CN103211959A - Traditional Chinese medicine composition used for tonifying yang and preparation method thereof - Google Patents
Traditional Chinese medicine composition used for tonifying yang and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition used for tonifying yang and a preparation method thereof. The traditional Chinese medicine composition is prepared from thirty five traditional Chinese medicines, namely cynomorium songaricum, rhizoma curculiginis, morinda officinalis, Chinese angelica, fructus cnidii, cistanche, tuber onion seed, schisandra chinensis, red ginseng, penis and testis of ox, kidney of dog, cornua cervi pantotrichum, black prepared lateral root of aconite, cinnamon, fennel, actinolite, wild pepper, semen cuscutae, the bark of eucommia, flatstem milkvetch seed, codonopsis pilosula, dogwood, herba epimedii, milkvetch, Chinese yam, prepared rehmannia root, fructus psoraleae, barbary wolfberry fruit, raspberry, polygala tenuifolia, lotus stamen, cherokee rose fruit, rhizoma alismatis, liquorice and poria cocos. The traditional Chinese medicine composition used for tonifying yang has the effects of invigorating the kidney, strengthening yang, replenishing essence and solidifying genuine qi and is mainly used for treating impotence, spermatorrhea and premature ejaculation caused by deficiency of kidney yang or kidney yin. A preparation process is advanced, the contents of active ingredients are high, clinical pharmacodynamic test effect is obvious, bioavailability is high, and no toxic or side effect is produced.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that is used for tonifying YANG and preparation method thereof, belong to the pharmaceutical technology field.
Technical background
Sexual impotence, seminal emission, premature ejaculation belong to clinical middle more common and multiple a kind of disease, and clinical treatment is difficulty relatively, has seriously influenced people's quality of life; The Chinese patent medicine that uses clinically is also more at present, but curative effect is undesirable mostly.Prior art: the Herba Cynomorii capsule for tonifying kidney is a kind of pure Chinese medicinal preparation under 12 WS3-B-2438-97 items of ministry standard " Chinese traditional patent formulation preparation ", and this medicine is being obtained certain curative effect through clinical application for many years aspect treatment sexual impotence, seminal emission, the premature ejaculation; But exist technology thicker, active constituent content is low, and curative effect is not ideal enough in the process of practical application.In the time in recent years, we are by excavating the abundant natural resources of Chinese medicinal materials of motherland, in conjunction with a large amount of traditional Chinese medical science prescription theory and Study on clinical pharmacodynamics, use the modern pharmaceutical technology this product technology is made significant improvement, grope by a large amount of experiments, the unexpected discovery with after " water is carried " part changes " using 60% ethanol extraction " in the former technology, the preparation made from this technology, the active constituent content height, better stability of preparation, evident in efficacy, clinical pharmacodynamics test effect significantly improves, and without any side effects.We routinely technology made: capsule, tablet and granule.
Summary of the invention
The purpose of this invention is to provide a kind of technology advanced person, active constituent content height, more significant a kind of Chinese medicine composition that is used for tonifying YANG of better stability of preparation, curative effect and preparation method thereof.This preparation has kidney invigorating and YANG supporting, the genuine admittedly effect of replenishing essence; Be mainly used in diseases such as sexual impotence that insufficiency of kidney-YANG or deficiency of the kidney yin cause, seminal emission, premature ejaculation.
Prior art: the Herba Cynomorii capsule for tonifying kidney is a kind of pure Chinese medicinal preparation under 12 WS3-B-2438-97 items of ministry standard " Chinese traditional patent formulation preparation ", and this medicine is being obtained certain curative effect through clinical application for many years aspect treatment sexual impotence, seminal emission, the premature ejaculation; The applicant, finds to exist technology thicker in recent years time back warp development test to above prior art, the preparation instability of making, and defective such as active constituent content is low, curative effect is not ideal enough in the process of practical application.
