CN117752753A - A kind of traditional Chinese medicine composition for nourishing yin, activating blood circulation and relieving fetus - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for nourishing yin, activating blood and preventing miscarriage, which comprises an external plaster and an internal medicine, wherein the external plaster is prepared from Chinese taxillus twig, himalayan teasel root, chinese dodder seed, pilose asiabell root, largehead atractylodes rhizome, stir-fried hyacinth bean, chinese yam, villous amomum fruit, kudzuvine root, dendrobium, chinese angelica, danshen root, tree peony bark, szechuan lovage rhizome, membranous milkvetch root, frankincense, myrrh, dahurian angelica root, peppermint, liquoric root and Chinese pricklyash peel in specific proportions. The oral medicine is prepared from herba Taxilli, radix Dipsaci, semen Cuscutae, radix Codonopsis, atractylodis rhizoma, parched semen lablab album, rhizoma Dioscoreae, fructus Amomi, radix Puerariae, herba Dendrobii, radix Angelicae sinensis, saviae Miltiorrhizae radix, cortex moutan, and rhizoma Ligustici Chuanxiong in specific proportion. The invention treats both principal and secondary aspect of disease through orally taking and externally applying Yongquan, blood sea and Zusanli acupoints, has the effects of tonifying qi and nourishing blood, nourishing yin and promoting fluid production, activating blood and dissolving stasis, and improving uterine blood supply in gestation period, and is used for treating symptoms such as vaginal bleeding, dysphoria with smothery sensation in chest, dry mouth and throat, slow embryo development, red tongue or dark tongue with blood stasis points, ecchymosis, less tongue fur and thin and slippery pulse in gestation period caused by deficiency of qi and blood, deficiency of kidney yin and qi stagnation and blood stasis.

Description

A kind of traditional Chinese medicine composition for nourishing yin, activating blood circulation and relieving fetus

Technical field

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for nourishing yin, activating blood circulation and preventing fetus.

Background technique

In recent years, spontaneous abortion has become a common disease and frequently-occurring disease in obstetrics and gynecology. Its overall incidence rate among women of pregnant age is about 15%. Therefore, early miscarriage is particularly important. "Ye's Gynecological Syndrome and Treatment" says: "When a woman is pregnant, she relies entirely on blood to nourish her and Qi to protect her." It points out that the completion of pregnancy depends on the accumulation of Qi and blood in the mother's body to nourish it. If the maternal Qi is deficient or stagnate or Blood deficiency and blood stasis can affect fetal growth and development. Qing Dynasty. Wang Qingren stated in "Yilin Gaicuo·Volume 2": "There are often cases where several fetuses are injured in succession... I don't know that in the uterus, blood stasis first takes up its place, and when the fetus grows in three months, there is no room for it. "Ground, fetal disease depends on squeezing... so blood is seen first; the blood does not enter the fetus, and the fetus has no blood to nourish it, so it causes miscarriage." It is proposed that blood stasis can cause miscarriage. Blood stasis can be caused by external pathogenic factors, internal injuries, falls, injuries, etc. Blood stasis is both a pathogenic factor and a pathological product. After pregnancy, in order to support the fetus, the body is often in a state of excess qi and insufficient blood. Insufficient yin blood will lead to yin deficiency and internal heat. Heat burns and yin fluid will form blood stasis over time. If blood stasis blocks the uterus, the fetal element will not be solid, thus It leads to local blood stagnation and blockage in the uterus, poor circulation of intracellular veins, blood stasis in the cells, and loss of nourishment for the fetus, which can eventually lead to fetal instability or fetal wilting and miscarriage. Therefore, methods of nourishing yin, activating blood circulation, and removing blood stasis are needed to treat the fetus. .

The clinical manifestations of pregnant women with yin deficiency and blood stasis type include vaginal bleeding with or without vaginal bleeding during pregnancy, bright red color, irritability and heat, dry mouth and throat, red tongue with petechiae or ecchymosis, less coating, thin and slippery pulse, etc. The blood of pregnant women of this type is often in an abnormally hypercoagulable state, which is highly consistent with modern medicine’s understanding of prothrombotic state. Prethrombotic state refers to the deposition of fibrin in the placenta and uterus due to abnormally increased coagulation function and reduced fibrinolytic function. tissue, changing the blood flow status of the placenta, forming micro-thrombi in local tissues, affecting maternal-fetal material exchange, reducing placental blood perfusion, reducing the placental blood supply capacity, and placing the fetus in a state of hypoxia and ischemia, leading to fetal miscarriage due to poor development. Patients are prone to thrombosis, which is also associated with multiple adverse pregnancy outcomes such as recurrent miscarriage, gestational hypertension, gestational diabetes, placental abruption, premature birth, fetal growth restriction, and stillbirth. There are two causes of prothrombotic state: hereditary and acquired. The former is caused by coagulation-related gene mutations and related protein deficiency, while the latter is mainly related to anticardiolipin syndrome, acquired hyperhomocysteinemia, and acquired activity. Protein C resistance and other diseases that cause hypercoagulable states. Clinical auxiliary examinations for prothrombotic states include: related genetic examination, D-dimer, anti-β2 protein antibody, platelet aggregation rate, lupus anticoagulant, anticardiolipin antibody, vaginal B-ultrasound examination of uterine artery blood flow, etc. In early pregnancy, the blood supply of the uterine artery is crucial to the development of the embryo. The higher the pulsatility index (PI) and resistance index (RI) of the uterine spiral artery hemodynamic indicators, the higher the probability of inevitable miscarriage. Both blood stasis syndrome and the pre-thrombotic state of modern medicine can cause blood hypercoagulability. Whether the intrauterine blood supply is sufficient is closely related to the development of the embryo. The method of nourishing yin and activating blood circulation can improve the hypercoagulability of pregnant women's blood and reduce blood viscosity. Reduce uterine artery resistance, regulate the circulation of qi and blood throughout the body, ensure adequate blood supply to the uterus, fully nourish the fetus, and improve the success rate of miscarriage.

