CN1772119A - Medicine for treating coronary heart disease and angina pectoris and its prepn - Google Patents
Medicine for treating coronary heart disease and angina pectoris and its prepn Download PDFInfo
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Abstract
The medicine for treating coronary heart disease and angina pectoris is prepared with red sage, red peony root prepared fleeceflower root, wolfberry fruit, kudzu vine root and other Chinese medicinal materials in certain weight proportion. It may be prepared into different orally taken preparation forms. The medicine of the present invention has the functions of promoting blood circulation to disperse blood clots, relieving stasis, relieving pain, dilate blood vessels and increase blood flow of coronary artery, and is suitable for treating coronary heart disease, angina pectoris and other diseases clinically.
Description
Technical field
The present invention relates to a kind of treatment coronary heart disease, anginal medicine and preparation method thereof, belong to tcm field.
Background technology
The coronary heart disease full name is a coronary atherosclerotic heart disease, is the common multiple diseases of person in middle and old age, is one of the highest disease of contemporary M ﹠ M, serious danger side of body human health.According to statistics, the number that the U.S. suffers from a heart complaint every year reaches 1,250,000, and is annual because of the dead person of coronary heart disease reaches 60～700,000 people, almost accounts for half of the dead sum of the U.S. in the same year, before wherein over half approximately the dying from 65 years old.What mortality rate was the highest is Finland, and in 25～64 years old male, annual death rate is 350 people/100,000.Bael,Switzerland plug city population is about 300,000, and the teaching hospital in this city accepts example surplus the acute myocardial infarction 200 every year for medical treatment; There is 140 on sick bed in intracardiac section of Paris, FRA hospital, and year is accepted example surplus the acute myocardial infarction 1100 for medical treatment.China is in the old people of over-65s, and what the male suffered from this disease reaches 20%, and the women is 12%.This disease now is a modal heart disease kind in middle-aged and elderly people heart failure and the death, accounts for the 77-88% (man) and the 72-81% (woman) of deaths from heart disease.Also have rejuvenation to reach trend of rising gradually at present.
Though it is multiple that the existing market of primary disease Chinese and western drugs has, how from simple coronary artery dilator treatment, can delay its table symptom, but may not necessarily Zhi Qiben, often to get half the result with twice the effort, curative effect is unsatisfactory.The western medicine angina coronary heart disease mainly is coronary dilating medicine and anticoagulant medicine, and as nitroglycerin, Ismo 20 etc., the anticoagulant medicine has aspirin, persantin, Ticlopidine, heparin etc.The internal medicine curative effect is effective.Modern age is along with the development of Chinese medicine, the raising of pharmaceutical technology (tcd), the patent medicine that some treatment coronary heart disease are arranged on the existing market, close soft capsule, SHANHAI PILL, DIAOXINXUE KANG JIAONANG, XUEFU ZHUYU JIAONANG, Heart pill of Musk, red rhizome of chuanxiong TONGMAI KELI, XUESHUANTONG PIAN etc. such as FUFANG DANSHEN PIAN, FUFANG DANSHEN DIWAN, coronary disease Soviet Union, these medicines roughly action function are blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain; Blood circulation promoting and blood stasis dispelling, antalgic; Vital energy regualting and blood circulation-promoting, nourishing kidney yin; The chest stuffiness relieving pain relieving of regulating the flow of vital energy; Dehumidifying is eliminated the phlegm, blood circulation promoting and blood stasis dispelling; Aromatic herbs activating YANG invigorates vital energy and reinforce the heart etc.These products have some effects to improving symptom mostly, but a lot of effect is slow, and objective indicators such as electrocardiogram, cardiac function are improved not obvious, the delay course of treatment.
Summary of the invention
Therefore, people still wish to find a kind of rapid-action, eutherapeutic treatment coronary heart disease, anginal medicine.Up to now, also do not find the report of any relevant medicine of the present invention.The inventor is according to theory of Chinese medical science, and the sick experience of long-term treatment " thoracic obstruction ", and through modern science processing development, and what obtained finally that a kind of effect is fast, effect is definite is used for the treatment of coronary heart disease, anginal oral medicinal herb medicine, thereby has finished the present invention.
