CN1278712C - Antifungal ointment of Chinese traditional medicine and preparation method - Google Patents
Antifungal ointment of Chinese traditional medicine and preparation method Download PDFInfo
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Abstract
The present invention provides traditional Chinese medicine antifungal ointment suitable for treating various tinea symptoms, eczema and dermatitis and a preparation method thereof. The traditional Chinese medicine antifungal ointment is prepared from the following raw materials: 250 to 350 portions by weight of golden larch bark, 150 to 250 portions by weight of lightyellow sophora root, 10 to 30 portions by weight of rhubarb, 10 to 30 portions by weight of phellodendron bark, 5 to 15 portions by weight of red ginseng, 5 to 15 portions by weight of snake fat, 15 to 25 portions by weight of menthol, 15 to 25 portions by weight of borneol and 600 to 800 portions by weight of ointment base. The preparation method for the antifungal ointment comprises the following steps: firstly, the golden larch bark, the lightyellow sophora root, the phellodendron bark, the rhubarb and the red ginseng are pulverized and then are soaked in an ethanol solution; secondly, the soaked medicines are percolated, and the percolate is concentrated into thick ointment; thirdly, the thick ointment and the ointment base are mixed into a uniform ointment body; fourthly, the snake fat, the menthol and the borneol are added in the ointment body to be uniformly mixed, and the mixture is prepared into ointment. The ointment has the effects on insect disinfestation and itching relief, and heat clearing and damp drying, is suitable for treating various tinea symptoms, eczema and dermatitis and has the advantages of obvious treatment effects, no toxic or side effects and safe use.
Description
Technical field
The present invention relates to treat the medicine of dermatosis, specifically, relate to a kind of Chinese medicine antifungal ointment for the treatment of various ringworms, eczema and dermatitis and preparation method thereof.
Background technology
Along with increasing of population, the increasing the weight of of environmental pollution, dermatosis becomes human frequently-occurring disease, and wherein sickness rate such as ringworm, eczema, dermatitis are high, and the course of disease is long, and relapse rate is high; Treat such dermatosis clinically, except that more oral antibiotic are protected from infection, just be to use the preparation (ointment, solution etc.) of external; Wherein pure Western medicine preparation has accounted for very big ratio, and Chinese medicine for external application seldom.Chang Yong Western medicine preparation mainly contains the product of external antifungal ointment, external glucocorticoid hormone ointment, topical antibiotic ointment and three's compound recipe clinically; Clinical traditional Chinese medicine preparation product commonly used has the happy ointment of the yellow skin of ice, restrains the products such as quick fine wine, antiphlogistic tinea and eczema treating ointment, tinea miraculous cure water of itching.Through clinical practice for many years, the side effect of Western medicine preparation shows gradually, and quite serious.In Chinese medicine preparation few in number, ice the happy ointment of yellow skin, restrain the quick fine wine special-purpose for treating skin itching of itching, antiphlogistic tinea and eczema treating ointment, tinea miraculous cure water are mainly used in the ringworm that the treatment cutaneous fungal infection causes, formed certain market, for the expansion use clinically of Chinese medicine externally-applied ointment is laid a good foundation, but insufficient is narrower with the treatment disease scope of raising variety, and has limited the further expansion in its market.On the other hand, along with the raising of people's living standard, the upsurge that the mankind go back to nature heats up, and tcm product has obtained the approval of extensive patients, also comes into the market the opportunity of having created for the new-type traditional Chinese antifungal ointment.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine antifungal ointment that is applicable to treatment various ringworms, eczema and dermatitis, and the preparation method of this Chinese medicine antifungal ointment.
On the one hand, the invention provides a kind of Chinese medicine antifungal ointment, it is made by the following weight proportion raw material: 250～350 parts of Cortex Pseudolariciss, 150～250 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 5～15 parts of Radix Ginseng Rubra, 5～15 parts of Adeps Serpentis, 15～25 parts of Mentholums, 15～25 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.Described Chinese medicine antifungal ointment is the unguentum of making by conventional method.