Contents of the invention

The purpose of the present invention is to provide a traditional Chinese medicine composition for nourishing yin, activating blood circulation and anti-fetus. The present invention treats both the symptoms and root causes by oral administration and external application at the Yongquan, Xuehai and Zusanli acupoints. It has the effect of promoting blood circulation and removing blood stasis, improving uterine blood supply during pregnancy, and is used for vaginal bleeding during pregnancy caused by Qi and blood deficiency, kidney yin deficiency, Qi stagnation and blood stasis, five heart upsets and heat, dry mouth and throat, slow embryonic development, and red tongue. Or there are symptoms such as dark tongue with petechiae, ecchymoses, less coating, thin and slippery pulse.

In order to achieve the above objects, the technical solutions adopted by the present invention are:

A traditional Chinese medicine composition for nourishing yin, activating blood circulation and relieving fetuses. The traditional Chinese medicine composition includes a traditional Chinese medicine composition for external use and a traditional Chinese medicine composition for oral administration;

Wherein, the traditional Chinese medicine composition for external use plaster is made of the following components by weight: 15-30 parts by weight of Locust locust, 15-30 parts by Dipsacus Dipsacus, 15-30 parts by Semen Cuscuta, 15-30 parts by Codonopsis Codonopsis, and 15-30 parts by Atractylodes Atractylodes. 30 parts, fried lentils 15-30 parts, yam 15-30 parts, amomum villosum 6-12 parts, kudzu root 15-30 parts, dendrobium 15-30 parts, angelica 10-20 parts, salvia miltiorrhiza 15-30 parts, paeonol 10 parts -20 parts, 6-12 parts of Chuanxiong, 15-30 parts of Astragalus, 15-30 parts of frankincense, 15-30 parts of myrrh, 10-20 parts of Angelica dahurica, 10-20 parts of mint, 6-12 parts of licorice, 5-5 parts of Zanthoxylum bungeanum. 10 servings;

The described Chinese medicine composition for oral administration consists of the following components by weight: 15-30 parts by weight of locust, 15-30 parts by Dipsacus bark, 15-30 parts by Cuscuta, 15-30 parts by Codonopsis pilosula, 15-30 parts by Atractylodes, and fried lentils. 15-30 parts, 15-30 parts of yam, 6-12 parts of amomum villosum, 15-30 parts of kudzu root, 15-30 parts of dendrobium, 10-20 parts of angelica root, 15-30 parts of salvia miltiorrhiza, 10-20 parts of paeonol bark, Ligusticum chuanxiong Serves 6-12.

Preferably, the external plaster is made of the following components by weight: 20 parts of locust, 20 parts of Dipsacus, 20 parts of Cuscuta, 20 parts of Codonopsis pilosula, 20 parts of Atractylodes, 20 parts of fried lentils, 20 parts of Chinese yam, 8 parts amomum villosum, 20 parts kudzu root, 20 parts dendrobium, 15 parts angelica, 20 parts salvia miltiorrhiza, 15 parts paeonol bark, 8 parts chuanxiong, 20 parts astragalus, 20 parts frankincense, 20 parts myrrh, 15 parts angelica dahurica, 15 parts mint , 8 parts of licorice, and 7 parts of Sichuan peppercorns.

Preferably, the oral medicine is composed of the following components by weight: 20 parts of locust, 20 parts of Dipsacus, 20 parts of Cuscuta, 20 parts of Codonopsis pilosula, 20 parts of Atractylodes, 20 parts of fried lentils, 20 parts of yam, Amomum villosum. 8 parts, 20 parts of kudzu root, 20 parts of dendrobium, 15 parts of angelica root, 20 parts of salvia miltiorrhiza, 15 parts of paeonol bark, and 8 parts of chuanxiong.