Purpose of the present invention is exactly that a kind of rapid-action, effective treatment coronary heart disease, anginal medicine will be provided.
Another object of the present invention provides the preparation method of this medicine.
Medicine of the present invention is prepared from by 13 flavor crude drug such as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, Fructus Lycii, Radix Puerariae, Rhizoma Chuanxiong, Flos Carthami, Radix Notoginseng, Olibanum (stir-fry), Myrrha (stir-fry), Semen Persicae (stir-fry), Borneolum Syntheticum, Radix Glycyrrhizae, has blood circulation promoting and blood stasis dispelling, the effect of understand things pain-stopping, can blood vessel dilating, coronary blood flow increasing clinically is used for the treatment of diseases such as coronary heart disease, angina pectoris.Radix Salviae Miltiorrhizae in the medicament composing prescription of the present invention, sweet, be slightly cold, go into the heart, pericardium channel has blood circulation promoting and blood stasis dispelling, removing heat from blood, nourishing blood to tranquillize the mind effect, and Radix Salviae Miltiorrhizae has the merit of control trusted subordinate pain again; Radix Notoginseng, sweet, little hardship, temperature is gone into liver, the stomach warp, blood stasis dispelling, the clots absorbing pain relieving is applicable to that stagnation of QI blood hinders all pains; Borneolum Syntheticum, suffering, hardship is slightly cold, and goes into the heart, spleen, lung meridian, and analepsia is had one's ideas straightened out, and clearing away heat to alleviate pain is good at Xin Xiang and is walked to scurry.The merit of Radix Salviae Miltiorrhizae, Radix Notoginseng, the total blood circulation promoting and blood stasis dispelling of Borneolum Syntheticum, understand things pain-stopping is so be monarch drug.Radix Paeoniae Rubra promoting blood circulation to remove blood stasis in the side, the Rhizoma Chuanxiong blood-activating and qi-promoting, stasis-dispelling and pain-killing, " the up head ", " the descending sea of blood " are " gas medicine in the blood ", the QI and blood of leading to, and make tonify without causing stagnation; Flos Carthami, stimulates the menstrual flow at blood circulation promoting and blood stasis dispelling; Olibanum, Myrrha two medicine functions are similar, and promoting blood circulation to remove blood stasis pain relieving function for oral administration is remarkable; Semen Persicae is a removing blood stasis medicine commonly used, and the clinical disease that is usually used in qi depression to blood stasis has purging and intestine lubricating action concurrently, the promoting the circulation of blood of invigorating blood circulation of above-mentioned Radix Paeoniae Rubra, Flos Carthami, Olibanum, Myrrha, Semen Persicae, and eliminating stasis to stop pain is strengthened blood circulation promoting and blood stasis dispelling with principal drug assistance, and the inducing menstruation to relieve menalgia effect is a ministerial drug.The soft and moist many liquid of Fang Zhongyong Fructus Lycii, the kidney invigorating and essence nourishing, the YIN nourishing nourishing the liver, with meaning that should " kind YANG invigorating person, must in treating YANG within YIN ", its sweet in the mouth is flat, and the merit of liver and kidney tonifying is arranged; Radix Polygoni Multiflori, invigorating the liver and kidney, benefiting essence-blood, loosening bowel to relieve constipation, detoxifcation, make ripe product then distinguish the flavor of hold concurrently sweet, the clinical thoracic obstruction commonly used, dizzy all diseases; Radix Puerariae, sweet, hot, flat, have to rise the effect of scattered Tianjin, face card headache commonly used, a pain, thoracic obstruction disease etc.Above-mentioned Fructus Lycii, Radix Polygoni Multiflori, Radix Puerariae play the kidney invigorating and essence nourishing to help monarch-minister drug, the YIN nourishing nourishing the