CN117180381A - Traditional Chinese medicine composition for warming yang and assisting pregnancy and application and external preparation thereof - Google Patents
Traditional Chinese medicine composition for warming yang and assisting pregnancy and application and external preparation thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for warming yang and assisting pregnancy, which comprises salted morinda officinalis, cinnamon, galangal, raw licorice, epimedium herb, curculigo rhizome and hairyvein agrimony. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying kidney and replenishing essence, warming yang and assisting pregnancy, and is suitable for pre-pregnancy conditioning of patients with kidney deficiency and blood stasis in need of pregnancy preparation. The traditional Chinese medicine composition has good conditioning effects on infertility caused by deficiency-cold of lower elements, irregular menstruation, lower abdomen crymodynia and the like. The invention also provides an external application agent prepared from the traditional Chinese medicine composition and application thereof.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for warming yang and assisting pregnancy, and an application and an external preparation thereof.
Background
Infertility refers to female infertility caused by no contraceptive life for at least 12 months, and the latest data of the international auxiliary fertility monitoring committee show that since the first example of test-tube infants in the world in 1978 are born, about 500 ten thousand test-tube infants are born worldwide, and the number of patients who make test-tube infants in China per year is up to 20 ten thousand. The human assisted reproduction technology is a technology for manually operating sperm, ovum, fertilized ovum or embryo of a human by using advanced medical technology to help a patient achieve the purpose of conception. The application of the in vitro fertilization-embryo transfer (IVF-ET) technology is one of the most effective methods for treating infertility, however, researches show that the pregnancy rate of IVF-ET is only 30 percent and certain adverse reaction exists, and the traditional Chinese medicine is widely applied in the assisted reproduction field as a safe and effective treatment method, and the traditional Chinese medicine is proved to be a warm yang pregnancy-assisting external application formula and can increase the endometrium of an infertility patient, improve the endometrium type and improve the clinical pregnancy rate of embryo transfer.
Disclosure of Invention
The first aim of the invention is to provide a traditional Chinese medicine composition for preparing yang-warming pregnancy-promoting medicines, which comprises salt morinda officinalis, cinnamon, galangal, raw licorice, epimedium, curculigo rhizome and hairyvein agrimony.
4-10 parts of morinda officinalis, 2-10 parts of cinnamon, 2-10 parts of galangal, 1-10 parts of raw licorice, 1-10 parts of epimedium herb, 1-10 parts of curculigo rhizome and 1-10 parts of hairyvein agrimony.
4 parts of morinda officinalis, 2 parts of cinnamon, 2 parts of galangal, 1 part of raw licorice, 1 part of epimedium, 1 part of curculigo rhizome and 1 part of hairyvein agrimony.
A Chinese medicinal composition for preparing yang warming and pregnancy promoting medicine comprises radix Morindae officinalis, cortex Cinnamomi, rhizoma Alpiniae Officinarum, glycyrrhrizae radix, herba Epimedii, rhizoma Curculiginis, herba et Gemma Agrimoniae, herba Cannabis and herba Polygoni Avicularis.
4-10 parts of morinda officinalis, 2-10 parts of cinnamon, 2-10 parts of galangal, 1-10 parts of raw licorice, 1-10 parts of epimedium herb, 1-10 parts of curculigo rhizome, 1-10 parts of hairyvein agrimony, 1-10 parts of hemp donor and 1-10 parts of electric lifting appliance.
4 parts of morinda officinalis, 2 parts of cinnamon, 2 parts of galangal, 1 part of raw licorice, 1 part of epimedium, 1 part of curculigo rhizome, 1 part of hairyvein agrimony, 1 part of hemp donor and 1 part of electric lifting.
The second purpose of the invention is to provide the traditional Chinese medicine composition which is added with pharmaceutically acceptable auxiliary materials to prepare an external preparation.
The third purpose of the invention is to provide the traditional Chinese medicine composition which is prepared into an application by adding pharmaceutically acceptable auxiliary materials.
The medicinal powder is mixed with boiled water to paste, and then applied in the patch after a small amount of water is added.
The fourth aim of the invention is to provide an application of the plaster in preparing a pre-pregnancy conditioning medicine for patients with kidney deficiency and blood stasis.
The fifth aim of the invention is to provide an application of the plaster in preparing medicines for conditioning infertility caused by cold deficiency and cold in lower energizer, irregular menstruation and cold pain in lower abdomen.