Preferably, the preparation steps of the external plaster are as follows:

Weigh the Chinese medicinal materials according to the above components, mix the Chinese medicinal materials evenly, then crush them, and then pass them through a 100-150 mesh sieve to make a fine powder. Add a small amount of at least one of honey, petroleum jelly, and acetic acid to the fine powder. Stir thoroughly to form a paste to obtain an external patch.

Preferably, the preparation steps of the oral medicine are as follows: weigh each pharmaceutical raw material in proportion, wash, grind and crush them respectively, then put all the grinded and crushed medicines into a porcelain jar to mix, and add 4-8 times the weight of the medicine with water. Soak to cover the medicine, then heat and decoct for 30 to 60 minutes, then filter and remove the residue to obtain the first medicine liquid; continue to put the filtered medicine residue into the porcelain jar, and add 4 to 8 times the total amount of the medicine by weight. Cover the medicine with distilled water, decoct the medicine over high heat, and then boil over slow fire for 30 to 60 minutes. Filter and pour out the second medicine. Mix the medicine obtained from the first time with the second medicine to obtain the above-mentioned medicine. Take medications internally.

The present invention also provides a method of using the external plaster in the pharmaceutical composition prepared by the above method. The method of use is: applying acupoint therapy, and applying the external plaster to the Yongquan, Xuehai and Zusanli acupoints on both sides. .

The present invention also provides the use of the above-mentioned traditional Chinese medicine composition in preparing yin-nourishing, blood-activating and tocolytic medicines.

In the present invention, the properties and functions of the traditional Chinese medicine used are as follows:

Locust: It is the leafy stem and branch of the small shrub plant Loranthaceae. It is sweet, pungent, bitter and flat in nature. Returns to the liver and kidney meridians. It can dispel rheumatism, unblock meridians, nourish liver and kidneys, strengthen muscles and bones, and calm the fetus.

Dipsacus Dipsafolia: It is a perennial herbaceous plant of Dipsaceae family. It can nourish the liver, strengthen muscles and bones, regulate meridians, relieve pain, relieve miscarriage, treat leucorrhea in women, produce new blood, break blood stasis, relieve cough and hemoptysis, and treat red and white stools. .

Cuscuta: Cuscuta is the mature seed of the annual parasitic twining herb Cuscuta of the Convolvulaceae family. Sweet, astringent, warm in nature. Returns to the kidney, liver and spleen meridians. Tonifying kidney yang, replenishing kidney essence, improving eyesight, fixing essence, reducing urination, stopping vaginal discharge, stopping diarrhea, and preventing miscarriage.

Codonopsis pilosula: It is the root of Codonopsis pilosula, a perennial herbaceous plant of the Campanulaceae family. Sweet and flat in nature. Returns to the spleen and lung meridians. Replenishes spleen and lung qi, produces body fluids, and nourishes blood.

Atractylodes macrocephala: It is the rhizome of Atractylodes macrocephala, a perennial herbaceous plant of the Asteraceae family. Sweet, bitter, warm in nature. Returns to the spleen and stomach meridians. Replenishing spleen, drying dampness, diuresis, fixing surface and antiperspirant, and preventing miscarriage.

Fried lentils: Lentils are sweet in taste, enter the spleen and stomach meridians, nourish the spleen without making them greasy, and remove dampness without dryness. It is used for fatigue, fatigue, less food and loose stools caused by spleen deficiency and dampness. It can strengthen the spleen and remove dampness. force.

Yam: It is the rhizome of Dioscorea, a perennial herbaceous plant of the Dioscoreaceae family. Sweet and flat in nature. Returns to the spleen, lung, and kidney meridians. Tonify spleen, lung and kidney qi, and benefit spleen, lung and kidney yin.

Amomum villosum: It is the dried and mature fruit of Yangchunsha or Hainansha, a herbaceous plant of the Zingiberaceae family. Pungent and warm in nature. Returns to the spleen and stomach meridians. Removing dampness, promoting Qi, warming the body, and stopping vomiting.

Pueraria lobata: It is the dried root of the leguminous plant Pueraria lobata, dried. Sweet, pungent, cool. It has the functions of relieving muscles and reducing fever, clearing rash, promoting body fluids and quenching thirst, promoting yang and stopping diarrhea, dredging menstruation and activating collaterals, and detoxifying alcohol.

Dendrobium: It returns to the stomach and kidney meridian. It is sweet in taste and slightly cold in nature. It can clear the stomach and promote fluid production, nourish yin and clear away heat. Modern pharmacology shows that it has anti-tumor, anti-inflammatory, antioxidant, hypoglycemic and other pharmacological effects.

Angelica sinensis: It is a perennial herbaceous plant belonging to the family Apiaceae. It belongs to the liver, heart, and spleen meridians. It tastes sweet, pungent, and is warm in nature. It has the effects of nourishing blood, activating blood circulation, moistening dryness and smoothing the intestines.

