CN1756533B - 非聚乙二醇化的长期循环的脂质体 - Google Patents

非聚乙二醇化的长期循环的脂质体 Download PDF

Info

Publication number
CN1756533B
CN1756533B CN2003801100257A CN200380110025A CN1756533B CN 1756533 B CN1756533 B CN 1756533B CN 2003801100257 A CN2003801100257 A CN 2003801100257A CN 200380110025 A CN200380110025 A CN 200380110025A CN 1756533 B CN1756533 B CN 1756533B
Authority
CN
China
Prior art keywords
composition
doxorubicin
liposomes
hydrochloride
pegylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2003801100257A
Other languages
English (en)
Chinese (zh)
Other versions
CN1756533A (zh
Inventor
G·V·达夫塔里
S·A·派
S·H·里范卡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zidus Bsv Pharmaceutical Pte Ltd
Zidus Bsv Research And Development Pte Ltd
Original Assignee
Bsv Research And Development Pte Ltd
Bharat Serums and Vaccines Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bsv Research And Development Pte Ltd, Bharat Serums and Vaccines Ltd filed Critical Bsv Research And Development Pte Ltd
Publication of CN1756533A publication Critical patent/CN1756533A/zh
Application granted granted Critical
Publication of CN1756533B publication Critical patent/CN1756533B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2003801100257A 2002-12-31 2003-12-31 非聚乙二醇化的长期循环的脂质体 Expired - Fee Related CN1756533B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1101MU2002 2002-12-31
IN1101/MUM/02 2002-12-31
PCT/IN2003/000424 WO2004058140A2 (en) 2002-12-31 2003-12-31 Non-pegylated long-circulating liposomes

Publications (2)

Publication Number Publication Date
CN1756533A CN1756533A (zh) 2006-04-05
CN1756533B true CN1756533B (zh) 2010-06-16

Family

ID=32500467

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2003801100257A Expired - Fee Related CN1756533B (zh) 2002-12-31 2003-12-31 非聚乙二醇化的长期循环的脂质体

Country Status (18)

Country Link
EP (1) EP1435231B8 (enExample)
JP (1) JP5355842B2 (enExample)
KR (2) KR101133084B1 (enExample)
CN (1) CN1756533B (enExample)
AT (1) ATE453381T1 (enExample)
AU (1) AU2003303368B2 (enExample)
BR (1) BR0317882A (enExample)
CA (1) CA2511464C (enExample)
DE (1) DE60330745D1 (enExample)
DK (1) DK1435231T3 (enExample)
EA (1) EA008930B1 (enExample)
ES (1) ES2337563T3 (enExample)
IL (1) IL169364A (enExample)
MX (1) MXPA05007102A (enExample)
NZ (1) NZ540778A (enExample)
PT (1) PT1435231E (enExample)
WO (1) WO2004058140A2 (enExample)
ZA (1) ZA200504850B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2152312B1 (en) * 2007-05-16 2014-12-31 KTB Tumorforschungsgesellschaft mbH Low-viscous anthracycline formulation
WO2010113983A1 (ja) 2009-03-30 2010-10-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 リポソーム組成物の製造方法
PE20120923A1 (es) * 2009-03-30 2012-08-27 Eisai Randd Man Co Ltd Composiciones farmaceuticas comprendiendo liposomas que contiene eribulina o una sal del mismo
US20130337051A1 (en) * 2011-03-01 2013-12-19 To-Bbb Holding B.V. Advanced active liposomal loading of poorly water-soluble substances
AU2015352685B2 (en) * 2014-11-25 2020-09-17 Nanobiotix Pharmaceutical composition, preparation and uses thereof
WO2017188350A1 (ja) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍の成長を抑制する方法
MX394860B (es) * 2016-09-27 2025-03-24 Vertex Pharma Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk).
ES3075649T3 (en) 2019-07-26 2026-08-06 Eisai R&D Man Co Ltd Pharmaceutical composition for treating tumor
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN116570775B (zh) * 2023-05-16 2024-08-02 万瑞飞鸿(北京)医疗器材有限公司 一种药物涂层、血管支架及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
EP0153955A1 (en) * 1983-09-06 1985-09-11 Health Research, Inc. Liposome delivery method for decreasing the toxicity of an antitumor drug
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
JPH0720857B2 (ja) 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US6132763A (en) 1988-10-20 2000-10-17 Polymasc Pharmaceuticals Plc Liposomes
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ATE252372T1 (de) * 1996-08-23 2003-11-15 Sequus Pharm Inc Liposome enthaltend cisplatin
CA2346879A1 (en) * 1998-09-16 2000-04-27 Alza Corporation Liposome-entrapped topoisomerase inhibitors
KR20000061075A (ko) * 1999-03-23 2000-10-16 린 중친 리포솜의 응집을 방지하기 위한 방법 및 조성물
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes

Also Published As

Publication number Publication date
KR101171045B1 (ko) 2012-08-03
MXPA05007102A (es) 2005-08-26
EP1435231A1 (en) 2004-07-07
AU2003303368A1 (en) 2004-07-22
ATE453381T1 (de) 2010-01-15
KR20110075051A (ko) 2011-07-05
JP2006513189A (ja) 2006-04-20
IL169364A0 (en) 2007-07-04
EP1435231B8 (en) 2010-03-03
EA200500850A1 (ru) 2006-02-24
NZ540778A (en) 2008-04-30
WO2004058140A3 (en) 2004-10-28
DK1435231T3 (da) 2010-04-26
ZA200504850B (en) 2006-08-30
EP1435231B1 (en) 2009-12-30
WO2004058140B1 (en) 2004-12-16
AU2003303368B2 (en) 2010-06-17
JP5355842B2 (ja) 2013-11-27
WO2004058140A2 (en) 2004-07-15
KR20050088233A (ko) 2005-09-02
CA2511464A1 (en) 2004-07-15
DE60330745D1 (de) 2010-02-11
BR0317882A (pt) 2005-12-13
IL169364A (en) 2012-05-31
ES2337563T3 (es) 2010-04-27
PT1435231E (pt) 2010-04-08
CN1756533A (zh) 2006-04-05
EA008930B1 (ru) 2007-08-31
KR101133084B1 (ko) 2012-04-04
HK1089946A1 (en) 2006-12-15
CA2511464C (en) 2011-08-23

Similar Documents

Publication Publication Date Title
US9005655B2 (en) Non-pegylated long-circulating liposomes
Uchegbu et al. Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse
Cattel et al. From conventional to stealth liposomes: a new frontier in cancer chemotherapy
Gulati et al. Development of liposomal amphotericin B formulation
EP1539102A2 (en) Pharmaceutically active lipid based formulation of sn38
JP2001501173A (ja) シスプラチン化合物を含有するリポソーム
JPH0526767B2 (enExample)
US5560923A (en) Method of encapsulating anthracycline in liposomes
CN103622909A (zh) 一种含心磷脂的脂质体新制剂及其在抗肿瘤药物中的应用
EP1435231B1 (en) Non-pegylated long-circulating liposomes
US20020058060A1 (en) Liposome for incorporating large amounts of hydrophobic substances
Moribe et al. Enhanced encapsulation of amphotericin B into liposomes by complex formation with polyethylene glycol derivatives
KR102708349B1 (ko) 씨 알지디 에이씨피 케이로 변형된 장시간 순환 리포솜
Uchegbu et al. Drug distribution and a pulmonary adverse effect of intraperitoneally administered doxorubicin niosomes in the mouse
WO2000009071A2 (en) A novel liposomal formulation useful in treatment of cancer and other proliferation diseases
CN103830182A (zh) 一种长循环伊立替康脂质体组合物及其制备方法
HK1089946B (en) Non-pegylated long-circulating liposomes
EP4529915A1 (en) Liposomal preparations for use in treating cancer
EP1089727B1 (en) Liposomal formulations of busulphan

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: BSV RESEACH AND DEVELOPMENT PERSONAL CO., LTD.

Free format text: FORMER OWNER: BHARAT SERUMS + VACCINES LTD.

Effective date: 20061027

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20061027

Address after: Ahmedabad

Applicant after: BSV Research and Development Pte. Ltd.

Address before: India Fontana

Applicant before: Bharat Serums & Vaccines Ltd.

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1089946

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1089946

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: ZYDUS BSV PHARMA PVT. LTD.

Free format text: FORMER OWNER: ZYDUS BSV R + D PVT. LTD.

Effective date: 20110818

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: ZYDUS BSV R + D PVT. LTD.

Free format text: FORMER NAME: BHARAT SERUMS + VACCINES LTD.

CP01 Change in the name or title of a patent holder

Address after: Ahmedabad

Patentee after: Zidus BSV research and development Pte. Ltd.

Address before: Ahmedabad

Patentee before: BSV Research and Development Pte. Ltd.

TR01 Transfer of patent right

Effective date of registration: 20110818

Address after: Ahmedabad

Patentee after: Zidus BSV pharmaceutical Pte. Ltd.

Address before: Ahmedabad

Patentee before: Zidus BSV research and development Pte. Ltd.

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100616

Termination date: 20151231

EXPY Termination of patent right or utility model