For overcoming the defective that prior art exists, the applicant is by excavating the abundant natural resources of Chinese medicinal materials of motherland, in conjunction with a large amount of traditional Chinese medical science prescription theory and Study on clinical pharmacodynamics, use the modern pharmaceutical technology this product technology is made significant improvement, grope by a large amount of experiments, the unexpected discovery with after " water is carried " part changes " using 60% ethanol extraction " in the former technology, the preparation made from this technology, the active constituent content height, better stability of preparation, evident in efficacy, clinical pharmacodynamics test effect significantly improves, and without any side effects.We routinely technology made: capsule, tablet and granule have better met needs of medical treatment.
The present invention constitutes like this: it mainly is the capsule of 35 flavor Chinese crude drugs through being processed into by following weight proportion, Chinese medicine composition of the present invention, and its prescription is composed as follows:
Preparation method is:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae add 60% ethanol extraction secondary, and each 3 hours, merge extractive liquid, filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
The present invention program is a repeatedly repetition test of process inventor, update to adjust and sum up out, compared with prior art, the present invention has the technology advanced person, active constituent content height, better stability of preparation, curative effect is more remarkable, its clinical pharmacodynamics test effect significantly improves, the bioavailability height, and without any side effects.
Pharmacodynamic test of active extract
One, the preparation of experiment medicine:
The a group is capsule group of the present invention: the method according to the embodiment of the invention 1 makes capsule.
The b group is: make according to Herba Cynomorii capsule for tonifying kidney formulation and technology under 12 WS3-B-2438-97 items of ministry standard " Chinese traditional patent formulation preparation ":
Prescription:
Preparation method is:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, merge decoction liquor, filter, filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
Two: process of the test and result of the test
Experiment purpose: the pharmacological experiment study by anoxia enduring, resisting fatigue, immunity of organisms and treatment yang deficiency syndrome etc. to Capsules group of the present invention and b group act on, Capsules group of the present invention and b group are compared, observe the power of its pharmacological action.
Test method: Capsules group of the present invention and b group is to the synthetic influence of yang deficiency mouse liver DNA due to the alkyl urea; Turnover of Mouse Peritoneal Macrophages is engulfed the influence of chicken red blood cell function; Influence to the mice delayed hypersensitivity; Influence to the mice serum hemolytic antibody; Influence to the mice resisting oxygen lack; Effect to mouse anti-reflecting fatigue.
One, to the synthetic influence of yang deficiency mouse liver DNA due to the alkyl urea
Experiment material
1, animal: Kunming mouse, male, body weight 22～28g.
2, medicine: b group; Large, medium and small three the dosage groups of capsule of the present invention.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male, body weight 22～28g is divided into 5 groups at random, 10 every group.Each treated animal is irritated stomach alkyl urea suspension 7.5mg/0.75ml respectively, and simultaneously, large, medium and small three the dosage groups of capsule of the present invention are gastric infusion 4.8,2.4,1.2g crude drug/kg respectively; B group gastric infusion 4.8g crude drug/kg.Successive administration 13d, every day 1 time is behind the last administration 24h, in animal lumbar injection tritiated thymidine 0.3ml.With sacrifice of animal, take out hepatic tissue after 1h hour.Getting hepatic tissue 200mg adds 10 times of amount distilled water and makes 10% homogenate, add equivalent 10%TCA again, centrifugal, 3000r/min5min, taking precipitate adds 5%TCA and washes secondary, is suspended in then among the original volume 5%TCA, places 95 ℃ of water-baths to heat 20min, the centrifugal 5min of 3000r/min, supernatant are the DNA crude extract.Get DNA sample liquid 1ml, add 2ml diphenylamines reagent, 100 ℃ of water-bath 20min, 600nm colorimetric determination absorbance calculates the DNA synthetic ratio.Experimental result: see Table 1
The synthetic influence of yang deficiency mouse liver DNA due to the table 1 pair alkyl urea
Compare * * P＜0.01 with matched group; Organize than △ P＜0.05 with b.
The result shows: Capsules group of the present invention and b group can obviously improve the synthetic ratio of yang deficiency mouse liver DNA, have compared utmost point significant difference (P＜0.01) with matched group; The heavy dose of group of capsule of the present invention is organized the significant difference (P＜0.05) of having compared with b.As seen, Capsules group of the present invention is stronger than the effect of b group treatment yang deficiency syndrome.
