CN102908398B - Medicinal composition for relieving female sexual fatigue - Google Patents
Medicinal composition for relieving female sexual fatigue Download PDFInfo
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- CN102908398B CN102908398B CN201210439583.9A CN201210439583A CN102908398B CN 102908398 B CN102908398 B CN 102908398B CN 201210439583 A CN201210439583 A CN 201210439583A CN 102908398 B CN102908398 B CN 102908398B
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Abstract
The invention relates to a medical preparation, in particular to a medicinal composition for relieving female sexual fatigue. The medicinal composition is characterized in that: active ingredients of the composition consist of the following raw materials in parts by weight: 0.4-4 percent of an aqueous extract of glossy privet fruit and astragalus of equal weight, 0.1-0.3 percent of oviductus ranae, 0.1-0.5 percent of taurine and 0.05-0.5 percent of ferrous sulfate. The composition disclosed by the invention can be used for relieving female sexual fatigue, and is suitable for sportsmen, brainworkers and tourists, in particular for tourists on high plateaus to drink.
Description
Technical field
The present invention relates to a kind of medical configuration product, be specifically related to a kind of Chinese medicine and western medicine mixture.
Background technology
Because modern life rhythm is accelerated and modern life style, the anxiety that in life, various pressure, frustration are brought, the unhealthy emotion such as suspicious, and tobacco and wine, food, medicine, environment, emotion etc. factor causes women to produce fatigue.Fatigue is followed and what come is a series of problem, such as hyposexuality, female incretion imbalance, pain in the low back and legs, hyposexuality, menoxenia, breast disease, affect women's appearance etc.
According to relevant report women fatigue ratio, reach 35%, and male only has 12%, the product that improves at present male's sexual is more, and it is also fewer to improve women's fatigue functional product, is mainly to improve by supplementing some estrogen or progestogen etc.
The patent application that relates to alleviating physical fatigue in Chinese patent database reaches 69; involved Chinese medicine has tens of kinds more than, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, Radix Panacis Quinquefolii, Radix Rhodiolae, Cordyceps, Lac regis apis, Fructus Lycii, Cornu Cervi Pantotrichum etc.; involved chemicals has taurine, vitamin C, vitamin B1, vitamin B6 and mineral etc., and the representative person that wherein fills a prescription is as follows:
Application number be CN02122924.4 application for a patent for invention disclose a kind of treated make love, stay up late, fatigue, poor memory, immunity of organism are low, the medicine " precious after liking " of endocrine regulation.It is with pure prepared slices of Chinese crude drugs such as Radix Achyranthis Bidentatae, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Alismatis, Poria, Cortex Moutans, the pure Chinese medicinal preparation of two kinds of dosage forms of a formula of making by conventional method, there is kidney-tonifying and brain tonic, improve immunity, the function of endocrine regulation, effectively allaying tiredness, enhancing brain memory, immunity enhancing, endocrine regulation balance.
Publication number is that CN02128918.2 patent of invention relates to a kind of anti-fatigue health-product containing; system makes powder by calcium pyruvate, high-quality Radix Panacis Quinquefolii, the Radix Astragali, taurine, zinc gluconate, vitamin C and excipient starch; this powder Main Ingredients and Appearance is eaten shared natural plants from medicine; these composition places of production and pharmacological action are clearer, and easily obtain moderate cost; through a large amount of crowd's tests, show; effect is unique, and main manifestations is strengthening energy, and antifatigue effect is remarkable.
Publication number is the preparation described in the application for a patent for invention of CN200510014724.2, can improve a health food for human body physical agility, endurance, by following raw materials according, according to following weight proportion, be made: 0.01～1 part, 20～100 parts of ferrous porphyrins, 100～500 parts, Colla Corii Asini, 100～500 parts of Herba Epimedii extracts, 50～100 parts of Radix Rhodiolae extracts, VB15～100 part, VB60.1～2 part, folic acid.Described in above-mentioned patent application, the advantage of scheme is: have alleviating physical fatigue and the effect that improves iron deficiency anemia, its applicable crowd comprises the physical fatigue that causes because of various factors and the crowd of iron deficiency anemia, especially the athlete of high strength, highdensity training and match and heavy physical labourer one is crossed to hemorrhagic anemia and the fatigue of property more suitable; The hemogram abnormity that Radiotherapy chemotherapy is caused and Mental fatigue power are weary, loss of appetite, and the cancer patient that body's immunity declines also can be used as auxiliary health food.
But scheme is not still specifically designed to the medicine of alleviating women's fatigue described in above-mentioned patent application.
