CN1771945A - 托拉塞米分散片及其制备方法和应用 - Google Patents
托拉塞米分散片及其制备方法和应用 Download PDFInfo
- Publication number
- CN1771945A CN1771945A CN 200510117649 CN200510117649A CN1771945A CN 1771945 A CN1771945 A CN 1771945A CN 200510117649 CN200510117649 CN 200510117649 CN 200510117649 A CN200510117649 A CN 200510117649A CN 1771945 A CN1771945 A CN 1771945A
- Authority
- CN
- China
- Prior art keywords
- torasemide
- tablet
- disperese
- hyprolose
- microcrystalline cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
处方 | 托拉塞米 | 微晶纤维素 | 乳糖 | 羟丙纤维素 | 羧甲基淀粉钠 | 甜菊素 | 滑石粉 |
1 | 2.0g | 6.6g | 0.5g | 0.6g | 0.3g | ||
2 | 2.0g | 6.6g | 0.5g | 0.6g | 0.3g | ||
3 | 2.0g | 5.1g | 2.0g | 0.6g | 0.3g |
处方 | 考察结果 |
1 | 崩解较快(6.9分钟),不混悬 |
2 | 崩解慢(9.6分钟),不混悬 |
3 | 崩解慢(11分钟),不混悬 |
实施例1~4 | 崩解快(25~48秒),混悬 |
考察条件 | 时间(天) | 外观 | 分散均匀性 | 崩解时限(秒) | 含量(%) | 有关物质(%) |
0 | 外观光洁,微黄色片 | 符合规定 | 32 | 99.4 | 0.28 | |
高温(60℃) | 5 | 外观光洁,微黄色片 | 符合规定 | 34 | 99.5 | 0.34 |
10 | 外观光洁,微黄色片 | 符合规定 | 31 | 99.3 | 0.41 | |
高湿(RH92.5%) | 5 | 外观光洁,微黄色片 | 符合规定 | 37 | 99.3 | 0.37 |
10 | 微黄色片,片变软 | 符合规定 | 28 | 99.4 | 0.45 | |
强光(4500Lx) | 5 | 外观光洁,微黄色片 | 符合规定 | 31 | 99.2 | 0.30 |
10 | 外观光洁,微黄色片 | 符合规定 | 35 | 99.4 | 0.36 |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005101176492A CN100421662C (zh) | 2005-11-08 | 2005-11-08 | 托拉塞米分散片及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005101176492A CN100421662C (zh) | 2005-11-08 | 2005-11-08 | 托拉塞米分散片及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1771945A true CN1771945A (zh) | 2006-05-17 |
CN100421662C CN100421662C (zh) | 2008-10-01 |
Family
ID=36759198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005101176492A Expired - Fee Related CN100421662C (zh) | 2005-11-08 | 2005-11-08 | 托拉塞米分散片及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100421662C (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101632665B (zh) * | 2009-09-01 | 2011-08-17 | 严洁 | 一种托拉塞米口服药物组合物 |
CN106038500A (zh) * | 2016-05-26 | 2016-10-26 | 南京正科医药股份有限公司 | 一种托拉塞米片 |
CN107157994A (zh) * | 2017-06-09 | 2017-09-15 | 董鹏 | 一种托拉塞米的舌下口服制剂 |
CN115778912A (zh) * | 2021-09-09 | 2023-03-14 | 苏中药业集团股份有限公司 | 一种含有托拉塞米的片剂及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1292303T1 (de) * | 2000-02-17 | 2003-09-18 | Teva Pharma | Eine stabile pharmazeutische formulierung die torsemid modifikation ii enthält |
HRP20000162B1 (en) * | 2000-03-20 | 2004-06-30 | Pliva D D | Amorphous torasemide modification |
HRP20000328A2 (en) * | 2000-05-19 | 2002-02-28 | Pliva Farmaceutska Ind Dionik | Novel polymorph v of torasemide |
-
2005
- 2005-11-08 CN CNB2005101176492A patent/CN100421662C/zh not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101632665B (zh) * | 2009-09-01 | 2011-08-17 | 严洁 | 一种托拉塞米口服药物组合物 |
