CN104027586A

CN104027586A - Traditional Chinese medicine preparation for treating nasopharynx cancer caused by liver and lung phlegm-heat and preparation method of traditional Chinese medicine preparation

Info

Publication number: CN104027586A
Application number: CN201410303103.5A
Authority: CN
Inventors: 宋海平
Original assignee: Individual
Current assignee: Yu Jiayou
Priority date: 2014-06-30
Filing date: 2014-06-30
Publication date: 2014-09-10
Anticipated expiration: 2034-06-30
Also published as: CN104027586B

Abstract

The invention discloses a traditional Chinese medicine preparation for treating a nasopharynx cancer caused by liver and lung phlegm-heat and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following raw herbal materials: artemisia anomalas, radix angelicae, cocklebur fruit, mongolian bluebeard, magnolia flower, centipeda minima, mint, white strawberry, bombyx batryticatus, fructus arctii, radix bupleuri, chinaroot greenbrier, rattletop, scutellaria baicalensis, pandanaceae pandanus tectorius, rhizoma decumbentis, fructus forsythia, red-knees herb, folium isatidis, radix isatidis, golden cypress, indigo naturalis, rhizoma fagopyri dibotryis, blackberry lily, water chestnuts, Chinese olive, radix tinosporae, spirogyra, semen oroxyli, edible tulip, bear gall, blackend swallowwort root, Chinese starjasmine stem, scaphium scaphigerum, prinsepia uniflora, concha arcae, cortex albiziae, she lingya grass, polygala tenuifolia and canscora lucidissima. The traditional Chinese medicine preparation has the beneficial effects that the traditional Chinese medicine preparation has the effects of soothing the liver and clearing away the lung-heat, and purging heat and detoxifying, is mainly used for treating the nasopharynx cancer caused by liver and lung phlegm-heat, is short in remission time, not easy to reappear after remission, quick to take effect, short in treatment course, high in safety and strong in pertinence, and achieves the antitumor effect, and syndrome differentiation and treatment can be carried out from the overall layout, so that the pesticide effect is through the focus of infection, the traditional Chinese medicine preparation is free of toxic and side effects, and the drug resistance is not easily generated.

Description

A kind of Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma and preparation method thereof

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Technical field

The present invention relates to pharmaceutical technology field, particularly a kind of Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma.

Background technology

Nasopharyngeal carcinoma is the common cancer of head and neck that is apt to occur in nasopharynx part, and grade malignancy is high, and onset is hidden, and early stage normal non-evident sympton, often has deradenoncus and whole body internal organs to shift late period.Its cause of disease comprises genetic predisposition, food environment and ebv infection etc., and its Carcinogenesis is relatively very long, relates to multiple oncogene, antioncogene and interaction thereof.

Basic disease cause mainly contains the following aspects: one, inherited genetic factors aspect: 1, primary disease has ethnic paresthesia, yellow is more than white people, settle down the sickness rate of other provinces, external Guangdong nationality people or its descendant and quadroon's nasopharyngeal carcinoma higher than local resident, it is higher 40 times than local resident male that external Chinese suffers from nasopharyngeal carcinoma, and women is high 50 times.2, there is family's clustering phenomena.Nasopharyngeal carcinoma has obvious family clustering phenomena, and exceeding 10% Nasopharyngeal Carcinoma Patients has family history, and the genetic predisposition of nasopharyngeal carcinoma may be a key factor of morbidity.3, find that there is immune genetic labelling, in human leucocyte antigen (HLA), the HLA-A2 site in A site occurs relevant with nasopharyngeal carcinoma.

Clinical symptoms mainly contains the following aspects: 1. resorption tears blood: can have in early days and inhale sputum mixed with blood after nose, or in tears, be with blood when blowing the nose, or cut in and out.Can have obvious epistaxis late period.2. ear's symptom: when nasopharyngeal carcinoma occurs in nasopharynx sidewall or pharyngotympanic tube opening upper lip, can there is one-sided property tinnitus or auditory dysesthesia in oncothlipsis pharyngotympanic tube, secretory otitis media also can occur, and one-sided property tinnitus or auditory dysesthesia, the inaccessible sense of in ear etc., may be early stage nasopharyngeal carcinoma symptom.3. headache: have a headache for common sympton, can be onset symptoms or unique symptom, it is intermittent that the position of having a headache in early days is not fixedly, and be persistence migraine late period, and position is fixed.Early stage headache may be that neural blood vessel reflection causes, or to due to the stimulation of first branch of trigeminal nerve peripheral nerve, and the headache of patients with terminal is often tumor destruction basis cranii or spreads and involve cranial nerve and cause at intracranial.4. other symptom: as diplopia, face fiber crops, nasal obstruction, cervical lymph node metastasis symptom, lingualis atrophy and the deflection that lolls, blepharoptosis, eyeball are fixed, visual deterioration or disappearance etc.

Nasopharyngeal carcinoma is divided into the types such as liver lung stagnated heat type, the poly-type of the turbid knot of expectorant, QI and blood condensation type, the tired junction type of fire-toxin, the stagnant type of weakened body resistance poison by its clinical syndrome, and nasopharyngeal carcinoma is after radiotherapy, because the fire-toxin of lonizing radiation is burnt, consumption impairment of QI the moon, cause lung-stomach yin deficiency and taste imbalance, with the passing of time consume smart blood trouble, cause deficiency of qi and blood or deficiency of the kidney.

1, liver lung stagnated heat type: nasal obstruction, in tears, be with blood, micro-expectoration Huang, xerostomia, headache, diet is normal, yellowish urine constipation.Red tongue, tongue fur BOHUANG, rapid pulse.Feelings will is unsuccessful, depression of liver-QI, strongly fragrant fire-transformation upper punch of a specified duration; Lung opening at nose, in wind and heat in the lung meridian enters, liver lung is hot and suffocating, fights in neck forehead, causes raw cancerous protuberance." Zhang Shi doctor logical " think " disease of former husband's exhaustion of nutrient QI, waste basis not in strongly fragrant ", " Waike Zhengzong, Orthodox Manual of External Diseases " calls the cervical carcinoma with cachexia origin cause of formation " or because of six wishs unsuccessful ".

2, the poly-type of the turbid knot of expectorant: dysfunction of the spleen in transportation, the turbid interior life of expectorant, expectorant is coagulated in stagnated fire, and the expectorant piece that congeals into, ties in neck forehead, neck and forms." Waike Zhengzong, Orthodox Manual of External Diseases " meaning cervical carcinoma with cachexia system " stagnated fire is coagulated, and tunnel expectorant is lost on the way, stops knot and forms ".

3, QI and blood condensation type: stagnation of QI due to depression of the liver, blood is obstructed, and coagulation of QI-blood gathers in bulk, and neck forehead tumor becomes." surgery great achievement " meaning indurated subcutaneous mass system " in meridians, QI and blood is condensed and formed by heavy cold visitor ".

4, the tired junction type of fire-toxin: eating and drinking without temperance, the raw poison of taste intrinsic heat, superior clear key, or pathogenic fire derived from stagnation of liver-QI, fire-toxin is by giving birth to, upper bright neck forehead, rotten film erosion meat, causes raw cancerous protuberance.

5, the stagnant type of weakened body resistance poison: innate deficiency, to get rid of evils unable, heresy is left trouble, with the passing of time zang-fu disharmony, QI and blood is not smooth, blockage of meridian, evil poison is detained, and causes raw cancerous protuberance.In the cancer later stage, QI and blood gradually consumes, and internal organs day declines, and loses flourish supporting, but cancer poison internal memory also can show as weakened body resistance.

The hot and suffocating card nasopharyngeal carcinoma of Chinese medicine liver lung history for a long time, also becomes one of important measures of the hot and suffocating card Multimodality Therapy for Nasopharyngeal Carcinoma of liver lung.The hot and suffocating card nasopharyngeal carcinoma of Chinese medicine liver lung is mainly reflected in: 1. alleviate radiotherapy side effect and sequela: YIN nourishing and the production of body fluid promoting, and the agent of heat-clearing and toxic substances removing can alleviate the damage of " pyretic toxicity " Radiation On Human body; 2. sensitization: blood-activating and stasis-removing can be improved microcirculation, accelerates blood circulation, stops the fibrin of the tissue that swells and ache to be assembled, and makes weary oxygen condition improved, thereby increases radiocurable sensitivity.3. strive for " people's tumor coexists ", regulate patient's immune function to improve life in patients." Fuzheng Huoxue Chinese medicine associating radiotherapy can improve immunity of organisms, prevention is shifted, and obviously improves the hot and suffocating card nasopharyngeal cancer patient of liver lung long term survival rate.And for the hot and suffocating card nasopharyngeal carcinoma of some liver lung in late period owing to occurring metastasis, or physical function state decline, can not or be reluctant to accept radiotherapy or chemotherapy, should be taking Chinese medicine as main.