ZHENQI FUZHENG KELI by member of Chinese Academy of Engineering professor Sun Yan research and development is made by the water extract of Fructus Ligustri Lucidi and the Radix Astragali, and the function that cures mainly of this granule is, boosting qi and nourishing yin; Deficient for prolonged illness, deficiency of both vital energy and Yin; Auxiliary tumor operation, radiotherapy, chemotherapy.But the effect of ZHENQI FUZHENG KELI alleviation women fatigue is not ideal enough.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of compositions of alleviating the effect of women's fatigue that has.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of pharmaceutical composition of alleviating women's fatigue; it is characterized in that, said composition active ingredient is comprised of the raw material of following weight parts: etc. the Fructus Ligustri Lucidi of weight and the water extract of the Radix Astragali 0.4～4, Oviductus Ranae 0.1～0.3, taurine 0.1～0.5 and ferrous sulfate 0.05～0.5.
In such scheme, described water extract can adopt the extracting method of Fructus Ligustri Lucidi and the Radix Astragali in ZHENQI FUZHENG KELI preparation technology to prepare, and gets Fructus Ligustri Lucidi and the Radix Astragali and decocts with water three times, and collecting decoction, filters, and filtrate concentrates and get final product.The method that the inventor recommends is as described below:
Fructus Ligustri Lucidi and the Radix Astragali of the weight such as getting decoct with water twice, add for the first time 10 times, water (bulking value doubly) amount and decoct 2.0h after soaking 0.5h, add for the second time 8 times, water (bulking value doubly) amount, decoct 1.0h; Merge decocting liquid twice, filter, filtrate is centrifugal with 16000rpm tubular type, and centrifugal liquid is concentrated into the thick paste that at 60 ℃, relative density is 1.30～1.35, in temperature, is then 60 ℃ and vacuum dry for condition vacuum drying or the spraying of-0.08Mpa, obtains extract powder.
The preparation method of pharmaceutical composition of the present invention is, gets the water extract of Fructus Ligustri Lucidi and the Radix Astragali, adds Oviductus Ranae fine powder, taurine, ferrous sulfate to mix, and then technique is made various common solid orally ingestibles routinely, as granule, tablet or capsule.
Pharmaceutical composition of the present invention, the best proportioning of wherein said active ingredient is, water extract 2 weight portions of Fructus Ligustri Lucidi and the Radix Astragali, Oviductus Ranae 0.2 weight portion, taurine 0.2 weight portion, ferrous sulfate 0.1 weight portion.
Pharmaceutical composition of the present invention coordinates supplementary to be prepared from by natural material, by mice being carried out to the experiment of anti-stress, finds, this product has resisting fatigue, make the fast quick-recovery physical ability of body, the effect of raising anoxia enduring etc., and without any side effects, be applicable to women's fatigue person and take.
Below by the effect that proves that by experiment the present invention has.
Impact test on sex hormone level, sexual organ
This test is with serum estradiol (SE
2), luteotropic hormone (LH), sexual organ's weight be index, seminar's compound is to serum estradiol (SE
2), the impact of luteotropic hormone (LH) level, sexual organ's weight.Existing Chinese patent medicine body resistance-strengthening Zhenqi side is comprised of the Radix Astragali, Fructus Ligustri Lucidi simultaneously; be improved immune function of human body; protection bone marrow and adrenal cortex function; what for various diseases, cause is deficient; coordinate operation, lonizing radiation, chemotherapy; promote the recovery of orthofunction, we also select body resistance-strengthening Zhenqi side to compare experiment for this reason.
1 reagent and material
(1) trial drug and reagent
Given the test agent 1: be the tablet of following embodiment 1.
Given the test agent 2: be the capsule of following embodiment 2.
Given the test agent 3: be the granule of following embodiment 3.
Control drug 1: diethylstilbestrol tablet, 0.1g/ sheet, Guangzhou Qiaoguang Pharmaceutical Plant is produced, lot number 120306.
Control drug 2: ZHENQI FUZHENG KELI, 5g*12 Dai/He， Xiuzheng Pharmaceutical Group. Jilin limited company produces, lot number 201204016.
Estrogen radioimmunoassay, RIA medicine box, lutropin radioimmunoassay, RIA medicine box are all purchased from Tianjin City Coordinate Pharmaceutical Technology Co., Ltd.Pentobarbital sodium and other reagent are analytical pure.
(2) animal
SD rat, female ，You Nanfang Medical Univ Experimental Animal Center provides, the animal feeding quality certification: No. 2012009, the moving word of Guangdong doctor.
