CN101897784A - Chinese medicinal composition for treating gout and preparation method thereof - Google Patents
Chinese medicinal composition for treating gout and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating gout and a preparation method thereof. The Chinese medicinal composition is prepared from rhubarb, gardenia, root-bark of tree peony, prepared frankincense, prepared myrrh, toad venom, artificial musk and borneol in a certain weight ratio. The composition has the effects of clearing heat and expelling dampness, cooling blood and removing blood stasis, reducing swelling and easing pain, is used for treating damp and hot blockage, traumatic injury, local swelling and thermal pain and movement disorder, and is used for treating the patients with the symptoms of acute gouty arthritis and acute soft issue injury.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used for acute gouty arthritis and acute soft tissue injury due to the gout and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
With the blood uric acid rising is that the gout of main biochemical indicator belongs to the modern medicine metabolic disease, and according to the foreign literature record, the west was as far back as B.C. 460～370 years, and Hip-pocrates has promptly done record to the clinical manifestation of this disease.According to the record of traditional Chinese medical science ancient literature, " gout " this name of disease is also arranged as far back as the gold dollar epoch.
Gout is by the caused a kind of disease of purine metabolic disturbance in the body, main clinical manifestation is to be that the gouty arthritis of feature is shown effect repeatedly with the hyperuricemia, the joint of getting involved is maximum with thumb and toe joint, is other joints of ankle, hands, wrist, knee joint, elbow and foot etc. secondly.Hyperesthesia, remarkable symptoms such as redness, heating, tenderness hyperpyrexia, pained, cardiopalmus, tired, anorexia appear in arthralgia after a few hours, sustainable a few days (being generally 3 to 10) or disappear gradually after several weeks. and joint motion can recover fully.For months to come or the several years just occurs once again or repeatedly the outbreak.Progressively frequent as outbreak, the related joint of at every turn showing effect is also cumulative many.Clinical manifestation Chang Buneng complete obiteration such as swell and ache after the outbreak, this moment, how conditions of patients advanced people's chronic phase.Often have joint deformity stiff, urate is separated out in the skeleton of juxtra-articular, in seminal vesicle film, stndon sheath and the cartilage and is formed tophus, lithangiuria, and kidney is got involved and caused that renal function is not normal, and also can cause hypertension and heart disease late period.According to the cause of disease gout is divided into constitutional and Secondary cases two classes clinically, characteristics such as that primary gout has is congenital, heritability.
Gout is a kind of senior health and fitness's of harm a disease.Some external sickness rate peaks that studies show that gout are more than 50 years old, and male, women ratio is 20: 1: China man, women ratio are lower than western countries.In recent years, along with trophic level improves, dietary structure changes, the prolongation of average life, and China's gout sickness rate also raises year by year, and age of onset obviously descends simultaneously.The treatment of gout is very thorny, adopts some anti-inflammatory analgesics mostly and suppresses the medicine that uric acid synthesizes or promote urate excretion, can obtain certain effect.
Summary of the invention
The object of the present invention is to provide a kind of new Chinese medicine composition, said composition has the effect of removing damp-heat, cooling blood and removing stasis, reducing swelling and alleviating pain; Be used for damp and hotly being hampered, traumatic injury, local red and swollen heat pain, moving obstacle; The treatment acute gouty arthritis, acute soft tissue injury is seen above-mentioned disease person.
Another object of the present invention provides the preparation method of above-mentioned Chinese medicine composition.
The 3rd purpose of the present invention provides above-mentioned Chinese medicine composition in treatment acute gouty arthritis, the application in the diseases such as acute soft tissue injury.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material: Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part, artificial Moschus 0.03-0.1 part, Borneolum Syntheticum 0.2-0.5 part.
Preferred weight proportion is: 10 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Moutans, 5 parts of Olibanum (processed)s, 5 parts of Myrrha (processed)s, 0.03 part of Venenum Bufonis, 0.1 part of artificial Moschus, 0.3 part of Borneolum Syntheticum.
