CN1745083A - 作为血管加压素激动剂的吡咯并[2,1－c][1,4]苯并二氮杂庚因 - Google Patents

作为血管加压素激动剂的吡咯并[2,1－c][1,4]苯并二氮杂庚因 Download PDF

Info

Publication number
CN1745083A
CN1745083A CNA2003801095935A CN200380109593A CN1745083A CN 1745083 A CN1745083 A CN 1745083A CN A2003801095935 A CNA2003801095935 A CN A2003801095935A CN 200380109593 A CN200380109593 A CN 200380109593A CN 1745083 A CN1745083 A CN 1745083A
Authority
CN
China
Prior art keywords
compound
alkyl
alkylene
group
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801095935A
Other languages
English (en)
Chinese (zh)
Inventor
A·J·莫利纳里
E·J·特里布尔斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of CN1745083A publication Critical patent/CN1745083A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CNA2003801095935A 2002-12-16 2003-12-16 作为血管加压素激动剂的吡咯并[2,1－c][1,4]苯并二氮杂庚因 Pending CN1745083A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/320,761 2002-12-16
US10/320,761 US7138393B2 (en) 1998-07-24 2002-12-16 Biologically active vasopressin agonist metabolites

Publications (1)

Publication Number Publication Date
CN1745083A true CN1745083A (zh) 2006-03-08

Family

ID=32710746

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801095935A Pending CN1745083A (zh) 2002-12-16 2003-12-16 作为血管加压素激动剂的吡咯并[2,1－c][1,4]苯并二氮杂庚因

Country Status (15)

Country Link
US (1) US7138393B2 (https=)
EP (1) EP1572694B1 (https=)
JP (1) JP2006514956A (https=)
CN (1) CN1745083A (https=)
AR (1) AR042467A1 (https=)
AT (1) ATE410428T1 (https=)
AU (1) AU2003297127A1 (https=)
BR (1) BR0317383A (https=)
CA (1) CA2508764A1 (https=)
DE (1) DE60324018D1 (https=)
DK (1) DK1572694T3 (https=)
ES (1) ES2312859T3 (https=)
MX (1) MXPA05006241A (https=)
TW (1) TW200413355A (https=)
WO (1) WO2004060894A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216304A (zh) * 2008-11-18 2011-10-12 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
NO3085381T3 (https=) * 2008-05-21 2018-09-15
US9532959B2 (en) 2010-07-08 2017-01-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US10010514B2 (en) 2010-07-08 2018-07-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
MX2014008283A (es) * 2012-01-04 2015-03-03 Wellesley Pharmaceutical Llc Formulacion de liberacion prolongada para reducir la frecuencia de orinar y metodos de uso de esta.
BR112014016550A8 (pt) * 2012-01-04 2017-07-04 Wellesley Pharmaceuticals Llc formulação de liberação retardada para reduzir a frequência de urinação e método de uso da mesma
US10278925B2 (en) 2012-01-04 2019-05-07 Wellesley Pharmaceuticals, Llc Delayed-release formulations, methods of making and use thereof
US10105330B2 (en) 2012-01-04 2018-10-23 Wellesley Pharmaceuticals, Llc Extended, delayed and immediate release formulation method of manufacturing and use thereof
US10105328B2 (en) 2014-06-06 2018-10-23 Wellesley Pharmaceuticals, Llc Composition for reducing frequency of urination, method of making and use thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1251767B (de) * 1964-02-28 1968-04-18 Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen
US4680298A (en) 1983-05-31 1987-07-14 Schering Corporation Tricyclic anti-allergy and use as anti-inflammatory agents
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
US4839355A (en) 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
CA2048003A1 (en) 1990-08-21 1992-02-22 Serge Burner Tricyclic pyridone derivatives
US5516774A (en) 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5420270A (en) * 1993-10-07 1995-05-30 G. D. Searle & Co. Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
ES2199251T3 (es) 1994-06-15 2004-02-16 Otsuka Pharmaceutical Company, Limited Derivados benzoheterociclicos utilizables como moduladores de vasopresina o de oxitocina.
JPH0881460A (ja) 1994-09-08 1996-03-26 Yamanouchi Pharmaceut Co Ltd 新規なテトラヒドロベンゾジアゼピン誘導体又はその塩
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
AU727654B2 (en) 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
DE69826487T2 (de) 1997-07-30 2005-12-01 Wyeth Trizyclische vasopressin-agonisten
US6194407B1 (en) * 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
WO2000046228A2 (en) 1999-02-04 2000-08-10 American Home Products Corporation Pyrrolobenzodiazepine carboxyamide vasopressin agonists
CN1391476A (zh) 1999-09-27 2003-01-15 美国氰胺公司 血管升压素激动剂制剂和方法
CN1399542A (zh) 1999-09-27 2003-02-26 美国氰胺公司 药用载体制剂
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216304A (zh) * 2008-11-18 2011-10-12 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚
CN102216304B (zh) * 2008-11-18 2014-07-09 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚

Also Published As

Publication number Publication date
JP2006514956A (ja) 2006-05-18
EP1572694B1 (en) 2008-10-08
WO2004060894A1 (en) 2004-07-22
DK1572694T3 (da) 2009-02-02
US7138393B2 (en) 2006-11-21
DE60324018D1 (de) 2008-11-20
AR042467A1 (es) 2005-06-22
CA2508764A1 (en) 2004-07-22
AU2003297127A1 (en) 2004-07-29
ATE410428T1 (de) 2008-10-15
MXPA05006241A (es) 2005-08-19
US20030134845A1 (en) 2003-07-17
ES2312859T3 (es) 2009-03-01
TW200413355A (en) 2004-08-01
BR0317383A (pt) 2005-11-16
EP1572694A1 (en) 2005-09-14

Similar Documents

Publication Publication Date Title
CN1022566C (zh) 制备新的取代的1-哌啶亚烷基-吡啶并嘧啶酮或噻唑并嘧啶酮的方法
CN1745083A (zh) 作为血管加压素激动剂的吡咯并[2,1－c][1,4]苯并二氮杂庚因
EP1268466B1 (en) Decahydro-isoquinolines
US6156898A (en) Substituted 1,4-dihydro-4-oxonicotinic carboxamides; GABA brain receptor ligands
CN105121423A (zh) 新型3-(4-(苄氧基)苯基)己-4-炔酸衍生物、其制备方法、和包括其作为有效成分的用于预防和治疗代谢性疾病的药物组合物
BG61365B2 (bg) Тиазепинови съединения
WO2016073633A1 (en) SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
US5861398A (en) Benzoperimidine-carboxylic acids and derivatives thereof
EP2294068B1 (fr) DERIVES DE 1,3-DIHYDRO-2H-PYRROLO(3,2-b) PYRIDIN-2-ONE, LEUR PREPARATION ET LEURS APPLICATIONS EN THERAPEUTIQUE
US20020013329A1 (en) Iminopyrimidine NMDA NR2B receptor antagonists
CN102869665B (zh) 苯并氮杂环庚三烯化合物
CN101094852A (zh) 作为cns活性剂的取代的吲嗪以及衍生物
CN1294134C (zh) 环己基苯基血管升压素激动剂
JP6230626B2 (ja) ベンゾチアゾロン化合物を含む製剤
CN107793350A (zh) 芳乙基哌啶基衍生物及其治疗精神分裂症的应用
CZ25295A3 (en) Novel 3-benzoyl-3,7-diazabicyclo/3,3,1/nonane compounds containing a medicament
EP0595364B1 (en) Benz[e]indene derivatives and a process for preparing them as well as medicaments containing them and the use of them
CN1339035A (zh) 吡啶并苯并二吖庚因和吡啶并苯并氧杂吖庚因酰胺血管加压素激动剂
US20240398821A1 (en) Flavonoid derivatives with gabaa receptor activity and methods of use
JPH0566388B2 (https=)
WO2020142865A1 (zh) 一种苯甲酰胺类化合物、中间体、制备方法及应用
JP2021508342A (ja) トリアゾロキナゾリノンの合成
RU2777915C2 (ru) Имидазодиазепиновое соединение
CN121494831A (zh) 一种二芳基醚衍生物及其制备方法和应用
TWI429429B (zh) 苯并稠合之雜環磺醯胺衍生物於治療躁狂及兩極病症之用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned

Effective date of abandoning: 20060308

C20 Patent right or utility model deemed to be abandoned or is abandoned