Two, Turnover of Mouse Peritoneal Macrophages is engulfed the influence of chicken red blood cell function
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: b group; Large, medium and small three the dosage groups of capsule of the present invention.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Large, medium and small three the dosage groups of capsule of the present invention are gastric infusion 4.8,2.4,1.2g crude drug/kg respectively; B group gastric infusion 4.8g crude drug/kg.Successive administration 7d, every day 1 time is behind the last administration 2h, the chicken red blood cell 0.4ml of every mouse peritoneal injection 5%, after 12 hours mice is taken off cervical vertebra and put to death, face upward the position and be fixed in the Mus plate, the sterilization abdominal part, cut off skin, through intraperitoneal injection of saline 2ml, rotational fixation plate 1min extracts peritoneal fluid 1ml then, drip and be applied on the microscope slide, every 0.2ml places 37 ℃ of incubator incubation 30min, takes out slide, drop into rinsing in the normal saline, dry, with the fixing 5min of acetone-methanol solution (1: 1), reuse 4% Ji Mu Sa-Rui Teshi liquid dyeing 5min, use the distilled water rinsing, dry.Under oily mirror, count, and calculate the phagocytic index that peritoneal macrophage is engulfed chicken red blood cell.
Chicken red blood cell sum/200 that phagocytic index=quilt is engulfed a macrophage experimental result: see Table 2
Table 2 pair Turnover of Mouse Peritoneal Macrophages is engulfed the influence of chicken red blood cell function
Compare * * P＜0.01 with matched group; Organize than △ P＜0.05 with b.
The result shows: Capsules group of the present invention and b group can obviously strengthen the effect of macrophage phagocytic function, have compared utmost point significant difference (P＜0.01) with matched group; The heavy dose of group of capsule of the present invention is organized the significant difference (P＜0.05) of having compared with b.As seen, Capsules group of the present invention is stronger than the effect that the b group improves immunity.
Three, to the influence of mice delayed hypersensitivity
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: b group; Large, medium and small three the dosage groups of capsule of the present invention.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Large, medium and small three the dosage groups of capsule of the present invention are gastric infusion 4.8,2.4,1.2g crude drug/kg respectively; B group gastric infusion 4.8g crude drug/kg.Successive administration 7d, every day 1 time.In second day mouse part skin unhairing of administration, scope is 3cm * 3cm, and with 1% dinitro-chlorine propiophenone Oleum Sesami solution 0.05ml/ only, is applied in mouse web portion unhairing position sensitization of skin.1h behind the 7th day medicine of administration, being applied in the mouse right ear two sides with 1% dinitro-chlorine benzole soln, 10 μ l attacks, mice draws neck to put to death behind the 24h, cut two ears about mice, take off the auricle that diameter is 8mm with card punch, precision is weighed, with mice left and right sides auricle weight difference as mouse ear delayed hypersensitivity intensity.Experimental result: see Table 3
The influence of table 3 pair mouse ear delayed hypersensitivity
Compare * * P＜0.01 with matched group; Organize than △ P＜0.05 with b.
The result shows: Capsules group of the present invention and b group can significantly suppress dinitrochlorobenzene induced mice delayed hypersensitivity, with matched group utmost point significant difference (P＜0.01) are arranged relatively; The heavy dose of group of capsule of the present invention is organized the significant difference (P＜0.05) of having compared with b.As seen, Capsules group of the present invention is stronger than the effect that the b group improves immunity.
Four, to the influence of mice serum hemolytic antibody
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: b group; Large, medium and small three the dosage groups of capsule of the present invention.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Large, medium and small three the dosage groups of capsule of the present invention are gastric infusion 4.8,2.4,1.2g crude drug/kg respectively; B group gastric infusion 4.8g crude drug/kg.Successive administration 10d, every day 1 time.With 0.2ml/ sensitization of 20% lumbar injection sheep red blood cell (SRBC) suspension, next day is put to death animal in the last administration, gets blood, separation of serum in administration 2d.Serum is done 500 times of dilutions, and every pipe adds serum 1ml successively, each 0.5ml of 5% sheep red blood cell (SRBC) and complement (with normal saline dilution in 1: 10).Respectively establish the blank pipe that does not add complement, mixing is put temperature bath 30min in 37 ℃ of water-baths, moves into cessation reaction in the ice bath immediately, the centrifugal 10min of 3000r/min gets supernatant 0.5ml, adds 1.5ml Dou Shi liquid, leave standstill 10min behind the mixing, measure the trap value at the 540nm place, calculate half hemolysis value.Experimental result: see Table 4
Sample half hemolysis value=(trap value during absorption of sample degree value/SRBC HD50) * serum diluting multiple
The influence of table 4 pair mice serum hemolytic antibody
Compare * * P＜0.01 with matched group; Organize than △ P＜0.05 with b.