A kind of Chinese medicine composition that is used for gout, described preparation are oral formulations and external preparation; Comprise: tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, hard capsule, soft capsule, granule, pill, powder, drop pill, oral liquid, spray, gel, ointment, cataplasma, emplastrum, liniment, lotion, liniment.
A kind of preparation method that is used for the Chinese medicine composition of gout, it comprises each active drug composition, adding water or Different concentrations of alcohol respectively extracts, the extracting solution concentrate drying gets crude extract, or further adopt alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; With above-mentioned crude extract or extract directly be used as medicine take or add on the pharmaceutics acceptable auxiliary routinely prepared become required preparation.
Specifically, preparation method is as follows: above-mentioned 8 flavors, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter, filtrate adds artificial Moschus 0.03-0.1 part, the dissolving of Borneolum Syntheticum 0.2-0.5 part, solution for standby, add on the pharmaceutics acceptable adjuvant routinely technology make required liquid or semi-solid preparation.
Or above-mentioned 8 flavors, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter, filtrate recycling ethanol, drying under reduced pressure is ground into fine powder, medicated powder adds proper auxiliary materials, granulate, spray into artificial Moschus, Borneolum Syntheticum alcoholic solution, technology is made required solid preparation such as tablet, granule, capsule etc. routinely.
Described adjuvant can be different according to different preparations, as add diluent commonly used, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc. in solid preparations such as tablet, capsule, granule; In liquid preparation forms such as syrup, oral liquid, add surfactant commonly used, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; In external preparation forms such as gel, ointment, add medicinal oleaginous base commonly used, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.
A kind of Chinese medicine composition that is used for gout has removing damp-heat, cooling blood and removing stasis, and the effect of reducing swelling and alleviating pain is used at preparation treatment dampness and heat stasis, traumatic injury, local red and swollen heat pain, moving obstacle; Application in the disease medicament such as acute gouty arthritis, acute soft tissue injury.
The compatibility mechanism of pharmaceutical composition of the present invention is as follows:
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature.Return stomach, spleen, large intestine, liver, pericardium channel.The clots absorbing effect of stimulating the menstrual flow is used for menstruation apolipsis, postpartum stagnation, the lump in the abdomen of stagnation of blood stasis, and traumatic injury, swelling and pain due to blood stasis.The removing damp-heat effect is used for jaundice, dysuria, the constipation with dry stool of stagnation of damp-heat; But also cooling blood for hemostasis, be used for injury of blood collaterals by heat haematemesis, epistaxis, have blood in stool, metrorrhagia, leucorrhea with red and white discharge.
Fructus Gardeniae: be the mature fruit of Rubiaceae evergreen shrubs plant fruitlet Fructus Gardeniae Gardeniajasminoides Ellis.Bitter cold is gone into the heart, liver, lung, three warmers, stomach warp.Clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, promoting the function of the gallbladder to alleviate jaundice.Be used for calentura tired mad, jaundice due to damp-heat, pyretic stranguria, conjunctival congestion and swelling pain, haematemesis, epistaxis, hematuria, have blood in stool pathopyretic ulcer.External treatment is sprained congestive edema.
Cortex Moutan: be the root bark of the perennial machaka plant of Ranunculaceae Paeonia suffruticosa Paeonia suffruticosa Andr..Acrid in the mouth hardship, cold in nature.The effect of the Cool blood of invigorating blood circulation is arranged, can dissipating blood stasis blood ,ization Disorder Block, Xiao Carbuncle Swollen.Be used for the pathogenic warmth impairment of YIN, fever due to yin deficiency.