Summary of the invention

Technical problem to be solved by this invention is, provides one to have soothing the liver lung heat clearing, effect of the removing toxic substances of purging heat, cure mainly liver lung stagnated heat type nasopharyngeal carcinoma, remission time is short, rear recurrence, rapid-action, the short treating period of being difficult for of alleviation, safe, with strong points, reach antineoplastic action, from entirety, carry out dialectical opinion and control, make the drug effect focus of going directly, have no side effect, be difficult for producing drug resistance, the advantages such as processing technology is easy, and medicament is easy to manufacture, with low cost.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma, wherein, Chinese medicine preparation comprises following raw medicinal material: artemisia anomalas, the Radix Angelicae Dahuricae, Fructus Xanthii, cover Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae, Herba polygoni hydropiperis, Folium Isatidis, Radix Isatidis, Cortex Phellodendri, Indigo Naturalis, Rhizoma Fagopyri Dibotryis, Rhizoma Belamcandae, mountain Corm Eleocharitis, Fructus Canarii, Radix Tinosporae, water silk floss, Semen Oroxyli, Pseudobulbus Cremastrae Seu Pleiones, Fel Ursi, Radix Cynanchi Atrati, Caulis Trachelospermi, Semen Sterculiae Lychnophorae, Rui core, Concha Arcae, Cortex Albiziae, the Herba Gentianae tsinglingensis, Radix Polygalae and Herba Canscorae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: 10～35 parts of artemisia anomalas, 18～25 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Fructus Xanthii, cover 10～25 parts of Herba caryopteridis nepetaefoliaes, 17～35 parts of Flos Magnoliaes, 10～30 parts of Herba Centipedae, 15～35 parts of Herba Menthaes, 16～25 parts of white Fischer, 18～30 parts of Bombyx Batryticatus, 15～30 parts of Fructus Arctiis, 16～25 parts of Radix Bupleuri, 10～25 parts of Rhizoma Smilacis Chinensiss, 10～30 parts of Rhizoma Cimicifugaes, 18～35 parts of Radix Scutellariaes, 15～30 parts of Pandanus tectorius (L.) Parkins., 10～25 parts of Radix et Rhizoma Thalictri, 10～30 parts of Fructus Forsythiaes, 15～25 parts of Herba polygoni hydropiperis, 17～30 parts of Folium Isatidiss, 17～30 parts of Radix Isatidis, 15～30 parts of Cortex Phellodendris, 17～30 parts of Indigo Naturaliss, 10～35 parts of Rhizoma Fagopyri Dibotryiss, 15～35 parts of Rhizoma Belamcandae, 10～35 parts of mountain Corm Eleocharitiss, 10～30 parts of Fructus Canariis, 15～35 parts of Radix Tinosporaes, 10～30 parts, water silk floss, 17～35 parts of Semen Oroxylis, 15～30 parts of Pseudobulbus Cremastrae Seu Pleioness, 17～35 parts of Fel Ursis, 18～25 parts of Radix Cynanchi Atratis, 10～35 parts of Caulis Trachelospermis, 18～35 parts of Semen Sterculiae Lychnophoraes, 15～30 parts of Rui cores, 15～30 parts of Concha Arcaes, 15～32 parts of Cortex Albiziaes, 17～30 parts of the Herba Gentianae tsinglingensiss, 18～30 parts of 15～30 parts of Radix Polygalaes and Herba Canscoraes.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be preferably: 15～30 parts of artemisia anomalas, 19～24 parts of the Radixs Angelicae Dahuricae, 17～25 parts of Fructus Xanthii, cover 10～22 parts of Herba caryopteridis nepetaefoliaes, 17～30 parts of Flos Magnoliaes, 18～30 parts of Herba Centipedae, 17～30 parts of Herba Menthaes, 17～24 parts of white Fischer, 18～27 parts of Bombyx Batryticatus, 17～25 parts of Fructus Arctiis, 18～24 parts of Radix Bupleuri, 15～25 parts of Rhizoma Smilacis Chinensiss, 16～26 parts of Rhizoma Cimicifugaes, 18～30 parts of Radix Scutellariaes, 17～28 parts of Pandanus tectorius (L.) Parkins., 15～25 parts of Radix et Rhizoma Thalictri, 16～27 parts of Fructus Forsythiaes, 18～24 parts of Herba polygoni hydropiperis, 19～26 parts of Folium Isatidiss, 19～27 parts of Radix Isatidis, 17～27 parts of Cortex Phellodendris, 17～25 parts of Indigo Naturaliss, 15～30 parts of Rhizoma Fagopyri Dibotryiss, 17～30 parts of Rhizoma Belamcandae, 15～30 parts of mountain Corm Eleocharitiss, 15～28 parts of Fructus Canariis, 19～35 parts of Radix Tinosporaes, 10～22 parts, water silk floss, 19～30 parts of Semen Oroxylis, 17～25 parts of Pseudobulbus Cremastrae Seu Pleioness, 19～30 parts of Fel Ursis, 18～24 parts of Radix Cynanchi Atratis, 15～30 parts of Caulis Trachelospermis, 18～30 parts of Semen Sterculiae Lychnophoraes, 17～30 parts of Rui cores, 16～28 parts of Concha Arcaes, 19～30 parts of Cortex Albiziaes, 17～28 parts of the Herba Gentianae tsinglingensiss, 18～27 parts of 15～25 parts of Radix Polygalaes and Herba Canscoraes.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably again: 20 parts of artemisia anomalas, 22 parts of the Radixs Angelicae Dahuricae, 18 parts of Fructus Xanthii, cover 21 parts of Herba caryopteridis nepetaefoliaes, 26 parts of Flos Magnoliaes, 25 parts of Herba Centipedae, 19 parts of Herba Menthaes, 22 parts of white Fischer, 24 parts of Bombyx Batryticatus, 20 parts of Fructus Arctiis, 18 parts of Radix Bupleuri, 24 parts of Rhizoma Smilacis Chinensiss, 26 parts of Rhizoma Cimicifugaes, 27 parts of Radix Scutellariaes, 28 parts of Pandanus tectorius (L.) Parkins., 22 parts of Radix et Rhizoma Thalictri, 25 parts of Fructus Forsythiaes, 23 parts of Herba polygoni hydropiperis, 26 parts of Folium Isatidiss, 27 parts of Radix Isatidis, 21 parts of Cortex Phellodendris, 19 parts of Indigo Naturaliss, 28 parts of Rhizoma Fagopyri Dibotryiss, 19 parts of Rhizoma Belamcandae, 17 parts of mountain Corm Eleocharitiss, 24 parts of Fructus Canariis, 30 parts of Radix Tinosporaes, continuous 16 parts of water, 24 parts of Semen Oroxylis, 22 parts of Pseudobulbus Cremastrae Seu Pleioness, 25 parts of Fel Ursis, 24 parts of Radix Cynanchi Atratis, 19 parts of Caulis Trachelospermis, 22 parts of Semen Sterculiae Lychnophoraes, 25 parts of Rui cores, 26 parts of Concha Arcaes, 23 parts of Cortex Albiziaes, 25 parts of the Herba Gentianae tsinglingensiss, 27 parts of 22 parts of Radix Polygalaes and Herba Canscoraes.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably again: 30 parts of artemisia anomalas, 24 parts of the Radixs Angelicae Dahuricae, 22 parts of Fructus Xanthii, cover 20 parts of Herba caryopteridis nepetaefoliaes, 26 parts of Flos Magnoliaes, 21 parts of Herba Centipedae, 18 parts of Herba Menthaes, 23 parts of white Fischer, 24 parts of Bombyx Batryticatus, 20 parts of Fructus Arctiis, 19 parts of Radix Bupleuri, 24 parts of Rhizoma Smilacis Chinensiss, 26 parts of Rhizoma Cimicifugaes, 29 parts of Radix Scutellariaes, 23 parts of Pandanus tectorius (L.) Parkins., 22 parts of Radix et Rhizoma Thalictri, 17 parts of Fructus Forsythiaes, 19 parts of Herba polygoni hydropiperis, 26 parts of Folium Isatidiss, 27 parts of Radix Isatidis, 24 parts of Cortex Phellodendris, 19 parts of Indigo Naturaliss, 28 parts of Rhizoma Fagopyri Dibotryiss, 30 parts of Rhizoma Belamcandae, 25 parts of mountain Corm Eleocharitiss, 17 parts of Fructus Canariis, 20 parts of Radix Tinosporaes, continuous 22 parts of water, 30 parts of Semen Oroxylis, 25 parts of Pseudobulbus Cremastrae Seu Pleioness, 24 parts of Fel Ursis, 22 parts of Radix Cynanchi Atratis, 18 parts of Caulis Trachelospermis, 25 parts of Semen Sterculiae Lychnophoraes, 19 parts of Rui cores, 28 parts of Concha Arcaes, 27 parts of Cortex Albiziaes, 25 parts of the Herba Gentianae tsinglingensiss, 20 parts of 22 parts of Radix Polygalaes and Herba Canscoraes.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably again: 19 parts of artemisia anomalas, 22 parts of the Radixs Angelicae Dahuricae, 25 parts of Fructus Xanthii, cover 17 parts of Herba caryopteridis nepetaefoliaes, 28 parts of Flos Magnoliaes, 19 parts of Herba Centipedae, 24 parts of Herba Menthaes, 23 parts of white Fischer, 22 parts of Bombyx Batryticatus, 24 parts of Fructus Arctiis, 21 parts of Radix Bupleuri, 18 parts of Rhizoma Smilacis Chinensiss, 17 parts of Rhizoma Cimicifugaes, 20 parts of Radix Scutellariaes, 25 parts of Pandanus tectorius (L.) Parkins., 21 parts of Radix et Rhizoma Thalictri, 25 parts of Fructus Forsythiaes, 24 parts of Herba polygoni hydropiperis, 19 parts of Folium Isatidiss, 23 parts of Radix Isatidis, 25 parts of Cortex Phellodendris, 24 parts of Indigo Naturaliss, 19 parts of Rhizoma Fagopyri Dibotryiss, 28 parts of Rhizoma Belamcandae, 27 parts of mountain Corm Eleocharitiss, 28 parts of Fructus Canariis, 30 parts of Radix Tinosporaes, continuous 12 parts of water, 20 parts of Semen Oroxylis, 23 parts of Pseudobulbus Cremastrae Seu Pleioness, 27 parts of Fel Ursis, 22 parts of Radix Cynanchi Atratis, 19 parts of Caulis Trachelospermis, 26 parts of Semen Sterculiae Lychnophoraes, 28 parts of Rui cores, 21 parts of Concha Arcaes, 20 parts of Cortex Albiziaes, 24 parts of the Herba Gentianae tsinglingensiss, 26 parts of 21 parts of Radix Polygalaes and Herba Canscoraes.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma, and wherein, in the time that the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

The first step, each raw medicinal material in described Chinese medicine preparation is mixed in proportion, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 80～90%, reflux 2～5 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～3 times of described medicinal residues quality again, reflux 2～3 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained are placed in super micron mill and pulverize 1～2 hour, pulverize, and sieve, and obtain 200 order～300 object micropowders;

The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.2～0.4 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulates, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes tablet.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma, and wherein, in the time that the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, get mountain Corm Eleocharitis, Fructus Canarii, Radix Tinosporae, water silk floss, Semen Oroxyli, Pseudobulbus Cremastrae Seu Pleiones, Fel Ursi, Radix Cynanchi Atrati, Caulis Trachelospermi, Semen Sterculiae Lychnophorae and Rui core and mix in described ratio, add the water extraction volatile oil with respect to 3～5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3～5, stir 40 minutes～80 minutes, 30 DEG C～50 DEG C of temperature, obtain volatile oil clathrate compound, for subsequent use; The clear paste that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.15～1.18;

Second step, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae, Herba polygoni hydropiperis, Folium Isatidis, Radix Isatidis, Cortex Phellodendri, Indigo Naturalis and Rhizoma Fagopyri Dibotryis are mixed in described ratio, the alcohol reflux that to add with respect to 5～7 times, mixture amount determining alcohols be 85%～90% 2～4 times, each 3～5 hours, filter respectively, each time filtrate merges, reclaim ethanol, the clear paste that while being concentrated into 60 DEG C, relative density is 1.20～1.25, for subsequent use;

The 3rd step, by after the raw medicinal material except in the first step and second step, remaining raw medicinal material mixes in described ratio, adds with respect to 7～10 times of water gagings of mixture, boil 6～10 hours, filter, the clear paste that while being concentrated into 60 DEG C, relative density is 1.27～1.30;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～90 DEG C reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～7 weight portion carboxymethyl starch sodium, 5～40 weight portion starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, then pack in gelatine capsule, obtain capsule.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma, and wherein, in the time that the dosage form of described Chinese medicine preparation is oral liquid, its preparation method comprises the following steps:

The first step, will cover Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae and Herba polygoni hydropiperis and mix, the alcohol reflux that to add with respect to 3 times～5 times, mixture amount determining alcohols be 55%～65% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.30～1.32, for subsequent use;

Second step, will be except covering Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae and Herba polygoni hydropiperis, remaining raw medicinal material is mixed in proportion, add with respect to 3～5 times of water gagings of mixture, boil 2～4 hours, filter, be concentrated into the mastic that 80 DEG C of relative densities are 1.25～1.28;

The 3rd step, the described mastic that the first step, second step are obtained mix, and 55 DEG C～85 DEG C reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, and obtain containing alcohol mastic, described is 70%～90% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will in described dealcoholysis mastic, add cane sugar powder, active carbon, and carry out dilution process, be uniformly mixed to evenly, carry out successively heat treated, filtration treatment, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3～0.5; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002～0.004; The time of described heat treated is 30～50 minutes, and temperature is 120 DEG C～180 DEG C;

The 6th step, again by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding processing, sterilization treatment, obtain the oral liquid finished product of described Chinese medicine composition.

