CN1772087A - Prepn process of skin icing snake fat ointment - Google Patents
Prepn process of skin icing snake fat ointment Download PDFInfo
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Abstract
The skin icing snake fat ointment is prepared with snake fat, golden larch bark, flavescent sophora root, rhubarb, phellodendron bark, red ginseng, menthol, borneol and ointment matrix, and through the steps of: preparing materials, crushing, alcohol extraction, concentrating, mixing, etc. The present invention has rhubarb and red ginseng grinding into fine powder for fast absorption and best utilization. The skin icing snake fat ointment has high curative effect and no toxic side effect.
Description
Technical field
The present invention relates to treat the medicine of dermatosis, specifically, relate to a kind of preparation method for the treatment of the skin icing snake fat ointment of various ringworms, eczema and dermatitis.
Background technology
Along with increasing of population, the increasing the weight of of environmental pollution, dermatosis becomes human frequently-occurring disease, and wherein sickness rate such as ringworm, eczema, dermatitis are high, and the course of disease is long, and relapse rate is high; Treat such dermatosis clinically, except that more oral antibiotic are protected from infection, just be to use the preparation (ointment, solution etc.) of external; Wherein pure Western medicine preparation has accounted for very big ratio, and Chinese medicine for external application seldom.Through clinical practice for many years, the side effect of Western medicine preparation shows gradually, and quite serious; And Chinese medicine preparation has obtained the approval of extensive patients owing to possess determined curative effect, safe, advantage such as side effect is little, and progressively open in market.
The applicant in first to file, Chinese medicine antifungal ointment (being skin icing snake fat ointment) strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease that Chinese patent CN1660251A disclosed " a kind of Chinese medicine antifungal ointment and preparation method thereof " provides, effect with killing parasites for relieving itching, heat clearing and damp drying, be applicable to treatment various ringworms, eczema and dermatitis, therapeutic domain is wide, evident in efficacy, and nontoxic, have no side effect, safe in utilization; Technologies such as but its preparation method adopts traditional immersion, percolation, concentrate are extracted the active component of medicine (comprising Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and Radix Ginseng Rubra), because the complicated component of tcm product own, immersion, percolation can not extract whole active component, this causes the loss of active constituents of medicine to a certain extent, both wasted medical material, influence the integrity of ointment Chinese medicine composition again, limited the performance of curative effect of medication.
Summary of the invention
The purpose of this invention is to provide a kind of method for preparing skin icing snake fat ointment, making full use of medical material, and make the skin icing snake fat ointment therapeutic effect of making higher.The technical scheme that adopts is as follows:
A kind of preparation method of skin icing snake fat ointment is equipped with raw material by following weight proportion earlier: 250～350 parts of Cortex Pseudolariciss, 150～250 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 5～15 parts of Radix Ginseng Rubra, 5～15 parts of Adeps Serpentis, 15～25 parts of Mentholums, 15～25 parts of Borneolum Syntheticums, 600～800 parts of ointment bases; Then that Radix Ginseng Rubra, two kinds of medical material micropowders of Radix Et Rhizoma Rhei is broken, cross 300 mesh sieves, stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, use alcohol solution dipping then, then carry out percolation and percolate is condensed into thick paste, again thick paste is joined in the ointment base, be mixed into uniform mastic, in mastic, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is made skin icing snake fat ointment.
The broken medical material of normally respectively distinguishing the flavor of of the micropowder of Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei is carried out respectively, also can two kinds of medical materials mix and carry out.
In preferred embodiments, usually Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized the back and cross 20～40 mesh sieves, soak, soak time is 24～48 hours.Used alcoholic solution is that concentration is 70%～80% heavy alcoholic solution.The density of preferred described thick paste is 1.2～1.3 grams per milliliters.Preferred described Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.Preferred when adding Adeps Serpentis, Mentholum, Borneolum Syntheticum, Radix Ginseng Rubra and Radix Et Rhizoma Rhei the mastic temperature be 50～55 ℃.
More than broken to the micropowder of Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei be that the cell grade micropowder is broken, diameter of particle reaches below 47 microns.The cell grade micropowder is broken to be to break the disintegrating process technology that the Chinese crude drug cell is a purpose, cell wall in the crushing process (film) is broken, to more help alleviating it active ingredient will be discharged formed resistance, and cellular content is directly exposed and improve its dissolution, thereby make human body tangible breakthrough arranged, and correspondingly saved herb resource the assimilation ratio and the speed of effective ingredient; For the mineral substance medical material, the broken technology of cell grade micropowder can become pulverizing medicinal materials the quite little powder body of particle diameter, help disengaging of effective ingredient equally, make human body tangible breakthrough arranged, and correspondingly saved herb resource effective ingredient assimilation ratio and speed.