Olibanum (processed): this product is olive subject plant Boswellia carterii Birdw Boswellia carterii Birdw. and the oleo-gum-resin that belongs to several plants together thereof.Regulating QI is invigorated blood circulation, and pain relieving chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Myrrha (processed): be the gum resin of olive subject plant myrrh or Alan's fort myrrh.Diffusing blood blood stasis removing, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Venenum Bufonis:, form through dry processing for the ear rear gland of Bufonidae animal Bufo siccus or Bufo melanostictus etc. and the white serosity of skin gland secretion.Zoomorphism " Bufo siccus " bar of knowing clearly.Gan Xin, temperature, poisonous.Detoxifcation, detumescence, heart tonifying, last pain.The treatment skin ulcer, carbuncle, carbuncle on the back, scrofula, chronic osteomyelitis, laryngopharynx swelling and pain, infantile malnutrition, heart failure, wind, carious pain
Artificial Moschus: be the dry secretions in animal in deer family woods Moschus moschiferous Moschus berezovskii Flerov, horse Moschus moschiferous M.sifanicusPrzewalski or the ripe male body note capsule of former Moschus moschiferous M.moschiferus Linnaeus.How the artificial domestication Moschus moschiferous directly takes out Moschus core from sachet, dry in the shade.Suffering, temperature.GUIXIN, spleen channel.The refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.
Borneolum Syntheticum: be the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or for Camphora, Lignum Pini Nodi wet goods with the synthetic product of being processed into of chemical method.Arduous, cold.Logical all keys, the stagnated fire of loosing, removing nebula makes eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, the calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is the nebula film also, enterobiasis.
Being monarch drug with the Radix Et Rhizoma Rhei in the Chinese medicine composition of the present invention, is ministerial drug with Fructus Gardeniae, Cortex Moutan, and assistant is with Olibanum (processed), Myrrha (processed), Venenum Bufonis, artificial Moschus, serves as that assistant makes with the Borneolum Syntheticum refreshment of having one's ideas straightened out, and four medicines share the effect of playing removing damp-heat, cooling blood and removing stasis, reducing swelling and alleviating pain altogether.
Chinese medicine composition of the present invention is used for dampness and heat stasis, traumatic injury, local red and swollen heat pain, moving obstacle; Be used for the treatment of acute gouty arthritis, acute soft tissue injury is seen above-mentioned syndrome person.
The present invention is foundation with the theory of Chinese medical science, adopts the above-mentioned active drug prescription that cooperatively interacts, when research and compiling successive dynasties tradition name side speciality, and the clinical proved recipe that forms in conjunction with the achievement of modern scientific research.Various result of the tests show that it is definite effect aspect treatment gout illness, shows that its active drug cooperates in order, can be used for the treatment of gout effectively.
When stating medicine in the use, both can adopt with the medicine that is equivalent to described weight proportion is raw material, the above-mentioned raw materials medicine can be cleaned respectively, dry, pulverize, mix the granule or the powder that obtain meeting preparation requirement granularity and directly take.Certainly, also can adopt with the medicine that is equivalent to described weight proportion relation is that raw material adds pharmaceutic adjuvant through suitably handling the back, be made into various preparations as required, be mainly oral formulations and external preparation:, also can make the oral drugs of liquid preparation forms such as syrup, oral liquid as making the oral drugs of solid preparation forms such as tablet commonly used, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation; Can also make the external used medicine of external preparation forms such as spray, unguentum, gel, ointment, cataplasma, emplastrum, liniment, lotion, liniment.Be prepared into by the above-mentioned raw materials medicine in the process of preparation, the above-mentioned raw materials medicine can adopt following method to handle: add water or Different concentrations of alcohol respectively and extract, the extracting solution concentrate drying gets crude extract; Or adopt further that alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; Adoptable concrete operations and/or using method when above-mentioned effective medicinal ingredient is extracted, both can be that ingredient with described each proportional quantities is a raw material, extract decomposite mode behind its effective medicinal ingredient respectively, also can adopt each medicine material by said proportional quantities to mix after the mode of co-extracted again.Adopt different extraction means, equipment and actual conditionses such as required desirable or best extraction temperature, solvent load, extraction time, extraction time when extracting, then can be according to practical situation by testing screened and finding.With above-mentioned crude extract or extract directly be used as medicine take or add on the pharmaceutics acceptable auxiliary routinely prepared become required preparation.Therefore, except that effective ingredient, can also contain pharmaceutically acceptable adjuvant in this pharmaceutical composition.
