CN1720982A - Sugar decreasing composition of fenugreek seed - Google Patents
Sugar decreasing composition of fenugreek seed Download PDFInfo
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- CN1720982A CN1720982A CN 200510042788 CN200510042788A CN1720982A CN 1720982 A CN1720982 A CN 1720982A CN 200510042788 CN200510042788 CN 200510042788 CN 200510042788 A CN200510042788 A CN 200510042788A CN 1720982 A CN1720982 A CN 1720982A
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- fenugreek seed
- radix astragali
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- sugar decreasing
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Abstract
The invention relates to a antihypelipidemic composition of fenugreek seed, which comprises (by weight ratio) fenugreek seeds extract 30-90%, mulberry leaf extract 5-40%, astragalus root extract 3-30%, the fenugreek seeds extract contains total fiber 1-80%, the mulberry leaf extract contains total flavones 0.1-50%, and the astragalus root extract is the aqueous extract or organic solvent of astragalus root or the aqueous extract AND organic solvent of astragalus root.
Description
One, technical field
The present invention relates to a kind of compositions of plant extract, especially relate to a kind of sugar decreasing composition of fenugreek seed, form by fenugreek seed extract, Folium Mori extract, Radix Astragali extract.
Two, background technology
Diabetes are a kind of very ancient disease, the traditional Chinese medical science is referred to as " quenching one's thirst ", the meaning of the excessive thirst of promptly becoming thin, modern medicine finds that it is a kind of common endocrinopathy, be that concentration of glucose raises in the blood that causes owing to insulin in the human body definitely or relatively lacks, and then sugar discharges from urine in a large number, and polydipsia, polyuria, polyphagia occur, become thin, symptom such as dizzy, weak.The diabetes patient is because blood sugar level often exceeds normal range, further cause whole body various acute complication (as ketoacidosis, non-ketosis hyperosmolar coma) and chronic complicating diseases (comprise aspect pathological changes such as trunk, blood capillary and nerve, also have nephropathy change, oculopathy to become or the like) toward contact.The diabetes serious threat is healthy, unhealthful quality of life, makes patient, family and the serious burden of social back.
At present, medical circle has formed five big Therapeutic Principle of the diabetes of generally acknowledging:
1) diabetes education: the knowledge of study diabetes, understand harm, the grasp method.
2) state of illness monitoring: mainly be self-blood sugar monitoring.
3) Diet Therapy.
4) exercise therapy.
5) Drug therapy: comprise oral drug therapy and insulinize (injection).
At present, the orally-taken blood sugar reducing drug main will mainly be chemical synthetic drug (Western medicine) for sulphanylureas, biguanides, α glycosidase inhibitor, novel insulin sensitizer etc.Though these medicines help diabetes patient's glucose level control with the different mechanism of action, these medicines also all have weak point.
These medicine general action mode/approach are single.Produce insulin as the sulfonylurea drugs stimulating pancreas, make the insulin secretion level raise, thus the blood sugar lowering level; Biguanides suppresses the absorption of intestinal to glucose, strengthens the utilization of surrounding tissue to glucose, thus the blood sugar lowering level; The α glycosidase inhibitor suppresses combining of sucrose and saccharase competitively, delays the conversion of sucrose to glucose and fructose, reduces level of postprandial blood sugar; The novel insulin sensitizer promotes the glucose utilization of insulin stimulating, and the novel insulin sensitizer also and not really ripe.
These medicines have side effect toward contact.As sulfonylurea drugs hypoglycemia taking place easily, can lose efficacy, allergic phenomena occurs; Gastrointestinal reactions such as biguanides has anorexia, feels sick, vomiting, abdominal distention, diarrhoea, lactic acidosis etc.; Also have the α glycosidase inhibitor abdominal distention, times of defecation such as increase at gastrointestinal reaction; Euglycemic agent may have side effect such as upper respiratory tract infection, headache.
These medicines often act on obvious inadequately, or often need just can reach better effect with the other drug coupling.