Salvia miltiorrhiza: bitter in taste and slightly cold in nature. It has the functions of activating blood circulation and removing blood stasis, calming the nerves and calming the mind. Modern pharmacology shows that it can improve myocardial ischemia, improve microcirculation, resist platelet aggregation, lower blood lipids, enhance myocardial contractility, and clear ischemic parts. The role of free radicals.

Paeoniae: It is the root bark of the peony plant of the Paeoniaceae family. It tastes pungent, bitter, and is cool in nature. It has the functions of clearing heat, cooling blood, harmonizing blood, and eliminating blood stasis. It can treat heat entering the blood, vomiting blood, and bruises.

Ligusticum chuanxiong: It is the rhizome of the perennial herbaceous plant Ligusticum chuanxiong of the Umbelliferae family. Pungent and warm in nature. Guixin, liver meridian. It has the effects of promoting blood circulation and qi, dispelling wind and relieving pain.

Astragalus: sweet in taste, slightly warm in nature, has the functions of nourishing qi and strengthening the surface, diuresis, strengthening the heart, lowering blood pressure, antibacterial, relieving toxins, draining pus, promoting muscle growth, nourishing qi and raising yang, strengthening the surface and antiperspirant, diuresis and swelling, promoting body fluid and nourishing blood. , it has the effects of relieving stagnation and relieving paralysis, relieving toxins and draining pus, astringing sores and promoting muscle growth.

Frankincense: acrid and warm in nature, returns to the heart, liver, and spleen meridians. It can activate blood circulation, promote qi, relieve pain, reduce swelling, promote muscle growth, and stretch muscles.

Myrrh: bitter, pungent, neutral in nature, enters the liver, spleen, heart, and kidney meridians, and has the effects of activating blood circulation and relieving pain, reducing swelling and promoting muscle growth.

Angelica dahurica: warm in nature, pungent in taste, returns to the stomach meridian, large intestine meridian, and lung meridian. It can relieve external cold, dispel wind and relieve pain, clear the nasal passages, remove dampness and stop vaginal discharge, reduce swelling and expel pus. Modern pharmacology shows that it has anti-inflammatory properties. , antioxidant, antispasmodic, and shortening clotting time.

Mint: pungent in taste, cool in nature, enters the lung and liver meridians, can disperse wind-heat, clear the head and head, soothe the throat, relieve rash, soothe the liver and promote qi. Modern pharmacology shows that it can be used as a transdermal accelerator.

Licorice: sweet in taste, neutral in nature, enters the twelve meridians, has the effects of nourishing the spleen and replenishing qi, clearing away heat and detoxifying, moistening the lungs and relieving cough.

Zanthoxylum bungeanum: pungent in taste and warm in nature. Returns to the spleen, stomach and kidney meridians. Warm and relieve pain, kill insects and relieve itching. External use can increase transdermal absorption.

Compared with the prior art, the beneficial effects of the present invention are as follows:

(1) The present invention uses locust, Dipsacus, and Cuscuta to nourish the liver and kidneys, prevent fetuses, and nourish the innate; uses Codonopsis pilosula, Atractylodes, fried lentils, yam, and amomum villosum to strengthen the spleen and replenish qi, nourish the acquired environment, and promote medicine and food. Absorption in the gastrointestinal tract; supplement each other day by day; take Adenophora, Ophiopogon japonicus, Pueraria lobata, Dendrobium to nourish yin and promote fluid; take Angelica sinensis, Salvia miltiorrhiza, paeonol bark, and Ligusticum chuanxiong to activate blood circulation and remove blood stasis, improve the blood supply of uterine artery, take Angelica dahuricae and Angelica dahuricae, The aroma of mint and peppermint promotes transdermal absorption.

(2) The Chinese medicine composition of the present invention includes two parts: an external plaster and an oral Chinese medicine. The drug compatibility is scientific and reasonable. The external medicine is applied to the Yongquan, Xuehai, and Zusanli acupoints, which can nourish yin, activate blood circulation, and promote blood circulation; Taken internally, the medicine can nourish the kidneys and strengthen the spleen, nourish yin and activate blood circulation, and can be taken internally or externally. This method of nourishing yin and activating blood circulation can significantly improve the blood hypercoagulability of pregnant women with yin deficiency and blood stasis, reduce blood viscosity, reduce uterine artery resistance, thereby reducing the probability of miscarriage. . At the same time, by improving the regulation of qi and blood circulation throughout the pregnant woman's body, the blood supply in the uterus is abundant, the fetus is fully nourished, and the success rate of miscarriage is improved.

(3) The traditional Chinese medicine composition of the present invention has the effects of replenishing qi and nourishing blood, nourishing yin and promoting body fluid, activating blood and removing blood stasis, improving uterine blood supply during pregnancy, and is used for pregnancy caused by deficiency of both qi and blood, insufficient kidney yin, qi stagnation and blood stasis. Symptoms include early vaginal bleeding, five upset stomachs and fever, dry mouth and throat, slow embryonic development, red or dark tongue with petechiae, ecchymosis, less coating, thin and slippery pulse, and other symptoms.