(3) instrument
DL-45RC-L refrigerated centrifuger (Shen, Shanghai section); SN-682 radioimmunity gamma counter (Shanghai He Fu photoelectric instrument company limited).
2 methods and result
(1) Animal Model
Rat with 3% pentobarbital sodium with 40mg/kg lumbar injection
[5], under the most end rib of left and right, midaxillary line and apart from about 2cm infall outside spinal column, cut skin and dorsal muscles, extract both sides ovary, sew up the incision.
Within postoperative 3 days, start vaginal smear, continuous 5 days, to prove that castration is thorough.
(2) grouping and administration
Animal random packet, be divided into following group, every group 10, above-mentioned respectively by people with dosage convert (adopt general dosage conversion method, specifically referring to Qi Chen. herbal pharmacology research methodology. Beijing: People's Health Publisher [M] .2006:116) dissolve gavage and use for rat adds suitable quantity of water with dosage.
1. matched group; Do not give any processing.
2. model group: give normal saline 1ml/100g body weight gavage, every day 1 time, continuously 30d.
3. diethylstilbestrol group: water-soluble with diethylstilbestrol tablet, make 2.3 μ g/ml(1 sheet → 216ml), give 1ml/100g body weight gavage, every day 1 time, continuously 30d.
4. body resistance-strengthening Zhenqi group: water-soluble with ZHENQI FUZHENG KELI, make 3% concentration, gavage according to dosage, every day 1 time, continuously 30d.
5. given the test agent is 1 group: water-soluble with composition tablet, make 3% concentration, gavage according to dosage, every day 1 time, continuously 30d.
6. given the test agent is 2 groups: water-soluble with composition capsule, make 3% concentration, gavage according to dosage, every day 1 time, continuously 30d.
7. given the test agent is 3 groups: water-soluble with composition granule, make 3% concentration, gavage according to dosage, every day 1 time, continuously 30d.
(3) processing method
1h after last administration, takes respectively body weight, puts to death animal, gets hematometry estrogen SE
2, lutropin, minute get uterus to take weight, the results are shown in Table 1.
Estrogen algoscopy: take out estrogen radioimmunoassay, RIA medicine box from refrigerator, the description providing by it operates successively, measures successively each sample content through radioimmunity gamma counter.
Lutropin algoscopy: take out lutropin radioimmunoassay, RIA medicine box from refrigerator, the description operational approach 1 providing by it operates successively, measures successively each sample content through radioimmunity gamma counter.
Table 1 compositions is on the impact of hormonal readiness (n=10)
* P<0.05, model control group and each group are relatively; #P<0.05, each given the test agent group and model group comparison.
Result shows, uterus weight, estrogen SE
2, three indexs such as lutropin LH, model control group and blank group all have significant difference, illustrate that model forms.
In body weight index, diethylstilbestrol group, body resistance-strengthening Zhenqi group, blank group, 1 group of given the test agent, 2 groups of given the test agent, 3 groups of given the test agent and model control group there was no significant difference, but from numerical value, each group is still better than model control group, and body resistance-strengthening Zhenqi group, each group of given the test agent are also better than diethylstilbestrol group.
Uterus weight, estrogen SE
2, in three indexs such as lutropin LH, diethylstilbestrol group, blank group, 1 group of given the test agent, 2 groups of given the test agent, 3 groups of given the test agent etc. all have significant difference with model control group, body resistance-strengthening Zhenqi group and model control group there was no significant difference, illustrate that diethylstilbestrol tablet, each group of compositions can increase the uterus weight of rat model, can improve estrogen level, reduce lutropin level; And body resistance-strengthening Zhenqi group can not obviously increase the uterus weight of rat model, can not obviously improve estrogen level, can not obviously reduce lutropin level.From numerical value, each group of uterus weight given the test agent is also better than diethylstilbestrol group in addition.
Between given the test agent group, difference that there are no significant.
The research of mice anti-stress effect
This experiment is according to conventional anti-stress experiment, to having taken the hungry female mice of fatigue of pharmaceutical composition of the present invention, observes.Main experiment is: anoxia enduring experiment, resisting fatigue experiment, high temperature resistant experiment.
1 reagent and material
1.1 experimental subjecies: Kunming kind aged mouse (6 monthly age), body weight 45～55g, female.
1.2 given the test agent:
Body resistance-strengthening Zhenqi group: ZHENQI FUZHENG KELI is water-soluble, makes 3% concentration, according to dosage gavage.