In one preferred embodiment, described Chinese medicine antifungal ointment is made by the following weight proportion raw material: 300 parts of Cortex Pseudolariciss, 200 parts of Radix Sophorae Flavescentiss, 20 parts of Radix Et Rhizoma Rhei, 20 parts of Cortex Phellodendris, 10 parts of Radix Ginseng Rubra, 10 parts of Adeps Serpentis, 20 parts of Mentholums, 20 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
In another preferred embodiment, described Chinese medicine antifungal ointment is made by the following weight proportion raw material: 330 parts of Cortex Pseudolariciss, 240 parts of Radix Sophorae Flavescentiss, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Cortex Phellodendris, 14 parts of Radix Ginseng Rubra, 14 parts of Adeps Serpentis, 22 parts of Mentholums, 24 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
In another preferred embodiment, described Chinese medicine antifungal ointment is made by the following weight proportion raw material again: 260 parts of Cortex Pseudolariciss, 160 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Cortex Phellodendris, 6 parts of Radix Ginseng Rubra, 6 parts of Adeps Serpentis, 18 parts of Mentholums, 18 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
Again in another preferred embodiment, described Chinese medicine antifungal ointment is to make by the following method: earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and Radix Ginseng Rubra are pulverized, use alcohol solution dipping then, then carry out percolation and percolate is condensed into thick paste, make thick paste and ointment base be mixed into uniform mastic, add Adeps Serpentis, Mentholum and Borneolum Syntheticum then, mix homogeneously is made unguentum.
On the other hand, the invention provides a kind of preparation method of Chinese medicine antifungal ointment, comprise by described composition of raw materials, earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and Radix Ginseng Rubra are pulverized, used alcohol solution dipping then, then carry out percolation and percolate is condensed into thick paste, make thick paste and ointment base be mixed into uniform mastic again, add Adeps Serpentis, Mentholum and Borneolum Syntheticum then, mix homogeneously is made unguentum.
In one preferred embodiment, used alcoholic solution is 70%～80% heavy alcoholic solution.The mastic temperature is 50～55 ℃ when preferably adding Adeps Serpentis, Mentholum and Borneolum Syntheticum.The density of preferred described thick paste is 1.2～1.3 grams per milliliters.Preferred described Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.Usually Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and Radix Ginseng Rubra are pulverized the back and cross 20～40 mesh sieves, soak, soak time is 24～48 hours.
In the described Chinese medicine antifungal ointment prescription:
Cortex Pseudolaricis, killing parasites for relieving itching, its alcohol extract has in various degree antibacterial action to common fungus; Cortex Pseudolaricis mainly originates in ground such as Zhejiang, Anhui and Jiangsu;
Radix Sophorae Flavescentis, heat clearing away, removing dampness and killing parasites; Radix Sophorae Flavescentis mainly originates in ground such as Shanxi, Hubei, Henan and Hebei; Cortex Pseudolaricis, both compatibilities of Radix Sophorae Flavescentis are we's monarch drug altogether;
Cortex Phellodendri, heat clearing and damp drying, eliminating fire and detoxication; Prove that according to modern pharmacological research Cortex Phellodendri has antibacterial action, its effective ingredient is a berberine, and is all effective to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans etc.; Cortex Phellodendri decoct or preserved material have inhibitory action in various degree to some common pathogenic funguses; Cortex Phellodendri mainly originates in ground such as Sichuan, Guizhou, Hubei and Yunnan;
Radix Et Rhizoma Rhei, the poison that purges heat, removing mass stagnates, clots absorbing blood; Confirm that according to modern pharmacological research Radix Et Rhizoma Rhei has antibacterial action, also effective to diphtheria hay anthrax bacillus and typhoid fever, paratyphoid fever dysentery bacterium, its decoct also has inhibitory action to some common pathogenic funguses; Radix Et Rhizoma Rhei mainly originates in ground such as Hubei, Sichuan, Yunnan and Guizhou; Cortex Phellodendri, Radix Et Rhizoma Rhei are ministerial drug altogether;
Radix Ginseng Rubra, strongly invigorating primordial QI; Confirm that according to modern pharmacological research Radix Ginseng Rubra has anti-aging effects, and energy enhancing human body immunity power, set upright with eliminating evil; Radix Ginseng Rubra mainly originates in Jilin, ground such as limit are prolonged in Liaoning;
