wall to contact with the center culture dish, be placed on after 7 culture dishes are set its position is fixed.In the culture dish of center, put into 1000 of acarids, place filter paper and contrast filter paper, the area of filter paper and the culture dish floor space basically identical that scribbles except that the mite laundry soap at interval in 6 culture dishes around.On filter paper, respectively put acarid feed 0.05g.Be fixed on this cover experimental rig on the viscose glue cardboard put into one (30 * 20 * 5cm) cover porcelain dish, add saturated common salt solution and make that humidity remains on about 75% in the porcelain dish, (25 ℃ ± 1 ℃) was cultivated 24 hours in insulating box.Acarid in the feed is separated and collect with floatation, the method that washes with water collects the acarid on each culture dish and the filter paper.Write down the acarid number on the filter paper respectively, be calculated as follows the mite rate of driving:
Testing result: remove go out mite and the repellent effect (table 3, table 4) of mite laundry soap to acarid.
Table 3 removes the killing effect of mite laundry soap to acarid
| Test sample | Acarid number (only) | 30min knocks down number (only) | 30min rate of knockdown (%) | The 24h mite rate (%) of going out | The 48h mite rate (%) of going out | The 72h mite rate (%) of going out |
| Remove the contrast of mite laundry soap | 460 135 | 18 0 | 3.92 0 | 30.0 0 | 57.83 0 | 72.39 0 |
Table 4 removes the repellent effect of mite laundry soap to acarid
| Test sample | Test sample filter paper acarid number (only) | Contrast filter paper acarid number (only) | Drive mite rate (%) |
| Remove the mite laundry soap | 128 | 377 | 66.05 |
Evaluation of result:
By 3.1 driving the mite evaluating drug effect that goes out in No. (2003) 45, medicine inspection (the give birth to survey) letter " mite of going out, drive mite test method and evaluation criterion ", removing the mite laundry soap is 3.91%,＜80% to acarid 30min rate of knockdown.The 24h mite rate of going out is 30.0%, and the 48h mite rate of going out is 57.83%, and the 72h mite rate of going out is 72.39%.Removing the mite laundry soap is 66.05% to acarid 24h scattering ratio.
Remove the mite laundry soap certain driving mite effect of going out is arranged.
Three, white anti-mite washing powder of cat and white cat liquid detergent drive the acarid effect detection of going out
Test item: white anti-mite washing powder of cat and white cat liquid detergent drive the acarid effect detection of going out
Detect foundation: detect by No. (2003) 45, agricultural chemicals inspection (giving birth to survey) letter " mite of going out, drive full test method and evaluation criterion "
Sample presentation unit: Shanghai Baimao Co., Ltd
Date landed: 2004.10.29
Date of test: 2004.11.3
Reporting date: 2004.11.8
Submitted sample: white cat washing powder of the anti-mite washing powder of 0.05% white cat, the 0.10% anti-mite washing powder of white cat and contrast (without phosphorus cold water original washing powder) and white cat liquid detergent.
Sample title and purposes: white cat washing powder of the anti-mite washing powder of 0.05% white cat, the 0.10% anti-mite washing powder of white cat and contrast (without phosphorus cold water original washing powder) and white cat liquid detergent.Has the acarid effect of going out of driving.
Testing conditions: 25 ± 1 ℃ of laboratory's temperature, relative moisture are 70 ± 2%.
For trying insect: the sensitive strain acarid that adopts this to raise:
Acarid: method is had a liking for skin mite (Dermatophagoides farinae), female male imago.
Detection method: with the white cat washing powder of the anti-mite washing powder of 0.05% white cat, the 0.10% anti-mite washing powder of white cat and contrast (without phosphorus cold water original washing powder) with after cat liquid detergent water diluted with 1: 100 in vain, with 20mg/cm
2Dosage evenly spread upon on the filter paper to be detected.
1. the mite effect detection of going out
Get filter paper to be tested, placing straight warp respectively is the 9.0cm culture dish, and the culture dish inner rim is smeared white oil and vaseline (1: 1) mixture, in case acarid climbs out of, the acarid of some is respectively put at the culture dish center, allows it freely creep.Timing immediately places and supports the indoor acarid death toll on 24h, 48h, 72h observed and recorded filter paper of mite.