Adjuvant described here can be different according to different preparations, as diluent commonly used in solid preparations such as tablet, capsule, granule, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc.; The surfactant of in liquid preparation forms such as syrup, oral liquid, using always, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; The medicinal oleaginous base of in external preparation forms such as gel, ointment, using always, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.Its adjuvant commonly used such as starch, lactose, dextrin, Icing Sugar, microcrystalline Cellulose, mannitol, xylitol, Polyethylene Glycol, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, modified starch, sorbitol, polyvidon, Heavy Magnesium Carbonate, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, carboxymethylstach sodium, hydroxypropyl cellulose, 30 POVIDONE K 30 BP/USP 30, kaolin, pregelatinized Starch, magnesium stearate, Pulvis Talci, micropowder silica gel, stevioside, betanin, aspartame, glycyrrhizin, saccharin sodium, citric acid, sodium bicarbonate, sodium carbonate, carrageenan, agar, gelatin, sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, locust bean gum, POLY-karaya, stearic acid, glyceryl monostearate, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, thimerosal, dimethyl sulfoxide, azone, triethanolamine, sodium hydroxide, glycerol, propylene glycol, BHT, BHA, sodium lauryl sulphate, Tweens, spans etc.
For preparation above-mentioned, its preparation method is exemplified below:
Solid orally ingestible adopts following method preparation:
Above-mentioned 8 flavors, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter filtrate recycling ethanol, drying under reduced pressure, be ground into fine powder, can carry out following formulation preparation:
Medicated powder adds suitable filler, granulates, and sprays into artificial Moschus 0.03-0.1 part, Borneolum Syntheticum 0.2-0.5 part alcoholic solution, filled capsules; Filler can be one or more in starch, lactose, microcrystalline Cellulose, calcium sulfate, calcium hydrogen phosphate, modified starch, sorbitol, Heavy Magnesium Carbonate, the pregelatinized Starch;
Medicated powder adds suitable filler, granulate, spray into artificial Moschus, Borneolum Syntheticum alcoholic solution, add lubricant, tabletting, filler can be one or more in starch, lactose, microcrystalline Cellulose, calcium sulfate, calcium hydrogen phosphate, modified starch, sorbitol, Heavy Magnesium Carbonate, the pregelatinized Starch, in the hydroxypropyl methylcellulose;
Medicated powder adds one or more in dextrin, lactose, mannitol, xylitol, the sucrose, makes granule.
Spray is preparation like this in the external preparation:
Above-mentioned 8 flavors, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter, filtrate adds artificial Moschus 0.03-0.1 part, the dissolving of Borneolum Syntheticum 0.2-0.5 part, solution for standby, embedding, promptly.
Gel is preparation like this in the external preparation:
Above-mentioned 8 flavors, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter, filtrate adds artificial Moschus 0.03-0.1 part, the dissolving of Borneolum Syntheticum 0.2-0.5 part, solution adds the gel adjuvant again, stirring and evenly mixing, fully swelling promptly gets gel.Thickening agent can be the cross-linked polypropylene resin class, comprises Carbopol 941, and 974,934P, and different salt of cross-linked polypropylene resin and derivant also can be hydroxypropyl methylcellulose, xanthan gum.
Wetting agent can be one or more the mixture in glycerol, propylene glycol, the isopropyl alcohol.
The pH regulator agent can be organic amine such as triethanolamine, diethylamine, and triethylamine, lauryl amine also can be sodium hydroxide, sodium bicarbonate, sodium carbonate.
Transdermal agent can be azone, Mentholum, quintessence oil, dimethyl sulfoxine, propylene glycol.
Antiseptic can be one or more in potassium sorbate, sorbic acid, ethyl hydroxybenzoate, propyl hydroxybenzoate, methyl hydroxybenzoate, the phenol.
Above-mentioned preparation method is only enumerated the present invention's method of obtaining through refining, but this should be interpreted as that preparation method of the present invention only only limits to above-mentioned cited method.