In secular medical practice, China's Chinese medicine has also accumulated the invaluable experience of preventing and treating diabetes, sum up simple and easy to do Therapeutic Method such as Chinese herbal treatment (dialectical medicine, the folk prescription proved recipe of selecting), acupuncture and moxibustion therapy (acupuncture, moxibustion therapy, ear acupuncture etc.), Diet Therapy, physical exercise therapy, the qigong, massage or the like, made the contribution of Chinese medicine for the control of world's diabetes.These methods are to improving the diabetes clinical symptoms, blood sugar lowering, blood fat, and the control of microcirculation improvement and diabetes chronic pathological changes all has certain effect.Wherein there are diabetes pill, Jiangtangwan pill etc. in the oral drugs aspect.But weak points such as Chinese medicine class oral drugs often have prescription too complicated, and the active ingredient enrichment degree is not high, and curative effect is obvious inadequately or slow.
The present invention is directed to the pathogeny and the clinical manifestation of diabetes, use for reference western modern medicine theory and Chinese medical theory, extract (the fenugreek seed extract of selecting for use several traditional Chinese crude drugs to make, Folium Mori extract, Radix Astragali extract), make a kind of compositions of plant extract, here claim sugar decreasing composition of fenugreek seed, said composition can be made any acceptable peroral dosage form on pharmaceutics, be applicable to the high tendency crowd of diabetes patient and diabetes, has blood sugar lowering, and improve blood circulation, comprehensively regulating, improve physiological function, alleviate, other diseases that prevent diabetes causes.
The fenugreek seed extractThe Chinese medicine Semen Trigonellae is the dry mature seed of leguminous plant Semen Trigonellae Trigonellafoenum-graecum L..As Chinese medicine, return kidney channel, bitter in the mouth warm in nature; The kidney warming, cold relieving, pain relieving; Be used for the cold void of kidney, cold and pain in the lower abdomen, inguinal hernia, the disturbance of lower legs due to pathogenic cold and dampness.Active ingredients such as fenugreek seed rich cellulose class, amino acids (especially 4-hydroxyisoleucine), alkaloids, Saponin class.The fenugreek seed extract is the enrichment method thing that it is mainly contained effective constituent.
Folium Mori extractThe Chinese medicine Folium Mori, the dried leaves of flaccidity moraceae plants Mulberry Morus alba L..As Chinese medicine, return lung, Liver Channel, cold in nature, sweet in the mouth, hardship; Dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving; Be used for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.Folium Mori mainly contain active ingredients such as flavonoid, amino acids, steroidal and triterpenes, alkaloids.Folium Mori extract is the enrichment method thing that it is mainly contained effective constituent.
Radix Astragali extractChinese medicine astragalus is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch.) Bge..As Chinese medicine, return lung, spleen channel, warm in nature, sweet in the mouth; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation; It is weak to be used for the deficiency of vital energy, and lack of appetite is sugar just, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.The Radix Astragali mainly contains multiple active ingredients such as polysaccharide, flavonoid, Saponin class.Radix Astragali extract is the enrichment method thing that it is mainly contained effective constituent.
Cellulose can reduce degree of absorption to fat at enteral in the fenugreek seed extract, and the absorption of sugar is slowed down, and quickens glucose metabolism, increases Insulin receptor INSR sensitivity on every side, thus control, blood sugar lowering level.Cellulose can make on the type i diabetes patient mononuclear cell Insulin receptor INSR in conjunction with increase, thereby saves the requirement of insulin.Amino acids in the fenugreek seed extract is the 4-hydroxyisoleucine especially, can stimulate secretion of insulin, directly helps control, blood sugar lowering level.The cellulose family composition also helps to reduce low-density albumen and the total cholesterol level (blood fat reducing function) in the blood, improves blood circulation.The cellulose family composition also helps to improve gastrointestinal movement, prevents treating constipation weight-reducing.The flavonoid composition plays a part antioxidant in the Folium Mori extract, reduces the destruction of radical pair health, protection blood circulation and pancreas, and may certain repair be arranged to pancreatic function.The Radix Astragali extract instinct promotes to improve the vigor of body antioxidase and oxidation preventive content, so it can be regarded as a kind of promoter of antioxidant, the collaborative antioxidation that strengthens Folium Mori extract.In addition, the Radix Astragali have other the effect as: the enhancing human body immunity function; Suppress virus breeding, reduce the pathogenic effects of viral pair cell; Prolong the cells in vitro growth life-span; Improve experiment mice spleen and liver rna content; Astragaloside promotes DNA synthetic, quickens the liver differentiation and proliferation; Improve the stress ability of experimental rat; Anti-aging effects etc.Radix Astragali extract promotes to strengthen the physiological function of whole health, thereby is also promoting pancreatic function indirectly.Three kinds of extracts are complementary short mutually, and synergism had both fundamentally strengthened the whole machine body function, promote (even helping to repair) pancreatic function, and promote secretion of insulin in the body, reduce absorption again sugar, quicken glucose metabolism, thus control, blood sugar lowering level; Protect, improve blood circulation simultaneously, improve gastrointestinal movement, prevent and treat other concurrent diseases of diabetes.