With the data of testing three times, calculate the mite rate of going out.Be calculated as follows the mite rate of going out.
2. drive the mite effect detection
Get 7 little culture dishes (directly through 6cm, high 1.5cm), wherein 1 is the center culture dish, and all the other 6 training wares are put around the center culture dish, and have place's culture dish wall to contact with the center culture dish, be placed on after 7 culture dishes are set its position is fixed.In the culture dish of center, put into 1000 of acarids, place test filter paper and contrast filter paper, the area of filter paper and culture dish floor space basically identical at interval in 6 culture dishes around.On filter paper, respectively put acarid feed 0.05g.Be fixed on this cover experimental rig on the viscose glue cardboard put into one (30 * 20 * 5cm) cover porcelain dish, add saturated common salt solution and make that humidity remains on about 75% in the porcelain dish, (25 ℃ ± 1 ℃) was cultivated 24 hours in insulating box.Acarid in the feed is separated and collect with floatation, the method that washes with water collects the acarid on each culture dish and the filter paper.Write down the acarid number on the filter paper respectively, be calculated as follows the mite rate of driving:
Testing result: anti-mite washing powder of 0.05% and 0.10% white cat and white cat liquid detergent are to the mite and drive mite effect (table 5, table 6) of going out of acarid.
Table 5 0.05% and the anti-mite washing powder of 0.10% white cat and white cat liquid detergent are to the mite effect of going out of acarid
| Test sample | Acarid number (only) | 30min knocks down number (only) | 30min rate of knockdown (%) | The 24h mite rate (%) of going out | The 48h mite rate (%) of going out | The 72h mite rate (%) of going out |
| The contrast of 0.05% 0.10% liquid detergents | 334 315 361 135 | 60 79 65 0 | 17.96 25.08 18.01 0 | 23.05 40.95 26.04 0 | 30.24 62.22 33.52 0 | 52.10 86.03 53.19 0 |
Table 6 0.05% and the anti-mite washing powder of 0.10% white cat and white cat liquid detergent drive the mite effect to acarid
| Test sample | Test sample filter paper acarid number (only) | Contrast filter paper acarid number (only) | Drive mite rate (%) |
| 0.05% 0.10% liquid detergents | 186 127 171 | 141 66 111 | 24.19 51.97 35.09 |
Evaluation of result:
By 3.1 driving the mite evaluating drug effect that goes out in No. (2003) 45, medicine inspection (the give birth to survey) letter " mite of going out, drive full test method and evaluation criterion ", after 1: 100 times of anti-mite washing powder of 0.05% and 0.10% white cat and the white cat liquid detergent dilution, anti-mite washing powder of 0.05% and 0.10% white cat and white cat liquid detergent are respectively 24.19%, 51.97% and 35.09%1 to acarid 30min rate of knockdown.The 24h mite rate of going out is respectively 23.05%, 40.95% and 26.04%, the 48h mite rate of going out is respectively 30.24%, 62.22% and 33.52%, the 72h mite rate of going out is respectively the anti-mite washing powder of 52.10%, 86.03% and 53.19%, 0.05% and 0.10% white cat and white cat liquid detergent 24h the mite rate of driving of acarid is respectively 24.19%, 51.97% and 35.09%.Anti-mite washing powder of 0.05% and 0.10% white cat and white cat liquid detergent drive the anti-mite washing powder of acarid effect 0.10% anti-mite washing powder＞liquid detergent＞0.05% that goes out.Anti-mite washing powder of 0.05% and 0.10% white cat and white cat liquid detergent drive the anti-mite washing powder of mite effect 0.0 1% anti-mite washing powder＞liquid detergent＞0.05%.Has certain driving mite effect of going out.