The invention has the beneficial effects as follows: the present invention has soothing the liver lung heat clearing, effect of the removing toxic substances of purging heat, cures mainly liver lung stagnated heat type nasopharyngeal carcinoma, remission time is short, the rear difficult recurrence of alleviation, and rapid-action, short treating period is safe, with strong points, reach antineoplastic action, from entirety, carry out dialectical opinion and control, make the drug effect focus of going directly, have no side effect, be difficult for producing drug resistance, processing technology is easy, the advantages such as medicament is easy to manufacture, with low cost.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of nasopharyngeal carcinoma, wherein, described Chinese medicine preparation comprises following raw medicinal material: artemisia anomalas, the Radix Angelicae Dahuricae, Fructus Xanthii, illiteracy Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae, Herba polygoni hydropiperis, Folium Isatidis, Radix Isatidis, Cortex Phellodendri, Indigo Naturalis, Rhizoma Fagopyri Dibotryis, Rhizoma Belamcandae, mountain Corm Eleocharitis, Fructus Canarii, Radix Tinosporae, water silk floss, Semen Oroxyli, Pseudobulbus Cremastrae Seu Pleiones, Fel Ursi, Radix Cynanchi Atrati, Caulis Trachelospermi, Semen Sterculiae Lychnophorae, Rui core, Concha Arcae, Cortex Albiziae, the Herba Gentianae tsinglingensis, Radix Polygalae and Herba Canscorae.

Wherein, the pharmacological property of above-mentioned raw materials medical material is as follows:

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel." Japan hanako materia medica ": " control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mends fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, and evacuation of pus, scabies, desolation, pain relieving granulation promoting, go face Shao-defect scar." Compendium of Material Medica: " and control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, married woman's blood dizziness due to wind pathogen fortune, bleeding urine, regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound." function expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, the venom contained.

Fructus Xanthii: bitter in the mouth, sweet, pungent, warm in nature; Enter liver, kidney two warps.Shennong's Herbal: " spasm of the limbs pain, dislikes the dead flesh of meat for the cold pain of main air head, rheumatism general arthralgia." " Japan hanako materia medica ": " control all pathogenic wind, fill out marrow, warm waist foot.Control scrofula, scabies and pruritus." essentials of Matea Medica: " and kind diaphoresis, loose rheumatism, upper logical brain top, descending sufficient knee joint, reaches skin outward.Control headache, order is dark, toothache, and nasal sinusitis, deburring, " loose wind dehumidifying, clearing the nasal passage.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.

Flos Magnoliae: pungent, warm, nontoxic.Attach to the lung and stomach meridians.Dispersing wind and cold, clearing the nasal passage." detailed outline ": " nasal abscess after nasal sinusitis, allergic rhinitis, stuffy nose, nasal abscess and pox, and with grinding into powder, enter Moschus a little, Bulbus Allii Fistulosi is dipped into for several times." " Mingyi Bielu ": " and stuffy nose relieving plug, tears go out for warming middle-JIAO expelling pathogenic factors from muscles, sharp nine orifices, control swelling of the face and draw toothache, dizziness, body several as on car and boat person." for headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.Flos Magnoliae is of many uses, is domestic and international Chinese crude drug in short supply.

Herba Centipedae: dispersing wind-cold, clearing the nasal passage, cough-relieving, removing toxic substances.Compendium of Material Medica: " loose conjunctival congestion is swollen for removing toxic substances, improving eyesight, nebula, deafness, and headache olic acid, controls Tan Nve Snore clam, has a stuffy nose obstructed, and plug breath is from falling, and loose skin ulcer is swollen again.”

Herba Menthae: nature and flavor are pungent is cool.Enter lung meridian, Liver Channel.For anemopyretic cold, epidemic febrile disease from the beginning of.These product are pungent to disperse, cool to heat clearing away, clear light cool loose, are the product that dispelling wind and heat pathogens is conventional, control anemopyretic cold or epidemic febrile disease from the beginning of, evil defending point therefore available, and headache, heating, the micro evil wind person that trembles with fear often joins Flos Lonicerae, Fructus Forsythiae, Fructus Arctii, Herba Schizonepetae and is equal to use.Be used for the conjunctival congestion of having a headache, laryngopharynx swelling and pain.These product lightly float and rise floating, awakening consciousness, kind part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, the throat evacuated of merit.Attack with controlling in wind heat, headache conjunctival congestion, stops up Sheng, laryngopharynx swelling and pain with controlling wind heat.Modern study shows, Herba Menthae has antivirus action; Analgesia, itching-relieving action; Irritation, antitussive action; Bactericidal action; Antibacterial action: Herba Menthae has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, oral disease, makes breath freshening.Gargle with mint tea juice, can be anti-halitosis in advance.It is said that Herba Menthae also has the another name of " eyes grass ", can be used for treating ophthalmic.Physiological function: Herba Menthae is the best quintessence oil for the treatment of flu, can suppress fever and mucosa inflammation, and promote perspire; Cleaning throat and moistening larynx, elimination halitosis have good effect; Effect of relieveing pain and refreshing, can alleviate headache, migraine and toothache; In addition for respiratory system, digestive system, hormonal system, there is good effect.

Bombyx Batryticatus: salty, pungent, flat; Return liver, lung, stomach warp.Shennong's Herbal: " main pediatric epilepsy scared, night cry, go three worms, goes out black, makes us complexion good, the cloudy infections disease of man." Compendium of Material Medica: " erysipelas is had an itch for loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer ... all incised wounds, the furuncle wind hemorrhoid that swell." Bombyx Batryticatus alcohol water-leach liquor all has hypnosis, anticonvulsant action to mice, rabbit; Its extracting solution in vivo, all have a stronger anticoagulation outward; Bombyx Batryticatus powder has good hypoglycemic activity; In vitro tests, has slight bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, and the external breathing that suppresses human hepatoma cell of its alcohol extract, can be used for the treatment of rectum tumor type polyp.

Fructus Arctii: acrid in the mouth, hardship, cold in nature.Attach to the lung and stomach meridians.Can dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, lung qi dispersing sore-throat relieving be loose swollen.Cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; Sore swollen toxin and mumps etc.Raw with can loosening bowel to relieve constipation, pyretic toxicity red swelling and pain of throat, has constipation with heat retention concurrently especially suitable." Bencao Jingshu " said: " disliking in fact, is the key medicine of loose wind except thermal detoxification.Pungent can eliminating stagnation, hardship can expel the heat-evil, the loose visceral-qi of accumulation of heat Clear and Bright, therefore improving eyesight and invigorating middle warmer.The institute of wind hinders, defend gas and must stop up, stop up heating, Xin Liang dismiss show gas and, wind without stay.Hide the swollen all flaccidity of device main air poison; The main lung moistening of element, eliminating stagnation gas, sore-throat relieving diaphragm, peeling skin wind, logical twelve channels and collaterals person, know this meaning ear.Therefore in order to control urticaria, variola, especially obtain very and test ".

Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, " Bencao Tujing " carries: " between (Radix Bupleuri) modern pass, Shan, rivers and lakes, shortcut all has it, taking silver-colored state person as victory.Life in February Seedling, very fragrant, stem is livid purple, and leaf is slightly purple like Folium Bambusae ... open Hemerocallis citrina Baroni July ... root redness of the skin or complexion, like Radix Peucedani and strong.Reed head has red hair as Mus tail, and solely nest elder is good.Adopt root August in February." tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, cold and heat deficient fever.Children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Radix Bupleuri volatile oil has trivial solution heat effect to heating due to typhoid fever, paratyphoid fever vaccine, escherichia coli liquid, fermented milk, yeast etc., and can make animal normal body temperature decline.To ankle joint due to multiple proinflammatory agent, swollen and desmoplastic inflammation all has inhibitory action.

Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp." property of medicine opinion ": " control little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens.Can control the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, pyretic toxicity pus and blood.Remove cardiopulmonary pathogenic wind toxic heat obstructed and constipated, aphtha, unhappiness.Treat carbuncle, smallpox; Decocting silk floss is stained with and is wiped in skin ulcer." Compendium of Material Medica: " and speckle removing rash, clots absorbing blood are controlled sun and are fallen into dizzy fortune, and the empty pain of the breast side of body is heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot." function heat-clearing and toxic substances removing, rash.Thoroughly send out smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery for measles.

Radix Scutellariae: property hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri the best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so gives up Radix Scutellariae and can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, agent also first of Ci Gaizhu section half exterior and half interior." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.That Radix Scutellariae has is antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppress the effects such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus are had to certain inhibitory action, upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. are had to good curative effect.

Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging is except steaming, effect of detoxification sore treatment.Cortex Phellodendri is distributed in the area such as Northeast China and North China each province, and happiness grows among mountain area, assorted woods, and strong adaptability is applicable to sun-drenched local cultivation, also can anti-severe cold.

Radix et Rhizoma Thalictri: nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication.Control damp-heat dysentery, jaundice, calentura agitation, cough due to lung-heat, carbuncle pyogenic infections from tumour or sore, conjunctival congestion and swelling pain.Be applied to now enteritis, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.Fetidine has hypotensive effect, and its crude preparation by using can be controlled hypertension.

Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the real person of not opening of Chinese toon, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all little thin like sticking up greatly, and mountain people from south also uses it.Under modern capital, only with sticking up greatly son, spend also without stem." have antibacterial, heart tonifying, diuresis, town the pharmacological action such as to tell, be the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of symptom, its bacteriostasis and Flos Lonicerae broadly similars such as, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.Weakness of the spleen and stomach, fever due to deficiency of QI, carbuncle is burst, the light person of the rare color of pus avoids clothes.The contained oleanolic acid of this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.

Folium Isatidis: hardship, cold; Enter liver, the heart, stomach warp.Compendium of Material Medica: " main pyrotoxic dysentery, jaundice, sore throat, erysipelas." " LANYE juice, separates Mylabris, Yuan green grass or young crops, tree of heaven chicken, Cinnabaris, arsenicum sablimatum poison." " book on Chinese herbal medicine is just ": " controlled pestilence pyretic toxicity and goes mad, wind heat macule, and carbuncle and ulcer swells and ache, relieving thirst and restlessness, only epistaxis, haematemesis, kills infantile malnutrition erosion, incised wound curare.All with the heat malicious person that holds concurrently, all should LANYE smash juice and use it." heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Resisting pathogenic microbes effect: the in vitro tests of Folium Isatidis decoct has certain inhibitory action to staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium; Folium Isatidis also has inhibitory action to encephalitis b virus, mumps virus, influenza virus etc. and Folium Isatidis is killed leptospiral effect in addition.

Radix Isatidis: nature and flavor, bitter cold.Heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen, high heat headache, major part pestilence, crimson tongue is purple dark, scarlet fever, erysipelas, mumps, sore throat, skin ulcer is swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis." book on Chinese herbal medicine is stated ": control a day row major part pyretic toxicity." book on Chinese herbal medicine is just read ": Radix Isatidis is indigo-blue, its function nature and flavor and indigo-blue leaf with, can enter liver stomach blood system, but heat clearing away, detoxify, ward off epidemic disease, parasite killing.But leaf master is loose, and root master fall, this again with in different ear." classification medical herbs ": separate all malicious malignant boil, loose poison reduces internal heat, and smashes juice or clothes or painting." modern Practical Chinese medicinal ": rhizoma et radix baphicacanthis is refrigerant, antipyretic, antidote, for erysipelas, lochiopyra etc." Chinese medicinal herbal ": Qinghuo Jiedu, cooling blood for hemostasis.Control calentura and send out speckle, erysipelas, laryngopharynx swelling and pain, epidemic infection with swollen head, and the disease such as haematemesis, epistaxis." Chinese herbal medicine handbook is commonly used in Liaoning ": treating the liver inflammation, parotitis." Chinese herbal medicine is commonly used in Shanghai ": heating cures cold.

Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms for epidemic febrile disease, Indigo Naturalis, containing indigo, indirubin, has heat-clearing and toxic substances removing, the antiviral effect of sore, inhibited to cholera bacilli, Bacillus typhi, dysentery bacterium and part virus.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.As heat-clearing and toxic substances removing, according to Nantong experience, must take by stewing out of water juice, decoction curative effect is not remarkable.Clinical use is controlled laryngopharynx swelling and pain.Treatment brothers articular instability, the rheumatism muscles and bones disease such as ache.Though experiment in vitro is without obvious antibacterial action, coagulase, hemolysin and bacillus pyocyaneus endogenous toxin to staphylococcus aureus have antagonism.

Rhizoma Belamcandae: nature and flavor hardship, cold.Enter lung, Liver Channel.There is heat-clearing and toxic substances removing, throat, expectorant saliva, treats pharynx and closes, effect of eliminating carbuncle poison.Modern study shows, it has the effect of resisting pathogenic microbes, antiinflammatory.Rhizoma Belamcandae is used for experiencing wind heat, or expectorant heat is stopped up the diseases such as the laryngopharynx swelling and pain due to containing.Rhizoma Belamcandae is to control the medicine that laryngopharynx swelling and pain is conventional, can heat clearing away poison, detumescence pain, accumulation and obstruction of sputum, Rhizoma Belamcandae clearing away lung-heat when the diseases such as cough and asthma and expectorant saliva, also for controlling cough phlegm dyspnea.

Fructus Canarii: puckery, sour, sweet, flat; Enter liver, spleen, lung three warps.Compendium of Material Medica: " Fructus Canarii, although this fruit, its color is also blue or green therefore custom is exhaled Fructus Canarii, and eight have yellow skin, and person can't bear, and sick thing is also." function lung heat clearing, sore-throat relieving, promotes the production of body fluid, removing toxic substances.Control laryngopharynx swelling and pain, excessive thirst, cough is spitted blood, bacillary dysentery, epilepsy, separates river intestinal poison and alcoholism.The alcohol extract of seed gives male Fructus Canarii rabbit oral, has hypoglycemic activity, and its intensity is similar to D860 and slightly.Leaf feed animal has faint estrogen-like effects.The volatile oil of leaf has antibacterial action in vitro.Eat anemia of pregnant woman and age of sucking Fructus Canarii, baby's brain development is had to obvious facilitation, can make baby become clever.Modern medicine research is found, takes in the abundant material of calcium content, can reduce the danger of suffering from colon cancer and rectal cancer.

Radix Tinosporae: hardship, cold.Return lung, large intestine channel." property of medicine is examined ": " removing toxic substances.Throat numbness is anxious, and erosion of mucous membrane of the oral cavity should take.The red furuncle Skin-disease of cellulitis carbuncle carbuncle on the back ， inflammation, snakes and scorpions insect bite, mill is coated with.Control ophthalmalgia, bulge of the ear, cough due to heat, haze miasma, tells nosebleed, all outer diseases." " the little knowledge in Citrus chachiensis Hort. garden ": " and the inside and outside stagnation of pathogenic heat of dispelling, all over vicious, the communicable subtropical diseases that disappear, two single throat moth and toothache, shave contains; Mill is coated with furuncle swelling toxin." function heat-clearing and toxic substances removing, sore-throat relieving, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.

Semen Oroxyli: mildly bitter flavor, sweet, cold nature; Return lung, liver, stomach warp." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " broken legendary venomous insect is long-pending, except the poison of tympanitis due to blood stasis, gas legendary venomous insect for Dingchuan, expectorant.Again can tonify deficiency, alleviating distention in middle-JIAO, feed." " detailed outline is picked up any lost article from the road ": " and control motive pain, irritability pain, bottom is damp and hot.Xiang Qiuzi cloud again, all carbuncle poison do not close up, and paste it with this." sore-throat relieving lung moistening, dispersing the stagnated liver-QI for regulating the stomach, expelling pus and promoting granulation.Cure mainly pharyngalgia sore throat, hoarseness, cough, stomachache due to hyperactive liver-QI attacking the stomach, skin infection is burst and is not held back for a long time, acute eczema.Seed, peel of stem, containing baicaligenin, have antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the effect of cholesterol reducing.In seed and peel of stem, containing chrysin, human nasal pharyngeal cancer (KB) cell is had to cytotoxic activity, its median effective dose is 13mg/ml.

Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool.Dispersing swelling and dissipating binds, reduces phlegm, heat-clearing and toxic substances removing.Control carbuncle furuncle and phyma, laryngopharynx swelling and pain, sore throat, scrofula.Supplement to the Herbal: " vinegar mill applies it for main carbuncle skin ulcer fistula, scrofula tuberculosis etc." Compendium of Material Medica: " main furuncle is swollen, counteracting toxic substances broken skin.Separate all poison, snakeworm, mad dog wound.", carbuncle furunculosis swollen to acute mastitis, scrofula go through tuberculosis, for oral administration, external application, all can apply.For esophageal carcinoma, breast carcinoma; For lymph tumor, excision of benign breast.Iphigenia indica, Bulbus Lloydiae tibeticae toxicity is stronger, excessively causes poisoningly, and a large amount of clothes for a long time can cause gastrointestinal side effect, polyneuritis, leukopenia etc.

Fel Ursi: bitter, cold; Heat-clearing and toxic substances removing, improving eyesight, relieving convulsion.Tang Materia Medica: " when treatment, seasonal epidemic pathogens intenseness of heat becomes jaundice, the summer-heat moon chronic diarrhea, pained." heat-clearing and toxic substances removing, improving eyesight, relieving convulsion.For excessive heat of infant infantile convulsion, epilepsy, twitch, jaundice; Carbuncle is controlled in external, hemorrhoid, conjunctival congestion nebula.Be applicable to excessive heat of infant infantile convulsion, epilepsy, twitches, jaundice.Use white mice intestine in vitro; the spasm causing with acetylcholine; study the spasmolysis of 8 regional Fel Ursis and wild Bears, Fel Sus scrofa; wherein the strongest with Tibet product person spasmolytic effect; other area institute's black bear gallbladders that produce and the amber Fel Ursi spasmolytic effect of Japanese product are also stronger; the main component of spasmolysis is tauroursodeoxycholic acid, and its spasmolytic principle is similar to papaverine.Mice that UDCA causes strychnine is poisoning Detoxication, share and can strengthen its Detoxication with chenodeoxy cholic acid sodium and sodium cholate.

Radix Cynanchi Atrati: " modern Practical Chinese medicinal ": " control the extremity edema of apoplexy patient, again for the hectic fever of the scorching hot and weak disease in acute calenture latter stage, the osteopyrexia and fever of pulmonary tuberculosis etc., have the effect of refrigerant property nourishing; Also puckery for urine again, the cards such as cough due to lung-heat." clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.Be generally used for clearind deficient heat person in the majority, control cough due to lung-heat.

Caulis Trachelospermi: hardship, is slightly cold.GUIXIN, liver, kidney channel." herbal classic ": " carbuncle does not disappear for the dead flesh carbuncle wound of main air heat, xerostomia scorching tongue, and mouthpiece is swollen, water slurry not under." Tang Materia Medica: " treat blood agglomeration in puerperal.Agkistrodon halys skin ulcer, strand extracting juice is washed it, takes juice and also goes the snake venom heart vexed; The all skin ulcers of injury by sword or axe, Feng Zhi." there is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling, cures mainly dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.For rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.