Three, summary of the invention
The objective of the invention is to overcome the weak point of above-mentioned background technology, a kind of sugar decreasing composition of fenugreek seed is provided, provide solution for producing the hypoglycemic oral formulation products that efficient multiple-effect, the pure Chinese medicine of economical and practical type make.
For achieving the above object, the technical solution used in the present invention is:
A kind of sugar decreasing composition of fenugreek seed is made up of fenugreek seed extract, Folium Mori extract, Radix Astragali extract.Its special character is, forms in following ratio with percentage by weight: fenugreek seed extract 30-90%, Folium Mori extract 5-40%, Radix Astragali extract 3-30%.
Above-mentioned fenugreek seed extract contains total fiber 1-80%.
Above-mentioned Folium Mori extract contains total flavones 0.1-50%.
Above-mentioned Radix Astragali extract is the water extract or the extractive with organic solvent of the Radix Astragali, or the water of the Radix Astragali and extractive with organic solvent.
Above-mentioned compositions can be made any acceptable peroral dosage form on pharmaceutics.
Compared with prior art, advantage of the present invention and effect are as follows:
At present, in oral drugs, sulphanylureas, biguanides, α glycosidase inhibitor, novel insulin sensitizer mostly are chemical synthetic drug (Western medicine), as mentioned above, these medicines often model of action/approach are single, some product effect is obvious inadequately even can act on inefficacy, and side effect is in various degree often arranged.These medicines are conceived to blood sugar lowering itself more.And the present invention is a pure Chinese medicinal preparation, has no side effect, and is conceived to both fundamentally strengthen the whole machine body function, promote (even helping to repair) pancreatic function, and promote secretion of insulin in the body, reduce absorption again sugar, quicken glucose metabolism, thus control, blood sugar lowering level; Protect, improve blood circulation simultaneously, improve gastrointestinal movement, prevent and treat other concurrent diseases of diabetes.Weak points such as Chinese medicine class oral drugs often have prescription too complicated, and the active ingredient enrichment degree is not high, and curative effect is obvious inadequately or slow.Compare with existing Chinese medicine preparation, the present invention fills a prescription simply, active ingredient enrichment degree height, and the mechanism of action is clear and definite, and efficient multiple-effect is economical and practical.China Chinese crude drug Semen Trigonellae, Folium Mori, Radix Astragali aboundresources, the present invention also fully takes into account this resources advantage.