liver, and beneficial essence is promoted the production of body fluid and is adjuvant drug.Radix Glycyrrhizae is in order to relaxing all medicine property of medicine in the side, and can the tonifying the spleen and stomach deficiency and gas in the benefit, is messenger drug especially with the coordinating the actions of various ingredients in a prescription.Take a broad view of we and play blood circulation promoting and blood stasis dispelling altogether, understand things pain-stopping has the kidney invigorating and essence nourishing concurrently, and YIN nourishing nourishing the liver effect is applicable to diseases such as coronary heart disease, angina pectoris.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each crude drug consumption proportion of preparation medicine of the present invention all has better curative effect in following ranges:
9～15 parts in 35～45 parts of Radix Salviae Miltiorrhizaes, 35～45 parts of Radix Paeoniae Rubra, 15～25 parts of Radix Polygoni Multiflori Preparatas, 20～28 parts of Fructus Lycii, 20～28 parts of Radix Puerariaes, 20～28 parts of Rhizoma Chuanxiongs, 12～20 parts on Flos Carthami, 12～20 parts of Radix Notoginseng, 3～7 parts of Olibanums (stir-fry), 3～7 parts of Myrrhas (stir-fry), 4～9 parts in Semen Persicae (stir-fry), 1～2 part of Borneolum Syntheticum and Radix Glycyrrhizae.
Be preferably: 12 parts in 40 parts of Radix Salviae Miltiorrhizaes, 40 parts of Radix Paeoniae Rubra, 20 parts of Radix Polygoni Multiflori Preparatas, 24 parts of Fructus Lycii, 24 parts of Radix Puerariaes, 24 parts of Rhizoma Chuanxiongs, 16 parts on Flos Carthami, 16 parts of Radix Notoginseng, 5 parts of Olibanums (stir-fry), 5 parts of Myrrhas (stir-fry), 6 parts in Semen Persicae (stir-fry), 1.6 parts of Borneolum Syntheticums and Radix Glycyrrhizae.
The active component of medicine of the present invention can prepare in order to the below method:
A) take by weighing each crude drug of described weight proportion, wherein Radix Puerariae is divided into two parts pulverize separately in about 4: 1 ratio and becomes coarse powder and fine powder, and is standby;
B) get Radix Salviae Miltiorrhizae, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae coarse powder, add 5--10 times of water gaging and decoct 1--3 time, each 1--3 hour, filter, merging filtrate is concentrated into relative density and is the concentrated solution about 1.15～1.20 (50～60 ℃), adds ethanol, standing over night, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and it is 1.30～1.35 (50～60 ℃) that remaining aqueous solution is concentrated into relative density, get concentrated solution 1, standby;
C) get Rhizoma Chuanxiong power and be broken into coarse powder, add 5--10 times of water gaging, soaked 5--10 hour, steam distillation extracted volatile oil 2-8 hour, collected volatile oil, and the volatile oil beta-cyclodextrin inclusion compound is standby;
D) get Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, Radix Puerariae, Radix Notoginseng, Olibanum, Myrrha, Semen Persicae coarse powder, Rhizoma Chuanxiong medicinal residues behind the united extraction volatile oil add 5-15 and doubly measure 30-85% ethanol, reflux 1--3 time, each 1-3 hour, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, Rhizoma Chuanxiong aqueous solution behind the united extraction volatile oil, continuing to be concentrated into relative density is 1.30～1.35 (50～60 ℃), gets concentrated solution 2, standby;
E) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder adds Radix Puerariae fine powder, Borneolum Syntheticum fine powder, volatile oil beta cyclodextrin inclusion complex, and mix homogeneously just has been prepared into the active component of medicine of the present invention.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as drug excipients such as disintegrating agent, lubricant, binding agents, be prepared into any peroral dosage form commonly used with conventional method of Chinese medicinal, as capsule, soft capsule, drop pill, granule, tablet or oral liquid etc.
