CN101766638A - Local medicament for treating senile vaginitis by replacing estrogen - Google Patents
Local medicament for treating senile vaginitis by replacing estrogen Download PDFInfo
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- CN101766638A CN101766638A CN201010028091A CN201010028091A CN101766638A CN 101766638 A CN101766638 A CN 101766638A CN 201010028091 A CN201010028091 A CN 201010028091A CN 201010028091 A CN201010028091 A CN 201010028091A CN 101766638 A CN101766638 A CN 101766638A
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Abstract
The invention relates to a local medicament for treating senile vaginitis by replacing estrogen. The medicament consists of vitamin A, vitamin E, glucose, alpha-lactose, citric acid and butylparaben bacteriostat. The invention adopts the most common and familiar medicaments, utilizes the unique treatment effect of each medicament and synergism after combination, and provides the medicament for treating the senile vaginitis by replacing the estrogen for people; and the medicament is safe, has special effect, can rapidly change diseased environment of the senile vaginitis, promotes the propagation of lactic acid bacillus, further reduces pH value, inhibits and kills pathogenic bacteria, replenishes nutrition, regulates the moistening degree, strengthens local immunity function, improves local microcirculation, promotes metabolism, and recovers injured mucosal of vagina to a normal state.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of senile vaginitis, particularly a kind of local application of alternative estrin treatment senile vaginitis.
Background technology
Senile vaginitis is that the women enters old back because estrogen secretion reduces the degeneration that causes, minority women produces senile vaginitis because of chemicotherapy causes to reduce or stop to secrete estrogen after the impaired or spay of ovary.In addition, along with the normal regulating imbalance that regularity, anxious state of mind, spiritual neural factor etc. cause thalamus, adrenal gland, this sight alignment of ovary is owed in the increasing the weight of of environmental pollution, work strain, life, influencing estrogen level reduces, make Woman climacteric in advance, senile vaginitis also takes place thereupon in advance.
The histochemistry of senile vaginitis shows: top layer attenuation, increases of keratinization degree, minimizings of corium medium vessels, nympha atrophy, clitoris atrophy, sensitivity reduce, vaginal orifice exposes, vaginal wall is paler, degenerations of wrinkle wall, mucosal atrophy attenuation, pH value raise, the lactobacillus minimizing, and pathogenic bacterium breed in a large number, elastic fiber minimizing under the mucosa, collagen fiber increase, the reduction of vagina contractility, contraction in length, pliability weaken, because of seriously minimizing desiccation, spiral artery atrophy, smooth muscle layer attenuation etc. of secretions.In case senile vaginitis forms, senile vaginitis symptom in various degree occurs thereupon, mainly show as vagina and vulva atrophy, dry and astringent, burning pain, pruritus, touch pain, mucosa point-like or lamellar hyperemia, hemorrhagic table fester, involve the cystitis that urethra produces frequent micturition, dysurea, even the vagina epimere forms enclosed type vomica etc.In case suffer from senile vaginitis, patient self misery of being ashamed to mention not only then, and have a strong impact on love life.Lack the vicious cycle that sexual life brings the sex hormones secretion continuous decrease again, not only reduce the love life quality greatly, also seriously influence goodwill as between spouses and family harmony, be unfavorable for good health and a long life.
Therefore, actively treat senile vaginitis effectively, concern the health of thousands upon thousands sufferers, also concern thousands upon thousands family's wellbeings with harmonious.
At present the Therapeutic Method to senile vaginitis has whole body and local two kinds of medications usually: oral estrogen or locally use estrogen, or estrogen added with antibiotic, or the part with lubricator, Oleum Radix Arnebiae (Oleum Radix Lithospermi), irrigation etc.The side effect that the treatment of estrogens medicine might produce fearful side reaction-generation reproductive system cancer and breast carcinoma.
Summary of the invention
In view of the painful symptom of above-mentioned senile vaginitis patients and present treatment present situation, the objective of the invention is pathological changes mechanism at senile vaginitis patients intravaginal generation pathological changes, develop a kind of energy and substitute estrogen, safe in utilization, and can fundamentally improve the internal and external environment of vagina, thereby develop the local application of the having no side effect of treatment senile vaginitis, treating both the principal and secondary aspects of a disease.
The present invention is a kind of medicine of alternative estrin treatment senile vaginitis, it is characterized in that this medicine is made up of vitamin A, vitamin E, glucose, lactose, citric acid and oxybenzene esters, and its weight portion is as follows:
Vitamin A 0.69-150
Vitamin E 75-3950
Glucose 400-3200
A--lactose 3200-400
Citric acid 0.3676-472.5
The mixed ester in twos of methyl hydroxybenzoate, propyl ester, butyl ester, the weight portion of methyl ester, propyl ester, butyl ester is as follows respectively:
Methyl ester 0.47-1.137
Propyl ester 8.40-14.85
Butyl ester 7.39-9.94.