Four, the white cat air-conditioning cleaning agent test of pesticide effectiveness
Interventions Requested: the white cat air-conditioning cleaning agent test of pesticide effectiveness
Test basis: GB13917.2-92 " the indoor harmacological effect assay method of agriculture chemical registration hygienic insecticide indoor harmacological effect assay method aerosol " and standard GB/T17322.2-1998 " indoor harmacological effect of agriculture chemical registration hygienic insecticide is estimated aerosol "
Sample presentation unit: Shanghai Baimao Co., Ltd
Submitted sample: white cat air-conditioning cleaning agent, aerosol 400ml * 3 jar.
Date received: 2003.6.5
Date of test: 2003.6.10
Reporting date: 2003.6.18
Sample title and purposes: white cat air-conditioning cleaning agent, aerosol jar 400ml is three cans, pests such as energy kill bacteria and acarid.
Experimental condition: temperature is 26 ± 1 ℃, relative moisture 65 ± 5%.
For trying animal: adopting the acarid of this center raising and the bacterium of cultivation is staphylococcus aureus (staphylococcus aureus), about 500 the bacterium numbers of every ware; Escherichia coli factory (Escherichia coli), about 500 the bacterium numbers of every ware; Acarid: dirt mite (Dermatophagoidesfarinae, female male imago.
Test procedure:
1. the efficacy testing step that bacterium is directly sprayed
Inoculation there are staphylococcus aureus and colibacillary culture dish, insert the transparent organic glass tube bottom respectively.Tested white cat air-conditioning cleaning agent aerosol is plainly-packed respectively on electronic spraying controller frame trestle, electronic spraying controller frame post is set level, make the aerosol tube horizontal, nozzle vertically downward, be in plectane central circular hole place, regulate electronic controller time control knob to the time place of spraying the 1g medicament, press action button, circular hole is clogged (contact dose in culture dish surface is 0.1g) with plug immediately after the spraying.Timing immediately, and opening entry.Behind the 30min culture dish is taken out, place in 37 ℃ of incubators, when 24h, observe sterilization effect.
2. the efficacy testing step that acarid is directly sprayed
500 of acarids are put into culture dish, insert the transparent organic glass tube bottom respectively.Tested white cat air-conditioning cleaning agent aerosol is plainly-packed respectively on electronic spraying controller frame trestle, electronic spraying controller frame post is set level, make the aerosol tube horizontal, nozzle vertically downward, be in plectane central circular hole place, regulate electronic controller time control knob to the time place of spraying the 1g medicament, press action button, circular hole is clogged (contact dose in culture dish surface is 0.1g) with plug immediately after the spraying.Timing immediately, and opening entry.Behind the 30min culture dish is taken out, place in 26 ℃ of incubators, when 24h, observe the mite effect of going out.
The test triplicate, each EOT, cleaner assay device.Calculate the killing rate of staphylococcus aureus and Escherichia coli coccus 24h, acarid 24h lethality.
Result of the test: white cat air-conditioning cleaning agent is to the effect of staphylococcus aureus, Escherichia coli and acarid (see Table 7, table 8).
The white cat air-conditioning cleaning agent of table 7 is to the effect of staphylococcus aureus and large intestine sense bacterium
| Bacterial classification | Dosage (g) | The bacterium number | 24h kills number | 24h killing rate (%) |
| Staphylococcus aureus large intestine sense bacterium | 1.01 1.01 | 500 500 | 500 500 | 100 100 |
The white cat air-conditioning cleaning agent of table 8 is to the effect of acarid
| Dosage (g) | Acarid number (only) | 24h death toll (only) | 24h lethality (%) |
| 1.15 | 500 | 500 | 100 |
Evaluation of result: with reference to 3.2 pharmacodynamics index evaluations among standard GB/T17322.2-1998 " indoor harmacological effect of agriculture chemical registration hygienic insecticide is estimated aerosol ", white cat air-conditioning cleaning agent is respectively 100% and 100% to lock look staphylococcus and Escherichia coli 24h killing rate, is 100% to acarid 24h lethality.White cat air-conditioning cleaning agent is A level qualified products to the drug effect of bacterium mite.