Semen Sterculiae Lychnophorae: nature and flavor: sweet light, cool.Cure mainly: heat clearing away, lung moistening, sore-throat relieving, removing toxic substances.Control dry cough without phlegm, laryngalgia, hoarseness, hectic fever due to YIN-deficiency interior-heat, tells nosebleed hematochezia, conjunctival congestion, toothache, hemorrhoid fistulae.Be used for out lung qi, clearing away lung-heat.Zhang Shouyi: " this medicine is also said large sending out: obtain boiling water with one, bark is swollen, and is full of a bowl also therefore several.Person of modern times is with it, all to control the cough due to common cold, and the low voice speaking disease of waiting of having a stuffy nose.Warm in nature, therefore energy cold expelling wind, so its taste utmost point is talked, micro-containing sweet meaning, and the medicine that temperature is loose is never like this.Be good at out lung qi dispersing gas, and the fur of removing heat by catharsis, ailment said due to cold or exposure is closed outward, pays no attention to as trembling with fear as heat, and all leads it.Press down and can control secretly by sound producing, the refreshing eliminating phlegm of coughing.Zhao's meaning is controlled the pox that fire closes, and lid pyretic toxicity is stopped up in the flesh natural fibre line of meat, and pox goes out unhappy person, and this thing exploitation is the most prompt, should have immediate effect, and pardons saying of pavilion, when levying also.Light with two, three pieces, as lung closes very, cough and do not speak, or gold stops up the sound person of neighing, available to five, six pieces.This fruit of lid plant, different from Seedling leaf natural instincts, therefore that diaphoresis and the utmost point have is confirmed, the absolutely not fraud of temperature rise disturbance, especially can certificate."

Concha Arcae: salty, flat.Return lung, stomach, Liver Channel.Expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, thickness difficulty is coughed up, goiter, scrofula, abdominal mass mass in the abdomen, stomachache pantothenic acid.Concha Arcae salty in the mouth softening the hard mass, the pertinacious phlegm that disappears, Disperse hepatic depression.Control goiter, sucutaneous nodule, normal and Sargassum, Thallus Laminariae (Thallus Eckloniae) is equal to use, if " Standards of Diagnosis and Treatment surgeon " is containing changing ball.Control the scrofula that phlegm-fire condenses.For lump in the abdomen mass in the abdomen.Concha Arcae both can blood stasis-eliminating and stagnation-dissipating, again can eliminating phlegm and softening indurated mass, be suitable for the lump in the abdomen mass in the abdomen due to qi depression to blood stasis and accumulation of phlegm.Modern times are used treating the liver splenomegaly and digestive tract tumor etc. with this.Be used for the pantothenic acid of having a stomachache.The relieving gastric hyperacidity to alleviate stomachache of Concha Arcae energy, noisy, the general acid regurgitation water person that has a stomachache, treatment constipation person, stomach are liked dim person, the stagnant person of the prolonged illness stasis of blood.

Cortex Albiziae: sweet, flat; Enter the heart, Liver Channel." Japan hanako materia medica ": " soft extracts, subduing inflammation reuniting the fractured tendons and bones." Shennong's Herbal: " Herba Albiziae, sweet in the mouth is flat.Main settling five organs, sharp will, makes us happy carefree ... raw mountain valley." administration of antiallergic Cortex Albiziae decoct rat oral gavage can suppress its peritoneum mast cell degranulation, in vitro tests also has similar effect.Cortex Albiziae decoct can obviously suppress sensitization process and the antibody production process of antigen (horse serum) to rat.Cortex Albiziae is the bark of leguminous plant Herba Albiziae, Cortex Albiziae another name closes confused skin, night platform skin, Herba Albiziae veneer, Cortex Albiziae has the resolving depression of calming the nerves, effect of the eliminating carbuncle of invigorating blood circulation, Cortex Albiziae has the effect for the treatment of irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury, gastritis sufferer is careful takes Cortex Albiziae, and wind heat spontaneous perspiration, diseases caused by exogenous pathogenic factor sleeplessness person prohibit and take Cortex Albiziae.

Radix Polygalae: bitter, pungent, tepor; GUIXIN, kidney, lung meridian.Shennong's Herbal: ", except pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent for main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency, and normal hearing and eyesight is not forgotten, strong will times power." " Japan hanako materia medica ": " the frightened black mole of main diaphragm gas, longue meat, helps muscles and bones, married woman's blood aphonia of keeping silent, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, heart effect is low compared with skin zone.

Artemisia anomalas: nature and flavor: pungent, bitter, flat.Cure mainly: clearing away summer-heat and eliminating dampness, blood circulation promoting competent silt, inducing menstruation to relieve menalgia.For heatstroke, headache, enteritis, dysentery, amenorrhea stomachache, rheumatalgia, traumatic injury; Wound hemorrhage is controlled in external, mastitis.

Cover Herba caryopteridis nepetaefoliae: nature and flavor: sweet, temperature.Cure mainly: help digestion and regulate the flow of vital energy, wind-damp dispelling, promoting blood circulation and stopping pain.Cure mainly dyspepsia, abdominal distention; External treating rheumatic arthritis.

White Fischer: nature and flavor: hardship, cool.Cure mainly: heat-clearing and toxic substances removing, reunion of fractured tendons and bones.Control cough due to pathogenic wind-heat, pertussis, oral ulcer, hematuria, urinary system infection, venom, furuncle, burn and scald, tuberculosis of spine, fracture.

Rhizoma Smilacis Chinensis: nature and flavor: sweet, sour, flat.Cure mainly: expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling.Root stock: dispelling the wind and dampness pathogens arthralgia, traumatic injury, gastroenteritis, dysentery, dyspepsia, diabetes, chyluria, leucorrhea, cancer; Leaf: carbuncle furuncle furuncle is controlled in external, scalds.

Pandanus tectorius (L.) Parkins.: nature and flavor: sweet, light, cool.Cure mainly: relieving the exterior syndrome by diaphoresis, heat-clearing and toxic substances removing, diuretic reduces phlegm.Root: cold, fever, oedema due to nephritis, urinary system infection, lithangiuria, hepatitis, cirrhotic ascites, Infantile Summer Fever, eye keratitis.Really: dysentery, cough.Pit: orchitis, hemorrhoid.

Herba polygoni hydropiperis: nature and flavor: pungent, temperature.Cure mainly: expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.For dysentery, gastroenteritis, diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage; Venom is controlled in external, skin eczema.

Mountain Corm Eleocharitis: nature and flavor: hardship, flat.Cure mainly: heat-clearing and toxic substances removing, dehumidifying diuresis.For hepatitis, traumatic injury, rheumatalgia, cystitis, venom; Carbuncle pyogenic infections from tumour or sore is controlled in external.

Water silk floss: cure mainly: heat-clearing and toxic substances removing.For erysipelas, red trip, dermatitis rhus, burn and scald.

Rui core: nature and flavor: sweet, be slightly cold.Cure mainly: liver heat removing and eyesight improving.For eye conjunctivitis, blepharitis, corneal nebula.

The Herba Gentianae tsinglingensis: nature and flavor: hardship, flat.Cure mainly: regulating menstruation and activating blood, clearing away heat to improve acuity of vision, diuresis.For menoxenia, dysmenorrhea, dizziness, insomnia, dysuria, stranguria, metrorrhagia, leucorrhea, dysentery, stomachache.

Herba Canscorae: nature and flavor: micro-sweet, micro-hardship, flat.Cure mainly: heat-clearing and toxic substances removing, cough-relieving, pain relieving.For cough due to lung-heat, stomachache, icterohepatitis, venom.

Wherein, in the time that the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

Wherein, in the time that the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

Wherein, in the time that the dosage form of described Chinese medicine preparation is oral liquid, its preparation method comprises the following steps:

Embodiment 1 tablet of the present invention

The manufacturing process of oral medicine tablet of the present invention is: get artemisia anomalas 200g, Radix Angelicae Dahuricae 220g, Fructus Xanthii 180g, cover Herba caryopteridis nepetaefoliae 210g, Flos Magnoliae 260g, Herba Centipedae 250g, Herba Menthae 190g, white Fischer 220g, Bombyx Batryticatus 240g, Fructus Arctii 200g, Radix Bupleuri 180g, Rhizoma Smilacis Chinensis 240g, Rhizoma Cimicifugae 260g, Radix Scutellariae 270g, Pandanus tectorius (L.) Parkins. 280g, Radix et Rhizoma Thalictri 220g, Fructus Forsythiae 250g, Herba polygoni hydropiperis 230g, Folium Isatidis 260g, Radix Isatidis 270g, Cortex Phellodendri 210g, Indigo Naturalis 190g, Rhizoma Fagopyri Dibotryis 280g, Rhizoma Belamcandae 190g, mountain Corm Eleocharitis 170g, Fructus Canarii 240g, Radix Tinosporae 300g, the continuous 160g of water, Semen Oroxyli 240g, Pseudobulbus Cremastrae Seu Pleiones 220g, Fel Ursi 250g, Radix Cynanchi Atrati 240g, Caulis Trachelospermi 190g, Semen Sterculiae Lychnophorae 220g, Rui core 250g, Concha Arcae 260g, Cortex Albiziae 230g, Herba Gentianae tsinglingensis 250g, Radix Polygalae 220g and Herba Canscorae 270g,

Its preparation method comprises the following steps:

The first step, each raw medicinal material in described Chinese medicine preparation is mixed in proportion, the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 85%, reflux 5 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2 times of described medicinal residues quality again, reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained are placed in super micron mill and pulverize 2 hours, pulverize, and sieve, and obtain 300 object micropowders;

The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.3 times of its quality, 0.07 times of lactose, the starch of 0.2 times, sieve, and mix homogeneously, granulate, dry, add with respect to 0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes tablet.