Medicine of the present invention is through long-term clinical practice, prescription meets theory of Chinese medical science, the prescription refine, other opens the small stream footpath, take stopgap measures with understand things pain-stopping, blood circulation promoting and blood stasis dispelling reaches unobstructed vessel and is this, treating both the principal and secondary aspects of a disease, fast, the satisfactory effect of being effective is celebrated, and all theories of the traditional Chinese medical science such as deficiency and coldness, phlegm retention, the stagnation of QI, blood stasis and muscle arteries and veins contraction be anxious are brought into play.Clinical coronary heart disease, the angina pectoris treatment of being used for, particularly blood stasis due to qi deficiency disease person, effect is remarkable.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention (below win Xinshu capsule) by testing example.
[test example 1] arklemin capsule pharmacology, toxicologic study summary
Arklemin is a compound Chinese medicinal preparation, and we have made its pharmacodynamics test to dog and rat, chmice acute toxicity (maximum tolerance determination) and rat long term toxicity test, and result of the test is summarized as follows.
1 pharmacodynamics test
1.1 adopt dog left coronary artery anterior descending branch first branch below 2mm ligation method to prepare myocardial infarction and ischemia model, with the positive contrast medicine of FUFANG DANSHEN DIWAN, observe arklemin (0.73,1.46,2.92gkg
-1) to the protective effect of heart; the result shows; arklemin has the protection ischemic myocardium, reduces the myocardial ischemia necrosis area, reduces CK, CK-MB burst size; improve superoxide dismutase (SOD) activity in the cardiac muscular tissue; reduce the generation of peroxidating product malonaldehyde (MDA) in the cardiac muscular tissue; reduce myocardial oxygen consumption, effectively improve the effect of cardiac function.
Form rat acute " blood stasis " model fast 1.2 add cold stimulation with epinephrine, with the positive contrast medicine of FUFANG DANSHEN DIWAN, observe arklemin (1.71,3.42,6.84gkg
-1D
-1) to blood stasis type rat platelet aggregation and hemorheological influence.The result shows: the large, medium and small dosage of arklemin all can significantly suppress ADP, COL, the inductive blood stasis type rat platelet of Thro maximum agglutination rate; The whole blood height that significantly reduces the blood stasis type rat cuts, in cut, lowly cut, Casson's viscosity and erythrocyte electrophoretic time.The prompting arklemin has tangible function of promoting blood circulation to disperse blood clots.
2 acute toxicity tests
Arklemin is not seen the overt toxicity reaction to the mice mtd test, and maximum tolerated dose is 136.4gkg
-1Crude drug, maximum tolerated dose multiple are 559.96 times of clinical people's consumption, oral administration safety.
3 long term toxicity tests in mid-term
7,14,21kg arklemin shows rat long term toxicity result of the test in mid-term:
-1D
-1Three dosage, every day, amount was divided 2 times respectively to the rat oral gavage administration, continuous 3 months, each treated animal body weight gain, every day appetite, outward appearance, behavior, hair, feces and matched group relatively have no significant change, and the every index of hematological examination all fluctuates in normal range, and blood biochemistry checking is not seen notable difference, pathological examination is respectively organized the organ histology structure and is not seen difference, does not see clear and definite pathological change.
4 conclusions
In sum, the arklemin results of pharmacodynamic test proves that this medical instrument has obvious protection ischemic myocardium, improves the effect of cardiac function and blood circulation promoting and blood stasis dispelling.Its maximum tolerated dose multiple of acute toxicity test is 559.96 times of clinical people's consumption.Arklemin shows rat long term toxicity result of the test in mid-term: 3 months ordinary circumstances of each treated animal continuous use are normal, and blood routine and biochemical analysis are not seen notable difference, and pathological examination is respectively organized the organ histology structure and do not seen difference, does not have clear and definite pathological change.
Come further to set forth the preparation method of medicine of the present invention by the following examples.