The acaricidal The acute toxicity tests of inventor's development is as follows:
To the male acute oral clothes of rat LD
50Be 1451mg/kg, to female rats LD
50Be 1375mg/kg.Acute is 3200mg/kg through skin to rat, and cavy is 7100mg/kg; Acute skin irritation test is 0 to skin irritatin average integral average, and the stimulus intensity classification belongs to nonirritant.
N provided by the invention, the application of N diethylbenzene yl acetamide compound aspect antimite, can develop series of products according to this purposes, such as sterilization press down mite perfumed soap, anti-dandruff shampoo, anti-dandruff hair-cream, kill the mite liquid detergent, sterilization presses down the mite transparent laundry soap, special efficacy FUMANLING frost, acne rosacea baste, ringworm of the foot liniment, sterilization press down the mite air freshener, kill the mite spray and kill mite aerosol etc.Application promise in clinical practice is arranged in daily life.
Embodiment
Embodiment 1 bacterium mite clean (R-301) is to the repellent effect of acarid
| Dosage | The test group | Medicine filter paper | Contrast filter paper | Scattering ratio |
| (mg/cm 2) | Acarid number (only) | Acarid number (only) | (％) | |
| 0.1 0.3 0.5 | 1 2 3 1 2 3 1 2 3 | 0 0 0 0 0 0 0 0 0 | 121 134 137 121 134 127 121 134 137 | 100 100 100 100 100 100 100 100 100 |
Embodiment 2 bacterium mites clean (R-301) are to the effect of going out of driving of acarid
| Sample | Content (%) | Drive the rate of going out (%) | Scattering ratio (%) | Scattering ratio (%) behind the washing cotton 7d |
| Drive the mite soap and drive the mite perfumed soap | 0.6 2 | 98.95 100 | 100 100 | 45.45 53.33 |
Recommending working concentration (%w/w) is 0.2-2.
Embodiment 3 bacterium mites clean (R-301) are to the effect of five kinds of bacterium
The clean soap of bacterium mite, shampoo and shower cream are to the effect of five kinds of bacterium
| Sample | Concentration | Escherichia coli | Staphylococcus aureus | Candida albicans | Trichophyton purpureatum | The chaff daughter bacteria of satisfying |
| Soap shampoo shower cream | (restraining/100 milliliters) (restraining/100 milliliters) (restraining/100 milliliters) | 0.00625 - - | 0.00625 - 0.0625 | 0.05 - 0.0125 | 0.003125 - 0.0625 | 0.025 0.025 - |
Embodiment 4 removes the acarus and bacteria perfumed soap
Prescription (%, w/w):
1 neat soap 91.0697
2 brightening agent CBS-X 0.03
3 titanium dioxide A
1000.20
4 essence 1.5
5 soaps chelating agent H
5010.7
6 tin sharp bright blue 0.0003
7 medicinal white dextrins 5.7
8 N, N diethylbenzene yl acetamide 0.5
9 DP-300 0.3
The embodiment 5 mite spirit propellant that goes out
Prescription (%, w/w):
1 Permanone 0.3
2 N, N diethylbenzene yl acetamide 0.3
3 S
1 0.5
4 MGIL-164 0.75
5 BHT 0.1
6 Tx-
10 4
7 essence 0.15
8 medicinal alcohols 2/8.1
9 deionized waters 91.9
Embodiment 5 air-conditionings remove the antibiotic aerosol of mite
Prescription (%, w/w):
1 Tx-10 3
2 LAs-Na 3
3 Na
3PO
4 0.5
4 DETA-2Na 0.2
5 Na-CMC 0.15
6 6501 1
7 Sodium Benzoates 0.2
8 ethylene glycol monoethyl ethers 25
9 methylated spirit 10
10 essence 0.2
11 DEPA 0.5
12 DP-300 0.05/43.8
13 distilled water 56.2
14 propellants 50
Claims (4)
1.N, the application of N diethylbenzene yl acetamide compound in the anti-mite inhibiting-bacteria preparation of preparation.