The invention relates to Dai medicine, which is also named wild pepper.
The invention relates to a Dai medicine which occupies electricity and is also called Dai medicine with a name of large She Jianmu.
Researches show that the causes of infertility caused by deficiency of kidney and blood stasis are congenital deficiency, hopeful incoordination, liver qi stagnation, deficiency of vital body and kidney yang, decline of vital gate fire, deficiency of yang and qi, deficiency of liver and kidney, unsmooth qi movement of thoroughfare and conception vessels, so that channels and collaterals are blocked, blood stasis is reserved in cells Gong Baomai, wind cooling cold evil is blocked in uterus, biochemical loss is caused, kidney essence cannot be warmed to generate daily decyl, thoroughfare and conception vessels are reached, blood is cold coagulation, the blood is blocked in the cells and the menstrual flow cannot descend, so that amenorrhea and infertility are caused. Kidney stores essence, and has the symptoms of deficiency of essence, yin and yang, cold evil attacking uterus, inability to warm uterus, cold coagulation and occlusion, cold pain in lower abdomen, and difficult pregnancy; the ascending of kidney qi, the kidney yang activating kidney yin, and the deficiency of kidney yang leading to cold in the cells, both of which lead to the decline of heart-kidney two-fire, are marked by insomnia and amnesia due to the ascending of uterus and the descending of uterus. Liver governs smoothing flow of qi, and is favored by qi to promote qi movement to smooth qi movement, liver qi stagnation, blood stasis, and qi stagnation of thoroughfare and conception vessels, so that blood is congealed by cold and the blood vessels are blocked, and menstrual water cannot descend, liver and kidney deficiency and tendons and bones are not healthy, so that soreness and weakness of waist and knees are seen.
The main clinical manifestations of kidney deficiency and blood stasis type infertility are as follows: the symptoms of infertility, cold pain in lower abdomen, soreness and weakness of waist and knees, listlessness, insomnia and amnesia, and dark menstrual flow with blood clot, excessive leucorrhea, thin and watery womb, hyposexuality, cold lower abdomen, dark tongue with white coating, deep, thin and astringent pulse and weak ruler are all caused by the dark menstrual flow. The inventor considers that the infertility caused by deficiency of kidney and blood stasis is caused by liver-kidney deficiency, decline of vital gate fire, blood stasis and thoroughfare and conception vessels, and obstruction of the two essence to be combined. The treatment of infertility is mainly warming and nourishing liver and kidney, warming yang and assisting pregnancy. For this herb, it is indicated for kidney-tonifying, uterus-warming, blood-activating, stasis-resolving, and Chong and ren meridians-tonifying.
The external application formula for warming yang and assisting pregnancy takes the morinda officinalis as the monarch drug: sweet in flavor, slightly warm in nature, salty and slightly astringent, and is the key herb for warming and nourishing liver and kidney, for tonifying kidney yang, strengthening tendons and bones, dispelling wind-damp, entering liver and kidney meridians. In the formula, cinnamon and galangal are taken as ministerial drugs: cinnamon and galangal are used for tonifying fire and yang, warming channels and activating collaterals, dispelling cold and relieving pain, and are combined to enter kidney channels and spleen stomach channels, so that symptoms such as infertility caused by deficiency-cold of lower energizer, irregular menstruation, cold pain of lower abdomen and the like can be conditioned, and monarch drugs are used together to double the effects of warming and nourishing liver and kidney. Herba Epimedii, rhizoma Curculiginis, herba et Gemma Agrimoniae, and herba Cannabis (Dai medicine, wild fructus Zanthoxyli) as adjuvant, and herba et Gemma Agrimoniae with bitter and astringent taste, and with effects of strengthening and tonifying deficiency, tonifying deficiency and not nourishing greasy, containing herba Epimedii and rhizoma Curculiginis, invigorating kidney yang, strengthening tendons and bones, and dispelling dampness and cold, and all three can be combined to make the medicines complement without stagnation; the main effects of the hemp donation are ventilation and cold removal, and the main effects of the hemp donation are that the hemp donates electricity and the main effects are mainly that the qi is used for removing cold, and the qi is used for treating soreness and weakness of waist and knees, hyposexuality, impotence, seminal emission, premature ejaculation, cold sperm, infertility caused by deficiency of fire tower, and premature senility and physical weakness caused by deficiency of four towers. The compatibility and combination of the above auxiliary materials aim at enhancing the curative effect of warming yang and assisting pregnancy. Licorice root, radix Glycyrrhizae Praeparata is used as a guiding drug for tonifying deficiency and relieving spasm and harmonizing the drugs. The medicines are compatible, not only strengthen the body resistance and tonify deficiency, tonify qi and refresh, but also warm and nourish liver and kidney, and together play the roles of tonifying kidney and warming uterus, and tonifying thoroughfare and conception vessels.