The present invention realizes by jet mill, vibromill, ball mill or planetary mills the micropowder of medical material Radix Ginseng Rubra, Radix Et Rhizoma Rhei is broken, wherein jet mill comprise horizontal circle disc type jet mill, circulation tubular type jet mill, to spray formula inverted draft pulverizer, crash panel target formula jet mill, fluidized bed type jet mill.
High temperature gelatinizing in the pulverizing medicinal materials process is to the destruction of effective ingredient, and micropowder is broken to be operated in to be lower than under 10 ℃ and carry out.
In one preferred embodiment, adopt the following weight proportion raw material to prepare skin icing snake fat ointment: 300 parts of Cortex Pseudolariciss, 200 parts of Radix Sophorae Flavescentiss, 20 parts of Radix Et Rhizoma Rhei, 20 parts of Cortex Phellodendris, 10 parts of Radix Ginseng Rubra, 10 parts of Adeps Serpentis, 20 parts of Mentholums, 20 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
In another preferred embodiment, adopt the following weight proportion raw material to prepare skin icing snake fat ointment: 330 parts of Cortex Pseudolariciss, 240 parts of Radix Sophorae Flavescentiss, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Cortex Phellodendris, 14 parts of Radix Ginseng Rubra, 14 parts of Adeps Serpentis, 22 parts of Mentholums, 24 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
In another preferred embodiment, adopt the following weight proportion raw material to prepare skin icing snake fat ointment: 260 parts of Cortex Pseudolariciss, 160 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Cortex Phellodendris, 6 parts of Radix Ginseng Rubra, 6 parts of Adeps Serpentis, 18 parts of Mentholums, 18 parts of Borneolum Syntheticums, 600～800 parts of ointment bases again.
In the described skin icing snake fat ointment prescription:
Cortex Pseudolaricis, killing parasites for relieving itching, its alcohol extract has in various degree antibacterial action to common fungus; Cortex Pseudolaricis mainly originates in ground such as Zhejiang, Anhui and Jiangsu;
Radix Sophorae Flavescentis, heat clearing away, removing dampness and killing parasites; Radix Sophorae Flavescentis mainly originates in ground such as Shanxi, Hubei, Henan and Hebei; Cortex Pseudolaricis, both compatibilities of Radix Sophorae Flavescentis are we's monarch drug altogether;
Cortex Phellodendri, heat clearing and damp drying, eliminating fire and detoxication; Prove that according to modern pharmacological research Cortex Phellodendri has antibacterial action, its effective ingredient is a berberine, and is all effective to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans etc.; Cortex Phellodendri decoct or preserved material have inhibitory action in various degree to some common pathogenic funguses; Cortex Phellodendri mainly originates in ground such as Sichuan, Guizhou, Hubei and Yunnan;
Radix Et Rhizoma Rhei, the poison that purges heat, removing mass stagnates, clots absorbing blood; Confirm that according to modern pharmacological research Radix Et Rhizoma Rhei has antibacterial action, also effective to diphtheria hay anthrax bacillus and typhoid fever, paratyphoid fever dysentery bacterium, its decoct also has inhibitory action to some common pathogenic funguses; Radix Et Rhizoma Rhei mainly originates in ground such as Hubei, Sichuan, Yunnan and Guizhou; Cortex Phellodendri, Radix Et Rhizoma Rhei are ministerial drug altogether;
Radix Ginseng Rubra, strongly invigorating primordial QI; Confirm that according to modern pharmacological research Radix Ginseng Rubra has anti-aging effects, and energy enhancing human body immunity power, set upright with eliminating evil; Radix Ginseng Rubra mainly originates in Jilin, ground such as limit are prolonged in Liaoning;
Adeps Serpentis, skin moistening, antiinflammatory; Modern pharmacological research shows: Adeps Serpentis antiinflammatory, pain relieving, antipruritic, and the trace element, vitamin E and the multiple fatty acid that contain multiple needed by human, these materials are for promoting skin metabolism, keep that skin is lubricious, exquisiteness and elasticity, strengthen the skin physiology function, prevent skin aging, the adaptive capacity to environment that improves skin has certain effect; Adeps Serpentis forms through refining for the kill mouse fat of Serpentis, Colubridae animal Ptyasmucosus (Linnaeus). and Elapidae animal eyewear Serpentis of Colubridae animal; Both are adjuvant drug altogether for Radix Ginseng Rubra, Adeps Serpentis;
Borneolum Syntheticum, promoting blood circulation and stopping pain, anti-inflammation detumescence; Prove that according to modern pharmacological research the Borneolum Syntheticum external has clearing away heat to alleviate pain, anticorrosion itching relieving effect;
Herba Menthae, the heat clearing away of inducing sweat, diaphoresis dispelling wind; Prove that according to modern pharmacological research the Herba Menthae external can be benumbed teleneuron, play the pain relieving itching-relieving action; Mentholum is a kind of saturated cyclic alcohol that obtains in the Oleum menthae; Borneolum Syntheticum and the Herba Menthae effects such as more strengthening refrigerant antipruritic, anti-inflammatory analgetic, strong transdermal of working in coordination is messenger drug altogether;
In the above medical material: seven flavor medicine materials such as Cortex Pseudolaricis, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Ginseng Rubra, Mentholum and Borneolum Syntheticum are that " Chinese pharmacopoeia one one of version in 2000 is recorded kind, and Adeps Serpentis records kind for " Guangdong Province's drug standard " (first).