Adeps Serpentis, skin moistening, antiinflammatory; Modern pharmacological research shows: Adeps Serpentis antiinflammatory, pain relieving, antipruritic, and the trace element, vitamin E and the multiple fatty acid that contain multiple needed by human, these materials are for promoting skin metabolism, keep that skin is lubricious, exquisiteness and elasticity, strengthen the skin physiology function, prevent skin aging, the adaptive capacity to environment that improves skin has certain effect; Adeps Serpentis forms through refining for the kill mouse fat of Serpentis, Colubridae animal Ptyasmucosus (Linnaeus). and Elapidae animal eyewear Serpentis of Colubridae animal; Both are adjuvant drug altogether for Radix Ginseng Rubra, Adeps Serpentis;
Borneolum Syntheticum, promoting blood circulation and stopping pain, anti-inflammation detumescence; Prove that according to modern pharmacological research the Borneolum Syntheticum external has clearing away heat to alleviate pain, anticorrosion itching relieving effect;
Herba Menthae, the heat clearing away of inducing sweat, diaphoresis dispelling wind; Prove that according to modern pharmacological research the Herba Menthae external can be benumbed teleneuron, play the pain relieving itching-relieving action; Mentholum is a kind of saturated cyclic alcohol that obtains in the Oleum menthae; Borneolum Syntheticum and the Herba Menthae effects such as more strengthening refrigerant antipruritic, anti-inflammatory analgetic, strong transdermal of working in coordination is messenger drug altogether;
In the above medical material: seven flavor medicine materials such as Cortex Pseudolaricis, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Ginseng Rubra, Mentholum and Borneolum Syntheticum are that " Chinese pharmacopoeia one one of version in 2000 is recorded kind, and Adeps Serpentis is that drug standard 1987 years versions in Guangdong Province's are recorded kind.
The effect of ointment base is that effective ingredient is diluted to suitable concentration.
The present invention has adopted Chinese medicine Cortex Pseudolaricis that traditional tcm clinical practice treatment commonly used skin takes a disease, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Cortex Phellodendri, Mentholum, Borneolum Syntheticum etc., in conjunction with strengthening vital QI to eliminate pathogenic factors Chinese medicine Radix Ginseng Rubra, Adeps Serpentis, all medicines cooperatively interact, strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease play the effect of killing parasites for relieving itching, heat clearing and damp drying jointly, are applicable to treatment various ringworms, eczema and dermatitis, therapeutic domain is wide, evident in efficacy, and nontoxic, have no side effect, safe in utilization.
The specific embodiment
Embodiment 1
Get Cortex Pseudolaricis 300 grams, Radix Sophorae Flavescentis 200 grams, Radix Et Rhizoma Rhei 20 grams, Cortex Phellodendri 20 grams, Radix Ginseng Rubra 10 grams, Adeps Serpentis 10 grams, Mentholum 20 grams, Borneolum Syntheticum 20 grams;
Earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and the Radix Ginseng Rubra of above-mentioned weight are pulverized, crossed 20 mesh sieves; Use 70% soak with ethanol 48 hours then, then carry out percolation and percolate is condensed into the thick paste of density 1.25 grams per milliliters; Thick paste is added in the 700 gram ointment bases then, stir into uniform mastic; Add Adeps Serpentis, Mentholum and Borneolum Syntheticum then when the mastic temperature is 50 ℃, mix homogeneously is promptly made required Chinese medicine antifungal ointment, and Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 2
Get Cortex Pseudolaricis 330 grams, Radix Sophorae Flavescentis 240 grams, Radix Et Rhizoma Rhei 25 grams, Cortex Phellodendri 25 grams, Radix Ginseng Rubra 14 grams, Adeps Serpentis 14 grams, Mentholum 22 grams, Borneolum Syntheticum 24 grams;
Earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and the Radix Ginseng Rubra of above-mentioned weight are pulverized, crossed 40 mesh sieves; Use 75% soak with ethanol 36 hours then, then carry out percolation and percolate is condensed into the thick paste of density 1.28 grams per milliliters; Thick paste is added in the 760 gram ointment bases then, stir into uniform mastic; Add Adeps Serpentis, Mentholum and Borneolum Syntheticum then when the mastic temperature is 52 ℃, mix homogeneously is promptly made required Chinese medicine antifungal ointment, and Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 3
Get Cortex Pseudolaricis 260 grams, Radix Sophorae Flavescentis 160 grams, Radix Et Rhizoma Rhei 15 grams, Cortex Phellodendri 15 grams, Radix Ginseng Rubra 6 grams, Adeps Serpentis 6 grams, Mentholum 18 grams, Borneolum Syntheticum 18 grams;
Earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and the Radix Ginseng Rubra of above-mentioned weight are pulverized, crossed 20 mesh sieves; Use 70% soak with ethanol 40 hours then, then carry out percolation and percolate is condensed into the thick paste of density 1.20 grams per milliliters; Thick paste is added in the 750 gram ointment bases then, stir into uniform mastic; Add Adeps Serpentis, Mentholum and Borneolum Syntheticum then when the mastic temperature is 50 ℃, mix homogeneously is promptly made required Chinese medicine antifungal ointment, and Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 4
Get Cortex Pseudolaricis 330 grams, Radix Sophorae Flavescentis 170 grams, Radix Et Rhizoma Rhei 15 grams, Cortex Phellodendri 25 grams, Radix Ginseng Rubra 14 grams, Adeps Serpentis 7 grams, Mentholum 24 grams, Borneolum Syntheticum 16 grams;
Earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and the Radix Ginseng Rubra of above-mentioned weight are pulverized, crossed 20 mesh sieves; Use 75% soak with ethanol 30 hours then, then carry out percolation and percolate is condensed into the thick paste of density 1.25 grams per milliliters; Thick paste is added in the 620 gram ointment bases then, stir into uniform mastic; Add Adeps Serpentis, Mentholum and Borneolum Syntheticum then when the mastic temperature is 53 ℃, mix homogeneously is promptly made required Chinese medicine antifungal ointment, and Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
Embodiment 5
Get Cortex Pseudolaricis 270 grams, Radix Sophorae Flavescentis 220 grams, Radix Et Rhizoma Rhei 27 grams, Cortex Phellodendri 14 grams, Radix Ginseng Rubra 7 grams, Adeps Serpentis 14 grams, Mentholum 16 grams, Borneolum Syntheticum 22 grams;
Earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and the Radix Ginseng Rubra of above-mentioned weight are pulverized, crossed 40 mesh sieves; Use 78% soak with ethanol 30 hours then, then carry out percolation and percolate is condensed into the thick paste of density 1.22 grams per milliliters; Thick paste is added in the 620 gram ointment bases then, stir into uniform mastic; Add Adeps Serpentis, Mentholum and Borneolum Syntheticum then when the mastic temperature is 50 ℃, mix homogeneously is promptly made required Chinese medicine antifungal ointment, and Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
Be equipped with raw material in above ratio during batch process.
The described Chinese medicine antifungal ointment of the foregoing description is investigated through company's long-term stable experiment, and the result meets preparation stability and investigates requirement.
This Chinese medicine antifungal ointment carries out pharmacodynamics test through authoritative institutions such as Traditional Chinese Medicine University Of Guangzhou, Chengdu University of Traditional Chinese Medicines to be observed, the result shows: (1) this Chinese medicine antifungal ointment is to 8 kind of 18 strain of trichophyton, 3 kind of 5 strain of Microsporon, 1 kind of 1 strain of Epidermophyton, Candida albicans belongs to 5 strains, 1 kind of 1 strain of Eurotium, a kind of 2 strain of Sporothrix all has antibacterial and killing action in various degree; (2) this Chinese medicine antifungal ointment has the obvious treatment effect to tinea corporis model due to microsporon gypseum, trichophyton gypseum, the trichophyton; (3) this Chinese medicine antifungal ointment can significantly suppress foot swelling of rat Ovum Gallus domesticus album and dimethylbenzene induced mice auricle edema; The increase of xylol induced mice skin of abdomen capillary permeability has obvious inhibitory action; (4) this Chinese medicine antifungal ointment can obviously improve and causes the itch-threshold of agent histamine phosphate to Cavia porcellus of itching; (5) this Chinese medicine antifungal ointment all has the obvious suppression effect to rat passive cutaneous anaphylaxis, PCA of the same race (PCA-I allergic reaction type) and II type immunoreation animal model (reaction of guinea pig skin vasculitis).The result of study prompting: this Chinese medicine antifungal ointment has antifungal, antiinflammatory, inhibition anaphylaxis and itching relieving effect.This result is that this Chinese medicine antifungal ointment removing dampness and killing parasites is antipruritic, cures mainly cutaneous fungal infection, eczema, dermatitis etc. certain pharmacology's foundation is provided, thereby affirmed the effectiveness of this Chinese medicine antifungal ointment.
The toxicological study result of the test shows: this Chinese medicine antifungal ointment external safety, and nontoxic, have no side effect, be the external preparation for skin product of safety.