Given the test agent 1: be the tablet of following embodiment 1.
Given the test agent 2: be the capsule of following embodiment 2.
Given the test agent 3: be the granule of following embodiment 3.
1.3 grouping and administrations
Be divided at random 5 groups, 10 every group, it is respectively 1,2,3 groups of blank group (normal group) and given the test agent.Above-mentioned respectively by people with dosage convert (adopt general dosage conversion method, specifically referring to Qi Chen. herbal pharmacology research methodology. Beijing: People's Health Publisher [M] .2006:116) dissolve gavage and use for mice adds suitable quantity of water with dosage.Each treated animal is freely drunk 0.1%BSA acidifying water in experimentation, and blank group gavages normal saline every day, and other 4 groups gavage respectively given the test agent, every day 1 time, continuous 4 weeks.
2 methods and result
2.1 on the hungry 16h before last administration that affects of mice normobaric hypoxia endurance, after last administration, 1h puts into mice the 250ml wide mouthed bottle that fills 10g sodica calx, adds a cover vaseline sealing, records mice life span.The results are shown in following table 1.
The 2.2 hungry 24h before last administration that affect on mouse anti-reflecting fatigue effect, after last administration, 1h puts into 27 ± 2 ℃ of ponds by mice, record mice in water life span (record mice enter water to mouth and nose sink under the water reach the above time of 10s).The results are shown in following table 1.
2.3 after the administration of high temperature resistant test last, 1h puts into 75 ± 1 ℃ of calorstats by mice, records life span.The results are shown in following table 1.
Table 1 anti-stress result of the test table (n=10)
* P<0.05, blank group and each group are relatively.
Result shows, in three indexs such as anti-hypoxia, resisting fatigue, high temperature resistance, between blank group and each group, there is significant difference, illustrate that ZHENQI FUZHENG KELI and compositions of the present invention can increase aged mouse anoxia enduring, endurance, resistant to elevated temperatures time-to-live.
Between given the test agent, each index there was no significant difference.
More than experiment shows that compositions of the present invention not only has the effect that improves animal anoxia enduring, endurance, the anti-stress such as high temperature resistant, can increase animality organ weight simultaneously, affect sex hormone level, improves animality fatigue; And the effect of animal anoxia enduring, endurance, the anti-stress such as high temperature resistant can only improve in body resistance-strengthening Zhenqi side, fails to increase animality organ weight, affects sex hormone level, can not improve animality fatigue.
The specific embodiment
Example 1
1, the water extract of preparing Fructus Ligustri Lucidi and the Radix Astragali:
Fructus Ligustri Lucidi and the Radix Astragali of the weight such as getting decoct with water twice, add for the first time after 10 times of amounts of water are soaked 0.5h and decoct 2.0h, add for the second time 8 times of amounts of water, decoct 1.0h; Merge decocting liquid twice, filter, filtrate is centrifugal with 16000rpm tubular type, and centrifugal liquid is concentrated into the thick paste that at 60 ℃, relative density is 1.30～1.35, in temperature, is then 60 ℃ and vacuum dry for condition vacuum drying or the spraying of-0.08Mpa, obtains extract powder.
2, prepare tablet:
Get by Fructus Ligustri Lucidi and the prepared extract powder 0.4g of the Radix Astragali; add Oviductus Ranae fine powder 0.3g, taurine 0.5g and ferrous sulfate 0.05g; mix, add the pregelatinized Starch of suitable gross weight 10%, mix; use 80% alcohol granulation; dry, then add the magnesium stearate that makes particle weight 0.5% to mix, tabletting; film coating, is prepared into tablet.
3, instructions of taking: oral, one time 2,2 times on the one.
Example 2
1, prepare Fructus Ligustri Lucidi or Radix Astragali water extract:
Fructus Ligustri Lucidi and the Radix Astragali of the weight such as getting decoct with water twice, add for the first time after 10 times of amounts of water are soaked 0.5h and decoct 2.0h, add for the second time 8 times of amounts of water, decoct 1.0h; Merge decocting liquid twice, filter, filtrate is centrifugal with 16000rpm tubular type, and centrifugal liquid is concentrated into the thick paste that at 60 ℃, relative density is 1.30～1.35, in temperature, is then 60 ℃ and vacuum dry for condition vacuum drying or the spraying of-0.08Mpa, obtains extract powder.