Detailed ways

In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts should fall within the scope of protection of the present invention.

It should be noted that the terms "first", "second", etc. in the description and claims of the present invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It is to be understood that the data so used are interchangeable under appropriate circumstances so that the embodiments of the invention described herein are capable of being practiced in sequences other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, e.g., a process, method, system, product, or apparatus that encompasses a series of steps or units and need not be limited to those explicitly listed. Those steps or elements may instead include other steps or elements not expressly listed or inherent to the process, method, product or apparatus.

Example 1

A traditional Chinese medicine composition for nourishing yin, activating blood circulation and anti-fetus, including external plaster and oral medicine,

The external plaster is made of the following components by weight: 15 parts of locust, 15 parts of Dipsacus, 15 parts of Cuscuta, 15 parts of Codonopsis pilosula, 15 parts of Atractylodes, 15 parts of fried lentils, 15 parts of Chinese yam, and 6 parts of Amomum villosum. 15 parts of kudzu root, 15 parts of dendrobium, 10 parts of angelica root, 15 parts of salvia miltiorrhiza, 10 parts of paeonol bark, 6 parts of chuanxiong rhizome, 15 parts of astragalus, 15 parts of frankincense, 15 parts of myrrh, 10 parts of angelica angelica, 10 parts of mint, 6 parts of licorice 5 servings of Sichuan peppercorns.

The oral medicine is composed of the following components by weight: 15 parts of locust, 15 parts of Dipsacus, 15 parts of Cuscuta, 15 parts of Codonopsis pilosula, 15 parts of Atractylodes, 15 parts of fried lentils, 15 parts of Chinese yam, 6 parts of Amomum villosum, 15 parts of kudzu root, 15 parts of dendrobium, 10 parts of angelica root, 15 parts of salvia miltiorrhiza, 10 parts of paeonol bark, and 6 parts of chuanxiong.

The steps for making the above-mentioned external plaster are as follows: weigh the Chinese medicinal materials according to the above components, mix the Chinese medicinal materials evenly, then crush them, and then pass them through a 100-mesh sieve to make a fine powder. Add a small amount of the above-mentioned fine powder to honey, stir thoroughly to form a paste, and then evenly apply the paste-like traditional Chinese medicine composition on a gauze patch to obtain an external plaster.

The preparation method of the above-mentioned oral medicine, the steps are as follows: weigh each medicine raw material in proportion, wash, grind and crush respectively, then put all the medicine after grinding and crushing into a porcelain jar to mix, add 6 times the weight of the medicine and soak the lid in water Pass the medicine, then heat and decoct for 45 minutes, then filter and remove the residue to obtain the first medicine liquid; continue to put the filtered medicine residue into the porcelain jar, add distilled water that is 4 times the total amount of the medicine by weight to cover the medicine, and cover the medicine with Decoct the medicinal liquid over high fire, then decoct over low heat for 30 minutes, filter and pour out the second medicinal liquid, and mix the medicinal liquid obtained for the first time with the second medicinal liquid to obtain the oral medicine.

Example 2

A traditional Chinese medicine composition for nourishing yin, activating blood circulation and anti-fetus, including external plaster and oral medicine,

The external plaster is composed of the following components by weight: 30 parts of locust, 30 parts of Dipsacus, 30 parts of Cuscuta, 30 parts of Codonopsis pilosula, 30 parts of Atractylodes, 30 parts of fried lentils, 30 parts of Chinese yam, and 12 parts of Amomum villosum. , 30 parts of kudzu root, 30 parts of dendrobium, 20 parts of angelica root, 30 parts of salvia miltiorrhiza, 20 parts of paeonol bark, 12 parts of chuanxiong, 30 parts of astragalus, 30 parts of frankincense, 30 parts of myrrh, 20 parts of angelica, 20 parts of peppermint, 12 parts of licorice , 10 servings of Sichuan peppercorns.

The oral medicine is composed of the following components by weight: 30 parts of locust, 30 parts of Dipsacus, 30 parts of Cuscuta, 30 parts of Codonopsis pilosula, 30 parts of Atractylodes, 30 parts of fried lentils, 30 parts of Chinese yam, 12 parts of Amomum villosum, 30 parts of kudzu root, 30 parts of dendrobium, 20 parts of angelica root, 30 parts of salvia miltiorrhiza, 20 parts of paeonol bark, and 12 parts of chuanxiong.

The steps for making the above-mentioned external plaster are as follows: weigh the Chinese medicinal materials according to the above components, stir the Chinese medicinal materials evenly, then crush them, and then pass them through a 150-mesh sieve to make a fine powder. Add a small amount of the above-mentioned fine powder to Vaseline, stir thoroughly to form a paste, and then evenly apply the paste-like Chinese medicine composition on the gauze patch to obtain an external plaster.