Claims (10)
1. Chinese medicine antifungal ointment is characterized in that it is made by the following weight proportion raw material: 250～350 parts of Cortex Pseudolariciss, 150～250 parts of Radix Sophorae Flavescentiss, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 5～15 parts of Radix Ginseng Rubra, 5～15 parts of Adeps Serpentis, 15～25 parts of Mentholums, 15～25 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
2. Chinese medicine antifungal ointment according to claim 1 is characterized in that it is made by the following weight proportion raw material: 300 parts of Cortex Pseudolariciss, 200 parts of Radix Sophorae Flavescentiss, 20 parts of Radix Et Rhizoma Rhei, 20 parts of Cortex Phellodendris, 10 parts of Radix Ginseng Rubra, 10 parts of Adeps Serpentis, 20 parts of Mentholums, 20 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
3. Chinese medicine antifungal ointment according to claim 1 is characterized in that it is made by the following weight proportion raw material: 330 parts of Cortex Pseudolariciss, 240 parts of Radix Sophorae Flavescentiss, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Cortex Phellodendris, 14 parts of Radix Ginseng Rubra, 14 parts of Adeps Serpentis, 22 parts of Mentholums, 24 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
4. Chinese medicine antifungal ointment according to claim 1 is characterized in that it is made by the following weight proportion raw material: 260 parts of Cortex Pseudolariciss, 160 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Cortex Phellodendris, 6 parts of Radix Ginseng Rubra, 6 parts of Adeps Serpentis, 18 parts of Mentholums, 18 parts of Borneolum Syntheticums, 600～800 parts of ointment bases.
5. Chinese medicine antifungal ointment according to claim 1, it is characterized in that it makes by the following method: earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and Radix Ginseng Rubra are pulverized, use alcohol solution dipping then, then carry out percolation and percolate is condensed into thick paste, make thick paste and ointment base be mixed into uniform mastic, add Adeps Serpentis, Mentholum and Borneolum Syntheticum then, mix homogeneously is made unguentum.
6. the preparation method of Chinese medicine antifungal ointment according to claim 1, it is characterized in that: earlier Cortex Pseudolaricis, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Et Rhizoma Rhei and Radix Ginseng Rubra are pulverized, use alcohol solution dipping then, then carry out percolation and percolate is condensed into thick paste, make thick paste and ointment base be mixed into uniform mastic, add Adeps Serpentis, Mentholum and Borneolum Syntheticum then, mix homogeneously is made unguentum.
7. the preparation method of Chinese medicine antifungal ointment according to claim 6 is characterized in that: used alcoholic solution is 70%～80% heavy alcoholic solution.
8. the preparation method of Chinese medicine antifungal ointment according to claim 6 is characterized in that: the mastic temperature is 50～55 ℃ when adding Adeps Serpentis, Mentholum and Borneolum Syntheticum.
9. the preparation method of Chinese medicine antifungal ointment according to claim 6 is characterized in that: the density of described thick paste is 1.2～1.3 grams per milliliters.
10. the preparation method of Chinese medicine antifungal ointment according to claim 6 is characterized in that: described Mentholum and Borneolum Syntheticum were ground to molten before adding mastic earlier.
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| CN100446754C (en) * | 2005-11-03 | 2008-12-31 | 广东皮宝制药股份有限公司 | Prepn process of skin icing snake fat ointment |
| CN1985883B (en) * | 2005-12-24 | 2010-05-12 | 江苏中康药物科技有限公司 | Antifungal medicine composition and its preparing method and use |
| CN106619849A (en) * | 2017-03-14 | 2017-05-10 | 四川香龙丹医药科技有限公司 | Traditional Chinese medicine composition for treating superficial fungal diseases |
| CN113413422A (en) * | 2021-06-24 | 2021-09-21 | 李智民 | A topical pharmaceutical composition with antipruritic, antibacterial and antiinflammatory effects, and its preparation method |
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Address after: 515021 Guangdong city of Shantou province 11R2-2 Jinyuan Industrial Zone No. 1.2 block area Patentee after: Guangdong Taiantang Pharmaceutical Co., Ltd. Address before: 515021 Guangdong city of Shantou province 11R2-2 Jinyuan Industrial Zone No. 1.2 block area Patentee before: Pibao Pharmaceutical Co., Ltd., Guangdong |