2, prepare capsule:
Get by Fructus Ligustri Lucidi and the prepared extract powder 1.0g of the Radix Astragali, add Oviductus Ranae fine powder 0.2g, taurine 0.2g and ferrous sulfate 0.2g, mix; the pregelatinized Starch that adds suitable gross weight 10%, mixes, and uses 80% alcohol granulation; dry, encapsulated, be prepared into capsule.
3, instructions of taking: oral, one time 2,2 times on the one.
Example 3
1, prepare Fructus Ligustri Lucidi or Radix Astragali water extract:
Fructus Ligustri Lucidi and the Radix Astragali of the weight such as getting decoct with water twice, add for the first time after 10 times of amounts of water are soaked 0.5h and decoct 2.0h, add for the second time 8 times of amounts of water, decoct 1.0h; Merge decocting liquid twice, filter, filtrate is centrifugal with 16000rpm tubular type, and centrifugal liquid is concentrated into the thick paste that at 60 ℃, relative density is 1.30～1.35, in temperature, is then 60 ℃ and vacuum dry for condition vacuum drying or the spraying of-0.08Mpa, obtains extract powder.
2, prepare granule
Get by Fructus Ligustri Lucidi and the prepared extract powder 4g of the Radix Astragali, add Oviductus Ranae fine powder 0.1g, taurine 0.1g and ferrous sulfate 0.5g, mix; add the dextrin of suitable gross weight 10%, 30% Icing Sugar, mix, use 80% alcohol granulation; dry, pack (5g/ bag), is prepared into granule.
3, instructions of taking: oral, a 5g, 2 times on the one.
Claims (2)
1. a pharmaceutical composition of alleviating women's fatigue, it is characterized in that, said composition active ingredient is comprised of the raw material of following weight parts: etc. the Fructus Ligustri Lucidi of weight and the water extract of the Radix Astragali 0.4～4, Oviductus Ranae 0.1～0.3, taurine 0.1～0.5 and ferrous sulfate 0.05～0.5; Described Fructus Ligustri Lucidi and the water extract of the Radix Astragali are prepared by following methods:
Fructus Ligustri Lucidi and the Radix Astragali of the weight such as getting decoct with water twice, add for the first time after 10 times of amounts of water are soaked 0.5h and decoct 2.0h, add for the second time 8 times of amounts of water, decoct 1.0h; Merge decocting liquid twice, filter, filtrate is centrifugal with 16000rpm tubular type, and centrifugal liquid is concentrated into the thick paste that at 60 ℃, relative density is 1.30～1.35, in temperature, is then 60 ℃ and vacuum dry for condition vacuum drying or the spraying of-0.08Mpa, obtains extract powder.
2. compositions according to claim 1, is characterized in that, described active ingredient is comprised of the raw material of following weight parts: the water extract 1 of Fructus Ligustri Lucidi and the Radix Astragali, Oviductus Ranae 0.2, taurine 0.2 and ferrous sulfate 0.2.
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| CN201210439583.9A CN102908398B (en) | 2012-11-06 | 2012-11-06 | Medicinal composition for relieving female sexual fatigue |
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| CN201210439583.9A CN102908398B (en) | 2012-11-06 | 2012-11-06 | Medicinal composition for relieving female sexual fatigue |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1470629A (en) * | 2002-07-26 | 2004-01-28 | 李中明 | Wild fruit wine and its corresponding wild fruit juice beverage |
| CN102512615A (en) * | 2011-12-15 | 2012-06-27 | 天长市中医院 | Traditional Chinese medicinal composition used for cancer recovery stage |
| CN102688260A (en) * | 2012-05-17 | 2012-09-26 | 广州军区广州总医院 | Medicinal composition for treating vaginal dryness |
-
2012
- 2012-11-06 CN CN201210439583.9A patent/CN102908398B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1470629A (en) * | 2002-07-26 | 2004-01-28 | 李中明 | Wild fruit wine and its corresponding wild fruit juice beverage |
| CN102512615A (en) * | 2011-12-15 | 2012-06-27 | 天长市中医院 | Traditional Chinese medicinal composition used for cancer recovery stage |
| CN102688260A (en) * | 2012-05-17 | 2012-09-26 | 广州军区广州总医院 | Medicinal composition for treating vaginal dryness |
Non-Patent Citations (2)
| Title |
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| 于守洋.《保健食品常见主要活性物质资源简介》.《营养与保健食品研究及科学进展学术资料汇编》.2002,第3-16页. * |
| 姚嘉贇.《哈士蟆油及其复方抗疲劳作用的研究 》.《CNKI中国知网中国优秀硕士学位论文全文数据库》.2007,全文. * |
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