The invention aims at kidney deficiency and blood stasis type infertility, and treats the diseases of warming and nourishing liver and kidney, warming yang and assisting pregnancy. The invention takes morinda officinalis as a monarch, and is matched with ministerial drugs such as cinnamon, galangal and the like to play roles in warming and nourishing liver and kidney together, and takes part in tonifying deficiency and tonifying deficiency without greasiness by taking electricity as an auxiliary material for herba epimedii, curculigo rhizome, hairyvein agrimony and hemp donation, so that the aim of improving the pregnancy rate of patients is fulfilled. The invention has the following beneficial effects:
1. the external application formula for warming yang to promote pregnancy adopts the method of warming yang to promote pregnancy to treat infertility due to deficiency of kidney and blood stasis, and solves the root problem from the whole point of view. Each Chinese medicine in the prescription has the own drug effect, and when the Chinese medicines are used together, each mechanism of the body can be balanced and conditioned, so that the purpose of effectively improving the pregnancy rate of patients is achieved;
2. the frozen embryo transplantation is adopted to treat infertility, the side effect is large, the patient is afflicted with operation pain, and the success rate of transplantation is to be considered. The medicine has the effects of tonifying kidney, warming uterus, tonifying thoroughfare and conception vessels, strengthening body resistance, tonifying deficiency, warming yang, assisting pregnancy and the like, can effectively improve symptoms such as cold womb, infertility, irregular menstruation, lower abdomen cold pain and the like caused by the deficiency of liver and kidney, mainly treats the medicine and radically improves the pregnancy rate of patients;
3. under the theoretical guidance of treatment based on syndrome differentiation, the traditional Chinese medicine can treat infertility according to individuals, individuation and accurate treatment. The external application formula for warming yang and assisting pregnancy has the effects of tonifying kidney and warming uterus, tonifying thoroughfare and conception vessels, strengthening body resistance and tonifying deficiency, warming yang and assisting pregnancy, and the like, can often achieve satisfactory curative effects on deficiency of kidney and blood stasis, can treat infertility patients, is more suitable for pre-pregnancy conditioning of kidney deficiency and blood stasis type patients with pregnancy preparation requirements, and has the advantages of convenient use, low price, small side effect, simple and convenient operation and easy acceptance by people. In addition, the external treatment method of traditional Chinese medicine is still not applied much in the aspect of treating infertility, and the invention of the prescription fills the gap.
The external application formula for warming yang and helping pregnancy treats the patients with yang deficiency type infertility, treatsThe endometrial thickness level of the control group and the observation group patients with the implantation window period is increased compared with that before treatmentP<0.05 And the endometrium thickness of the observed group after treatment is obviously higher than that of the control groupP<0.05 A) is provided; the traditional Chinese medicine syndrome integration of two groups of patients with the implantation window period after treatment is reduced compared with that before treatmentP<0.05 Observation of the sub Chinese medicine syndrome integration of "implantation window period" after treatment of group is lower than that of control groupP<0.05 A) is provided; clinical pregnancy rate after treatment of the observation group is obviously higher than that of the control group, and the clinical pregnancy rate is obviously higher than that of the control groupP<0.05). The above results show that both groups have certain advantages in improving the symptoms of infertility, but the observed group is significantly better than the control group, and has statistical significance (P<0.05 The external application formula for warming yang and assisting pregnancy shows that the external application formula can effectively improve clinical symptoms of endometrium thickness and kidney yang deficiency of infertility patients in the implantation window period, finally improves clinical pregnancy rate, and has better curative effects than frozen embryo transfer control groups.
Detailed Description
The invention is further described below without limiting it in any way, and any modifications based on the invention fall within the scope of protection of the invention.
A Chinese medicinal composition for preparing yang warming and pregnancy promoting medicine comprises radix Morindae officinalis, cortex Cinnamomi, rhizoma Alpiniae Officinarum, glycyrrhrizae radix, herba Epimedii, rhizoma Curculiginis, and herba et Gemma Agrimoniae.