The preparation method of the above-mentioned oral medicine, the steps are as follows: weigh each medicine raw material in proportion, wash, grind and crush respectively, then put all the medicine after grinding and crushing into a porcelain jar to mix, add 5 times the weight of the medicine and soak the lid in water Pass the medicine, then heat and decoct for 60 minutes, then filter and remove the residue to obtain the first medicine liquid; continue to put the filtered medicine residue into the porcelain jar, add distilled water that is 4 times the total amount of the medicine by weight to cover the medicine, and cover the medicine with Decoct the medicinal liquid over high fire, then decoct over slow fire for 40 minutes, filter and pour out the second medicinal liquid, and mix the medicinal liquid obtained for the first time with the second medicinal liquid to obtain the oral medicine.

Example 3

A traditional Chinese medicine composition for nourishing yin, activating blood circulation and relieving fetuses, including external plaster and oral medicine.

The external plaster is composed of the following components by weight: 22 parts of locust, 22 parts of Dipsacus, 22 parts of Cuscuta, 22 parts of Codonopsis pilosula, 22 parts of Atractylodes, 22 parts of fried lentils, 22 parts of Chinese yam, and 9 parts of Amomum villosum. , 22 parts of kudzu root, 22 parts of dendrobium, 15 parts of angelica root, 22 parts of salvia miltiorrhiza, 15 parts of paeonol bark, 9 parts of chuanxiong, 22 parts of astragalus, 22 parts of frankincense, 22 parts of myrrh, 15 parts of angelica, 15 parts of peppermint, 9 parts of licorice , 7 servings of Sichuan peppercorns.

The oral medicine is composed of the following components by weight: 22 parts of locust, 22 parts of Dipsacus, 22 parts of Cuscuta, 22 parts of Codonopsis pilosula, 22 parts of Atractylodes, 22 parts of fried lentils, 22 parts of Chinese yam, 9 parts of Amomum villosum, 22 parts of kudzu root, 22 parts of dendrobium, 15 parts of angelica root, 22 parts of salvia miltiorrhiza, 15 parts of paeonol bark, and 9 parts of chuanxiong.

The steps for making the above-mentioned external plaster are as follows: weigh the Chinese medicinal materials according to the above components, stir the Chinese medicinal materials evenly, then crush them, and then pass them through a 125-mesh sieve to make a fine powder. Add a small amount of the above-mentioned fine powder to acetic acid, stir thoroughly to form a paste, and then evenly apply the paste-like traditional Chinese medicine composition on a gauze patch to obtain an external plaster.

The preparation method of the above-mentioned oral medicine, the steps are as follows: weigh each medicine raw material in proportion, wash, grind and crush respectively, then put all the medicine after grinding and crushing into a porcelain jar to mix, add 6 times the weight of the medicine and soak the lid in water Pass the medicine, then heat and decoct for 60 minutes, then filter and remove the residue to obtain the first medicine liquid; continue to put the filtered medicine residue into the porcelain jar, add distilled water that is 5 times the total amount of the medicine by weight to cover the medicine, and cover the medicine with Decoct the medicinal liquid over high fire, then decoct over slow fire for 45 minutes, filter and pour out the second medicinal liquid, and mix the medicinal liquid obtained for the first time with the second medicinal liquid to obtain the oral medicine.

clinical experiments

Case selection: Select patients who received nourishing yin and blood circulation and fetal preservation treatment at Hubei Maternal and Child Health Hospital from October 2020 to October 2022. 90 patients were observed and treated, with 30 cases in each group, divided into three categories: A, B, and C. Group.

After statistical analysis, the general information of the three groups of patients in terms of age, average number of miscarriages, average miscarriage, and current gestational age was not statistically significant (all P>0.05), and the groups were comparable. See Table 1 for details.

Comparison between the three groups P>0.05, there was no significant difference and no statistical significance. It is suggested that the two groups are comparable.

2. Diagnostic criteria: (1) Diagnostic criteria for threatened abortion in early pregnancy: refer to "Obstetrics and Gynecology" and "Clinical Guidelines for New Traditional Chinese Medicines (Trial)": ① A small amount of vaginal bleeding occurs before the 12th week of pregnancy, without discharge of pregnancy products, and occurs one after another Lower abdominal pain or low back pain; ② Gynecological examination, the cervix is not dilated, and the size of the uterus is consistent with the number of weeks of menopause; ③ B-ultrasound examination, the size of the uterus, the gestational sac, embryo or fetus are consistent with the gestational age.

(1) Inclusion criteria: ① Meet the diagnostic criteria for threatened abortion in early pregnancy; ② Subchorionic hematoma on B-ultrasound examination; ③ Aged 20 to 40 years old; ④ Voluntarily accept the treatment of this trial, no major diseases of heart, liver, kidney and other organs, spouse Good health (especially no organic disease in the reproductive system); ⑤ Sign the informed consent form.