The capsule preparation of [embodiment 1] medicine of the present invention
A) take by weighing Radix Salviae Miltiorrhizae 40 grams, Radix Paeoniae Rubra 40 grams, Radix Polygoni Multiflori Preparata 20 grams, Fructus Lycii 24 grams, Radix Puerariae 24 grams, Rhizoma Chuanxiong 24 grams, Flos Carthami 16 grams, Radix Notoginseng 16 grams, Olibanum (stir-fry) 5 grams, Myrrha (stir-fry) 5 grams, Semen Persicae (stir-fry) 6 grams, Borneolum Syntheticum 1.6 grams and Radix Glycyrrhizae 12 grams, standby;
B) get Radix Salviae Miltiorrhizae, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae coarse powder, add 8 times of water gagings and decoct each 2 hours 2 times, filter, merging filtrate is concentrated into relative density and is the concentrated solution about 1.15～1.20 (50～60 ℃), adds ethanol, standing over night, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and it is 1.30～1.35 (50～60 ℃) that remaining aqueous solution is concentrated into relative density, get concentrated solution 1, standby;
C) get Rhizoma Chuanxiong power and be broken into coarse powder, add 8 times of water gagings, soaked 8 hours, steam distillation extracted volatile oil 5 hours, collected volatile oil, and the volatile oil beta-cyclodextrin inclusion compound is standby;
D) get Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, 19 gram Radix Puerariaes, Radix Notoginseng, Olibanum, Myrrha, Semen Persicae coarse powder, Rhizoma Chuanxiong medicinal residues behind the united extraction volatile oil add 10 times of amount 75% ethanol, reflux 2 times, each 2 hours, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, Rhizoma Chuanxiong aqueous solution behind the united extraction volatile oil, continuing to be concentrated into relative density is 1.30～1.35 (50～60 ℃), gets concentrated solution 2, standby;
E) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder, add 5 gram Radix Puerariae fine powders, Borneolum Syntheticum fine powder, volatile oil beta cyclodextrin inclusion complex, mix homogeneously, the snap fit capsule of packing into.
This capsule can be oral for the patient, every day three times, each 2.
The preparation tablets of [embodiment 2] medicine of the present invention
A) take by weighing each crude drug by following weight proportion:
Radix Salviae Miltiorrhizae 35 grams, Radix Paeoniae Rubra 35 grams, Radix Polygoni Multiflori Preparata 15 grams, Fructus Lycii 20 grams, Radix Puerariae 20 grams, Rhizoma Chuanxiong 20 grams, Flos Carthami 12 grams, Radix Notoginseng 12 grams, Olibanum (stir-fry) 3 grams, Myrrha (stir-fry) 3 grams, Semen Persicae (stir-fry) 4 grams, Borneolum Syntheticum 1 gram and Radix Glycyrrhizae 9 grams, standby;
B) get Radix Salviae Miltiorrhizae, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae coarse powder, add 5 times of water gagings and decoct each 3 hours 3 times, filter, merging filtrate is concentrated into relative density and is the concentrated solution about 1.15～1.20 (50～60 ℃), adds ethanol, standing over night, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and it is 1.30～1.35 (50～60 ℃) that remaining aqueous solution is concentrated into relative density, get concentrated solution 1, standby;
C) get Rhizoma Chuanxiong power and be broken into coarse powder, add 5 times of water gagings, soaked 5 hours, steam distillation extracted volatile oil 4 hours, collected volatile oil, and the volatile oil beta-cyclodextrin inclusion compound is standby;
D) get Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, 16 gram Radix Puerariaes, Radix Notoginseng, Olibanum, Myrrha, Semen Persicae coarse powder, Rhizoma Chuanxiong medicinal residues behind the united extraction volatile oil add 5 times of amount 45% ethanol, reflux 2 times, each 3 hours, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, Rhizoma Chuanxiong aqueous solution behind the united extraction volatile oil, continuing to be concentrated into relative density is 1.30～1.35 (50～60 ℃), gets concentrated solution 2, standby;
E) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder, add 4 gram Radix Puerariae fine powders, Borneolum Syntheticum fine powder, volatile oil beta cyclodextrin inclusion complex, and drug excipient, compacting is in flakes.