4-10 parts of morinda officinalis, 2-10 parts of cinnamon, 2-10 parts of galangal, 1-10 parts of raw licorice, 1-10 parts of epimedium herb, 1-10 parts of curculigo rhizome and 1-10 parts of hairyvein agrimony.
4 parts of morinda officinalis, 2 parts of cinnamon, 2 parts of galangal, 1 part of raw licorice, 1 part of epimedium, 1 part of curculigo rhizome and 1 part of hairyvein agrimony.
A Chinese medicinal composition for preparing yang warming and pregnancy promoting medicine comprises radix Morindae officinalis, cortex Cinnamomi, rhizoma Alpiniae Officinarum, glycyrrhrizae radix, herba Epimedii, rhizoma Curculiginis, herba et Gemma Agrimoniae, herba Cannabis and herba Polygoni Avicularis.
4-10 parts of morinda officinalis, 2-10 parts of cinnamon, 2-10 parts of galangal, 1-10 parts of raw licorice, 1-10 parts of epimedium herb, 1-10 parts of curculigo rhizome, 1-10 parts of hairyvein agrimony, 1-10 parts of hemp donor and 1-10 parts of electric lifting appliance.
4 parts of morinda officinalis, 2 parts of cinnamon, 2 parts of galangal, 1 part of raw licorice, 1 part of epimedium, 1 part of curculigo rhizome, 1 part of hairyvein agrimony, 1 part of hemp donor and 1 part of electric lifting.
The external preparation of the traditional Chinese medicine composition is prepared into an external preparation by adding pharmaceutically acceptable auxiliary materials.
The Chinese medicinal composition is applied by adding pharmaceutically acceptable adjuvants.
The preparation method of the Chinese medicinal composition comprises concocting the medicinal powder with boiled water to paste, adding small amount of water, and applying into the patch.
Application of the plaster in preparing a pre-pregnancy conditioning medicine for patients with kidney deficiency and blood stasis.
Application of the patch in preparing medicines for regulating infertility caused by deficiency-cold in lower energizer, menoxenia and cold pain in lower abdomen.
The invention relates to Dai medicine, which is also named wild pepper.
The invention relates to a Dai medicine which occupies electricity and is also called Dai medicine with a name of large She Jianmu.
Example 1
The formula comprises the following components: 4g of morinda officinalis, 2g of cinnamon, 2g of galangal, 1g of raw licorice, 1g of epimedium, 1g of curculigo rhizome and 1g of hairyvein agrimony. The traditional Chinese medicine powder is mixed into paste by boiled water, a small amount of water is put into the paste, the paste is applied under the navel by about 10 cm, one dose is applied every day for 2-4 hours, and the first application is to observe whether the medicine taking part is allergic or not. The recipe is suitable for treating sterility caused by kidney-yang deficiency, and has the functions of strengthening body and tonifying deficiency and kidney-yang.
Example 2
4g of morinda officinalis, 2g of cinnamon, 2g of galangal, 1g of raw liquorice, 1g of epimedium, 1g of curculigo rhizome, 1g of hairyvein agrimony, 1g of hemp donation (Dai medicine, wild pepper) and 1g of electric lifting (Dai medicine, large She Jianmu). The traditional Chinese medicine powder is mixed into paste by boiled water, a small amount of water is put into the paste, the paste is applied under the navel by about 10 cm, one dose is applied every day for 2-4 hours, and the first application is to observe whether the medicine taking part is allergic or not. The recipe is suitable for kidney deficiency and blood stasis type infertility, and achieves the effects of warming and nourishing liver and kidney, warming yang and assisting pregnancy.
Case 1 Wang Mou, female, 30 years old.
The wedding is semi-non-pregnant for 2 years, and is intended to regulate the conception of the body. The traditional menstrual cycle is normal, the menstrual flow is small during menstruation, the color is dark, blood clots are present, the lower abdomen is stabbed and cool, and the waist is uncomfortable. The patients feel averse to cold, hands and feet cool in winter, sweat and feel tired, the patients can feel dry when speaking more, the patients can not relieve after drinking water, the throat is obstructed by foreign matters, cough can not appear, the throat is not fallen, sleep can be received, and the patients can regulate the urination and defecation. Dark and clear tongue with thin and white coating, dry and wiry and thready pulse.
