CN110339269A - A kind of gynecological external use gel and preparation method thereof - Google Patents
A kind of gynecological external use gel and preparation method thereof Download PDFInfo
- Publication number
- CN110339269A CN110339269A CN201910754079.XA CN201910754079A CN110339269A CN 110339269 A CN110339269 A CN 110339269A CN 201910754079 A CN201910754079 A CN 201910754079A CN 110339269 A CN110339269 A CN 110339269A
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- gel
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- powder
- honeysuckle
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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Abstract
The present invention relates to gynaecology external-use drugs, more particularly to a kind of good effect, gynecological external use gel of convenient drug administration and preparation method thereof, by Ganoderma Sinense, nanogold, honeysuckle, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, polygonum cuspidate is made, honeysuckle, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, polygonum cuspidate processes respectively, the biological nano gold of nanogold mung bean preparation, it is different with existing nanogold, to the highly-safe of human body, good dispersion, it is non-toxic, play the role of double, first is that itself has antibacterial and anti-inflammation functions, second is that instead of chemical preservative after having added nanogold, third is that overcoming the toxicity of chemical preservative, irritation.Gel of the invention have it is refrigerant antipruritic, medical effect for the treatment of both manifestation and root cause of disease, two courses for the treatment of i.e. 20 days can fully recover.
Description
Technical field
The present invention relates to gynaecology external-use drugs, and in particular to the gynecological external use gel and its system of a kind of good effect, convenient drug administration
Preparation Method.
Background technique
It exists in the prior art including a variety for the treatment of means such as endo-medicine and operation (including laser, cold therapy), but
The problems such as being limited to drug, the side effect of operation, indication, these treatment means are chiefly used in hospital's prescribed treatment.
Presently commercially available gynecological disease articles, such as Farr's yin, the clean, FUKE QIANJIN PIAN of woman's spirit etc., are generally used with liquid, are needed
It cannot be referred to as convenience by means of hand and special tool(s).These products are quickly treated and are treated to achieve the effect that, past
It is larger and palliative to patient's lesion irritation toward a large amount of chemicals of addition, it is disclosed in the prior art with Chinese medicine
Gynaecology's gel of composition, such as CN106727849A, CN106822714A, there are gel matrix polymer use for these gel products
Amount is big, gel uses rear bad dispersibility, and effective ingredient is difficult to the defects of discharging.Contain such as peppermint in its Chinese medicinal ingredients simultaneously
The strong and stimulatings composition such as brain, pericarpium zanthoxyli is not suitable for directly being in contact with human body mucosal tissue, and these irritations can be pierced further
Swash mucous membrane and cause rejection, oedema and inflammation have been further aggravated instead.
Summary of the invention
A kind of non-stimulated, good effect, administration are provided it is an object of the invention to overcome the deficiencies in the prior art
Convenient gynecological external use gel and preparation method thereof.
The technical scheme of the present invention is realized as follows:
A kind of gynecological external use gel, gel are mixed by Chinese medicine composition and matrix, and the Chinese medicine composition includes following
The Chinese medicine of parts by weight:
15-20 parts of Ganoderma Sinense, 0.1-0.15 parts of nanogold, 12-20 parts of honeysuckle, 10-20 parts of folium isatidis, 15-25 parts of shrubalthea root,
6-10 parts of spina gleditsiae, 20-30 parts of rde bean, 8-15 parts of polygonum cuspidate；
The matrix is made of Acritamer 940 powder, small molecule water and triethanolamine, and the Acritamer 940 powder contains
Amount is the 1% of matrix total amount, and the content of small molecule water and triethanolamine is the 99% of matrix total amount, and the content of small molecule water is not higher than
0.5%；
It further include borneol and menthol in gel, the weight of borneol accounts for the 0.1% of the total amount of Chinese medicine composition, the weight of menthol
Account for the 0.5% of the weight of Chinese medicine composition.
The Chinese medicine composition includes the Chinese medicine of following parts by weight:
It is 17 parts of Ganoderma Sinense, 0.125 part of nanogold, 16 parts of honeysuckle, 15 parts of folium isatidis, 20 parts of shrubalthea root, 8 parts of spina gleditsiae, red small
25 parts of beans, 12 parts of polygonum cuspidate.