The effect of ointment base is that effective ingredient is diluted to suitable concentration.
The Cortex Pseudolaricis Main Ingredients and Appearance is pseudolaric acid B, volatilization wet goods, the Radix Sophorae Flavescentis Main Ingredients and Appearance is compositions such as matrine, the Cortex Phellodendri Main Ingredients and Appearance is a berberine hydrochloride, three kinds of medical materials ethanol that adopt in the production use are done the extraction of solvent percolation more, the medical material effective component extraction rate is higher, make product and be extensive use of clinically, effect is comparatively desirable.
The Radix Et Rhizoma Rhei Main Ingredients and Appearance is an anthraquinone class composition, and it is bigger to be extracted temperature effect in leaching process; Radix Ginseng Rubra mainly contains the ginsenoside, is valuable medicinal, after traditional leaching process adopts ethanol percolate extraction more, carries out decocting in water again and extracts.Adopt the ethanol percolate extraction method to be difficult to extract fully active ingredient in Radix Et Rhizoma Rhei, these two kinds of medical materials of Radix Ginseng Rubra, wasted the part medical material, and influenced the product curative effect to a certain extent.For guaranteeing that active ingredient can all be applied in the skin icing snake fat ointment in Radix Et Rhizoma Rhei, two kinds of medical materials of Radix Ginseng Rubra, this preparation method is with Radix Et Rhizoma Rhei, two kinds of medical material micronizing of Radix Ginseng Rubra, the messenger drug powder directly reaches (fully by 300 mesh sieves) below 47 microns, guarantee whole addings of medical material active ingredient, make full use of medical material, and then improve the product curative effect.
The skin icing snake fat ointment that the present invention makes has the effect of killing parasites for relieving itching, heat clearing and damp drying, is applicable to treatment various ringworms, eczema and dermatitis, and therapeutic domain is wide; The present invention by to Radix Et Rhizoma Rhei, that two kinds of medical materials of Radix Ginseng Rubra carry out micropowder is broken, particle diameter reaches (100% by 300 eye mesh screens) below 47 microns, substantially reach cell breakage or naked state (the plant cell mean diameter is at 10-100um), and the degree of disengaging (being the target component emission and the ratio of crude drug content) and the rate of release (target component disengages peak time) of the effective ingredient of this two Chinese crude drug are all had increased significantly than original technology, make human body tangible breakthrough arranged, and make full use of this two kinds of medical materials the assimilation ratio and the speed of its effective ingredient; Through the qualitative identification analysis relatively, adopt the equivalent prescription, in the skin icing snake fat ointment product that this method is prepared into, the effective component content of Radix Et Rhizoma Rhei, two kinds of medical materials of Radix Ginseng Rubra all increases considerably than traditional method; The drug effect of the skin icing snake fat ointment that this method is made is significantly improved, and is evident in efficacy, and nontoxic, side effect, safe in utilization; Mastic is the mastic of fine and smooth homogeneous.