Diagnosis of traditional Chinese medicine: belongs to the infertility caused by kidney-yang deficiency, and cold congeals and stasis, thereby leading to infertility caused by deficiency of thoroughfare and conception vessels.
The treatment method comprises the following steps: for warming kidney, tonifying qi, activating blood and resolving stasis, warming and dredging meridians.
Treatment: 4g of morinda officinalis, 2g of cinnamon, 2g of galangal, 1g of raw licorice, 1g of epimedium, 1g of curculigo rhizome and 1g of hairyvein agrimony. The traditional Chinese medicine powder described in the example 1 is prepared into paste by boiling water, and is applied in the application paste after a small amount of water is put, about 10 x 8cm, and is applied under the navel, one dose is applied every day for 2-4 hours.
Two diagnoses: the medicine is applied in proper condition, and the medicine is applied for improving spirit, increasing physical strength, improving sleep, relieving constipation, relieving discomfort, and providing the medicine for continuous administration for maintenance treatment.
The preparation method comprises the following steps: kidney stores essence and refines qi, and kidney essence qi dominates the growth and reproduction of the adult, and deficiency of kidney qi is easy to cause kidney deficiency, so that deficiency of thoroughfare and conception vessels causes female infertility. The patient is kidney yang deficiency caused by kidney qi deficiency and has cold coagulation and blood stasis, so that the deficiency of thoroughfare and conception vessels can not take over sperm to become pregnant. Therefore, symptoms of aversion to cold, cold hands and feet in winter, little menstruation, dark color, blood clot, stabbing pain in lower abdomen, coldness, waist discomfort, dark and green tongue, thin and white coating, dryness and the like appear, and the morinda citrifolia is taken as the monarch: sweet in flavor, slightly warm in nature, salty and slightly astringent, and is the key herb for warming and nourishing liver and kidney, for tonifying kidney yang, strengthening tendons and bones, dispelling wind-damp, entering liver and kidney meridians. In the formula, cinnamon and galangal are taken as ministerial drugs: cinnamon and galangal are used for tonifying fire and yang, warming channels and activating collaterals, dispelling cold and relieving pain, and are combined to enter kidney channels and spleen stomach channels, so that symptoms such as infertility caused by deficiency-cold of lower energizer, irregular menstruation, cold pain of lower abdomen and the like can be conditioned, and monarch drugs are used together to double the effects of warming and nourishing liver and kidney. Herba Epimedii, rhizoma Curculiginis, herba et Gemma Agrimoniae, and herba Cannabis (Dai medicine, wild fructus Zanthoxyli) as adjuvant, and herba et Gemma Agrimoniae with bitter and astringent taste, and with effects of strengthening and tonifying deficiency, tonifying deficiency and not nourishing greasy, containing herba Epimedii and rhizoma Curculiginis, invigorating kidney yang, strengthening tendons and bones, and dispelling dampness and cold, and all three can be combined to make the medicines complement without stagnation; licorice root, radix Glycyrrhizae Praeparata is used as a guiding drug for tonifying deficiency and relieving spasm and harmonizing the drugs. The medicines are compatible, not only strengthening body resistance and tonifying deficiency, tonifying qi and refreshing, but also warming and nourishing liver and kidney.
Case 2 the age of 45 was a woman.
The patient had been self-contained for many years. In the last 1 year, menstrual cycle is irregular, menstruation is carried out once in 3 months, the quantity is small, and menstruation color is normal. Pain in the breast from the front and back of the menstrual period is reduced. Can be used for treating mental physical strength. The sleeping bag can be used for receiving sleep, the defecation is irregular, the defecation is laborious and has a sense of difficulty, and the urination is normal for 3-4 days. Itching throat with phlegm can be relieved in recent days, pale tongue with yellow and white coating. Fear of heat, easy sweating, easy urgency, red tongue tip, tooth trace, wiry pulse stagnation and weak ruler.
Diagnosis of traditional Chinese medicine: infertility due to kidney deficiency and blood stasis, loss of qi, kidney deficiency and phlegm dampness, which leads to ovulation dysfunction and infertility.
The treatment method comprises the following steps: it is the basic therapeutic principle for soothing liver-qi stagnation, promoting qi and blood circulation, tonifying kidney and nourishing blood, and drying dampness.