Embodiment 2 capsule of the present invention

The manufacturing process of oral medicine capsule of the present invention is: get artemisia anomalas 300g, Radix Angelicae Dahuricae 240g, Fructus Xanthii 220g, cover Herba caryopteridis nepetaefoliae 200g, Flos Magnoliae 260g, Herba Centipedae 210g, Herba Menthae 180g, white Fischer 230g, Bombyx Batryticatus 240g, Fructus Arctii 200g, Radix Bupleuri 190g, Rhizoma Smilacis Chinensis 240g, Rhizoma Cimicifugae 260g, Radix Scutellariae 290g, Pandanus tectorius (L.) Parkins. 230g, Radix et Rhizoma Thalictri 220g, Fructus Forsythiae 170g, Herba polygoni hydropiperis 190g, Folium Isatidis 260g, Radix Isatidis 270g, Cortex Phellodendri 240g, Indigo Naturalis 190g, Rhizoma Fagopyri Dibotryis 280g, Rhizoma Belamcandae 300g, mountain Corm Eleocharitis 250g, Fructus Canarii 170g, Radix Tinosporae 200g, the continuous 220g of water, Semen Oroxyli 300g, Pseudobulbus Cremastrae Seu Pleiones 250g, Fel Ursi 240g, Radix Cynanchi Atrati 220g, Caulis Trachelospermi 180g, Semen Sterculiae Lychnophorae 250g, Rui core 190g, Concha Arcae 280g, Cortex Albiziae 270g, Herba Gentianae tsinglingensis 250g, Radix Polygalae 220g and Herba Canscorae 200g,

Its preparation method comprises the following steps:

The first step, get mountain Corm Eleocharitis, Fructus Canarii, Radix Tinosporae, water silk floss, Semen Oroxyli, Pseudobulbus Cremastrae Seu Pleiones, Fel Ursi, Radix Cynanchi Atrati, Caulis Trachelospermi, Semen Sterculiae Lychnophorae and Rui core and mix in described ratio, add the water extraction volatile oil with respect to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3, stir 70 minutes, temperature 45 C, obtains volatile oil clathrate compound, for subsequent use; The clear paste that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.17;

Second step, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae, Herba polygoni hydropiperis, Folium Isatidis, Radix Isatidis, Cortex Phellodendri, Indigo Naturalis and Rhizoma Fagopyri Dibotryis are mixed in described ratio, the alcohol reflux that to add with respect to 6 times, mixture amount determining alcohols be 90% 3 times, each 5 hours, filter respectively, each time filtrate merges, reclaim ethanol, the clear paste that while being concentrated into 60 DEG C, relative density is 1.25, for subsequent use;

The 3rd step, by after the raw medicinal material except in the first step and second step, remaining raw medicinal material mixes in described ratio, adds with respect to 10 times of water gagings of mixture, boil 8 hours, filter, the clear paste that while being concentrated into 60 DEG C, relative density is 1.28;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 90 DEG C of reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5 weight portion carboxymethyl starch sodium, 30 weight portion starch mix homogeneously, adding 180 weight portion determining alcohols is 80% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3 weight portion magnesium stearate, then pack in gelatine capsule, obtain capsule.

Embodiment 3 oral liquid of the present invention

Oral liquid manufacturing process of the present invention is: get artemisia anomalas 190g, Radix Angelicae Dahuricae 220g, Fructus Xanthii 250g, cover Herba caryopteridis nepetaefoliae 170g, Flos Magnoliae 280g, Herba Centipedae 190g, Herba Menthae 240g, white Fischer 230g, Bombyx Batryticatus 220g, Fructus Arctii 240g, Radix Bupleuri 210g, Rhizoma Smilacis Chinensis 180g, Rhizoma Cimicifugae 170g, Radix Scutellariae 200g, Pandanus tectorius (L.) Parkins. 250g, Radix et Rhizoma Thalictri 210g, Fructus Forsythiae 250g, Herba polygoni hydropiperis 240g, Folium Isatidis 190g, Radix Isatidis 230g, Cortex Phellodendri 250g, Indigo Naturalis 240g, Rhizoma Fagopyri Dibotryis 190g, Rhizoma Belamcandae 280g, mountain Corm Eleocharitis 270g, Fructus Canarii 280g, Radix Tinosporae 300g, the continuous 120g of water, Semen Oroxyli 200g, Pseudobulbus Cremastrae Seu Pleiones 230g, Fel Ursi 270g, Radix Cynanchi Atrati 220g, Caulis Trachelospermi 190g, Semen Sterculiae Lychnophorae 260g, Rui core 280g, Concha Arcae 210g, Cortex Albiziae 200g, Herba Gentianae tsinglingensis 240g, Radix Polygalae 210g and Herba Canscorae 260g,

Its preparation method comprises the following steps:

The first step, will cover Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae and Herba polygoni hydropiperis and mix, the alcohol reflux that to add with respect to 5 times, mixture amount determining alcohols be 60% 4 times, each 3 hours, filter, filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 DEG C of relative densities are 1.31, for subsequent use;

Second step, will be except covering Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae and Herba polygoni hydropiperis, remaining raw medicinal material is mixed in proportion, add with respect to 5 times of water gagings of mixture, boil 4 hours, filter, be concentrated into the mastic that 80 DEG C of relative densities are 1.27;

The 3rd step, the described mastic that the first step, second step are obtained mix, and 75 DEG C of reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, and obtain containing alcohol mastic, described is 80% containing alcohol mastic containing alcohol amount; Carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment by described containing alcohol mastic, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 35 hours;

The 5th step, will in described dealcoholysis mastic, add cane sugar powder, active carbon, and carry out dilution process, be uniformly mixed to evenly, carry out successively heat treated, filtration treatment, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.4; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003; The time of described heat treated is 50 minutes, and temperature is 150 DEG C;

Long term toxicity test:

The tablet of respectively being prepared by the embodiment of the present invention 1, capsule prepared by embodiment 2, Oral Liquid On Mice prepared by embodiment 3 is by 10.78, 20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Acute toxicity testing:

80 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is divided into four groups at random, and 20 every group, i.e. matched group and administration group (embodiment group 1, embodiment group 2, embodiment group 3), fasting 12 hours before experiment; Oral liquid prepared by the tablet that just prepared by embodiments of the invention group 1 respectively, capsule prepared by embodiment group 2 and embodiment group 3 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

Tumor-inhibiting action experiment:

Subjects: 100 of ICR mices, body weight 19-24g, male.

Test inoculation content: S180 solid tumor.

Get ICR mice, in the subcutaneous conventional inoculation S180 cancerous cell suspension 0.2ml of right axil (approximately 5 × 106 cell/m1), be divided at random 5 groups next day.Treatment group is divided into three groups, is respectively high dose group, middle dosage group and low dose group, adopts the tablet of the embodiment of the present invention 1, and after pulverizing, distilled water dissolves, and every day is gastric infusion 1.2ml, 0.8m1 and 0.4m1 respectively, continuous 10 days; Matched group is divided into two groups, is respectively normal saline group and CTX group, and normal saline group stomach every day is raised 0.4m1 normal saline, continuous 10 days; CTX group administration cyclophosphamide, administration every day 0.2g, gastric infusion after distilled water dissolves, continuous 10 days; 5 groups are after drug withdrawal and put to death animal next day, stripping tumor is weighed, calculate tumour inhibiting rate, tumour inhibiting rate formula is: the average tumor of tumour inhibiting rate (%)=(the average tumor weight of the average tumor weight-medication of normal saline matched group group)/normal saline matched group heavy × 100%, result shows, to S180, growth has inhibitory action to medicine of the present invention, and its tumour inhibiting rate increases and increases progressively with dosage, has significant difference P<0.05 compared with matched group.Inhibitory action to S180 and tumor killing effect are in table 1.

Table 1: the inhibitory action to S180 and tumor killing effect

Group	Average tumor heavy (g)	Mice average weight changes (g)	Tumour inhibiting rate (%)
				High dose group	1.46±0.38	﹢3.82	54.93
Middle dosage group	1.52±0.62	﹢4.70	53.08
				Low dose group	1.65±0.26	﹢4.86	49.07
CTX group	1.38±0.42	﹣1.68	59.02
				Normal saline group	3.24±0.89	﹢5.03	0

Known by table 1: adopt the treatment group of Chinese medicine composition of the present invention, with the comparison of normal saline group, can suppress tumor bulk-growth, and tumour inhibiting rate to increase progressively with the increase of dosage, have significant difference P<0.05, (n=10, X ± SD); Adopt the treatment group of Chinese medicine composition of the present invention, with CTX group relatively, the body weight of the mice for the treatment of group has increase, and the Mouse Weight of CTX group alleviates, both significant difference P<0.05 that compared, (n=10, X ± SD).

Measure by fluid cell instrument in addition, result shows, Chinese medicine composition of the present invention has stoped tumor cell by S → G2 process, also affected the carrying out of G1 → S simultaneously, S and the cell of G1 phase are obviously increased, the cell of G2 and M phase is relatively low, has disturbed the propagation activity of tumor cell, reaches antineoplastic action.

Clinical treatment:

Case selection: fetch liver lung stagnated heat type Nasopharyngeal Carcinoma Patients 296 examples that come from the court, male 178 examples, female's 118 examples; 31～62 years old age, 48 years old mean age, medical history 6 months～8 years; 296 routine liver lung stagnated heat type Nasopharyngeal Carcinoma Patients are divided into two groups at random, are respectively treatment by Chinese herbs group and matched group, wherein, and treatment by Chinese herbs group 231 example and matched group 77 examples;

Treatment by Chinese herbs group: in 231 examples, male 139 examples, female's 82 examples, be divided into three groups at random, and every group of 77 routine patients, are respectively: tablet in treatment group, capsule treatment group and oral liquid treatment group; Wherein, matched group 77 examples, male 39 examples, female's 36 examples.

The patient of above-mentioned four experimental grouies comparison aspect sex and age, all, without significant difference (P>O.05), has comparability.