A kind of preparation method of gynecological external use gel, comprising the following steps:
Step 1) processes medicinal material: weighing polygonum cuspidate by above-mentioned weight, the weight ratio of 35 degree of wine wine system of polygonum cuspidate, polygonum cuspidate and wine is
Polygonum cuspidate is immersed in wine by 1:1, and 30 days, filtering obtained medical fluid, medical fluid is evaporated under reduced pressure with rotary evaporator, until nothing in medical fluid
Alcohol obtains Gentrin Knotweed P.E, spare；Rde bean, Ganoderma Sinense are weighed by weight, are added separately to impregnate 3-4 in the water of doubling dose
Hour, heating, continuous heating 1 hour, is cooled to room temperature after being heated to 100 DEG C, medical fluid is obtained after filtering, by medical fluid at 65-75 DEG C
It is concentrated and dried, with wall-breaking machine broken wall at powder, crosses 100 sieves, obtain rde bean water extract fine powder and Ganoderma Sinense water extract fine powder respectively, it is standby
With；Weigh spina gleditsiae by weight, with 9 degree of vinegar vinegar system, spina gleditsiae is 2:3 in the weight ratio of vinegar, by spina gleditsiae vinegar it is soft after,
It is dried at 45-65 DEG C, with wall-breaking machine broken wall at powder, crosses 200 sieves, obtain vinegar spina gleditsiae fine powder, it is spare；The rose of Sharon is weighed by weight
65 degree of wine is added when frying with mild fire frying in root, and the weight ratio of shrubalthea root and wine is 5:1, fries and is evaporated to wine and shrubalthea root
It in yellowish, is cooled to room temperature, with wall-breaking machine broken wall at powder, crosses 200 meshes, obtain wine shrubalthea root fine powder, it is spare；Claim by weight
Extracting honeysuckle, folium isatidis are crossed 200 meshes, obtain honeysuckle and folium isatidis mixing fine powders with wall-breaking machine broken wall after mixing at powder, standby
With；
Step 2, the honeysuckle by after processing, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, polygonum cuspidate, are obtained dense with water extraction and alcohol precipitation method
Contracting liquid, wherein honeysuckle, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, the weight summation of polygonum cuspidate and the volume of water after processing
Than for 1:2, obtained Chinese traditional medicine water extract is concentrated into 1:1-1:2ml/g, the Chinese traditional medicine water extract after cooling while stirring after concentration
The volume ratio of middle addition ethyl alcohol, concentrate and ethyl alcohol is 1:1,24~48h of closed refrigeration, is filtered, and filtrate recycling ethanol obtains essence
Liquid processed；
Step 3) prepares gel-type vehicle, weighs Acritamer 940 powder and small molecule water in proportion, Acritamer 940 powder is sprinkled into
In small molecule water, expands Acritamer 940 powder sufficiently, then be proportionally added into triethanolamine, stirs evenly, obtain gel-type vehicle,
It is spare；
Gel-type vehicle obtained in refined liquid obtained in step 2 and step 3) is uniformly mixed by step 4) by 1:1, must be mixed
Drug；
Step 5) weighs borneol and menthol in proportion, with etc. the ethyl alcohol of quality dissolve, be sufficiently stirred until be completely dissolved, obtain
Lysate；
Lysate obtained in step 5) is added in hybrid medicine obtained in step 4) by step 6), while while stirring
Ganoderma Sinense and nanogold is added, is sufficiently stirred, makes to be uniformly mixed, obtains gel, tubulature, sterilizing is packed and stored.
The small molecule water is the water that magnetic resonance detection value is lower than 100Hz.
The pharmacological property of prescription of the present invention:
The Quality of Sliced Herbal Medicine is improved when Chinese medicine preparation, while being the research for reinforcing processing Chinese patent drug, guarantees the peace of pharmaceutical drugs
Entirely, it effectively, and constantly brings forth new ideas, increases curative effect.By adjusting pharmacological property, reach reduction toxicity, enhancing or certain treatment of prominent drug
Effect.