Treatment: 4g of morinda officinalis, 2g of cinnamon, 2g of galangal, 1g of raw liquorice, 1g of epimedium, 1g of curculigo rhizome, 1g of hairyvein agrimony, 1g of hemp donation (Dai medicine, wild pepper) and 1g of electric lifting (Dai medicine, large She Jianmu). The traditional Chinese medicine powder described in example 2 is prepared into paste with boiled water, and is applied in the application paste after a small amount of water is added, about 10 x 8cm is applied under the navel, one dose is applied every day for 2-4 hours, and the first application is to observe whether the medicine taking part is allergic or not.
Two diagnoses: the patients have the same period of time as the present invention, and the patients have little amount and normal color. No abdominal pain and lumbago, and the labor is obviously felt to be powerful and the rest is smooth. The patients can receive sleep, regulate the stool and the tongue and pulse. Order it to be applied with medicine according to the upper part for consolidation. Half a year later, the patient is informed that pregnancy has been successful.
The preparation method comprises the following steps: menstrual flow is a prerequisite for conception, and requires kidney qi exuberance, heaven-decyl and conception vessel exuberance, and liver qi exuberance, and regulates normal menstrual cycle and blood volume. Liver stores blood, governs smoothing flow of qi and blood, and regulates yin and yang, which is a junction for inoculation. If liver qi stagnates and is lost, it is easy to cause dysfunction of ovulation and infertility. The patient has irregular period, 3 multi-month menstruation, less dosage, premenstrual bilateral breast distending pain, postmenstrual pain relief, easy emergency at ordinary times, red tongue tip, wiry pulse stagnation and weak ruler, which are typical symptoms of liver depression and qi stagnation. Liver governs smoothing flow of qi, and is good at dispersing stagnated liver qi, and it is indicated for treating qi stagnation, qi and blood circulation. The morinda citrifolia is taken as a monarch: sweet in flavor, slightly warm in nature, salty and slightly astringent, and is the key herb for warming and nourishing liver and kidney, for tonifying kidney yang, strengthening tendons and bones, dispelling wind-damp, entering liver and kidney meridians. In the formula, cinnamon and galangal are taken as ministerial drugs: cinnamon and galangal are used for tonifying fire and yang, warming channels and activating collaterals, dispelling cold and relieving pain, and are combined to enter kidney channels and spleen stomach channels, so that symptoms such as infertility caused by deficiency-cold of lower energizer, irregular menstruation, cold pain of lower abdomen and the like can be conditioned, and monarch drugs are used together to double the effects of warming and nourishing liver and kidney. Herba Epimedii, rhizoma Curculiginis, herba et Gemma Agrimoniae, and herba Cannabis (Dai medicine, wild fructus Zanthoxyli) as adjuvant, and herba et Gemma Agrimoniae with bitter and astringent taste, and with effects of strengthening and tonifying deficiency, tonifying deficiency and not nourishing greasy, containing herba Epimedii and rhizoma Curculiginis, invigorating kidney yang, strengthening tendons and bones, and dispelling dampness and cold, and all three can be combined to make the medicines complement without stagnation; the main effects of the hemp donation are ventilation and cold removal, and the main effects of the hemp donation are that the hemp donates electricity and the main effects are mainly that the qi is used for removing cold, and the qi is used for treating soreness and weakness of waist and knees, hyposexuality, impotence, seminal emission, premature ejaculation, cold sperm, infertility caused by deficiency of fire tower, and premature senility and physical weakness caused by deficiency of four towers. The compatibility and combination of the above auxiliary materials aim at enhancing the curative effect of warming yang and assisting pregnancy. Licorice root, radix Glycyrrhizae Praeparata is used as a guiding drug for tonifying deficiency and relieving spasm and harmonizing the drugs. The medicines are compatible, not only strengthen the body resistance and tonify deficiency, tonify qi and refresh, but also warm and nourish liver and kidney, and together play the roles of tonifying kidney and warming uterus, and tonifying thoroughfare and conception vessels.
Clinical efficacy evaluation:
1. clinical data
1.1 general data
The method includes the steps of recruiting patients meeting infertility and fitting IVF-ET from the first subsidiary hospital reproductive medicine department of Yunnan traditional Chinese medicine university, the outpatient service of the first subsidiary hospital acupuncture department of Yunnan traditional Chinese medicine university and the second subsidiary hospital reproductive department of Yunnan province from 1 month 1 day to 2023 month 3 days in 2019, wherein the differentiation of kidney-yang deficiency syndrome of traditional Chinese medicine is randomly divided into 30 cases of control group and traditional Chinese medicine group, and 60 cases are all taken.