(2) Exclusion criteria: ① Those with ≥ 3 consecutive spontaneous abortions; ② Those infected with rubella, cytomegalovirus, toxoplasmosis, or herpes simplex virus; ③ Those with severe anemia, heart failure, chronic nephritis, hypertension, diabetes, or systemic infection such as high fever; ④ Those with uterine malformation, uterine fibroids, or adenomyosis; ⑤ Those with untreated intrauterine adhesions, intrauterine effusions, endometrial polyps, or endometrial hyperplasia; ⑥ Those with mental illness; ⑦ Those who cannot adhere to the course of treatment.

3. Treatment methods:

Group A: Treatment started from the time of consultation. The medicines of the examples were taken orally, mixed, and taken once a day, divided into two times. The patients were instructed to take a rest and adjust their mood. One month of continuous use constitutes a course of treatment.

Group B: The patient takes a supine or sitting position, applies the external plaster prepared in Example 1, and applies acupoint therapy. The external plaster is applied to the Yongquan, Xuehai, and Zusanli acupoints, and one month of continuous use constitutes a course of treatment.

Group C: Treatment was started from the time of diagnosis, and the oral medicine and external plaster of Example 1 were used for combined treatment. Take the medicine for oral administration, 1 dose 1 day, divided into two times, use acupoint compress therapy, apply the external plaster on the Yongquan, Xuehai and Zusanli acupoints, and use it continuously for one month as a course of treatment.

4. Efficacy evaluation: (1) Color ultrasound examination: The ultrasound instrument used is the GE Voluson730 three-dimensional color Doppler ultrasound instrument with an abdominal probe frequency of 3.5MHz. It is operated by a specialized doctor before treatment, 10 days of treatment, 15 days of treatment, and 20 days of treatment. Transvaginal color Doppler ultrasound measured the patient's bilateral uterine arteries. (2) Use SPSS22.0 statistical software for data analysis. First, perform normality and homogeneity of variance tests. Measurement data that conform to normal distribution are expressed as mean ± standard deviation (x-±s). Comparison between two groups is done using two-dimensional tests. t-test for independent samples, paired-sample t-test for comparison before and after treatment within the group, and non-parametric rank-sum test for non-normal distribution; rank-sum test for clinical efficacy was used for comparison of clinical efficacy, and X-test was used for comparison of count data, with P<0.05 considered The difference was statistically significant.

5. Treatment results:

(1) Table 2 Comparison of the uterine artery blood flow resistance index RI on the left and right sides of patients in groups A, B, and C before treatment and after 10 days, 15 days, and 20 days of treatment.

The above table illustrates that the combined application of oral medicine and external plaster of the present invention has significant curative effect, and the therapeutic effect is better than simply using only oral medicine or only using external plaster.

(2) Clinical efficacy evaluation standards refer to the following guiding principles

Recovery: Vaginal bleeding stopped after 5 days of treatment, lower abdominal pain disappeared, gynecological color ultrasound examination showed that the size of the uterus and embryonic development were consistent with the gestational age, and the fetal development was normal;

Markedly effective: Vaginal bleeding stopped after 7 days of treatment, and lower abdominal pain was significantly relieved. Gynecological color ultrasound examination showed that the size of the uterus and embryonic development were consistent with the gestational age, and the fetal development was normal;

Effective: Vaginal bleeding stopped after 10 days of treatment, lower abdominal pain was relieved, and gynecological color ultrasound examination showed that the size of the uterus and embryonic development were basically consistent with the gestational age;

Ineffective: vaginal bleeding does not stop after 10 days of treatment, lower abdominal pain during menstruation does not improve significantly, gynecological color ultrasound examination shows that the size of the uterus and embryonic development are basically consistent with the gestational age or less than the gestational age, and the embryonic development is poor or stops developing.

Table 3 shows the comparative results of the efficacy of the above three groups A, B, and C.

(3) Comparison of pregnancy outcomes among the three groups of patients, see Table 3 below

Table 3 Comparison of pregnancy outcomes among 3 groups of patients

Group n abortion premature birth term birth Abortion gestational age gestational age Group A 30 3 2 25 10.7±1.5 38.0±1.2 Group B 30 5 4 twenty one 10.3±2.0 38.6±1.5 Group C 30 1 1 28 11.2±1.5 38.9±1.2

It can be seen from the above results that the combined application of the oral medicine and the external plaster prepared by the present invention has significant curative effect, has the effects of nourishing yin and promoting body fluid, promoting blood circulation and removing blood stasis, and is of great significance for miscarriage treatment.

The above are only preferred specific embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any person familiar with the technical field can obviously obtain the simple technical solutions within the technical scope disclosed in the present invention. Changes or equivalent substitutions fall within the protection scope of the present invention.