Four, the specific embodiment
Embodiment one
A kind of sugar decreasing composition of fenugreek seed adopts fenugreek seed extract, Folium Mori extract, Radix Astragali extract, forms by following weight proportion:
| Fenugreek seed extract (total fiber 18%) | 390 | 78.00％ |
| Folium Mori extract (total flavones 6%) | 70 | 14.00％ |
| Radix Astragali extract | 40 | 8.00％ |
| Add up to | 500 | 100.00％ |
Embodiment two
A kind of sugar decreasing composition of fenugreek seed adopts fenugreek seed extract, Folium Mori extract, Radix Astragali extract, forms by following weight proportion:
| Fenugreek seed extract (total fiber 25%) | 390 | 78.00％ |
| Folium Mori extract (total flavones 9%) | 70 | 14.00％ |
| Radix Astragali extract | 40 | 8.00％ |
| Add up to | 500 | 100.00％ |
Embodiment three
A kind of sugar decreasing composition of fenugreek seed adopts fenugreek seed extract, Folium Mori extract, Radix Astragali extract, forms by following weight proportion:
| Fenugreek seed extract (total fiber 35%) | 300 | 60.00％ |
| Folium Mori extract (total flavones 10%) | 100 | 20.00％ |
| Radix Astragali extract | 100 | 20.00％ |
| Add up to | 500 | 100.00％ |
Embodiment four
A kind of sugar decreasing composition of fenugreek seed adopts fenugreek seed extract, Folium Mori extract, Radix Astragali extract, forms by following weight proportion:
| Fenugreek seed extract (total fiber 30%) | 320 | 49.23％ |
| Folium Mori extract (total flavones 7.5%) | 180 | 27.69％ |
| Radix Astragali extract | 150 | 23.08％ |
| Add up to | 650 | 100.00％ |
Embodiment five
A kind of sugar decreasing composition of fenugreek seed adopts fenugreek seed extract, Folium Mori extract, Radix Astragali extract, forms by following weight proportion:
| Fenugreek seed extract (total fiber 40%) | 400 | 54.79％ |
| Folium Mori extract (total flavones 15%) | 150 | 20.55％ |
| Radix Astragali extract | 180 | 24.66％ |
| Add up to | 730 | 100.00％ |
Claims (5)
1, a kind of sugar decreasing composition of fenugreek seed is characterized in that being made up of following composition by weight percentage: fenugreek seed extract 30-90%, Folium Mori extract 5-40%, Radix Astragali extract 3-30%.
2. a kind of sugar decreasing composition of fenugreek seed according to claim 1 is characterized in that: above-mentioned fenugreek seed extract, contain total fiber 1-80%.
3. a kind of sugar decreasing composition of fenugreek seed according to claim 1 is characterized in that: above-mentioned Folium Mori extract, contain total flavones 0.1-50%.
4. a kind of sugar decreasing composition of fenugreek seed according to claim 1 is characterized in that: above-mentioned Radix Astragali extract, be the water extract or the extractive with organic solvent of the Radix Astragali, or the water of the Radix Astragali and extractive with organic solvent.
5. according to claim 1,2,3,4 described a kind of sugar decreasing composition of fenugreek seed, it is characterized in that: above-mentioned compositions can be made any peroral dosage form on pharmaceutics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100427883A CN100467046C (en) | 2005-06-09 | 2005-06-09 | Sugar decreasing composition of fenugreek seed |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100427883A CN100467046C (en) | 2005-06-09 | 2005-06-09 | Sugar decreasing composition of fenugreek seed |
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| CN1720982A true CN1720982A (en) | 2006-01-18 |
| CN100467046C CN100467046C (en) | 2009-03-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100427883A Expired - Fee Related CN100467046C (en) | 2005-06-09 | 2005-06-09 | Sugar decreasing composition of fenugreek seed |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100360145C (en) * | 2005-08-25 | 2008-01-09 | 吉林大学 | Fenugreek seed extract and its preparing process and application |
| WO2010140165A1 (en) | 2009-06-01 | 2010-12-09 | Kumar Pawan Goel | A novel antidiabetic furostanolic saponin rich (fsr) fraction from fenugreek seeds |
| CN101336974B (en) * | 2008-08-07 | 2012-05-23 | 华中科技大学同济医学院附属同济医院 | Traditional Chinese medicine for reducing blood sugar and regulating lipid with overall regulation of body metabolism and preparation method thereof |
-
2005
- 2005-06-09 CN CNB2005100427883A patent/CN100467046C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100360145C (en) * | 2005-08-25 | 2008-01-09 | 吉林大学 | Fenugreek seed extract and its preparing process and application |
| CN101336974B (en) * | 2008-08-07 | 2012-05-23 | 华中科技大学同济医学院附属同济医院 | Traditional Chinese medicine for reducing blood sugar and regulating lipid with overall regulation of body metabolism and preparation method thereof |
| WO2010140165A1 (en) | 2009-06-01 | 2010-12-09 | Kumar Pawan Goel | A novel antidiabetic furostanolic saponin rich (fsr) fraction from fenugreek seeds |
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| Publication number | Publication date |
|---|---|
| CN100467046C (en) | 2009-03-11 |
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Granted publication date: 20090311 |