The preparation of [embodiment 3] granule of the present invention
A) take by weighing Radix Salviae Miltiorrhizae 45 grams, Radix Paeoniae Rubra 45 grams, Radix Polygoni Multiflori Preparata 25 grams, Fructus Lycii 28 grams, Radix Puerariae 28 grams, Rhizoma Chuanxiong 28 grams, Flos Carthami 20 grams, Radix Notoginseng 20 grams, Olibanum (stir-fry) 7 grams, Myrrha (stir-fry) 7 grams, Semen Persicae (stir-fry) 9 grams, Borneolum Syntheticum 2 grams and Radix Glycyrrhizae 15 grams, standby;
B) get Radix Salviae Miltiorrhizae, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae coarse powder, add 10 times of water gagings and decoct each 2 hours 3 times, filter, merging filtrate is concentrated into relative density and is the concentrated solution about 1.15～1.20 (50～60 ℃), adds ethanol, standing over night, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and remaining aqueous solution is concentrated into relative density and is l.30～1.35 (50～60 ℃), get concentrated solution 1, standby;
C) get Rhizoma Chuanxiong power and be broken into coarse powder, add 10 times of water gagings, soaked 7 hours, steam distillation extracted volatile oil 8 hours, collected volatile oil, and the volatile oil beta-cyclodextrin inclusion compound is standby;
D) get Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, 22 gram Radix Puerariaes, Radix Notoginseng, Olibanum, Myrrha, Semen Persicae coarse powder, Rhizoma Chuanxiong medicinal residues behind the united extraction volatile oil add 15 times of amount 80% ethanol, reflux 3 times, each 3 hours, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, Rhizoma Chuanxiong aqueous solution behind the united extraction volatile oil, continuing to be concentrated into relative density is 1.30～1.35 (50～60 ℃), gets concentrated solution 2, standby;
E) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder, add 6 gram Radix Puerariae fine powders, Borneolum Syntheticum fine powder, volatile oil beta cyclodextrin inclusion complex, and pharmaceutic adjuvant, be pressed into granule.
Claims (5)
1. a treatment coronary heart disease, anginal medicine is characterized in that it is mainly made by following raw materials by weight proportions: 9～15 parts in 35～45 parts of Radix Salviae Miltiorrhizaes, 35～45 parts of Radix Paeoniae Rubra, 15～25 parts of Radix Polygoni Multiflori Preparatas, 20～28 parts of Fructus Lycii, 20～28 parts of Radix Puerariaes, 20～28 parts of Rhizoma Chuanxiongs, 12～20 parts on Flos Carthami, 12～20 parts of Radix Notoginseng, 3～7 parts of Olibanums (stir-fry), 3～7 parts of Myrrhas (stir-fry), 4～9 parts in Semen Persicae (stir-fry), 1～2 part of Borneolum Syntheticum and Radix Glycyrrhizae.
2. medicine according to claim 1, wherein the consumption of each crude drug is: 12 parts in 40 parts of Radix Salviae Miltiorrhizaes, 40 parts of Radix Paeoniae Rubra, 20 parts of Radix Polygoni Multiflori Preparatas, 24 parts of Fructus Lycii, 24 parts of Radix Puerariaes, 24 parts of Rhizoma Chuanxiongs, 16 parts on Flos Carthami, 16 parts of Radix Notoginseng, 5 parts of Olibanums (stir-fry), 5 parts of Myrrhas (stir-fry), 6 parts in Semen Persicae (stir-fry), 1.6 parts of Borneolum Syntheticums and Radix Glycyrrhizae.
3. medicine according to claim 1 and 2, it is pharmaceutics of Chinese drugs common formulations such as capsule, soft capsule, tablet, drop pill, granule or oral liquid.