2. N according to claim 1, the application of N diethylbenzene yl acetamide compound in the anti-mite inhibiting-bacteria preparation of preparation, it is characterized in that wherein said consumption to dirt mite, flour mite, wriggle mite and itch mite is 0.2-2%mg/ml, make frost, soap, washing powder, dew or liquor type.
3. N according to claim 1, the application of N diethylbenzene yl acetamide compound in the anti-mite inhibiting-bacteria preparation of preparation, it is characterized in that wherein said consumption to Escherichia coli, staphylococcus aureus and Candida albicans is 6-50%mg/ml, make soap, shampoo or shower cream formulation.
4. N according to claim 1, the application of N diethylbenzene yl acetamide compound in the anti-mite inhibiting-bacteria preparation of preparation, it is characterized in that wherein said consumption to full daughter bacteria of chaff and trichophyton purpureatum is 3.125-6.25%mg/ml, make soap, shampoo or shower cream formulation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510024640 CN1836509A (en) | 2005-03-25 | 2005-03-25 | Use of N,N-diethylphenylacetamide compound in mite-resistance and bacteria-suppression |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510024640 CN1836509A (en) | 2005-03-25 | 2005-03-25 | Use of N,N-diethylphenylacetamide compound in mite-resistance and bacteria-suppression |
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| CN103865669A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Heavy-duty laundry detergent |
| CN103865668A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Mild low-foaming laundry powder |
| CN103865671A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Bactericidal detergent powder |
| CN103865676A (en) * | 2014-02-13 | 2014-06-18 | 上海方木精细化工有限公司 | Concentrated liquid detergent |
| CN103865660A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Enzymatic laundry powder |
| CN103865662A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Bleach laundry powder |
| CN103865670A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Concentrated laundry powder |
| CN103865677A (en) * | 2014-02-13 | 2014-06-18 | 上海方木精细化工有限公司 | Laundry detergent |
| CN103865680A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Soft detergent powder |
| CN103865679A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Light-scale washing powder |
| CN106018757A (en) * | 2016-07-26 | 2016-10-12 | 紫罗兰家纺科技股份有限公司 | Method for checking anti-mite performance of household anti-mite probiotics textile |
-
2005
- 2005-03-25 CN CN 200510024640 patent/CN1836509A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103865676A (en) * | 2014-02-13 | 2014-06-18 | 上海方木精细化工有限公司 | Concentrated liquid detergent |
| CN103849483A (en) * | 2014-02-13 | 2014-06-11 | 上海方木精细化工有限公司 | Hand wash liquid detergent |
| CN103849482A (en) * | 2014-02-13 | 2014-06-11 | 上海方木精细化工有限公司 | Non-phosphate light-duty liquid detergent |
| CN103849485A (en) * | 2014-02-13 | 2014-06-11 | 上海方木精细化工有限公司 | Enzyme-containing liquid detergent |
| CN103865677A (en) * | 2014-02-13 | 2014-06-18 | 上海方木精细化工有限公司 | Laundry detergent |
| CN103849494A (en) * | 2014-02-13 | 2014-06-11 | 上海方木精细化工有限公司 | Infant laundry detergent |
| CN103849491A (en) * | 2014-02-13 | 2014-06-11 | 上海方木精细化工有限公司 | Bacteriostatic laundry detergent |
| CN103865669A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Heavy-duty laundry detergent |
| CN103865662A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Bleach laundry powder |
| CN103865668A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Mild low-foaming laundry powder |
| CN103865671A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Bactericidal detergent powder |
| CN103865670A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Concentrated laundry powder |
| CN103865660A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Enzymatic laundry powder |
| CN103865680A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Soft detergent powder |
| CN103865679A (en) * | 2014-02-15 | 2014-06-18 | 上海方木精细化工有限公司 | Light-scale washing powder |
| CN106018757A (en) * | 2016-07-26 | 2016-10-12 | 紫罗兰家纺科技股份有限公司 | Method for checking anti-mite performance of household anti-mite probiotics textile |
| CN106018757B (en) * | 2016-07-26 | 2018-07-03 | 紫罗兰家纺科技股份有限公司 | A kind of method of inspection of the anti-mite performance of the anti-mite household textiles of probiotics |
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