Ganoderma Sinense, mild-natured, warm, nontoxic, slight bitter are without any side effects；QI invigorating is strong, mental-tranquilization；It is thin to cure mainly consumptive disease
Weak, loss of appetite, palpitaition, insomnia, dizziness, spiritlessness and weakness, chronic cough is panted, physically weak etc. after tumor chemoradiotherapy；Water mentions, and plays nutrition
The effect of cell.The characteristics of nanogold is prepared with biological reducing method, this technology is antioxidant activity height, selects mung bean or people
Join leaf, using the biological nano gold of this plant preparation, to the highly-safe of human body, good dispersion is non-toxic, penetrates readily through suction
Skin and enterocyte are received, the penetrability of nanogold substance is compared with other physiological activator and is higher than under normal circumstances
1.4 times or more, intracellular matter metabolic activity can be participated in rapidly, and there is anti-inflammatory effect, treat caused by various chronic diseases
Pain.Honeysuckle, it is cold in nature, it is sweet in flavor, enter lung, the heart, stomach meridian, has effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treats wind；Cure mainly ulcer
Swelling and pain, ringworm sore, all poison of rheumatism, are really key medicine, and honeysuckle can most eliminate the poison of heat, and not gas consumption blood, therefore the medicine for the fire toxin that disappears, must
With honeysuckle, life can be taken by force with honeysuckle, forked rubbing can all not control it.Folium isatidis, taste bitter and cold, return liver warp, the heart channel of Hang-Shaoyin, stomach meridian,
The spleen channel；Clearing heat and detoxicating, the clear spot of cool blood cures mainly humidifier high fever, polydipsia, coma, macula, haematemesis, bleeding from five sense organs or subcutaneous tissue, jaundice, dysentery, pellet
Poison, sore throat, aphtha, mumps.Honeysuckle, folium isatidis broken wall are built up health at powder, clearing heat and detoxicating, the clear spot of cool blood.Shrubalthea root, it is sweet,
It is flat, it is sliding, it is nontoxic；Removing toxicity for detumescence cures mainly intestines wind and rushes down blood, dysentery, lung pain, intestinal cancer, hemorrhoid gall, leukorrhea with reddish discharge, scabies；Wine
System, it is clearing heat and detoxicating, there is obvious therapeutic action to leukorrhea with reddish discharge, scabies.Spina gleditsiae, acrid flavour are warm-natured；Return liver, stomach meridian；Detumescence is saturating
Purulence searches wind desinsection, cures mainly swollen ulcer drug, scrofula, gout, sore rash stubborn dermatitis, hypogalactia after delivery, retention of afterbirth；Vinegar system pierces angle with vinegar
It after maceration, is dried at 45-65 DEG C, there is strong curative effect after vinegar system to sore rash stubborn dermatitis.Rde bean, it is mild-natured, it is sweet in flavor, sour；Cure mainly carbuncle swells
Purulence blood, carbuncle swells purulence blood are blood system diseases, and oedema is gas point disease, and rde bean can control it, and lid qi and blood is all derived from spleen, to be to know blood and water
Homologous and different group, Jun Qiyuan, stream do not have the person of having some setbacks, right all objects in people, its Sheng person can be pressed down, it is not necessary to it can be played and declined, can be risen
Its person of declining, it is not necessary to its Sheng can be pressed down, carbuncle swells purulence blood is having a surplus for fire, and the deficiency of oedema then fire, both rde beans are simultaneous to be controlled, that is, damages it
It contains, and mends it and decline；Rde bean is mentioned with water, the prominent curative effect to carbuncle swells purulence blood.Polygonum cuspidate, nature and flavor slight bitter is slightly cold, returns liver, gallbladder, lung
Through；Clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain is relieving cough and reducing sputum.For arthralgia, jaundice with damp-heat pathogen, menostasis is produced
Hemostasis does not Xia , wei lump in the abdomen afterwards, coughing with a lot of sputum, scald, traumatic injury, carbuncle sore tumefacting virus；Antibacterial anti-inflammatory cures mainly fungoid vagina
It is scorching；Using wine system, the curative effect of prominent colpomycosis reaches 100% curative effect.
The present invention is abnormal the amount of leukorrhagia, color, matter, taste, or with whole body, local symptom person, referred to as " leukorrhagia pain ".West
Doctor is considered vaginal discharge caused by the diseases such as all kinds of vaginitis, cervicitis, pelvic inflammatory disease, endocrine disorder.Vagina with
The external world communicates, menstrual period or sexual life health is bad, childbirth and the factors such as uteroventral operation can cause vagina infection, sends out as disease, very
It so that inflammation is invaded internal reproductive organ, lead to pelvic inflammatory disease.The vaginitis state of an illness is touching, easy recurrent exerbation, and Chang Bingfa menstruation is not
The diseases such as tune, amenorrhoea, infertile, are the common diseases that menopathy is only second in Gynecology, which clinically often shows as leukorrhea
Amount, color, matter, the exception of taste, the symptoms such as pruritus vulvue.Generation and spleen kidney two dirty malfunction of the present invention around vaginal discharge diseases, lead
Cause to appoint two arteries and veins of band to lose in solid about in close relations, Etiological is related with wet, hot, worm, poison heresy, ferritic spleen deficiency or injury due to diet, or
Overstrain or suffering are depressed, damage temper, and spleen is wet poly-, and coke, which injures, under fluidization tower appoints two arteries and veins of band, cause conception vessel not solid, dai channel
Fail to keep an appointment, damp evil accumulating in the course of time heat, damp-heat gluing each other, damp invasion of lower energizer and send out as " vaginal discharge diseases ".It is considered herein that healthy tendency power is disease hair
Raw basic reason, and play a leading role in the development and change of disease and in lapsing to, and the prosperity and decline of human righteousness and spleen kidney
It is strong and weak related, therefore pay attention to the adjustment of kidney, spleen in formula, and the conditioning of spleen and stomach function is also most important, spleen kidney tune then transport by water-wet
Change normally, can preferably reach stop-band purpose.Select medicine with dialectical principle thus, and the principles of formulating prescriptions of " monarch minister, helps, makes ".It is purple
Ganoderma lucidum plays primary treatment to main disease in prescription, in the efficacy of a drug side of residence first of, be the monarch drug in a prescription drug that must have in prescription.
Shrubalthea root, honeysuckle, folium isatidis, rde bean are the ministerial drug drugs for assisting monarch drug in a prescription reinforcement to treat main disease, are risen mainly for simultaneous disease
The medicine of therapeutic effect.Spina gleditsiae, polygonum cuspidate are supplementary drugs, assist monarch-minister drug to reinforce the adjutant of therapeutic effect.Nanogold, first is that drawing
It, can all medicines guide drugs to illness station in the side of drawing drug through medicine；Second is that harmonizing drug, have the function of the medicine that makes of all medicines in reconciliation side, it is above-mentioned
All medical instruments have anti-inflammatory, antibacterial antiviral and antiallergic action, improve the effect of immunity of organisms.With the prescription of " monarch, minister, help, make "
Prescription adjusts the dirty malfunction of spleen kidney two, and to wet, hot, worm, poison is evil is effectively cured in spite of illness.
Clinical efficacy is summarized:
1. case selection
Age 17 to 55 years old, average age 38 years old.
2. diagnostic criteria
Leucorrhea increasing, yellow or smelly, pudendal pruritus, vaginal fluid smear for microscopic examination find trichomonad or mould.
3. treatment method
Wash hands and vulva, patient take clinostatism before sleeping every night, gel plastic pipe leading portion protective cap are removed, by the plastic tube of gel
It to be inserted into vagina depths, entangles protective cap with index finger or middle finger, the rear end that insertion plastic tube slightly expands slowly pushes built-in push rod,
Gel of the invention is injected into vagina depths, 10 days as a treatment course.
4. curative effect determinate standard
Cure: clinical symptoms all disappear；
Effective: clinical major part symptom disappears；
Improve: clinical cardinal symptom disappears；
Invalid: clinical symptoms are without improvement or aggravate.
5. clinical effectiveness
Patient uses external-use gel of the present invention, with control group using products such as commercially available doctor's Lei gynecological gels, treats two courses for the treatment of,
Treatment results such as following table.
1 two groups of patient medication comparison tables of table
The skin-penetrating index that nanogold manufactures product in conjunction with other physiologically substance see the table below table 2:
2 nanogold of table and other physiologically substance combine the skin-penetrating index of manufacture product
The biological nano gold of this plant preparation of nanogold mung bean of the invention, it is different with existing nanogold, to human body
Highly-safe, good dispersion is non-toxic, exactly in this regard with existing hydrogen boron sodium reduction or reduction of sodium citrate method not
Equally, the present invention combines drug and nanogold and is used to treat later, improves Cell permeable and absorbability, stable in vivo
In the presence of and play it, Half-life in vivo delay, medicinal effects nearly reach 10 times.
The positive effect of the present invention is: the bold applied nutrition of prescription of the invention, pure natural, clearing heat and detoxicating, the saturating purulence of detumescence,
Antibacterial anti-inflammatory, antimycotic pure Chinese medicine formula, curative for effect, prescription is pioneering, and treatment time is short, significant in efficacy, according to clinical verification
Effective percentage reaches 96.8%, cure rate 88%, and nanogold is courageously applied in prescription, play the role of it is double, first is that itself have it is anti-
Bacterium antiinflammation, second is that instead of chemical preservative after having added nanogold, third is that overcoming the toxicity of chemical preservative, stimulation
Property.Gel of the invention have it is refrigerant antipruritic, medical effect for the treatment of both manifestation and root cause of disease, two courses for the treatment of i.e. 20 days can fully recover.Technique
Advance, medicament effective component quick release can be made to go directly lesion, to also reduce amount of gel, reduce side effect hair
It is raw.
Specific embodiment
Embodiment 1
A kind of gynecological external use gel, the Chinese medicine including following weight:
15 grams of Ganoderma Sinense, 100 grams of nanogold, 12 grams of honeysuckle, 10 grams of folium isatidis, 15 grams of shrubalthea root, 6 grams of spina gleditsiae, rde bean
20 grams, 8 grams of polygonum cuspidate.
A kind of preparation method of gynecological external use gel, comprising the following steps:
Step 1) processes medicinal material: weighing polygonum cuspidate by above-mentioned weight, the weight ratio of 35 degree of wine wine system of polygonum cuspidate, polygonum cuspidate and wine is
Polygonum cuspidate is immersed in wine by 1:1, and 30 days, filtering obtained medical fluid, medical fluid is evaporated under reduced pressure with rotary evaporator, until nothing in medical fluid
Alcohol obtains Gentrin Knotweed P.E, spare；Rde bean, Ganoderma Sinense are weighed by weight, are added separately to impregnate 3-4 in the water of doubling dose
Hour, heating, continuous heating 1 hour, is cooled to room temperature after being heated to 100 DEG C, medical fluid is obtained after filtering, by medical fluid at 65-75 DEG C
It is concentrated and dried, with wall-breaking machine broken wall at powder, crosses 100 sieves, obtain rde bean water extract fine powder and Ganoderma Sinense water extract fine powder respectively, it is standby
With；Weigh spina gleditsiae by weight, with 9 degree of vinegar vinegar system, spina gleditsiae is 2:3 in the weight ratio of vinegar, by spina gleditsiae vinegar it is soft after,
It is dried at 45-65 DEG C, with wall-breaking machine broken wall at powder, crosses 200 sieves, obtain vinegar spina gleditsiae fine powder, it is spare；The rose of Sharon is weighed by weight
65 degree of wine is added when frying with mild fire frying in root, and the weight ratio of shrubalthea root and wine is 5:1, fries and is evaporated to wine and shrubalthea root
It in yellowish, is cooled to room temperature, with wall-breaking machine broken wall at powder, crosses 200 meshes, obtain wine shrubalthea root fine powder, it is spare；Claim by weight
Extracting honeysuckle, folium isatidis are crossed 200 meshes, obtain honeysuckle and folium isatidis mixing fine powders with wall-breaking machine broken wall after mixing at powder, standby
With；
Step 2, the honeysuckle by after processing, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, polygonum cuspidate, are obtained dense with water extraction and alcohol precipitation method
Contracting liquid, wherein honeysuckle, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, the weight summation of polygonum cuspidate and the volume of water after processing
Than for 1:2, obtained Chinese traditional medicine water extract is concentrated into 1:1-1:2ml/g, the Chinese traditional medicine water extract after cooling while stirring after concentration
The volume ratio of middle addition ethyl alcohol, concentrate and ethyl alcohol is 1:1,24~48h of closed refrigeration, is filtered, and filtrate recycling ethanol obtains essence
Liquid processed；
Step 3) prepares gel-type vehicle, weighs Acritamer 940 powder and small molecule water in proportion, Acritamer 940 powder is sprinkled into
In small molecule water, expands Acritamer 940 powder sufficiently, then be proportionally added into triethanolamine, stirs evenly, obtain gel-type vehicle,
It is spare；
Gel-type vehicle obtained in refined liquid obtained in step 2 and step 3) is uniformly mixed by step 4) by 1:1, must be mixed
Drug；
Step 5) weighs borneol and menthol in proportion, with etc. the ethyl alcohol of quality dissolve, be sufficiently stirred until be completely dissolved, obtain
Lysate；
Lysate obtained in step 5) is added in hybrid medicine obtained in step 4) by step 6), while while stirring
Ganoderma Sinense and nanogold is added, is sufficiently stirred, makes to be uniformly mixed, obtains gel, tubulature, sterilizing is packed and stored.
Embodiment 2
A kind of gynecological external use gel, the Chinese medicine including following weight:
20 grams of Ganoderma Sinense, 150 grams of nanogold, 20 grams of honeysuckle, 20 grams of folium isatidis, 25 grams of shrubalthea root, 10 grams of spina gleditsiae, rde bean
30 grams, 15 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Embodiment 3
A kind of gynecological external use gel, the Chinese medicine including following weight:
17 grams of Ganoderma Sinense, 125 grams of nanogold, 16 grams of honeysuckle, 15 grams of folium isatidis, 20 grams of shrubalthea root, 8 grams of spina gleditsiae, rde bean
25 grams, 12 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Embodiment 4
A kind of gynecological external use gel, the Chinese medicine including following weight:
16 grams of Ganoderma Sinense, 110 grams of nanogold, 14 grams of honeysuckle, 12 grams of folium isatidis, 17 grams of shrubalthea root, 7 grams of spina gleditsiae, rde bean
22 grams, 10 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Embodiment 5
A kind of gynecological external use gel, the Chinese medicine including following weight:
18 grams of Ganoderma Sinense, 120 grams of nanogold, 15 grams of honeysuckle, 14 grams of folium isatidis, 19 grams of shrubalthea root, 7 grams of spina gleditsiae, rde bean
24 grams, 11 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Embodiment 6
A kind of gynecological external use gel, the Chinese medicine including following weight:
19 grams of Ganoderma Sinense, 130 grams of nanogold, 17 grams of honeysuckle, 16 grams of folium isatidis, 21 grams of shrubalthea root, 8 grams of spina gleditsiae, rde bean
26 grams, 13 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Embodiment 7
A kind of gynecological external use gel, the Chinese medicine including following weight:
20 grams of Ganoderma Sinense, 140 grams of nanogold, 18 grams of honeysuckle, 17 grams of folium isatidis, 23 grams of shrubalthea root, 9 grams of spina gleditsiae, rde bean
28 grams, 14 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Embodiment 8
A kind of gynecological external use gel, the Chinese medicine including following weight:
20 grams of Ganoderma Sinense, 145 grams of nanogold, 19 grams of honeysuckle, 19 grams of folium isatidis, 24 grams of shrubalthea root, 10 grams of spina gleditsiae, rde bean
29 grams, 15 grams of polygonum cuspidate.
The preparation method is the same as that of Example 1.
Case 1
Mrs Huang, 39 years old, free worker, because of leucorrhea disease treatment in terms of disease seek medical advice for many years, through doctor's physical examination, leukorrhagia feature:
Sticky in canescence, uniformity can have bubble.Gynecologial examination: vagina mucosa is congested, tenderness.Leukorrhea checks: pH value increases,
It can look into and see clues cell, amine test is positive.Other symptoms: vulva pendant pain, scorching hot or pain are diagnosed as carefully according to inspection and chemical examination
Bacterium property vaginitis.Used Farr's yin washing lotion, suppository of women calm over the course for the treatment of, effect is not significant, often recurs.This hair is used afterwards
Bright external-use gel, wash hands and vulva, patient take clinostatism before sleeping every night, remove gel plastic pipe leading portion protective cap, will coagulate
The plastic tube of glue is inserted into vagina depths, entangles protective cap with index finger or middle finger, the rear end that insertion plastic tube slightly expands slowly pushes
Gel of the invention is injected vagina depths by built-in push rod, and symptom has clear improvement after one course for the treatment of of medication, two courses for the treatment of of medication
The leukorrhea color of leukorrhagia, sticky abnormal illness disappear afterwards, are restored to normal, vagina mucosa hyperemia, tenderness, through gynecologial examination
Normal, leukorrhea checks that amine test is negative, and vulva pendant pain, scorching hot, antalgesic disappear, and vaginitis is fully recovered.
Case 2
Mrs Li, 46 years old, peasant felt leukorrhea sallow yellow green, thin sometimes, is sometimes also in purulence shape, and bad smell has
Foam, often oneself it is uncomfortable with regard to attractable point Gyno-Daktarin with several days, mild symptoms are just discontinued, be not effectively treated,
Especially there is frequent micturition, urgent urination, urodynia, just have some antibiotic, 2019 beginning of the years, pain aggravation is gone to see a doctor, gynaecology's inspection
It looks into, vagina mucosa inflammation, is in cerise, above covers patch shape pseudomembrane.Leukorrhea finds trichomonad, other symptoms: pruritus vulvue, companion
There are frequent micturition, urgent urination, urodynia.By the agency of starts with external-use gel of the invention, every night with antipruritic after one, three days, one
After a course for the treatment of, leukorrhea is normal, gynecologial examination, vagina color, glutinous skin, on cover patch shape pseudomembrane and disappear, gynaecology looks into outer
Normal, leukorrhea inspection trichomonad feminine gender is seen, is fully recovered after two courses for the treatment of.
Case 3
Mrs Qiu, 28 years old, due to after the several months, observing leukorrhea in curdy, being sometimes also bean dregs with unclean amenities
Shape, matter is thin foul smell.Gynecologial examination: vaginal mucosa height is red and swollen, it is seen that white thrush sample patch attachment, it is easily peelable.It is white
Band, which checks, sees candida albicans, and vulva surprise is itched unbearably, because surprise, which is itched, can not unbearably sleep, goes to see the doctor, and opens kuh-seng lotion, drive drip cock into
Row treatment, does not reach promising result.Afterwards with external-use gel of the invention, symptom disappears recovery from illness after two courses for the treatment of.
Case 4
Ms Zhang, 69 years old, retired worker, it was thin to feel leukorrhea in recent years, was in purulence blood leucorrhea when serious in faint yellow,
There is foul smell, originally more than 10 years of disconnected diameter, leukorrhea of breaking after is substantially without it is increasingly severe above-mentioned symptom occur, just goes to hospital
Gynecologial examination is done, vaginal mucosa is congested, has small blutpunkte, there are also superficial ulcer.Leukorrhea checks cleannes-Degree, it is other to go back
There are pruritus of vagina and burning heat sensation.By above-mentioned inspection, senile vahinitis, used doctor Lei gynaecology are diagnosed as in conjunction with clinical symptoms
The nursing of gel privates, goes drug irrigation mistake to hospital, through treatment all without thoroughly solving patient it is ailing, often or vagina scabies
Itch and burning heat sensation, has influenced her quality of life.With external-use gel of the invention, after three days, pruritus of vagina and scorching hot
Sense disappears, and a continuous course for the treatment of, leukorrhea problem are good.After using second course for the treatment of, vagina sticks skin hyperemia and superficial is burst
Ulcer is fully recovered, senile vahinitis symptom without.
Case 5
Mrs Liu 34 years old, often goes on business, and lives without rule, feels ill and just meets an urgent need in online or pharmacy's attractable point medicine.Time
Minor illness has been dragged into grave illness, the beginning of this year long, it is found that prolonged leukorrhea is abnormal, purulent secretion occur, and with a small amount of
Blood, or be mingled with the trace of blood, at this moment just cause her attention, go to see specialist, through gynecologial examination, cervical orifice lesion mucous membrane is in
Scarlet erosion sample area.Other itching of vulva pain, lower abdomen and waist and sacrum pain also occur, it is different that doctor is diagnosed as uterine neck columnar epithelium
Position.After by the agency of begins to use one course for the treatment of of product of the invention, above-mentioned illness is substantially reduced, continues with after second course for the treatment of,
Above-mentioned symptom disappears, fully recovers.
Case 6
Mrs Tong, 40 years old, because of waist and sacrum pain, perineum falling inflation saw a doctor, is all to take some analgesics by pain therapy for nearly 1 year
Medicine, such as paracetamol oral medicine.Hou Qu gynaecology sees the doctor, and observes leukorrhea white or faint yellow mucus, and when acute attack is in purulence
Property.It is examined in gynaecology, increases 4 times or so compared with normal cervix, matter is hard, according to clinical manifestation, is diagnosed as cervical hypertrophy moderate illness.Into
Ice therapy of having gone does not adhere to the course for the treatment of to finish, effect is general because hospital is gone to wait in line.Through with of the invention outer
With gel, first course for the treatment of, waist and sacrum pain perineum pendant sense is disappeared, until after second course for the treatment of, leukorrhea and the hard palace of matter
Neck returns to normal value, and the state of an illness is fully recovered.
Case 7
Mrs Ma, 45 years old, physical examination found the faint yellow mucus of leukorrhea, and the small tumour of cervical surface Bluish white includes white mucus, in conjunction with
Sufferers themselves main suit is diagnosed as body of gland tumour, and laser has controlled the state of an illness several times and improved, but does not cure.With of the invention
After one course for the treatment of of external-use gel, hospital's further consultation is gone, Naboth's cysts is clearly better substantially, and further consultation after two courses for the treatment of is thoroughly controlled
More, symptom completely disappears.
Case 8
Mrs Zhao 54 years old, is in menopause, and menstruation is irregular, after menopause half a year, there is a small amount of cerise drop bleeding,
Also have a small amount of bleeding after sexual life, feel and menstruation is different goes hospital's gynecologial examination: leukorrhea white mucus accompanies the trace of blood, woman
Section checks the prominent multiple tongue sample cerise neoplasms of cervical orifice, is diagnosed as cervical polyp, removes breath under iodine fluorine detoxicating at that time
Meat, but spent some months and gone check and be reoccurred.Start with one course for the treatment of of external-use gel of the invention, periodic review does not recur
Until recovery from illness.
Claims (3)
1. a kind of gynecological external use gel, which is characterized in that gel is mixed by Chinese medicine composition and matrix, the Chinese medicine group
Close the Chinese medicine that object includes following parts by weight:
15-20 parts of Ganoderma Sinense, 0.1-0.15 parts of nanogold, 12-20 parts of honeysuckle, 10-20 parts of folium isatidis, 15-25 parts of shrubalthea root,
6-10 parts of spina gleditsiae, 20-30 parts of rde bean, 8-15 parts of polygonum cuspidate；
The matrix is made of Acritamer 940 powder, small molecule water and triethanolamine, and the Acritamer 940 powder contains
Amount is the 1% of matrix total amount, and the content of small molecule water and triethanolamine is the 99% of matrix total amount, and the content of small molecule water is not higher than
0.5%；
It further include borneol and menthol in gel, the weight of borneol accounts for the 0.1% of the total amount of Chinese medicine composition, the weight of menthol
Account for the 0.5% of the weight of Chinese medicine composition.
