CN1727362B - 癌胚抗原阳性肿瘤治疗性疫苗的制备及应用 - Google Patents

癌胚抗原阳性肿瘤治疗性疫苗的制备及应用 Download PDF

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CN1727362B
CN1727362B CN200410053313XA CN200410053313A CN1727362B CN 1727362 B CN1727362 B CN 1727362B CN 200410053313X A CN200410053313X A CN 200410053313XA CN 200410053313 A CN200410053313 A CN 200410053313A CN 1727362 B CN1727362 B CN 1727362B
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cell
fusion rotein
cea
hsp70l1
antigen
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CN1727362A (zh
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万涛
吴艳峰
周向阳
李楠
陈国友
曹雪涛
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Second Military Medical University SMMU
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00118Cancer antigens from embryonic or fetal origin
    • A61K39/001182Carcinoembryonic antigen [CEA]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4615Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622Antigen presenting cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464476Heat shock proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46448Cancer antigens from embryonic or fetal origin
    • A61K39/464482Carcinoembryonic antigen [CEA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6043Heat shock proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200410053313XA 2004-07-30 2004-07-30 癌胚抗原阳性肿瘤治疗性疫苗的制备及应用 Expired - Lifetime CN1727362B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN200410053313XA CN1727362B (zh) 2004-07-30 2004-07-30 癌胚抗原阳性肿瘤治疗性疫苗的制备及应用
PCT/CN2005/000763 WO2006010308A1 (fr) 2004-07-30 2005-05-31 Preparation et application de vaccins therapeutiques a une tumeur

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Application Number Priority Date Filing Date Title
CN200410053313XA CN1727362B (zh) 2004-07-30 2004-07-30 癌胚抗原阳性肿瘤治疗性疫苗的制备及应用

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CN1727362A CN1727362A (zh) 2006-02-01
CN1727362B true CN1727362B (zh) 2010-12-01

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WO (1) WO2006010308A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1865281B (zh) 2006-06-02 2012-08-22 北京大学人民医院 卵巢癌抗独特型抗体6b11 t细胞表位肽及其应用
CN100391980C (zh) * 2006-08-02 2008-06-04 中国人民解放军军事医学科学院基础医学研究所 抗肿瘤多靶点复合抗原及其编码基因与应用
BRPI0814140A2 (pt) * 2007-07-27 2017-03-28 Immatics Biotechnologies Gmbh composição de peptídeos associados a tumor e vacina anticâncer relacionada
CN102154223A (zh) * 2010-02-11 2011-08-17 中国人民解放军第二军医大学 携带融合蛋白基因的重组腺病毒及其制备方法和应用
CN105693862B (zh) * 2016-03-07 2019-06-18 中国人民解放军第二军医大学 抗融合蛋白cea576-669hsp70l1单克隆抗体4e8及其用途
CN105693863B (zh) * 2016-03-07 2019-06-18 中国人民解放军第二军医大学 抗融合蛋白cea576-669hsp70l1单克隆抗体3c1及其用途
CN106749673B (zh) * 2016-11-22 2021-07-02 张震宇 一种融合蛋白、制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1270635A (zh) * 1997-08-05 2000-10-18 斯特思吉生物技术公司 包含hpv抗原和应激蛋白或者其表达载体的组合物激发的抗hpv抗原免疫应答
CN1491116A (zh) * 2001-02-05 2004-04-21 \ Hbv治疗方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0700445T3 (da) * 1993-06-04 2002-05-13 Whitehead Biomedical Inst Stressproteiner og anvendelser deraf
CN1411512A (zh) * 1999-10-20 2003-04-16 约翰霍普金斯大学医学院 嵌合的免疫原性组合物及其编码核酸
CN1141142C (zh) * 2001-02-08 2004-03-10 北京迪威华宇生物技术有限公司 人乳腺癌muc-1抗原基因工程疫苗
CN1517437B (zh) * 2003-01-15 2010-06-09 张聪慧 特异性治疗肿瘤或胞内感染的疫苗及应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1270635A (zh) * 1997-08-05 2000-10-18 斯特思吉生物技术公司 包含hpv抗原和应激蛋白或者其表达载体的组合物激发的抗hpv抗原免疫应答
CN1491116A (zh) * 2001-02-05 2004-04-21 \ Hbv治疗方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
马俊芬.转染癌胚抗原基因的人树突状细胞疫苗表达的研究.河南肿瘤学杂志16 3.2003,16(3),164-166.
马俊芬.转染癌胚抗原基因的人树突状细胞疫苗表达的研究.河南肿瘤学杂志16 3.2003,16(3),164-166. *
黄爱强.带免疫佐剂CEA基因疫苗的构建一起稳定同步表达的研究.癌症23 3.2003,23(3),282-287.
黄爱强.带免疫佐剂CEA基因疫苗的构建一起稳定同步表达的研究.癌症23 3.2003,23(3),282-287. *

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WO2006010308A1 (fr) 2006-02-02

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