1.2 diagnostic criteria
(1) Western diagnostic criteria: infertility diagnostic criteria: excluding men's causes, not taking contraceptive measures but not pregnant for 1 year;
(2) Traditional Chinese medicine dialectical standard: kidney yang deficiency syndrome differentiation standard: main symptoms are as follows: infertility for wedding; menstrual flow is more or less; the menstruation is pale and dark, and the menstruation is clear and thin. Secondary symptoms: soreness and weakness of waist and knees; dizziness and tinnitus; aversion to cold and cold limbs; edema of lower limb; frequent nocturia; apathy; the complexion is dark; the belt is more in quantity; listlessness; insomnia and forgetfulness. Tongue pulse: a pale tongue with a thin and white coating and a deep and weak pulse are essential for the main symptoms, and the secondary symptoms have at least 2 items, so that kidney-yang deficiency syndrome can be diagnosed by consulting the tongue and the pulse.
1.3 inclusion criteria
(1) Meets the above diagnostic criteria, and is intended for IVF-ET; (2) age 24-45 years old; (3) menstrual cycle (27-35 d), and natural cycle with normal ovulation; (4) serum basic Follicle Stimulating Hormone (FSH) is less than or equal to 15 IU/L in menstrual cycle 2-5 days, and the number of bilateral ovarian basic sinus follicles is more than or equal to 6; (5) still has more than or equal to 2 high-quality frozen embryos.
1.4 exclusion criteria
(1) Spouse has serious oligospermia and asthenozoospermia; it is combined with other system diseases and has bad preference for smoking and drinking.
2 methods of treatment
2.1 control group
Pre-frozen embryo transfer protocol. Screening high-quality embryos after conventional thawing and embryo recovery in a laboratory (1-class embryos are high-quality embryos according to embryo morphology, and embryo blastocysts are uniform in size, transparent and free of fragments); blood human chorionic gonadotrophin (Human chorionic gonadotropin, HCG) was tested 12-14 days after frozen embryo transfer to determine if pregnancy, and ultrasound was examined after 5w to determine clinical pregnancy.
2.2 viewing group
The external application formula for warming yang and helping pregnancy is applied on the basis of the control group, each pack of medicinal powder is mixed into paste by boiled water, and is applied in the application paste after a small amount of water is put, about 10 x 8cm is applied under the navel, one dose is applied every day for 2-4 hours until the medicinal powder is stopped after transplantation.
3 observation of curative effect
3.1 observations index
3.1.1 Main outcome index
(1) Endometrium thickness double layer endometrium was measured by performing vaginal ultrasound examination at the implantation window period (menstrual cycle day 21) before and after treatment, and by cutting the long axis of uterus.
(2) The Chinese medicine syndromes are integrated: the Chinese medicine syndrome scoring scale is prepared by referring to the clinical guidelines of Chinese medicine new medicine clinical research (trial run) and Chinese medicine women science for treating kidney deficiency and blood stasis, and is used for evaluating the syndrome of patients.
3.1.2 Secondary outcome measures
(1) Clinical pregnancy rate-vaginal ultrasound examination at week 5 after transplantation, pregnant bursa were clinical pregnancy, clinical pregnancy rate = (number of clinical pregnancy cases +.total cases) ×100%.
3.2 evaluation of safety
Is effective in treating the safety problems (such as adverse drug reaction, etc.) in the treatment of patients in time.
3.3 statistical treatment
Statistical analysis was performed using SPSS26.0 software, and the mean ± standard was used for normal distribution of the metrology data
Differences (x + -s) indicate that the intra-group comparison uses paired sample t-test, and the inter-group comparison uses two independent sample t-tests; count data is expressed as frequency or percent (%), χ is used 2 And (5) checking. To be used forPA difference of < 0.05 is statistically significant. (the corner mark (1) has statistical significance in comparison before and after the group, and the corner mark (2) has statistical significance in comparison after the treatment between the groups)
3.4 results
(1) Comparison of general data for two groups of patients
The common data such as age, infertility, endometrium thickness, type, chinese medicine syndrome score and the like of two groups of patients have no statistical significanceP> 0.05), with comparability, see table 1.