The specific embodiment
Embodiment 1
Get Cortex Pseudolaricis 300 grams, Radix Sophorae Flavescentis 200 grams, Radix Et Rhizoma Rhei 20 grams, Cortex Phellodendri 20 grams, Radix Ginseng Rubra 10 grams, Adeps Serpentis 10 grams, Mentholum 20 grams, Borneolum Syntheticum 20 grams;
Micropowder is broken respectively with two kinds of medical materials of Radix Ginseng Rubra, Radix Et Rhizoma Rhei, crosses 300 mesh sieves, and is stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, cross 20 mesh sieves, be 70% heavy alcohol solution dipping 48 hours with concentration then, then carry out percolation and percolate is condensed into the thick paste of density 1.25 grams per milliliters, again thick paste is joined in the 700 gram ointment bases, be mixed into uniform mastic, when above-mentioned mastic temperature is 50 ℃, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is promptly made required skin icing snake fat ointment.Wherein Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 2
Get Cortex Pseudolaricis 330 grams, Radix Sophorae Flavescentis 240 grams, Radix Et Rhizoma Rhei 25 grams, Cortex Phellodendri 25 grams, Radix Ginseng Rubra 14 grams, Adeps Serpentis 14 grams, Mentholum 22 grams, Borneolum Syntheticum 24 grams;
Micropowder is broken respectively with two kinds of medical materials of Radix Ginseng Rubra, Radix Et Rhizoma Rhei, crosses 300 mesh sieves, and is stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, cross 40 mesh sieves, be 75% heavy alcohol solution dipping 36 hours with concentration then, then carry out percolation and percolate is condensed into the thick paste of density 1.28 grams per milliliters, again thick paste is joined in the 760 gram ointment bases, be mixed into uniform mastic, when above-mentioned mastic temperature is 52 ℃, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is promptly made required skin icing snake fat ointment.Wherein Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 3
Get Cortex Pseudolaricis 260 grams, Radix Sophorae Flavescentis 160 grams, Radix Et Rhizoma Rhei 15 grams, Cortex Phellodendri 15 grams, Radix Ginseng Rubra 6 grams, Adeps Serpentis 6 grams, Mentholum 18 grams, Borneolum Syntheticum 18 grams;
Micropowder is broken respectively with two kinds of medical materials of Radix Ginseng Rubra, Radix Et Rhizoma Rhei, crosses 300 mesh sieves, and is stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, cross 20 mesh sieves, be 70% heavy alcohol solution dipping 40 hours with concentration then, then carry out percolation and percolate is condensed into the thick paste of density 1.20 grams per milliliters, again thick paste is joined in the 750 gram ointment bases, be mixed into uniform mastic, when above-mentioned mastic temperature is 50 ℃, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is promptly made required skin icing snake fat ointment.Wherein Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 4
Get Cortex Pseudolaricis 330 grams, Radix Sophorae Flavescentis 170 grams, Radix Et Rhizoma Rhei 15 grams, Cortex Phellodendri 25 grams, Radix Ginseng Rubra 14 grams, Adeps Serpentis 7 grams, Mentholum 24 grams, Borneolum Syntheticum 16 grams;
Micropowder is broken respectively with two kinds of medical materials of Radix Ginseng Rubra, Radix Et Rhizoma Rhei, crosses 300 mesh sieves, and is stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, cross 20 mesh sieves, be 75% heavy alcohol solution dipping 30 hours with concentration then, then carry out percolation and percolate is condensed into the thick paste of density 1.25 grams per milliliters, again thick paste is joined in the 620 gram ointment bases, be mixed into uniform mastic, when above-mentioned mastic temperature is 53 ℃, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is promptly made required skin icing snake fat ointment.Wherein Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 5
Get Cortex Pseudolaricis 270 grams, Radix Sophorae Flavescentis 220 grams, Radix Et Rhizoma Rhei 27 grams, Cortex Phellodendri 14 grams, Radix Ginseng Rubra 7 grams, Adeps Serpentis 14 grams, Mentholum 16 grams, Borneolum Syntheticum 22 grams;
Micropowder is broken respectively with two kinds of medical materials of Radix Ginseng Rubra, Radix Et Rhizoma Rhei, crosses 300 mesh sieves, and is stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, cross 40 mesh sieves, be 78% heavy alcohol solution dipping 30 hours with concentration then, then carry out percolation and percolate is condensed into the thick paste of density 1.22 grams per milliliters, again thick paste is joined in the 620 gram ointment bases, be mixed into uniform mastic, when above-mentioned mastic temperature is 50 ℃, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is promptly made required skin icing snake fat ointment.Wherein Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Among the above embodiment, broken jet mill, vibromill, ball mill or the planetary mills utilized of the micropowder of medical material Radix Ginseng Rubra, Radix Et Rhizoma Rhei realized, wherein jet mill can be horizontal circle disc type jet mill, circulation tubular type jet mill, to spray formula inverted draft pulverizer, crash panel target formula jet mill, fluidized bed type jet mill.The broken operation of micropowder is generally carried out being lower than under 10 ℃.
The described skin icing snake fat ointment of the foregoing description is investigated through company's long-term stable experiment, and the result meets preparation stability and investigates requirement.
This skin icing snake fat ointment carries out pharmacology test through Chengdu University of Traditional Chinese Medicine to be observed, and result of study shows that this skin icing snake fat ointment has stronger antifungal, antiinflammatory, inhibition anaphylaxis and itching relieving effect; Carry out toxicology test and observe, result of study shows this skin icing snake fat ointment external safety, and is nontoxic, have no side effect, and is the external preparation for skin product of safety.
Claims (9)
1. the preparation method of a skin icing snake fat ointment is characterized in that: be equipped with raw material by following weight proportion earlier: 250～350 parts of Cortex Pseudolariciss, 150～250 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 5～15 parts of Radix Ginseng Rubra, 5～15 parts of Adeps Serpentis, 15～25 parts of Mentholums, 15～25 parts of Borneolum Syntheticums, 600～800 parts of ointment bases; Then that Radix Ginseng Rubra, two kinds of medical material micropowders of Radix Et Rhizoma Rhei is broken, cross 300 mesh sieves, stand-by; Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized, use alcohol solution dipping then, then carry out percolation and percolate is condensed into thick paste, again thick paste is joined in the ointment base, be mixed into uniform mastic, in mastic, add Adeps Serpentis, Mentholum, Borneolum Syntheticum then and through fine Radix Ginseng Rubra, two kinds of medical materials of Radix Et Rhizoma Rhei, mix homogeneously is made skin icing snake fat ointment.
2. the preparation method of skin icing snake fat ointment according to claim 1 is characterized in that: described Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri are pulverized the back cross 20～40 mesh sieves, soak, soak time is 24～48 hours.
3. the preparation method of skin icing snake fat ointment according to claim 1 is characterized in that: used alcoholic solution is that concentration is 70%～80% heavy alcoholic solution.
4. the preparation method of skin icing snake fat ointment according to claim 1, it is characterized in that: the density of described thick paste is 1.2～1.3 grams per milliliters.
5. the preparation method of skin icing snake fat ointment according to claim 1 is characterized in that: described Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
6. the preparation method of skin icing snake fat ointment according to claim 1 is characterized in that: the mastic temperature is 50～55 ℃ when adding Adeps Serpentis, Mentholum, Borneolum Syntheticum, Radix Ginseng Rubra and Radix Et Rhizoma Rhei.
7. according to the preparation method of each described skin icing snake fat ointment of claim 1～6, it is characterized in that: realize by jet mill, vibromill, ball mill or planetary mills the micropowder of medical material Radix Ginseng Rubra, Radix Et Rhizoma Rhei is broken.
8. the preparation method of skin icing snake fat ointment according to claim 7 is characterized in that: described jet mill comprises horizontal circle disc type jet mill, circulation tubular type jet mill, to spray formula inverted draft pulverizer, crash panel target formula jet mill, fluidized bed type jet mill.
9. the preparation method of skin icing snake fat ointment according to claim 7 is characterized in that: described micropowder is broken to be operated in to be lower than under 10 ℃ and carries out.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101890100A (en) * | 2010-07-08 | 2010-11-24 | 叶正文 | Medicament for curing dermatitis and eczema and preparation method thereof |
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| CN1278712C (en) * | 2004-12-13 | 2006-10-11 | 广东皮宝制药有限公司 | Antifungal ointment of Chinese traditional medicine and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101890100A (en) * | 2010-07-08 | 2010-11-24 | 叶正文 | Medicament for curing dermatitis and eczema and preparation method thereof |
| CN101890100B (en) * | 2010-07-08 | 2012-02-15 | 叶正文 | Medicament for curing dermatitis and eczema and preparation method thereof |
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Owner name: GUANGDONG TAI ANTANG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: GUANGDONG PIBAO PHARMACEUTICAL CO., LTD. |
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| CP01 | Change in the name or title of a patent holder |
Address after: 515021 Guangdong city of Shantou province 11R2-2 Jinyuan Industrial Zone area block 1,2 Patentee after: Guangdong Taiantang Pharmaceutical Co., Ltd. Address before: 515021 Guangdong city of Shantou province 11R2-2 Jinyuan Industrial Zone area block 1,2 Patentee before: Pibao Pharmaceutical Co., Ltd., Guangdong |