The result shows: Capsules group of the present invention and b group can obviously improve the content of mice serum hemolytic antibody, compare the difference (P＜0.01) that utmost point significance is arranged with matched group; The heavy dose of group of capsule of the present invention is organized the significant difference (P＜0.05) of having compared with b.As seen, Capsules group of the present invention is stronger than the effect that the b group improves humoral immunity of organism.
Five, to the influence of mice resisting oxygen lack
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: b group; Large, medium and small three the dosage groups of capsule of the present invention.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Large, medium and small three the dosage groups of capsule of the present invention are gastric infusion 4.8,2.4,1.2g crude drug/kg respectively; B group gastric infusion 4.8g crude drug/kg.Successive administration 7d behind the last administration 1h, puts into the 250ml wide mouthed bottle with mice every day 1 time, is coated with vaseline around the bottleneck, observes and time 20 ℃ of the room temperatures of record anoxia in mice death, and stopping with heart beating is the dead mouse standard.Experimental result: see Table 5
The influence of table 5 pair mice resisting oxygen lack
Compare * * P＜0.01 with matched group; Organize than △ P＜0.05 with b.
The result shows: but Capsules group of the present invention and b organize the significant prolongation time-to-live of mice in the normal pressure closed environment, have compared utmost point significant difference (P＜0.01) with matched group; The heavy dose of group of capsule of the present invention is organized the significant difference (P＜0.05) of having compared with b.As seen, Capsules group of the present invention is stronger than b group resisting oxygen lack.
Six, to the effect of mouse anti-reflecting fatigue
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: b group; Large, medium and small three the dosage groups of capsule of the present invention.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Large, medium and small three the dosage groups of capsule of the present invention are gastric infusion 4.8,2.4,1.2g crude drug/kg respectively; B group gastric infusion 4.8g crude drug/kg.Successive administration 7d, every day 1 time, behind the last administration 1h, give mouse tail application of load (galvanized wire) by 10% of body weight, mice is put in the swimming pool of people 55cm * 35cm * 15cm 25 ℃ of water temperatures, 27 ℃ of room temperatures are observed mouse tail application of load swimming time, and mice nose submerged 10s no longer emerges and is drowned index.Experimental result: see Table 6
The effect of table 6 pair mouse anti-reflecting fatigue
Compare * * P＜0.01 with matched group; Organize than △ P＜0.05 with b.
The result shows: Capsules group of the present invention and b group can obviously prolong the swimming with a load attached to the body time of mice, and a certain amount of effect relationship is arranged, and dosage is big more, and the swimming with a load attached to the body time is long more, has compared utmost point significant difference (P＜0.01) with matched group; The heavy dose of group of capsule of the present invention is organized the significant difference (P＜0.05) of having compared with b.As seen, Capsules group of the present invention is stronger than the antifatigue effect of b group.
Experimental result: Capsules group of the present invention and b group obviously improve the synthetic ratio of yang deficiency mouse liver DNA; Obviously strengthen the effect of macrophage phagocytic function; Can significantly suppress dinitrochlorobenzene induced mice delayed hypersensitivity; Obviously improve the content of mice serum hemolytic antibody; But the time-to-live of significant prolongation mice in the normal pressure closed environment; Can obviously prolong the swimming with a load attached to the body time of mice.