Table 1 comparison of general data for two groups of patients
(2) Endometrial thickness comparison before and after treatment for two groups of patients
The endometrial thickness level of two groups of patients with implantation window period after treatment is increased compared with that of the patients before treatmentP<0.05 And the endometrium thickness of the observed group after treatment is obviously higher than that of the control groupP<0.05 See table 2).
Table 2 comparison of endometrial thicknesses before and after treatment for two groups of patients
Note that compared with the group before treatment, (1) P<0.05, compared with the treatment of the control group, (2) P<0.05。
(3) Traditional Chinese medicine syndrome integral comparison before and after treatment of two groups of patients
The traditional Chinese medicine syndrome integration of two groups of patients with the implantation window period after treatment is reduced compared with that before treatmentP<0.05 Observation of the sub Chinese medicine syndrome integration of "implantation window period" after treatment of group is lower than that of control groupP<0.05). Details are shown in Table 3.
Table 3 comparison of the integral of the symptoms of chinese medicine before and after treatment of two groups of patients
Note that compared with the group before treatment, (1) P<0.05, compared with the treatment of the control group, (2) P<0.05。
(4) Pregnancy outcome comparison for two groups of patients
Clinical pregnancy rate after treatment of the observation group is obviously higher than that of the control group, and the clinical pregnancy rate is obviously higher than that of the control groupP<0.05 See table 4).
Table 4 pregnancy outcome comparison for two groups of patients
The injection is compared with the treatment of the control group, (1) P<0.05。
conclusion(s)
The research result shows that the external application formula for warming yang and assisting pregnancy can effectively improve the clinical symptoms of endometrium thickness and kidney yang deficiency of infertility patients in the implantation window period, and finally improve the clinical pregnancy rate.
Claims (10)
1. A Chinese medicinal composition for preparing yang warming and pregnancy promoting medicine is characterized by comprising radix morindae officinalis, cortex cinnamomi, rhizoma alpiniae officinarum, radix glycyrrhizae, herba epimedii, rhizoma curculiginis and herba agrimoniae.
2. The Chinese medicinal composition according to claim 1, comprising 4-10 parts of morinda officinalis, 2-10 parts of cinnamon, 2-10 parts of galangal, 1-10 parts of raw licorice, 1-10 parts of epimedium, 1-10 parts of curculigo rhizome and 1-10 parts of hairyvein agrimony.
3. The Chinese medicinal composition of claim 1, comprising 4 parts of morinda officinalis, 2 parts of cinnamon, 2 parts of galangal, 1 part of licorice, 1 part of epimedium, 1 part of curculigo rhizome and 1 part of hairyvein agrimony.
4. The composition of claim 1, comprising the salt morinda officinalis, cinnamon, galangal, licorice, epimedium, curculigo rhizome, hairyvein agrimony, hemp donor and electric lifting.
5. The Chinese medicinal composition according to claim 4, comprising 4-10 parts of morinda officinalis, 2-10 parts of cinnamon, 2-10 parts of galangal, 1-10 parts of licorice, 1-10 parts of epimedium, 1-10 parts of curculigo rhizome, 1-10 parts of hairyvein agrimony, 1-10 parts of hemp donor and 1-10 parts of common knotweed herb.
6. The Chinese medicinal composition of claim 4, comprising 4 parts of morinda officinalis, 2 parts of cinnamon, 2 parts of galangal, 1 part of raw licorice, 1 part of epimedium, 1 part of curculigo rhizome, 1 part of hairyvein agrimony, 1 part of hemp donor and 1 part of electric lifting.
7. An external preparation based on the traditional Chinese medicine composition as claimed in claim 1 or 4, wherein pharmaceutically acceptable auxiliary materials are added.
8. An application based on the traditional Chinese medicine composition according to claim 1 or 4, characterized in that pharmaceutically acceptable auxiliary materials are added.
9. The use of the patch according to claim 8 for the preparation of a pre-pregnancy conditioning medicament for patients with kidney deficiency and blood stasis.
10. The application of the plaster according to claim 8 in preparing medicines for conditioning infertility caused by deficiency-cold in lower energizer, irregular menstruation and cold pain in lower abdomen.
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| CN117205231A (en) * | 2023-11-08 | 2023-12-12 | 云南中医药大学 | Traditional Chinese medicine composition for nourishing blood and increasing film and preparation thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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