The clinical symptoms main manifestations of 296 routine liver lung stagnated heat type Nasopharyngeal Carcinoma Patients is: 1. nasal obstruction, in tears, be with blood, and micro-expectoration Huang, diet is normal, yellowish urine constipation, red tongue, tongue fur BOHUANG, xerostomia headache, rapid pulse is the hot and suffocating performance of liver lung.2. hemorrhage, can there is in early days bleeding, show as while inhaling after nose sputum mixed with blood or blowing the nose and be with blood in tears.In early stage apoplexy due to phlegm or tears, only there is a small amount of blood streak, cut in and out.Monitor is more, can have nose bleeding.3. tinnitus, auditory dysesthesia, the inaccessible sense of in ear nasopharyngeal carcinoma occur in nasopharynx sidewall, and when side nest or pharyngotympanic tube opening upper lip, one-sided property tinnitus or auditory dysesthesia can occur oncothlipsis pharyngotympanic tube, and catarrhal otitis media also can occur.One-sided property tinnitus or auditory dysesthesia, the inaccessible sense of in ear are one of early stage nasopharyngeal carcinoma symptoms.4. headache, is common sympton.Early stage headache position is unfixing, intermittence.Be persistence migraine late period, and position is fixed.Trace it to its cause, early stage patient may be that neural blood vessel reflection causes, or to due to the stimulation of first branch of trigeminal nerve peripheral nerve.End-stage patients are often tumor destruction basis craniis, spread and involve cranial nerve and cause at intracranial.5. diplopia, due to tumor invading nervus abducens, often outwards causes and is slur depending on thing.Trochlear nerve is invaded, and often causes to esotropia, diplopia.Normal impaired with the nervi trigeminus while.6. a fiber crops, refer to skin of face feeling of numbness, and clinical examination is the pain sensation and hypopselaphesia or disappearance.Tumor invade cavernous sinus often cause the 1st of nervi trigeminus or the 2nd impaired; Tumor intrusion oval foramen, belemnoid proparea, the 3rd of nervi trigeminus often cause auricle front portion, temples, buccal portion, lower lip and skin of chin numbness or paraesthesia.7. nasal obstruction, tumor is stopped up choana can there is nasal obstruction.Tumor hour, have a stuffy nose lighter, and along with tumor is grown up, nasal obstruction increases the weight of, and mostly is one-sided property and has a stuffy nose.If stopping up bilateral choana, tumor can there is bilateral nasal obstruction.8. cervical lymph node metastasis symptom, easily there is cervical lymph node and shift in nasopharyngeal carcinoma, and wherein half is that bilateral shifts.It is the onset symptoms of nasopharyngeal carcinoma that cervical lymph node often shifts.Have a few patients examination of nasopharynx can not find primary lesion, and cervical lymph node transfer is unique clinical manifestation.And relevant to expanding in submucosa tissue.9. lingualis atrophy and the deflection that lolls, nasopharyngeal carcinoma directly invade or lymphatic metastasis to belemnoid back zone or hypoglossal canal.Nervus sublingualis is invaded, cause the sick side of deflection that lolls, with the atrophy of sick side lingualis.10. a danger is sagging, eyeball is fixing relevant with oculomotorius infringement.Visual deterioration or disappearance are invaded relevant with optic nerve lesion or socket of the eye cone.11. metastasis, the metastasis of nasopharyngeal carcinoma is the one of the main reasons for the treatment of of nasopharyngeal carcinoma failure.Common metastasis site is bone, lung, liver etc., and many organs shift common simultaneously.12. dermatomyositiss that occur together, dermatomyositis also can occur together with nasopharyngeal carcinoma, therefore no matter dermatomyositis patient is had or not to the symptom of nasopharyngeal carcinoma, all should carefully check nasopharynx part.13. menolipsis, very rare as initial syndromes in rhinopharyngocele, relevant with hypophysis cerebri with nasopharyngeal carcinoma intrusion sphenoid sinus.

Diagnostic criteria: 1. pharyngorhinoscopy: can see swollen thing in nasopharynx top, posterior wall of nasopharynx and pharyngeal recess.Swollen thing is under speckle, tuberosity or film and swells.When wellability changes, surface is canescence, coarse, ulcer, has hemorrhage.2. examination of castoff cells: get nasopharynx diseased region surface secretions and make smear, can find cancerous cell.3. biopsy: the living tissue of getting nasopharynx part neoplasm, metastasis is made pathologic finding, finds cancerous tissue hypertrophy.4. Serological testing: VCA mono-ICA antibody test can be used as auxiliary diagnosis.5.X ray examination: x-ray basis cranii is taken the photograph sheet, nasopharynx part contrast examination etc., understand basis cranii sclerotin and have or not destruction, assist to check to have or not tumor invading.CT is lesions showed more accurately.And hope, hear, ask, cut the dialectical liver lung stagnated heat type nasopharyngeal carcinoma that is further diagnosed as according to the traditional Chinese medical science.

Therapeutic Method:

Tablet in treatment group: take tablet prepared by the embodiment of the present invention 1, every day 3 times, one time 4, within every 60 days, be 1 course for the treatment of;

Capsule treatment group: take capsule prepared by the embodiment of the present invention 2, every day 3 times, one time 2, within every 60 days, be a course for the treatment of;

Oral liquid treatment group: take oral liquid prepared by the embodiment of the present invention 3, every day 3 times, 30ml/ time every 60 days is a course for the treatment of.

Treatment by Chinese herbs group: oral mannatide sheet, 1 time 1,2 times on the one 60 days is a course for the treatment of.

The standard of curative effect evaluation: change according to the maximum volume of the nasopharynx cervical region CT before and after treatment or MRI observation tumor kitchen range.Evaluate by WHO and NCI grade scale and RTOG standard, the objective efficacy assessment standard of solid tumor (RESIST1.0) that short term effect adopts WHO (1981) to formulate is assessed, be divided into and alleviate (CR), partial rcsponse (PR), improvement (MR), stable (SD) and progression of disease (PD) completely, CR+PR is effective percentage (RR), and CR+PR+MR+SD calculates disease control rate (DCR).

Alleviate completely (CR): nasal obstruction, tinnitus, headache, diplopia, face fiber crops, cervical lymph node metastasis symptom, lingualis atrophy and the deflection that lolls, a dangerous sagging and transference cure such as dermatomyositis that occur together;

Partial rcsponse (PR): have a stuffy nose, tinnitus, headache, diplopia, face fiber crops and cervical lymph node metastasis symptom, lingualis atrophy and the deflection that lolls, eye danger is sagging to alleviate more than 50% with the symptoms such as dermatomyositis that occur together;

Take a turn for the better (MR): have a stuffy nose, tinnitus, headache, diplopia, face fiber crops and cervical lymph node metastasis symptom, lingualis atrophy and the deflection that lolls, eye danger is sagging to alleviate below 50% with the symptoms such as dermatomyositis that occur together;

Stable (SD): nasal obstruction, tinnitus, headache, diplopia, face fiber crops and cervical lymph node metastasis symptom, lingualis atrophy and the deflection that lolls, eye danger is sagging and the symptoms such as dermatomyositis that occur together are unchanged.

Therapeutic outcome:

Referring to table 2 and table 3, as can be seen from Table 2, adopt treatment by Chinese herbs liver lung stagnated heat type nasopharyngeal carcinoma of the present invention, on therapeutic effect, there is significant improvement with respect to conventional medicament; As can be seen from Table 3, adopt treatment by Chinese herbs liver lung stagnated heat type nasopharyngeal carcinoma of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.

Four groups, table 2 is treated respectively Clinical efficacy comparison after 4 courses for the treatment of

Group	Number of cases	Alleviate number completely	Complete remission rate (%)	Partial rcsponse number	Good revolution	Alleviate completely and partial rcsponse rate (%)	Stable number
								Tablet in treatment group	77	49	63.6％	25	2	96.1％	1
Capsule treatment group	77	51	66.2％	24	2	97.4％	0
								Oral liquid treatment group	77	49	63.6％	27	1	98.7％	0
Matched group	77	29	37.7％	21	4	64.9％	23

Four groups, table 3 is alleviated and partial rcsponse number and time comparative example (%) after treating respectively 4 courses for the treatment of completely

Group	Number of cases	The 1st course for the treatment of	The 2nd course for the treatment of	The 3rd course for the treatment of	The 4th course for the treatment of
						Tablet in treatment group	74	14（18.9％）	17（23％）	20(27％）	23（31.1％）
Capsule treatment group	75	15（20％）	18（24％）	20（26.7％）	22（29.3％）
						Oral liquid treatment group	76	16（21％）	18（23.7％）	19（25％）	23（30.3％）
Matched group	50	3（6％）	5（10％）	9（18％）	33（66％）

Known according to the clinical statistics in above table, Chinese medicine provided by the invention have complete remission time short, be difficult for recurrence after alleviating completely, effective percentage is high, short treating period, good effect, safe, with strong points; Treatment group is alleviated completely with 225 examples of partial rcsponse number and matched group and alleviated completely with 50 routine patients of partial rcsponse and follow up a case by regular visits to 1 year half simultaneously, result statistics, tablet in treatment group alleviate completely with partial rcsponse 74 examples in completely alleviate 49 examples in 1 case relapsed, in 25 examples of partial rcsponse, recur 2 examples, relapse rate is 4%; Capsule treatment group alleviate completely with partial rcsponse 75 examples in completely alleviate 51 examples in 1 case relapsed, in 24 examples of partial rcsponse, recur 3 examples, relapse rate is 5.3%; Oral liquid treatment group alleviate completely with partial rcsponse 76 examples in completely alleviate 49 examples in without recurrence, 1 case relapsed in 27 examples of partial rcsponse, relapse rate is 1.3%; Matched group is alleviated 50 examples with partial rcsponse completely, in the 29 routine patients of alleviating completely, and recurrence 13 examples, in 21 routine patients of partial rcsponse, recurrence 15 examples, relapse rate 56%; Above-mentioned recurrence refers to that patient treatment effect reaches after alleviation completely and partial rcsponse, obviously occurs the nasal obstruction before treatment, tinnitus, headache in 1 year half of following up a case by regular visits to, diplopia, face fiber crops, cervical lymph node metastasis symptom, lingualis atrophy and the deflection that lolls, eye danger is sagging, and the symptoms such as dermatomyositis occur together.

Model case: Xu certain, male, 42 years old, because of nasal obstruction; often have tinnitus, follow headache, once in a while face fiber crops; cervical lymph node metastasis symptom, is further diagnosed as nasopharyngeal carcinoma through nasopharynx cervical region CT examination, and hopes, hears, asks, cuts the dialectical liver lung stagnated heat type nasopharyngeal carcinoma that is further diagnosed as according to the traditional Chinese medical science.Take the tablet of Chinese medicine preparation embodiment 1 of the present invention, every day 3 times, each 4, treat 2 the course for the treatment of partial rcsponse, alleviate completely 2 courses for the treatment of of continuing to take medicine, follow up a case by regular visits to 1 year half not recurrence.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. treat the Chinese medicine preparation of liver lung stagnated heat type nasopharyngeal carcinoma for one kind, it is characterized in that, comprise following raw medicinal material: artemisia anomalas, the Radix Angelicae Dahuricae, Fructus Xanthii, illiteracy Herba caryopteridis nepetaefoliae, Flos Magnoliae, Herba Centipedae, Herba Menthae, white Fischer, Bombyx Batryticatus, Fructus Arctii, Radix Bupleuri, Rhizoma Smilacis Chinensis, Rhizoma Cimicifugae, Radix Scutellariae, Pandanus tectorius (L.) Parkins., Radix et Rhizoma Thalictri, Fructus Forsythiae, Herba polygoni hydropiperis, Folium Isatidis, Radix Isatidis, Cortex Phellodendri, Indigo Naturalis, Rhizoma Fagopyri Dibotryis, Rhizoma Belamcandae, mountain Corm Eleocharitis, Fructus Canarii, Radix Tinosporae, water silk floss, Semen Oroxyli, Pseudobulbus Cremastrae Seu Pleiones, Fel Ursi, Radix Cynanchi Atrati, Caulis Trachelospermi, Semen Sterculiae Lychnophorae, Rui core, Concha Arcae, Cortex Albiziae, the Herba Gentianae tsinglingensis, Radix Polygalae and Herba Canscorae.