According to foregoing,,, obviously can also make modification, replacement and the change of other various ways according to the ordinary skill knowledge and the customary means of this area not breaking away under the basic fundamental thought prerequisite of the present invention.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Below, foregoing of the present invention is described in further detail by the specific embodiment:
The specific embodiment:
" part " in the embodiment of the invention is a unit of weight, as gram, kilogram, ton etc.
Embodiment 1: 10 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Moutans, 5 parts of Olibanum (processed)s, 5 parts of Myrrha (processed)s, 0.03 part of Venenum Bufonis, 0.1 part of artificial Moschus, 0.3 part of Borneolum Syntheticum
The spray preparation method:
Above-mentioned 8 flavors, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Moutans, 5 parts of Olibanum (processed)s, 5 parts of Myrrha (processed)s, 0.03 part of 6 flavor of Venenum Bufonis add 70% soak with ethanol 24h, with the 5ml/min percolation, collect percolate, filter, filtrate adds 0.05 part of artificial Moschus, 0.3 part of dissolving of Borneolum Syntheticum, solution for standby, embedding, promptly.
Embodiment 2: 5 parts of Radix Et Rhizoma Rhei, 5 parts of Fructus Gardeniaes, 15 parts of Cortex Moutans, 8 parts of Olibanum (processed)s, 8 parts of Myrrha (processed)s, 0.015 part of Venenum Bufonis, 0.1 part of artificial Moschus, 0.2 part of Borneolum Syntheticum
The gel preparation method:
Above-mentioned 8 flavors, 5 parts of Radix Et Rhizoma Rhei, 5 parts of Fructus Gardeniaes, 15 parts of Cortex Moutans, 8 parts of Olibanum (processed)s, 8 parts of Myrrha (processed)s, 0.015 part of 6 flavor of Venenum Bufonis add 50% soak with ethanol 24h, with the 10ml/min percolation, collect percolate, filter, filtrate adds 0.1 part of artificial Moschus, 0.2 part of dissolving of Borneolum Syntheticum, solution for standby; Add 2 parts of gel adjuvant Carbopol 941s, 0.5 part of triethanolamine, 4 parts of glycerol, abundant swelling, promptly.
Embodiment 3: 15 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 5 parts of Cortex Moutans, 2 parts of Olibanum (processed)s, 2 parts of Myrrha (processed)s, 0.03 part of Venenum Bufonis, 0.03 part of artificial Moschus, 0.5 part of Borneolum Syntheticum
Process for producing granula: above-mentioned 8 flavors, 15 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 5 parts of Cortex Moutans, 2 parts of Olibanum (processed)s, 2 parts of Myrrha (processed)s, 0.03 part of 6 flavor of Venenum Bufonis add 60% soak with ethanol 24h, with the 4ml/min percolation, collect percolate, filter filtrate recycling ethanol, drying under reduced pressure, be ground into fine powder, add 10 portions of sucrose, 5 parts smart, alcohol granulation, spray into 0.03 part of artificial Moschus, 0.5 part of alcoholic solution of Borneolum Syntheticum, promptly.
Embodiment 4: 10 parts of Radix Et Rhizoma Rhei, 12 parts of Fructus Gardeniaes, 12 parts of Cortex Moutans, 5 parts of Olibanum (processed)s, 5 parts of Myrrha (processed)s, 0.02 part of Venenum Bufonis, 0.06 part of artificial Moschus, 0.4 part of Borneolum Syntheticum
Method for preparing tablet thereof: above-mentioned 8 flavors, 10 parts of Radix Et Rhizoma Rhei, 12 parts of Fructus Gardeniaes, 12 parts of Cortex Moutans, 5 parts of Olibanum (processed)s, 5 parts of Myrrha (processed)s, 0.02 part of 6 flavor of Venenum Bufonis add 55% soak with ethanol 24h, with the 2ml/min percolation, collect percolate, filter filtrate recycling ethanol, drying under reduced pressure, be ground into fine powder, add 20 parts of microcrystalline Cellulose and granulate, spray into artificial Moschus, Borneolum Syntheticum alcoholic solution, add magnesium stearate, tabletting, promptly.