Claims (7)

1. A traditional Chinese medicine composition for nourishing yin, activating blood circulation and relieving fetuses, characterized in that the traditional Chinese medicine composition consists of a traditional Chinese medicine composition for external use and a traditional Chinese medicine composition for oral administration; Wherein, the traditional Chinese medicine composition for external use plaster is made of the following components by weight: 15-30 parts by weight of Locust locust, 15-30 parts by Dipsacus Dipsacus, 15-30 parts by Semen Cuscuta, 15-30 parts by Codonopsis Codonopsis, and 15-30 parts by Atractylodes Atractylodes. 30 parts, fried lentils 15-30 parts, yam 15-30 parts, amomum villosum 6-12 parts, kudzu root 15-30 parts, dendrobium 15-30 parts, angelica 10-20 parts, salvia miltiorrhiza 15-30 parts, paeonol 10 parts -20 parts, Ligusticum chuanxiong 6-12 parts, Astragalus 15-30 parts, Frankincense 15-30 parts, Myrrh 15-30 parts, Angelica dahurica 10-20 parts, Mint 10-20 parts, Licorice 6-12 parts, Zanthoxylum bungeanum 5- 10 servings; The described Chinese medicine composition for oral administration consists of the following components by weight: 15-30 parts by weight of locust, 15-30 parts by Dipsacus bark, 15-30 parts by Cuscuta, 15-30 parts by Codonopsis pilosula, 15-30 parts by Atractylodes, and fried lentils. 15-30 parts, 15-30 parts of yam, 6-12 parts of amomum villosum, 15-30 parts of kudzu root, 15-30 parts of dendrobium, 10-20 parts of angelica root, 15-30 parts of salvia miltiorrhiza, 10-20 parts of paeonol bark, Ligusticum chuanxiong Serves 6-12. 2. The traditional Chinese medicine composition according to claim 1, characterized in that the external plaster is made of the following components by weight: 20 parts of Locust locust, 20 parts of Dipsacus Dipsacus, 20 parts of Semen Cuscuta, and 20 parts of Codonopsis Codonopsis. , 20 parts of Atractylodes macrocephala, 20 parts of fried lentils, 20 parts of yam, 8 parts of amomum villosum, 20 parts of kudzu root, 20 parts of dendrobium, 15 parts of angelica root, 20 parts of salvia miltiorrhiza, 15 parts of paeonol bark, 8 parts of chuanxiong, 20 parts of astragalus, 20 parts of frankincense 20 parts of myrrh, 15 parts of Angelica dahurica, 15 parts of mint, 8 parts of licorice, and 7 parts of Zanthoxylum bungeanum. 3. The traditional Chinese medicine composition according to claim 1, characterized in that the oral medicine is composed of the following components by weight: 20 parts of Locust locust, 20 parts of Dipsacus Dipsacus, 20 parts of Semen Cuscuta, 20 parts of Codonopsis Codonopsis, and Atractylodes Rhizome. 20 parts, fried lentils 20 parts, yam 20 parts, amomum villosum 8 parts, kudzu root 20 parts, dendrobium 20 parts, angelica root 15 parts, salvia miltiorrhiza 20 parts, paeonol 15 parts, Chuanxiong 8 parts. 4. The traditional Chinese medicine composition according to any one of claims 1-2, characterized in that the preparation steps of the traditional Chinese medicine composition for external use plaster are as follows: Weigh the Chinese medicinal materials according to the above components, mix the Chinese medicinal materials evenly and then crush them, and then pass them through a 100-150 mesh sieve to make a fine powder, and then add a small amount of at least one of honey, petroleum jelly, and acetic acid to the fine powder. Stir thoroughly to form a paste, and then apply the paste-like traditional Chinese medicine composition evenly on the gauze patch to obtain an external-use patch. 5. The Chinese medicine composition according to claim 1 or 3, characterized in that the preparation steps of the oral Chinese medicine composition are as follows: weigh each pharmaceutical raw material in proportion, wash and grind it separately, and then grind and crush it. Put all the medicine into a porcelain jar and mix, add 4-8 times the weight of the medicine and soak in water to cover the medicine, then heat and decoct for 30-60 minutes, then filter and remove the residue to get the first medicine liquid; continue to put the filtered medicine residue into Put it into a porcelain jar, add distilled water 4 to 8 times the total amount of the medicine by weight to cover the medicine, decoct the medicine over high heat, then simmer over slow fire for 30 to 60 minutes, filter and pour out the second medicine. The medicinal liquid obtained once is mixed with the second medicinal liquid to obtain the medicine for oral administration. 6. The traditional Chinese medicine composition according to claim 4, characterized in that the method of using the external plaster is: applying acupoint therapy, applying the external plaster to the Yongquan, Xuehai and Zusanli acupoints on both sides. . 7. Application of the traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of yin-nourishing, blood-activating and tocolytic drugs.