2. gynecological external use gel according to claim 1, which is characterized in that the Chinese medicine composition includes following weight
The Chinese medicine of number:
It is 17 parts of Ganoderma Sinense, 0.125 part of nanogold, 16 parts of honeysuckle, 15 parts of folium isatidis, 20 parts of shrubalthea root, 8 parts of spina gleditsiae, red small
25 parts of beans, 12 parts of polygonum cuspidate.
3. a kind of preparation method of gynecological external use gel, which comprises the following steps:
Step 1) processes medicinal material: weighing polygonum cuspidate by above-mentioned weight, the weight ratio of 35 degree of wine wine system of polygonum cuspidate, polygonum cuspidate and wine is
Polygonum cuspidate is immersed in wine by 1:1, and 30 days, filtering obtained medical fluid, medical fluid is evaporated under reduced pressure with rotary evaporator, until nothing in medical fluid
Alcohol obtains Gentrin Knotweed P.E, spare；Rde bean, Ganoderma Sinense are weighed by weight, are added separately to impregnate 3-4 in the water of doubling dose
Hour, heating, continuous heating 1 hour, is cooled to room temperature after being heated to 100 DEG C, medical fluid is obtained after filtering, by medical fluid at 65-75 DEG C
It is concentrated and dried, with wall-breaking machine broken wall at powder, crosses 100 sieves, obtain rde bean water extract fine powder and Ganoderma Sinense water extract fine powder respectively, it is standby
With；Weigh spina gleditsiae by weight, with 9 degree of vinegar vinegar system, spina gleditsiae is 2:3 in the weight ratio of vinegar, by spina gleditsiae vinegar it is soft after,
It is dried at 45-65 DEG C, with wall-breaking machine broken wall at powder, crosses 200 sieves, obtain vinegar spina gleditsiae fine powder, it is spare；The rose of Sharon is weighed by weight
65 degree of wine is added when frying with mild fire frying in root, and the weight ratio of shrubalthea root and wine is 5:1, fries and is evaporated to wine and shrubalthea root
It in yellowish, is cooled to room temperature, with wall-breaking machine broken wall at powder, crosses 200 meshes, obtain wine shrubalthea root fine powder, it is spare；Claim by weight
Extracting honeysuckle, folium isatidis are crossed 200 meshes, obtain honeysuckle and folium isatidis mixing fine powders with wall-breaking machine broken wall after mixing at powder, standby
With；
Step 2, the honeysuckle by after processing, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, polygonum cuspidate, are obtained dense with water extraction and alcohol precipitation method
Contracting liquid, wherein honeysuckle, folium isatidis, shrubalthea root, spina gleditsiae, rde bean, the weight summation of polygonum cuspidate and the volume of water after processing
Than for 1:2, obtained Chinese traditional medicine water extract is concentrated into 1:1-1:2ml/g, the Chinese traditional medicine water extract after cooling while stirring after concentration
The volume ratio of middle addition ethyl alcohol, concentrate and ethyl alcohol is 1:1,24~48h of closed refrigeration, is filtered, and filtrate recycling ethanol obtains essence
Liquid processed；
Step 3) prepares gel-type vehicle, weighs Acritamer 940 powder and small molecule water in proportion, Acritamer 940 powder is sprinkled into
In small molecule water, expands Acritamer 940 powder sufficiently, then be proportionally added into triethanolamine, stirs evenly, obtain gel-type vehicle,
It is spare；
Gel-type vehicle obtained in refined liquid obtained in step 2 and step 3) is uniformly mixed by step 4) by 1:1, must be mixed
Drug；
Step 5) weighs borneol and menthol in proportion, with etc. the ethyl alcohol of quality dissolve, be sufficiently stirred until be completely dissolved, obtain
Lysate；
Lysate obtained in step 5) is added in hybrid medicine obtained in step 4) by step 6), while while stirring
Ganoderma Sinense and nanogold is added, is sufficiently stirred, makes to be uniformly mixed, obtains gel, tubulature, sterilizing is packed and stored.
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| CN114425098A (en) * | 2022-02-08 | 2022-05-03 | 褚二喜 | Antibacterial and anti-inflammatory medical gel and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109431830A (en) * | 2018-12-18 | 2019-03-08 | 陈东升 | A kind of oxidation resistant natural composition, food, cosmetics, health care product and drug |
-
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109431830A (en) * | 2018-12-18 | 2019-03-08 | 陈东升 | A kind of oxidation resistant natural composition, food, cosmetics, health care product and drug |
Non-Patent Citations (1)
| Title |
|---|
| 杨雨: "运用灵芝粉配合中西医结合治疗附件炎初探", 《中国民间疗法》 * |
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| CN114425098A (en) * | 2022-02-08 | 2022-05-03 | 褚二喜 | Antibacterial and anti-inflammatory medical gel and preparation method thereof |
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Application publication date: 20191018 |