The present invention is from changing the ill environment of senile vaginitis, strengthen the breeding of lactobacillus, and then reduction pH value, press down and kill pathogenic bacterium, supplement the nutrients simultaneously, regulate and moisten degree, treat impaired mucosa, improve vagina local immunity function, improve local microcirculation, enhance metabolism, the target that allows vagina quickly recover to normal state is set out, and adopts the most common, modal health product composition, utilize its separately unique curative effect and the combination after mutual synergism, a kind of safety of alternative estrin treatment senile vaginitis is provided for people, the specific medicine of tool can make vagina quickly recover to normal state through treatment.
The main effect of each component is as follows in the side:
Vitamin A
Vitamin A is the oil-soluble free radical scavenger, and it is the most complicated unsaturated monohydric alcohol, because of the tool unsaturated bond easily oxidized, so be the oiliness antioxidant.Vitamin A also has following effect:
1, keeps ovary and regulate estrogen level;
2, the integrity of regulate the epithelial cell differentiation, keeping epithelial tissue, mucosa plays an important role, and also is somatotrophic neccessary composition;
3, enhancing immunity, the normal secretion of protection globulin A is not damaged, and impels lymphocyte, T hyperplasia, improves body immunity;
4, keep the activity of adenosine triphosphate-sulfurylase and sulfate transferase in skin and the mucosa;
5, promote the synthetic of acid mucopolysaccharide, antiinflammatory and help ulcer healing;
6, can suppress tumor growth, differentiation, prevent skin carcinoma etc.;
7, with the vitamin E use in conjunction, reduce the toxicity of some poisonous substance, strengthen the immunity of environmental pollution, the tool protective effect on cancer risk.
Vitamin E
1, vitamin E is a kind of very strong antioxidant; be the oil-soluble free radical scavenger; easily oxidized; thereby protect other material not oxidized; prevent that cell membrane and other cyto-architectural polyvalent unsaturated fatty acid etc. are not damaged by peroxidating, thereby keep biomembranous normal configuration and physiological function.Be oil-soluble inhibitor in the prescription, can promote the absorption of vitamin A, quicken the utilization of vitamin A and the toxicity of reduction vitamin A as vitamin A;
2, promote pituitary secretion, it is unbalance to regulate organism endocrine;
3, promote the biosynthesis of hemoglobin, the protection erythrocyte is exempted from haemolysis;
4, neuroprotective and muscle are avoided radical damage, keep the normal development and the function of nerve-muscle, improve progressive myatrophy;
5, participate in the plurality of enzymes activity, protection cell hydrogen peroxide enzyme and Peroxidase activity;
6, suppress wound location and form too much collagen protein, reduce the formation of cicatrix, the blood vessel wall cicatrix is had repair, be beneficial to the release of wound healing, inhibition sensitization source histamine, reduce erythema and edema, the tool antiinflammatory action promotes ulcer healing;
8, promote blood tubule and blood capillary proliferation, keep the permeability of blood capillary, increase the flow of blood capillary, circulation around improving enhances metabolism, and improves local nutrition, promotes the damage quickly-healing greatly;
9, improve immunity, protect immune cell not oxidized, increase the weight of thymus, increase the generation of spleen antibody cell, strengthen the effect of T cell, B cell, neutrophilic granulocyte, change the stress of immunity, thereby improve resistance and the tolerance of host microorganism;
10, the effect of the effect of tool defying age and prophylaxis of tumours and adjusting estrogen level.
Citric acid
1, makes the regulator of buffer agent, pH value, make product tool acidity of the present invention;
2, do antioxidant synergist, chelating agen, help finished product not oxidized.
α--lactose
Make dilution filler, nutrient, also under the effect of enzyme, lactose is converted into the sugared source of lactic acid as lactobacillus.
Glucose
Make dilution filler, osmotic pressure regulator, can cause local penetration pressure reduction, improve intravaginal dry and astringent environment, intravaginal is moistened, transudate also has the flushing inflammation excremental effect in position of festering, reduce the refuse alluvial, be beneficial to clearly and hinder, impel impaired healing, can prevent from that vitamin A and vitamin E from reducing to tire, because of having gentle reproducibility, to VE, VA etc. easily the medicine of oxidation Stabilization is arranged, also have a Nutrition, be the preferred sugared source of non-intestinal treatment.
Oxybenzene esters mixed ester
Make antibacterial antiseptic.With their mutual mixture tool synergism, effect is stronger than using separately, also can make antibacterial according to the salt of dosage form selection oxybenzene esters and benzoic acid and potassium, sodium salt etc.