Conclusion: Capsules group of the present invention is stronger than the pharmacological actions such as anoxia enduring, resisting fatigue, immunity of organisms and treatment yang deficiency syndrome of b group.Therefore, it is strong that Capsules group of the present invention clinically is used for disease effects such as sexual impotence that insufficiency of kidney-YANG or deficiency of the kidney yin cause, seminal emission, premature ejaculation than b group.
The specific embodiment
1, the preparation of Chinese medicinal composition capsules agent of the present invention:
Prescription:
Preparation method is:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae add 60% ethanol extraction secondary, and each 3 hours, merge extractive liquid, filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
Claims (1)
1. preparation method that is used for the Chinese medicine composition of tonifying YANG is characterized in that the crude drug prescription of described Chinese medicine composition consists of:
Preparation method is:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae add 60% ethanol extraction secondary, and each 3 hours, merge extractive liquid, filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405615A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation method of TCM composition |
| CN103405616A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation and detection methods of TCM composition |
| CN103405618A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation and detection methods of TCM composition |
| CN103405614A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation method of TCM composition |
| CN104472958A (en) * | 2014-12-31 | 2015-04-01 | 施宇光 | Feed additive of Kunming mouse for pharmaceutical experiment |
| CN105796942A (en) * | 2016-03-10 | 2016-07-27 | 厦门塔斯曼生物工程有限公司 | Formula for improving physical strength of animal or human body |
| CN105998736A (en) * | 2016-07-26 | 2016-10-12 | 李厚建 | Traditional Chinese medicine composition for treating spermatorrhea |
| CN106620130A (en) * | 2016-08-29 | 2017-05-10 | 武淑霞 | Medicine for treating male sexual dysfunction |
| CN107375887A (en) * | 2017-08-15 | 2017-11-24 | 山东仲景健康服务有限公司 | One kind is for yang-deficiency constitution massage Chinese medicine oil breast |
| CN110151913A (en) * | 2019-07-03 | 2019-08-23 | 曹全富 | A kind of Chinese medicine composition and its preparation application method |
| CN117180381A (en) * | 2023-11-07 | 2023-12-08 | 云南中医药大学 | Traditional Chinese medicine composition for warming yang and assisting pregnancy and application and external preparation thereof |
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2013
- 2013-05-13 CN CN201310175312.1A patent/CN103211959B/en active Active
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| WS3-B-2438-97: "《中药成方制剂 第十二册》", 31 December 1997 * |
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|---|---|---|---|---|
| CN103405616B (en) * | 2013-08-09 | 2015-06-10 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation and detection methods of TCM composition |
| CN103405616A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation and detection methods of TCM composition |
| CN103405618A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation and detection methods of TCM composition |
| CN103405614A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation method of TCM composition |
| CN103405615B (en) * | 2013-08-09 | 2015-04-08 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation method of TCM composition |
| CN103405615A (en) * | 2013-08-09 | 2013-11-27 | 陕西步长高新制药有限公司 | TCM (Traditional Chinese Medicine) composition for invigorating kidney and strengthening Yang and preparation method of TCM composition |
| CN104472958A (en) * | 2014-12-31 | 2015-04-01 | 施宇光 | Feed additive of Kunming mouse for pharmaceutical experiment |
| CN105796942A (en) * | 2016-03-10 | 2016-07-27 | 厦门塔斯曼生物工程有限公司 | Formula for improving physical strength of animal or human body |
| CN105998736A (en) * | 2016-07-26 | 2016-10-12 | 李厚建 | Traditional Chinese medicine composition for treating spermatorrhea |
| CN106620130A (en) * | 2016-08-29 | 2017-05-10 | 武淑霞 | Medicine for treating male sexual dysfunction |
| CN107375887A (en) * | 2017-08-15 | 2017-11-24 | 山东仲景健康服务有限公司 | One kind is for yang-deficiency constitution massage Chinese medicine oil breast |
| CN110151913A (en) * | 2019-07-03 | 2019-08-23 | 曹全富 | A kind of Chinese medicine composition and its preparation application method |
| CN117180381A (en) * | 2023-11-07 | 2023-12-08 | 云南中医药大学 | Traditional Chinese medicine composition for warming yang and assisting pregnancy and application and external preparation thereof |
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