Embodiment 5: 12 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Moutans, 6 parts of Olibanum (processed)s, 3 parts of Myrrha (processed)s, 0.03 part of Venenum Bufonis, 0.1 part of artificial Moschus, 03 part of Borneolum Syntheticum
Capsule preparation method thereof: above-mentioned 8 flavors, 12 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Moutans, 6 parts of Olibanum (processed)s, 3 parts of Myrrha (processed)s, 0.03 part of 6 flavor of Venenum Bufonis add 65% soak with ethanol 24h, with the 8ml/min percolation, collect percolate, filter, filtrate recycling ethanol, drying under reduced pressure is ground into fine powder, add 50 parts of starch, 0.03 part of artificial Moschus, 0.25 part of Borneolum Syntheticum, filled capsules, promptly.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment:
By Ovum Gallus domesticus album being caused antiinflammatory and the analgesic activity that rat paw edema experiment and glacial acetic acid cause mouse writhing method analgesic test research Chinese medicine composition of the present invention.
1 materials and methods
1.1 be subjected to reagent thing, laboratory animal and grouping SD rat, NIH mice, animal are divided into four groups at random: low, the high dose group of Chinese medicine composition composition spray of the present invention: 100%, 200% Chinese medicine composition composition spray of the present invention is coated with outward; XUESHAN JINLUOHAN pain relieving membranous patch; Substrate matched group: with the finished product congeniality, be coated with outward with the solvent of concentration.
1.2 method
1.2.1 rat paw edema experimental technique (Ovum Gallus domesticus album method) press document (Huang Keer is etc. the scorching analgesic spray anti-inflammatory and analgesic effect research in. Shuangbo County [J] for Wu Qiduan, Fang Yongqi. the Chinese experimental pharmacology of Chinese medical formulae, 1999,5 (5): 49-50) method carry out this experimentation.The SD rat, male, body weight 160～220g, 48, male and female half and half, be divided into 4 groups at random, 12 every group, the experiment before rat anesthesia (3% pentobarbital that, 30mg/Kg ip), measure with the improvement volumetric method and respectively to organize the right back sufficient sole of the foot normal volume of rat (at the positive clear graticule of doing of foot), coating 0.3mL then, coating for the second time behind the 0.5h, behind the 1h at the subcutaneous injection of right hind foot sole of the foot 0.1ml 100% fresh albumen, coating is once measured and is caused inflammation back 1h, 2h, the right back sufficient sole of the foot volume of 4h, 6h more simultaneously, measures the back coating 1 time at every turn.
1.2.2 the mouse writhing analgesic experiment press document (Liu Jinyuan, Chen Peijia, Yang Dongdi. the experimentation [J] of gout pain-relieving powder for treating treatment acute gouty arthritis. the Jilin Chinese medicine, 2005,25 (3): 52-53) method is carried out the mouse writhing analgesic experiment.The NIH mice, 45, body weight 18～22g, male and female half and half are divided into 5 groups at random, Chinese medicine composition composition spray high dose group promptly of the present invention, middle dosage group, low dose group, XUESHAN JINLUOHAN pain relieving membranous patch, normal saline negative control group, writhing response (abdominal cavity indent, trunk and back leg extension, hips up) takes place each mice in the 20min behind the injection algogen number of times and incubation period, result of the test is organized a t check, comparable group differences.
2 experimental results
2.1 Chinese medicine composition composition spray of the present invention is to the effect of rat paw edema due to the Ovum Gallus domesticus album
Chinese medicine composition composition spray high dose group of the present invention, low dose group can obviously suppress rat paw edema due to the Ovum Gallus domesticus album, reduce swelling degree (seeing Table 1).Chinese medicine composition composition spray high dose group of the present invention is at time point 1h, 2h, 4h, and low dose group has rat paw edema due to the obvious inhibition Ovum Gallus domesticus album, reduces the effect of swelling degree at time point 1h, 2h.Low dose group, XUESHAN JINLUOHAN pain relieving membranous patch also have effect trend, but difference does not have significance.Though do not have significant difference between high and low 2 the dosage groups of Chinese medicine composition composition spray, exist certain dose-effect relationship trend.
Table 1 Chinese medicine composition composition spray of the present invention is to the influence of rat paw edema due to the Ovum Gallus domesticus album
Compare * p＜0.05, * * p＜0.01 with the substrate matched group.Down together.
2.2 Chinese medicine composition composition spray of the present invention is to the effect of glacial acetic acid induced mice writhing response
Chinese medicine composition composition spray of the present invention can obviously suppress glacial acetic acid induced mice writhing response, reduces the writhing response number of times, prolongs writhing response incubation period, and is better than XUESHAN JINLUOHAN pain relieving membranous patch group, sees Table 2.
Table 2 Chinese medicine composition composition spray of the present invention is to the influence of glacial acetic acid induced mice generation writhing response
Annotate: compare P＜0.05, P＜0.001 with negative control group;
Annotate: compare P＜0.05 with XUESHAN JINLUOHAN pain relieving membranous patch
High, medium and low 3 the dosage groups of Chinese medicine composition composition spray of the present invention are energy obvious suppression glacial acetic acid induced mice generation writhing response all, and the effect highly significant, compares difference extremely significantly (P＜0.001) with negative control group.Chinese medicine composition composition spray high dose group of the present invention obviously is better than XUESHAN JINLUOHAN pain relieving membranous patch, and writhing response is obviously prolonged incubation period.Though do not have significant difference between high, medium and low 3 the dosage groups of Chinese medicine composition composition spray of the present invention, exist certain dose-effect relationship trend.
3 conclusions
Result of study also shows, Chinese medicine composition composition spray of the present invention can effectively reduce the serum uric acid level of gout animal pattern, and the trend that increases urate excretion is arranged, therefore the action pathway of this medicine gout may be to realize this and clinical observation result basically identical by the drainage that reduces blood uric acid, quickening uric acid.
Claims (8)
1. Chinese medicine composition that is used for gout, it is characterized in that it is to be made by the raw material of following weight portion: Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 5-15 part, Cortex Moutan 5-15 part, Olibanum (processed) 2-8 part, Myrrha (processed) 2-8 part, Venenum Bufonis 0.015-0.03 part, artificial Moschus 0.03-0.1 part, Borneolum Syntheticum 0.2-0.5 part.
2. Chinese medicine composition according to claim 1, it is characterized in that it is to be made by following bulk drugs: 10 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Moutans, 5 parts of Olibanum (processed)s, 5 parts of Myrrha (processed)s, 0.03 part of Venenum Bufonis, 0.1 part of artificial Moschus, 0.3 part of Borneolum Syntheticum.
3. a kind of Chinese medicine composition that is used for gout according to claim 1 and 2 is characterized in that described preparation is oral formulations and external preparation; Comprise: tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, hard capsule, soft capsule, granule, pill, powder, drop pill, oral liquid, spray, gel, ointment, cataplasma, emplastrum, liniment, lotion, liniment.
4. a kind of preparation method that is used for the Chinese medicine composition of gout according to claim 1 and 2, it is characterized in that, it comprises each active drug composition, adding water or Different concentrations of alcohol respectively extracts, the extracting solution concentrate drying gets crude extract, or further adopt alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; With above-mentioned crude extract or extract directly be used as medicine take or add on the pharmaceutics acceptable auxiliary routinely prepared become required preparation.
5. a kind of preparation method that is used for the Chinese medicine composition of gout according to claim 4, it is characterized in that, above-mentioned 8 flavors, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Moutan, Olibanum (processed), Myrrha (processed), Venenum Bufonis 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter, filtrate adds artificial Moschus, Borneolum Syntheticum dissolving, solution for standby; Add on the pharmaceutics acceptable adjuvant routinely technology make required liquid or semi-solid preparation.
6. a kind of preparation method that is used for the Chinese medicine composition of gout according to claim 4, it is characterized in that, above-mentioned 8 flavors, Radix Et Rhizoma Rhei, Fructus Gardeniae, Cortex Moutan, Olibanum (processed), Myrrha (processed), Venenum Bufonis 6 flavors add 50%～70% soak with ethanol 24h, with the 2-10ml/min percolation, collect percolate, filter, filtrate recycling ethanol, drying under reduced pressure is ground into fine powder, medicated powder adds proper auxiliary materials, granulate, spray into artificial Moschus, Borneolum Syntheticum alcoholic solution, technology is made required solid preparation such as tablet, granule, capsule etc. routinely.
7. according to claim 4 or 5 or 6 described a kind of preparation methoies that are used for the Chinese medicine composition of gout, it is characterized in that, described adjuvant, can be different according to different preparations, as in solid preparations such as tablet, capsule, granule, adding diluent commonly used, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc.; In liquid preparation forms such as syrup, oral liquid, add surfactant commonly used, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; In external preparation forms such as gel, spray, ointment, add medicinal oleaginous base commonly used, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.
8. a kind of Chinese medicine composition that is used for gout according to claim 1 and 2 has removing damp-heat, cooling blood and removing stasis, and the effect of reducing swelling and alleviating pain is used at preparation treatment dampness and heat stasis, traumatic injury, local red and swollen heat pain, moving obstacle; Application in the disease medicament such as acute gouty arthritis, acute soft tissue injury.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186895A (en) * | 2018-02-09 | 2018-06-22 | 贵州苗康医药科技有限公司 | A kind of external preparation for treating gout and preparation method thereof |
| WO2018195111A1 (en) * | 2017-04-17 | 2018-10-25 | Ampersand Biopharmaceuticals, Llc | Parenteral non-systemic administration of buffering agents for inhibiting metastasis of solid tumors, hyperpigmentation and gout |
| CN113769016A (en) * | 2021-11-01 | 2021-12-10 | 平顶山咏圣医药科技有限公司 | External health care liquid for relieving gout and preparation method thereof |
| US11357792B2 (en) | 2017-09-15 | 2022-06-14 | Dyvve Biosciences, Inc. | Method of administration and treatment |
| US11491225B2 (en) | 2014-12-23 | 2022-11-08 | Dyve Biosciences, Inc. | Transdermal carrier |
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2009
- 2009-05-27 CN CN2009100849900A patent/CN101897784A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11491225B2 (en) | 2014-12-23 | 2022-11-08 | Dyve Biosciences, Inc. | Transdermal carrier |
| US12070503B2 (en) | 2014-12-23 | 2024-08-27 | Dyve Biosciences, Inc. | Transdermal carrier |
| WO2018195111A1 (en) * | 2017-04-17 | 2018-10-25 | Ampersand Biopharmaceuticals, Llc | Parenteral non-systemic administration of buffering agents for inhibiting metastasis of solid tumors, hyperpigmentation and gout |
| US11357792B2 (en) | 2017-09-15 | 2022-06-14 | Dyvve Biosciences, Inc. | Method of administration and treatment |
| US11389472B2 (en) | 2017-09-15 | 2022-07-19 | Dyve Biosciences, Inc. | Method of administration and treatment |
| US11730756B2 (en) | 2017-09-15 | 2023-08-22 | Dyve Biosciences, Inc. | Method of administration and treatment |
| US11744853B2 (en) | 2017-09-15 | 2023-09-05 | Dyve Biosciences, Inc. | Method of administration and treatment |
| US11793830B2 (en) | 2017-09-15 | 2023-10-24 | Dyve Biosciences, Inc. | Method of administration and treatment |
| CN108186895A (en) * | 2018-02-09 | 2018-06-22 | 贵州苗康医药科技有限公司 | A kind of external preparation for treating gout and preparation method thereof |
| CN113769016A (en) * | 2021-11-01 | 2021-12-10 | 平顶山咏圣医药科技有限公司 | External health care liquid for relieving gout and preparation method thereof |
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Application publication date: 20101201 |