2. the Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma according to claim 1, is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: 10～35 parts of artemisia anomalas, 18～25 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Fructus Xanthii, cover 10～25 parts of Herba caryopteridis nepetaefoliaes, 17～35 parts of Flos Magnoliaes, 10～30 parts of Herba Centipedae, 15～35 parts of Herba Menthaes, 16～25 parts of white Fischer, 18～30 parts of Bombyx Batryticatus, 15～30 parts of Fructus Arctiis, 16～25 parts of Radix Bupleuri, 10～25 parts of Rhizoma Smilacis Chinensiss, 10～30 parts of Rhizoma Cimicifugaes, 18～35 parts of Radix Scutellariaes, 15～30 parts of Pandanus tectorius (L.) Parkins., 10～25 parts of Radix et Rhizoma Thalictri, 10～30 parts of Fructus Forsythiaes, 15～25 parts of Herba polygoni hydropiperis, 17～30 parts of Folium Isatidiss, 17～30 parts of Radix Isatidis, 15～30 parts of Cortex Phellodendris, 17～30 parts of Indigo Naturaliss, 10～35 parts of Rhizoma Fagopyri Dibotryiss, 15～35 parts of Rhizoma Belamcandae, 10～35 parts of mountain Corm Eleocharitiss, 10～30 parts of Fructus Canariis, 15～35 parts of Radix Tinosporaes, 10～30 parts, water silk floss, 17～35 parts of Semen Oroxylis, 15～30 parts of Pseudobulbus Cremastrae Seu Pleioness, 17～35 parts of Fel Ursis, 18～25 parts of Radix Cynanchi Atratis, 10～35 parts of Caulis Trachelospermis, 18～35 parts of Semen Sterculiae Lychnophoraes, 15～30 parts of Rui cores, 15～30 parts of Concha Arcaes, 15～32 parts of Cortex Albiziaes, 17～30 parts of the Herba Gentianae tsinglingensiss, 18～30 parts of 15～30 parts of Radix Polygalaes and Herba Canscoraes.

3. the Chinese medicine preparation for the treatment of liver lung stagnated heat type nasopharyngeal carcinoma according to claim 1 and 2, is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: 15～30 parts of artemisia anomalas, 19～24 parts of the Radixs Angelicae Dahuricae, 17～25 parts of Fructus Xanthii, cover 10～22 parts of Herba caryopteridis nepetaefoliaes, 17～30 parts of Flos Magnoliaes, 18～30 parts of Herba Centipedae, 17～30 parts of Herba Menthaes, 17～24 parts of white Fischer, 18～27 parts of Bombyx Batryticatus, 17～25 parts of Fructus Arctiis, 18～24 parts of Radix Bupleuri, 15～25 parts of Rhizoma Smilacis Chinensiss, 16～26 parts of Rhizoma Cimicifugaes, 18～30 parts of Radix Scutellariaes, 17～28 parts of Pandanus tectorius (L.) Parkins., 15～25 parts of Radix et Rhizoma Thalictri, 16～27 parts of Fructus Forsythiaes, 18～24 parts of Herba polygoni hydropiperis, 19～26 parts of Folium Isatidiss, 19～27 parts of Radix Isatidis, 17～27 parts of Cortex Phellodendris, 17～25 parts of Indigo Naturaliss, 15～30 parts of Rhizoma Fagopyri Dibotryiss, 17～30 parts of Rhizoma Belamcandae, 15～30 parts of mountain Corm Eleocharitiss, 15～28 parts of Fructus Canariis, 19～35 parts of Radix Tinosporaes, 10～22 parts, water silk floss, 19～30 parts of Semen Oroxylis, 17～25 parts of Pseudobulbus Cremastrae Seu Pleioness, 19～30 parts of Fel Ursis, 18～24 parts of Radix Cynanchi Atratis, 15～30 parts of Caulis Trachelospermis, 18～30 parts of Semen Sterculiae Lychnophoraes, 17～30 parts of Rui cores, 16～28 parts of Concha Arcaes, 19～30 parts of Cortex Albiziaes, 17～28 parts of the Herba Gentianae tsinglingensiss, 18～27 parts of 15～25 parts of Radix Polygalaes and Herba Canscoraes.

4. according to the Chinese medicine preparation of the treatment liver lung stagnated heat type nasopharyngeal carcinoma described in claim 1-3 any one, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: 20 parts of artemisia anomalas, 22 parts of the Radixs Angelicae Dahuricae, 18 parts of Fructus Xanthii, cover 21 parts of Herba caryopteridis nepetaefoliaes, 26 parts of Flos Magnoliaes, 25 parts of Herba Centipedae, 19 parts of Herba Menthaes, 22 parts of white Fischer, 24 parts of Bombyx Batryticatus, 20 parts of Fructus Arctiis, 18 parts of Radix Bupleuri, 24 parts of Rhizoma Smilacis Chinensiss, 26 parts of Rhizoma Cimicifugaes, 27 parts of Radix Scutellariaes, 28 parts of Pandanus tectorius (L.) Parkins., 22 parts of Radix et Rhizoma Thalictri, 25 parts of Fructus Forsythiaes, 23 parts of Herba polygoni hydropiperis, 26 parts of Folium Isatidiss, 27 parts of Radix Isatidis, 21 parts of Cortex Phellodendris, 19 parts of Indigo Naturaliss, 28 parts of Rhizoma Fagopyri Dibotryiss, 19 parts of Rhizoma Belamcandae, 17 parts of mountain Corm Eleocharitiss, 24 parts of Fructus Canariis, 30 parts of Radix Tinosporaes, continuous 16 parts of water, 24 parts of Semen Oroxylis, 22 parts of Pseudobulbus Cremastrae Seu Pleioness, 25 parts of Fel Ursis, 24 parts of Radix Cynanchi Atratis, 19 parts of Caulis Trachelospermis, 22 parts of Semen Sterculiae Lychnophoraes, 25 parts of Rui cores, 26 parts of Concha Arcaes, 23 parts of Cortex Albiziaes, 25 parts of the Herba Gentianae tsinglingensiss, 27 parts of 22 parts of Radix Polygalaes and Herba Canscoraes.

5. according to the Chinese medicine preparation of the treatment liver lung stagnated heat type nasopharyngeal carcinoma described in claim 1-4 any one, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: 30 parts of artemisia anomalas, 24 parts of the Radixs Angelicae Dahuricae, 22 parts of Fructus Xanthii, cover 20 parts of Herba caryopteridis nepetaefoliaes, 26 parts of Flos Magnoliaes, 21 parts of Herba Centipedae, 18 parts of Herba Menthaes, 23 parts of white Fischer, 24 parts of Bombyx Batryticatus, 20 parts of Fructus Arctiis, 19 parts of Radix Bupleuri, 24 parts of Rhizoma Smilacis Chinensiss, 26 parts of Rhizoma Cimicifugaes, 29 parts of Radix Scutellariaes, 23 parts of Pandanus tectorius (L.) Parkins., 22 parts of Radix et Rhizoma Thalictri, 17 parts of Fructus Forsythiaes, 19 parts of Herba polygoni hydropiperis, 26 parts of Folium Isatidiss, 27 parts of Radix Isatidis, 24 parts of Cortex Phellodendris, 19 parts of Indigo Naturaliss, 28 parts of Rhizoma Fagopyri Dibotryiss, 30 parts of Rhizoma Belamcandae, 25 parts of mountain Corm Eleocharitiss, 17 parts of Fructus Canariis, 20 parts of Radix Tinosporaes, continuous 22 parts of water, 30 parts of Semen Oroxylis, 25 parts of Pseudobulbus Cremastrae Seu Pleioness, 24 parts of Fel Ursis, 22 parts of Radix Cynanchi Atratis, 18 parts of Caulis Trachelospermis, 25 parts of Semen Sterculiae Lychnophoraes, 19 parts of Rui cores, 28 parts of Concha Arcaes, 27 parts of Cortex Albiziaes, 25 parts of the Herba Gentianae tsinglingensiss, 20 parts of 22 parts of Radix Polygalaes and Herba Canscoraes.

6. according to the Chinese medicine preparation of the treatment liver lung stagnated heat type nasopharyngeal carcinoma described in claim 1-5 any one, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: 19 parts of artemisia anomalas, 22 parts of the Radixs Angelicae Dahuricae, 25 parts of Fructus Xanthii, cover 17 parts of Herba caryopteridis nepetaefoliaes, 28 parts of Flos Magnoliaes, 19 parts of Herba Centipedae, 24 parts of Herba Menthaes, 23 parts of white Fischer, 22 parts of Bombyx Batryticatus, 24 parts of Fructus Arctiis, 21 parts of Radix Bupleuri, 18 parts of Rhizoma Smilacis Chinensiss, 17 parts of Rhizoma Cimicifugaes, 20 parts of Radix Scutellariaes, 25 parts of Pandanus tectorius (L.) Parkins., 21 parts of Radix et Rhizoma Thalictri, 25 parts of Fructus Forsythiaes, 24 parts of Herba polygoni hydropiperis, 19 parts of Folium Isatidiss, 23 parts of Radix Isatidis, 25 parts of Cortex Phellodendris, 24 parts of Indigo Naturaliss, 19 parts of Rhizoma Fagopyri Dibotryiss, 28 parts of Rhizoma Belamcandae, 27 parts of mountain Corm Eleocharitiss, 28 parts of Fructus Canariis, 30 parts of Radix Tinosporaes, continuous 12 parts of water, 20 parts of Semen Oroxylis, 23 parts of Pseudobulbus Cremastrae Seu Pleioness, 27 parts of Fel Ursis, 22 parts of Radix Cynanchi Atratis, 19 parts of Caulis Trachelospermis, 26 parts of Semen Sterculiae Lychnophoraes, 28 parts of Rui cores, 21 parts of Concha Arcaes, 20 parts of Cortex Albiziaes, 24 parts of the Herba Gentianae tsinglingensiss, 26 parts of 21 parts of Radix Polygalaes and Herba Canscoraes.

7. according to the Chinese medicine preparation of the treatment liver lung stagnated heat type nasopharyngeal carcinoma described in claim 1-6 any one, it is characterized in that, in the time that the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

8. according to the Chinese medicine preparation of the arbitrary described treatment liver lung stagnated heat type nasopharyngeal carcinoma of claim 1-6, it is characterized in that, in the time that the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

9. according to the Chinese medicine preparation of the arbitrary described treatment liver lung stagnated heat type nasopharyngeal carcinoma of claim 1-6, it is characterized in that, in the time that the dosage form of described Chinese medicine preparation is oral liquid, its preparation method comprises the following steps: