CN1739580A - Recipe and prepn process of Chinese medicine gel prepn - Google Patents
Recipe and prepn process of Chinese medicine gel prepn Download PDFInfo
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- CN1739580A CN1739580A CN 200510094332 CN200510094332A CN1739580A CN 1739580 A CN1739580 A CN 1739580A CN 200510094332 CN200510094332 CN 200510094332 CN 200510094332 A CN200510094332 A CN 200510094332A CN 1739580 A CN1739580 A CN 1739580A
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Abstract
The present invention relates to the recipe and preparation process of Chinese medicine gel preparation. The recipe includes mixed medicine powder, gel matrix material, preservative, humectant I, humectant II and water in certain proportion. The preparation process includes dissolving preservative in hot water, adding gel matrix material slowly while stirring to form slurry, mixing medicine powder with humectant I and humectant II via stirring, adding the mixture into the slurry through stirring, regulating pH value to precipitated value, adding water to required amount, stirring, and packing. The Chinese medicine gel preparation is convenient in use, homogeneous, fine, non-toxic and stable, may be sterilized in different methods and has moderate viscosity.
Description
Technical field
The present invention relates to a kind of prescription and preparation method for the treatment of the Chinese medicine gel of vaginitis, cervicitis, cervical erosion.
Background technology
Gynecological inflammations such as vaginitis, cervicitis, cervical erosion are the women of child-bearing age's commonly encountered diseases, frequently-occurring disease, and sickness rate accounts for the women of child-bearing age's 60% to 80%.At present, there are many Western medicine to can be used for the treatment of vaginitis, cervicitis, cervical erosion, but the defective of Western medicine is apparent in view, as act on single, easily develop immunity to drugs, zest, anaphylaxis, internal organs such as Liver and kidney there is bigger toxic and side effects, being unsuitable for anemia of pregnant woman or women breast-feeding their children uses, intravaginal profitable strain (as lactobacillus) had killing action equally, easily cause the intravaginal dysbacteriosis, destroy self-cleaning system of vagina or the like, some medicine itself may be carcinogenic in addition, the potential danger of teratogenesis (as metronidazole etc.).
Many deficiencies of chemical medicine both can have been overcome by the compound Chinese medicinal preparation of theory of Chinese medical science prescription, the incomparable many-sided therapeutical effect of chemical medicine (invigorate blood circulation as putrefaction-removing granulation-promoting, dampness removing etc.) can be brought into play again, the former caused gynecological inflammation that causes a disease such as antibacterial, fungus, protozoon, chlamydia, mycoplasma can be widely used in.Modern disease Neo-Confucianism thinks that human papillomavirus, herpesvirus especially II herpes simplex virus type are one of main inducing of cervical cancer, and Chinese medicine will be better than Western medicine far away to the comprehensive inhibitory action of virus.Therefore, aspect the treatment gynecological inflammation, the exploitation determined curative effect, the pure Chinese medicinal preparation of dosage form novelty has vast market prospect.Yet, make a general survey of the Chinese medicine preparation of employed clinically treatment gynecological inflammation at present, as health woman antiinflammatory bolt, control rotten effervescence tablet etc., at the treatment vaginitis, cervicitis, all there is certain curative effect aspects such as cervical erosion, but kind is single generally, indication is narrower, and dosage form is outmoded, some medicine because of the development time early, preparation method, quality standard is all relatively backward, dosage is bigger than normal, use inconvenience, and pharmacological basis is unsturdy, the pharmacodynamics index imperfection, what have does not reach desired therapeutic effect because of the adjuvant quality passes a test, and the performance that all these has directly influenced the Chinese medicine advantage has weakened the competitiveness of Chinese medicine on gynecological market.In view of this, be necessary that very exploitation can overcome the defective of many Western medicine, can remedy the gynecological insufficient of new generation good medicine of similar Chinese medicine again, to benefit numerous women.
Summary of the invention
In order to overcome the defective of the many Western medicine that are used for vaginitis, cervicitis, cervical erosion at present, can remedy the deficiency of similar Chinese medicine again and invented a kind of prescription and preparation method of Chinese medicine gel.
A kind of Chinese medicine gel for the treatment of vaginitis, cervicitis, cervical erosion of the present invention, its prescription is: gel matrix material 5～50g, antiseptic 0.1～5g, wetting agent (I) 50～200g, wetting agent (II) 40～160g, the mixed powder that makes in advance are a certain amount of, water adds to 1000g.
Wherein gel matrix material is a carbomer 934, and consumption is 0.5～5%.Antiseptic is a chlorocresol, and consumption is 0.01～0.5%, and wetting agent (I) is a propylene glycol, and wetting agent (II) is a glycerol.
Preparation method of the present invention is: the chlorocresol that takes by weighing ormal weight is dissolved in the warm water about 400ml, slowly adds carbomer 934, and the limit edged stirs, and is until stirring fine and smooth rubber cement, standby.Take by weighing the propylene glycol and the glycerol of ormal weight, add the mixed powder for preparing in advance, fully grind well or stir evenly.Drug moiety is slowly added in the substrate, stir evenly, regulate pH, add water to 1000g, fully stir evenly to setting, the single dose packing, promptly.
The reagent that is used to regulate pH value is triethanolamine, regulates pH value to 4～8.
The present invention is different from the characteristics of other gel: gel is a kind of ointment shape preparation of making as substrate with some water-soluble high-molecular materials, easy to use, onset is rapid, be convenient to clean, compare with effervescent tablet with suppository, it is not subjected to the influence of body temperature or vagina humidity, can fill whole vagina, does not stay the dead angle.Owing to be water-soluble base, medicine can contact closely with vaginal mucosa, and drug release rate is very fast, and can be in whole vagina and uterus neck performance drug effect.
Available gel matrix material is a lot, and as cellulose derivative, carbomer, alginate etc., wherein carbomer has many models and specification again.Through repeated screening, we select the gel matrix material of carbomer as this product for use at decision, and select 934 these models for use.Because the prepared gel stability of carbomer can adopt high compressed steam or radiation sterilization, and carbomer can form with a large amount of alkaloids composition such as berberine in this product, and the gel derived thing of solubility---inner salt makes finished product more stable.Compare with the carbomer of other model, " carbomer 934 " prepared gel is fine and smooth more, and viscosity is moderate, almost non-toxic property.
Available antiseptic kind is a lot of in the Chinese medicine preparation, select " chlorocresol " for use at this, except that the antiseptic and inhibiting bacteria function effect of chlorocresol in carbomer gel preferably, also can overcome other antiseptic (as benzoic acids) carbomer gel viscosity is reduced, and produce sedimentary deficiency.
The wetting agent kind is a lot, and the most frequently used is glycerol and propylene glycol.Through relatively, we select glycerol and two kinds of wetting agents of propylene glycol, and the consumption of propylene glycol is greater than glycerol, and at this moment, moistening effect is better, and the oiliness of finished product is less.
In a word, by above prescription and the outstanding feature of the prepared gel of technology be: even, fine and smooth, nontoxic, stable; Can adopt several different methods to carry out sterilization treatment, viscosity is moderate.
The specific embodiment
Prescription according to gel: carbomer 934 5～50g, chlorocresol 0.1～5g, propylene glycol 50～200g, glycerol 40～160g, the mixed powder that makes in advance are a certain amount of, water adds to 1000g.The chlorocresol that takes by weighing ormal weight is dissolved in the warm water about 400ml, slowly adds carbomer 934, and the limit edged stirs, and is until stirring fine and smooth rubber cement, standby.Take by weighing the propylene glycol and the glycerol of ormal weight, add the mixed powder for preparing in advance, fully grind well or stir evenly.Drug moiety is slowly added in the substrate, stir evenly, regulate pH, add water to 1000g, fully stir evenly to setting, the single dose packing, promptly.