CN106038500A (zh) * | 2016-05-26 | 2016-10-26 | 南京正科医药股份有限公司 | 一种托拉塞米片 |
CN107157994A (zh) * | 2017-06-09 | 2017-09-15 | 董鹏 | 一种托拉塞米的舌下口服制剂 |
CN115778912A (zh) * | 2021-09-09 | 2023-03-14 | 苏中药业集团股份有限公司 | 一种含有托拉塞米的片剂及其制备方法 |
CN115778912B (zh) * | 2021-09-09 | 2024-10-01 | 苏中药业集团股份有限公司 | 一种含有托拉塞米的片剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100421662C (zh) | 2008-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1149083C (zh) | 含依必沙丹的药物组合物 | |
CN1732952A (zh) | 一种治疗高血压的复方分散片 | |
CN1658838A (zh) | 口腔崩解片及其制备方法 | |
CN1035433A (zh) | 药剂制粒 | |
CN101073563A (zh) | 一种含有右旋布洛芬和左旋西替利嗪的手性组合物及其缓速释双层片 | |
CN1221256C (zh) | 药物组合物 | |
CN1771945A (zh) | 托拉塞米分散片及其制备方法和应用 | |
CN101032489A (zh) | 头孢丙烯分散片及其制备方法 | |
CN1799543A (zh) | 替米沙坦分散片及其制备方法 | |
CN1883480A (zh) | 一种含卢帕他定的药物组合物 | |
CN1732953A (zh) | 一种治疗高血压的分散片 | |
CN1943561A (zh) | 普卢利沙星口腔崩解片及其制备方法 | |
CN1608621A (zh) | 双环醇微粉化及口服控释制剂 | |
CN1316978C (zh) | 复方硫酸氨基葡萄糖分散片制剂及其制备方法 | |
CN1887277A (zh) | 含有降血脂成分的分散片及其制备方法 | |
CN1903208A (zh) | 阿德福韦酯口崩片药物制剂及其制备方法 | |
CN1850083A (zh) | 一种治疗感冒的分散片及其制备工艺 | |
CN101066267A (zh) | 一种含有阿立哌唑微晶的固体口服药物组合物 | |
CN1868466A (zh) | 布洛伪麻缓释片及制备方法 | |
CN1237965C (zh) | 盐酸班布特罗口腔崩解片及其制备方法 | |
CN1768751A (zh) | 酚麻美愈分散片的制备方法 | |
CN1297263C (zh) | 葡萄糖酸钙口腔崩解片及其制备工艺 | |
CN1660098A (zh) | 含有盐酸西替利嗪的口服药物组合物 | |
CN1895250A (zh) | 一种格列喹酮的缓释制剂 | |
CN1742726A (zh) | 阿魏酸哌嗪口腔崩解片及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Guangdong Aimin Pharmaceutical Co., Ltd. Assignor: Zhou Zhuohe Contract fulfillment period: 2008.10.20 to 2014.10.20 contract change Contract record no.: 2009440001747 Denomination of invention: Disperese torasemide tablet and its prepn and application Granted publication date: 20081001 License type: Exclusive license Record date: 20091026 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.10.20 TO 2014.10.20; CHANGE OF CONTRACT Name of requester: GUANGDONG AIMIN MEDICINE CO., LTD. Effective date: 20091026 |
|
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Guangdong Aimin Pharmaceutical Co., Ltd. Assignor: Zhou Zhuohe Contract record no.: 2009440001747 Date of cancellation: 20100416 |
|
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Guangdong Aimin Pharmaceutical Co., Ltd. Assignor: Zhou Zhuohe Contract record no.: 2011440001032 Denomination of invention: Disperese torasemide tablet and its prepn and application Granted publication date: 20081001 License type: Exclusive License Open date: 20060517 Record date: 20111116 |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081001 Termination date: 20141108 |
|
EXPY | Termination of patent right or utility model |