4. the preparation method of each described medicine among the claim 1-3, it may further comprise the steps:
A) take by weighing each crude drug of described weight proportion, wherein Radix Puerariae is divided into two parts pulverize separately in about 4: 1 ratio and becomes coarse powder and fine powder, and is standby;
B) get Radix Salviae Miltiorrhizae, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae coarse powder, add 5--10 times of water gaging and decoct 1--3 time, each 1--3 hour, filter, merging filtrate is concentrated into relative density and is the concentrated solution about 1.15～1.20 (50～60 ℃), adds ethanol, standing over night, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and it is 1.30～1.35 (50～60 ℃) that remaining aqueous solution is concentrated into relative density, get concentrated solution 1, standby;
C) get Rhizoma Chuanxiong power and be broken into coarse powder, add 5--10 times of water gaging, soaked 5--10 hour, steam distillation extracted volatile oil 2-8 hour, collected volatile oil, and the volatile oil beta-cyclodextrin inclusion compound is standby;
D) get Radix Paeoniae Rubra, Radix Polygoni Multiflori Preparata, Radix Puerariae, Radix Notoginseng, Olibanum, Myrrha, Semen Persicae coarse powder, Rhizoma Chuanxiong medicinal residues behind the united extraction volatile oil add 5-15 and doubly measure 30-85% ethanol, reflux 1--3 time, each 1-3 hour, filter, merging filtrate reclaims ethanol to there not being the alcohol flavor, Rhizoma Chuanxiong aqueous solution behind the united extraction volatile oil, continuing to be concentrated into relative density is 1.30～1.35 (50～60 ℃), gets concentrated solution 2, standby;
E) merge concentrated solution 1 and concentrated solution 2, drying under reduced pressure, and dry thing is ground into fine powder adds Radix Puerariae fine powder, Borneolum Syntheticum fine powder, volatile oil beta cyclodextrin inclusion complex, and mix homogeneously just has been prepared into the active component of medicine of the present invention.
5. according to the preparation method of the described medicine of claim 4, wherein active component that step e) is made and appropriate amount of drug mixed with excipients are made conventional peroral dosage forms such as capsule, soft capsule, drop pill, granule, tablet or oral liquid.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101313989B (en) * | 2007-06-01 | 2010-11-03 | 北京同仁堂股份有限公司 | Chinese medicinal composition for treating coronary disease, stenocardia |
| CN101537068B (en) * | 2008-03-19 | 2011-07-20 | 北京绿源求证科技发展有限责任公司 | Chinese medicine for treating angina |
| CN110151941A (en) * | 2019-06-21 | 2019-08-23 | 吉林修正药业新药开发有限公司 | It is a kind of with activating microcirculation and removing stasis medicinal, sensible analgesic, promoting the circulation of qi promote blood circulation the Chinese medicine composition and preparation method thereof of effect |
| AU2017204887B2 (en) * | 2008-12-24 | 2019-10-17 | National Yang-Ming University | Compounds and methods for enhancing erythropoiesis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1290536A (en) * | 2000-10-18 | 2001-04-11 | 于宠耀 | Capsule for cerebral thrombosis and high blood pressure |
| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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2005
- 2005-11-04 CN CNB2005101175273A patent/CN1331504C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101313989B (en) * | 2007-06-01 | 2010-11-03 | 北京同仁堂股份有限公司 | Chinese medicinal composition for treating coronary disease, stenocardia |
| CN101537068B (en) * | 2008-03-19 | 2011-07-20 | 北京绿源求证科技发展有限责任公司 | Chinese medicine for treating angina |
| AU2017204887B2 (en) * | 2008-12-24 | 2019-10-17 | National Yang-Ming University | Compounds and methods for enhancing erythropoiesis |
| CN110151941A (en) * | 2019-06-21 | 2019-08-23 | 吉林修正药业新药开发有限公司 | It is a kind of with activating microcirculation and removing stasis medicinal, sensible analgesic, promoting the circulation of qi promote blood circulation the Chinese medicine composition and preparation method thereof of effect |
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| Publication number | Publication date |
|---|---|
| CN1331504C (en) | 2007-08-15 |
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