Claims (6)
1, a kind of prescription of Chinese medicine gel is: gel matrix material 5～50g, antiseptic 0.1～5g, wetting agent (I) 50～200g, wetting agent (II) 40～160g, the mixed powder that makes in advance are a certain amount of, water adds to 1000g.
2, prescription according to claim 1 is characterized in that gel matrix material is a carbomer 934, and consumption is 0.5～5%.
3, prescription according to claim 1 is characterized in that wetting agent (I) is a propylene glycol, and consumption is 5～20%; Wetting agent (II) is a glycerol, and consumption is 4～16%.
4, prescription according to claim 1 is characterized in that antiseptic is a chlorocresol, and consumption is 0.01～0.5%.
5, a kind of preparation method of Chinese medicine gel is: the antiseptic that takes by weighing ormal weight is dissolved in the warm water about 400ml, and it is a certain amount of slowly to add gel matrix material, and the limit edged stirs, until stirring fine and smooth rubber cement, standby, take by weighing the wetting agent (I) and the wetting agent (II) of ormal weight, add the mixed powder for preparing in advance, fully grind well or stir evenly, slowly add drug moiety in the substrate, stir evenly, regulate pH to setting, add water to 1000g, fully stir evenly, the single dose packing gets product.
6, preparation method according to claim 5, the reagent that it is characterized in that being used to regulating pH value is triethanolamine, regulates pH value to 4～8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510094332 CN1739580A (en) | 2005-09-13 | 2005-09-13 | Recipe and prepn process of Chinese medicine gel prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510094332 CN1739580A (en) | 2005-09-13 | 2005-09-13 | Recipe and prepn process of Chinese medicine gel prepn |
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| CN1739580A true CN1739580A (en) | 2006-03-01 |
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| CN 200510094332 Pending CN1739580A (en) | 2005-09-13 | 2005-09-13 | Recipe and prepn process of Chinese medicine gel prepn |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370982C (en) * | 2006-03-10 | 2008-02-27 | 浙江大学 | Anemonin gel |
| CN104873768A (en) * | 2015-06-08 | 2015-09-02 | 山东大学齐鲁医院 | Traditional Chinese medicine preparation for treating cervicitis and preparation method thereof |
| CN104906229A (en) * | 2015-06-08 | 2015-09-16 | 山东大学齐鲁医院 | Traditional Chinese medicine gel preparation for treating cervicitis |
| CN104906414A (en) * | 2015-06-08 | 2015-09-16 | 山东大学齐鲁医院 | Traditional Chinese medicine gel preparation for treating chronic cervicitis |
| CN107260791A (en) * | 2017-08-17 | 2017-10-20 | 蔡挺 | A kind of honeysuckle antibacterial gel and its preparation method and application |
| CN110179918A (en) * | 2019-06-12 | 2019-08-30 | 张家港市中医医院 | Treat vaginitis, cervicitis, the Chinese medicine of cervical erosion and preparation and preparation method |
-
2005
- 2005-09-13 CN CN 200510094332 patent/CN1739580A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370982C (en) * | 2006-03-10 | 2008-02-27 | 浙江大学 | Anemonin gel |
| CN104873768A (en) * | 2015-06-08 | 2015-09-02 | 山东大学齐鲁医院 | Traditional Chinese medicine preparation for treating cervicitis and preparation method thereof |
| CN104906229A (en) * | 2015-06-08 | 2015-09-16 | 山东大学齐鲁医院 | Traditional Chinese medicine gel preparation for treating cervicitis |
| CN104906414A (en) * | 2015-06-08 | 2015-09-16 | 山东大学齐鲁医院 | Traditional Chinese medicine gel preparation for treating chronic cervicitis |
| CN107260791A (en) * | 2017-08-17 | 2017-10-20 | 蔡挺 | A kind of honeysuckle antibacterial gel and its preparation method and application |
| CN110179918A (en) * | 2019-06-12 | 2019-08-30 | 张家港市中医医院 | Treat vaginitis, cervicitis, the Chinese medicine of cervical erosion and preparation and preparation method |
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