VA and VE use in conjunction in the present invention's prescription, the two each Xingqi effect plays complementary synergism again, selecting for use in right amount, play the optimum effect of treatment and nutrition, is the main medicine of curing senile vaginitis, adopt two kinds of sugar to do outside diluent and the filler, the two is its physiological action of each tool again.
Under the normal condition, intravaginal pH value is about 4.8, is faintly acid.Fungal component has 18 kinds more than in this environment, and wherein lactobacillus is the necessary main bacteria of physiology, and the vagina pH value of senile vaginitis patients is alkalescence, can reach 8-9 through the actual senile vaginitis severe patient pH value that records.
Product tool acidity of the present invention, help killing the pathogenic bacterium in the alkaline environment, help the existence and the breeding of the necessary lactobacillus of vagina physiology simultaneously, and then impel the generation of lactic acid, reduce pH value, can make pH value be returned to normal state about 4.8 with product of the present invention.
The present invention overcomes the various symptoms of senile vaginitis targetedly, from improving the interior environment of vagina, reduce that pH value, extra-nutrition, adjusting moisten degree, treat impaired mucosa, strengthen local microcirculation and metabolism, raising local immunity function is set about, select for use the health-care components of the most common and safety non-toxic to constitute, in prescription, each composition is being brought into play positive role alone, its compatibility plays omnibearing synergy again, no matter vagina alliance tissue damaged degree weight all can be cured rapidly.After this often use maintenance dose to get final product treating both the principal and secondary aspects of a disease, never recurrence.
It is feasible through fully proving in theory that the present invention substitutes estrogenic design philosophy with common health product composition prescription, and in the practice of treatment senile vaginitis, obtained check, pass through the preliminary zoopery result of white mice again, curative effect has been given the therapeutic evaluation of height.Avoided using estrogen may produce the toxic and side effects of canceration.It is one that the present invention collects science, reasonability, practicality, adopt the common health care composition of safety non-toxic to form, has the definite curative effect of curing senile vaginitis rapidly, safely, filled up domestic and international blank without the estrin treatment senile vaginitis, for the vast patient who endures the painful torment of senile vaginitis to the fullest extent has removed slight illness, be subjected to the consistent favorable comment of vast user.
The specific embodiment
Embodiment 1-9
Provide nine the different embodiment of part by weight that are made of prescription vitamin A, vitamin E, glucose, citric acid, methyl parahydroxybenzoate, ethyl ester, propyl ester, butyl ester by table 1 with form, unit of weight wherein can be selected kg or g for use.
Table 1
In the foregoing description, vitamin A, vitamin E are to convert and get from iu.In the actual production, be to go into operation with weight.Vitamin A can select for use cod-liver oil to make raw material, because vitamin D wherein has functions such as immunomodulating widely, the present invention is played potentiation.
Operation: with solid constituent respectively porphyrize cross No. 5 or No. 6 sieve back with equivalent incremental method mixing after as the oil phase adsorbent of vitamin A and vitamin E mixing, mediate that evenly the back is encapsulated, promptly get the product that the present invention writes out a prescription.Vitamin A and vitamin E need lucifuge, and be anti-oxidation, and therefore, that this product should be stored in is airtight in the brown bottle, lucifuge, place shady and cool dry place to preserve.
Because of playing the effect of flooding after the capsule disintegrate, can be rapidly, give full play to curative effect, therefore, capsule is good as first-selected dosage form with lighttight hard capsule, capsulae vacuus is with " 00 " number or " 0 " number.
The present invention can also be made into suppository, tablet, pill etc. except capsule formulation, according to the dosage form difference, can select for use the salt of oxybenzene esters and benzoic acid and potassium, sodium salt etc. to make antibacterial.
Attached treatment case
Case 1
Poplar, 50 years old, outpatient service on April 9 in 94 year, readme vaginal dryness, burning sensation, contact bleeding, pruritus can not be crossed love life.Sign: the hyperemia of vaginal mucosa point-like, vagina is senile pathological changes, mucus pH value 7.5 ±, cytolgical examination: senile vaginitis.Use capsule for treating of the present invention, once a day, after course of treatment 10 times, above-mentioned symptom disappears, and pH value reduces to 5.0 ±, point-like is congested to disappear.Recovered normal love life after the medication, the spy sends a telegraph thanks.
Case 2
What certain, 64 years old, on October 27th, 93 went to a doctor, readme intravaginal burning sensation is obvious, pain unbearably, the frequent micturition dysurea just as pain as tearing, causes and is reluctant to drink water when defecation is squatted down, and courageous and upright secretions is arranged.Sign: vagina is senile pathological changes, the hyperemia of mucosa severe, fragmentary shallow table ulcer several, the Semen Glycines size.After the medication ten days, the self-induction symptom is clearly better, the cystitis transference cure, and vagina and the peripheral pain that involves thereof alleviate greatly.Check after having treated three courses of treatment, the rehabilitation of mucous hyperemia and ulcer, pH value by 8.5 ± reduce to 5.6 ±.Adhere to using maintenance dose later on, be used for substituting and complementing estrogen with one in 3 days.Up to now, used 16 years, existing 79 years old, full of energy, as 70 years old people.
Case 3
The Wang, 60 years old, on April 11st, 95 went to a doctor, the readme vaginal dryness, burning sensation is obvious, and the pain of itching has yellow fluid sample secretions.Sign: the hyperemia of vaginal mucosa point-like, table fester, 3 of soybean grain sizes, pH value 8.0 ±, cytoscopy: senile vaginitis.The medication treatment, once a day, i.e. subjective symptoms disappearance after 20 days two courses of treatment.Sign: pH value 5.8 ±, hyperemia and ulcer recovery from illness.
Case 4
Zhang, 49 years old, outpatient service on March 6 in 2008, readme is dry and astringent, the paroxysmal pruritus, hypodynia, contact bleeding.Sign: the vaginal mucosa mild hyperaemia, slight senile vaginitis pathological changes, pH value 6.5 ±.Cytolgical examination: slight senile vaginitis.Medication is checked subjective symptoms and is disappeared after 20 days, love life is normal.Sign: mucous hyperemia disappears, moistens, and pH value 5.5 ±.Its mother, grandmother all suffer from senile vaginitis, and three people regularly get it filled to be used for replenishing and keep alternative estrogen.
Case 5
The Qin, 34 years old, on August 3rd, 2007 went to a doctor, ovarian cancer post operation radiotherapy causes all pain severity of the outer bladder urethra crissum of intravaginal and whole lower abdomen position muscle, nerve, because oophorectomize does not have estrogen secretion, intravaginal is atrophy, dry shape, except smear the impaired painful area this medicine of intravaginal, every day each 1 time sooner or later with other medicines, logotype 30 days, sign: vagina changes slightly moist, the smooth shape of tool into by atrophy, dry shape, and the inflammation after the radiotherapy is clearly better, and effect is remarkable, pH value 5.7 ±, the doctor advises the patient to continue to use this medicine.
Claims (1)
1. substitute the local application of estrin treatment senile vaginitis, it is characterized in that this medicine is made up of vitamin A, vitamin E, glucose, lactose, citric acid and oxybenzene esters, its weight portion is as follows:
Vitamin A 0.69-150
Vitamin E 75-3950
Glucose 400-3200
Alpha-lactose 3200-400
Citric acid 0.3676-472.5,
The mixed ester in twos of methyl hydroxybenzoate, propyl hydroxybenzoate, butyl hydroxybenzoate, their weight portion is as follows respectively:
Methyl ester 0.47-1.137
Propyl ester 8.40-14.85
Butyl ester 7.39-9.94.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100280911A CN101766638B (en) | 2010-01-14 | 2010-01-14 | Local medicament for treating senile vaginitis by replacing estrogen |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100280911A CN101766638B (en) | 2010-01-14 | 2010-01-14 | Local medicament for treating senile vaginitis by replacing estrogen |
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| Publication Number | Publication Date |
|---|---|
| CN101766638A true CN101766638A (en) | 2010-07-07 |
| CN101766638B CN101766638B (en) | 2011-06-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010100280911A Expired - Fee Related CN101766638B (en) | 2010-01-14 | 2010-01-14 | Local medicament for treating senile vaginitis by replacing estrogen |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412127A (en) * | 2015-11-30 | 2016-03-23 | 北京爱特普科技有限公司 | Mucosa lesion micro-ecology regulator and preparation method thereof |
| CN108635585A (en) * | 2018-08-02 | 2018-10-12 | 兰州大学第医院 | A kind of pharmaceutical composition for treating senile vahinitis and temperature sensitive slow-releasing gel used and preparation method |
| CN110327287A (en) * | 2019-08-05 | 2019-10-15 | 江西鼎中科技有限公司 | It is a kind of for prevent and treat vaginitis containing lactose prod and its production technology |
-
2010
- 2010-01-14 CN CN2010100280911A patent/CN101766638B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412127A (en) * | 2015-11-30 | 2016-03-23 | 北京爱特普科技有限公司 | Mucosa lesion micro-ecology regulator and preparation method thereof |
| CN108635585A (en) * | 2018-08-02 | 2018-10-12 | 兰州大学第医院 | A kind of pharmaceutical composition for treating senile vahinitis and temperature sensitive slow-releasing gel used and preparation method |
| CN110327287A (en) * | 2019-08-05 | 2019-10-15 | 江西鼎中科技有限公司 | It is a kind of for prevent and treat vaginitis containing lactose prod and its production technology |
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| Publication number | Publication date |
|---|---|
| CN101766638B (en) | 2011-06-08 |
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