CN1709390A - Medicine for treating cold - Google Patents
Medicine for treating cold Download PDFInfo
- Publication number
- CN1709390A CN1709390A CN 200510043694 CN200510043694A CN1709390A CN 1709390 A CN1709390 A CN 1709390A CN 200510043694 CN200510043694 CN 200510043694 CN 200510043694 A CN200510043694 A CN 200510043694A CN 1709390 A CN1709390 A CN 1709390A
- Authority
- CN
- China
- Prior art keywords
- medicine
- powder
- dioxopromethazine
- days
- acetaminophen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses a medicine for curing common cold with obvious therapeutic effect. Said medicine is made up by using (by weight portion) 10-1000 portion of acetaminophen, 1-100 portions of pseudoephedrine hydrochloride, 0.1-10 portions of dioxopromethazine, 5-500 portions of vitamin C and 20-2000 portions of extrace powder of any one of isatis root and isatis leaf or their mixture.
Description
Technical field
The present invention relates to a kind of coldrex, belong to medicine.
Background technology
Flu is a kind of commonly encountered diseases, and about the general 3-7 of the course of disease days, severe patient can reach more than 1 month, can cause tonsillitis, bronchitis, pneumonia etc.The medicine of treatment flu at present divides Western medicine and Chinese medicine, Western medicine instant effect, but cure the symptoms, not the disease, and it is big to take toxic and side effects for a long time; Chinese medicine is longer the course of treatment, and the patient often thinks ineffective and abandon that delay treatment very easily causes PD, causes various flu complication midway.The patient who has now also gets used to Western medicine, Chinese medicine is taken together, but often be from writing out a prescription " nontoxic drink of a lot, Chinese medicine of various tablets ", not only trouble more, sometimes also can be because of interacting between the medicine, and the treatment of the state of an illness is played very bad influence.
Summary of the invention
Purpose of the present invention is intended to overcome the shortcoming of prior art, provides a kind of therapeutic effect good, the bonded coldrex of the Chinese medicine and western medicine of instant effect.
The objective of the invention is to be achieved through the following technical solutions, a kind of coldrex, be characterized in, it is made by the following weight proportion raw material: acetaminophen 10-1000 part, pseudoephedrine hydrochloride 1-100 part, dioxopromethazine 0.1-10 part, vitamin C 5-500 part, extract powder 20-2000 part of any one or two kinds of mixture in Radix Isatidis, the Folium Isatidis.
Each component optimum proportion scheme of the present invention is: 400 parts of acetaminophen, 40 parts of pseudoephedrine hydrochlorides, 2 parts of dioxopromethazine, 100 parts of vitamin Cs, 400 parts of the extract powders of any one or two kinds of mixture in Radix Isatidis, the Folium Isatidis.
The pharmacological property of each component is in the medicament of the present invention:
Acetaminophen, white crystals or crystalline powder, odorless, mildly bitter flavor is an antipyretic analgesic fast and effectively, and it can suppress the synthetic of prostaglandin, produce analgesic effect by maincenter and periphery, produce refrigeration function by the thermotaxic centre that acts on hypothalamus; Clinical headache, heating and the multiple pain of being mainly used in also is applicable to the caused headache of common cold and viral infection, throat pain, heating and general malaise.
Pseudoephedrine hydrochloride, white crystal or crystalline powder, odorless, bitter in the mouth is Beta-3 adrenergic receptor agonists, optionally shrinks the upper respiratory tract mucosa blood capillary, alleviates nose, pharyngeal mucosa hyperemia, alleviates symptoms such as nasal obstruction, watery nasal discharge.
Dioxopromethazine has another name called dioxopromethazine, white or micro-yellow powder or crystalline powder, odorless, bitter in the mouth.Have stronger antitussive effect, and have anti-resistance amine, releasing smooth muscle spasm, antiinflammatory drawn game anaesthetic effect.Clinical practice can antitussive, relieving asthma, antiallergic, alleviates symptoms such as cough, asthma uncomfortable in chest, itching of the throat, rhinocnesmus, sneeze, can be used for treating chronic bronchitis, allergic asthma, allergic bronchitis etc.Do not see drug resistance and addiction.
Vitamin C has another name called ascorbic acid, when human body lacks, easily causes various anemias, aphtha, flu etc.Replenish the resistance that dimension C energy enhancing body infects antibacterial, virus etc. during flu.
Radix Isatidis, Folium Isatidis are root and the leaf of same plant, and bitter in the mouth is cold, GUIXIN, stomach warp.Both act on similar, and heat-clearing and toxic substances removing, antiviral cure cold, and various bacteria (as bacillus subtilis, staphylococcus aureus etc.) is all had certain inhibitory action.Clinically be usually used in treating laryngopharynx swelling and pain that flu causes, tonsillitis, bronchitis, pneumonia etc.
The present invention compares with existing coldrex, the most tangible advantage is that prescription adopts the Chinese medicine and western medicine combination, it is analgesic to carry out pain relieving by western medicine composition mediator somatic nervous system wherein, antitussive and antiasthmatic, alleviate nasal obstruction, symptoms such as pharyngeal congestion swells and ache, Chinese medicine ingredients such as essential dimension C of body metabolism and Radix Isatidis have been added again, start with from improving autoimmunity, strengthen human body to antibacterial, the resistance that virus etc. infect, treating both the principal and secondary aspects of a disease, short treating period, instant effect, do not contain PPA (phenylpropanolamine) in the component, caffeine and morphine class medicine, toxic and side effects is little, can not produce drug dependence.Good effect of the present invention, cost are very cheap, are a kind of ideal coldrexs.
Provide embodiment and clinical observation material that the present invention is explained further below.
The specific embodiment
Embodiment 1, get finished product acetaminophen powder 10kg, pseudoephedrine hydrochloride powder 1kg, dioxopromethazine powder 0.1kg, vitamin C 5kg, the Folium Isatidis extract powder 20kg (making of extract powder, be the herbal pharmaceutical conventional process), mix homogeneously, pharmaceutical technology is made tablet routinely, every 0.5g, dress box packing.
Embodiment 2, get finished product acetaminophen powder 1000kg, pseudoephedrine hydrochloride powder 100kg, dioxopromethazine powder 10kg, vitamin C 500kg, Folium Isatidis and Radix Isatidis (herb) extract powder 2000kg, mix homogeneously, pharmaceutical technology is made capsule routinely, every 0.5g, dress box packing.
Embodiment 3, get finished product acetaminophen powder 50kg, pseudoephedrine hydrochloride powder 10kg, and dioxopromethazine powder 1kg, vitamin C 20kg, Radix Isatidis extract powder 100kg, mix homogeneously, pharmaceutical technology is made tablet routinely, every 0.5g, dress box packing.
Embodiment 4, get finished product acetaminophen powder 500kg, pseudoephedrine hydrochloride powder 60kg, dioxopromethazine powder 5kg, vitamin C 200kg, Folium Isatidis and Radix Isatidis (herb) extract powder 1000kg, mix homogeneously, pharmaceutical technology is made capsule routinely, every 0.5g, dress box packing.
Embodiment 5, get finished product acetaminophen powder 400kg, pseudoephedrine hydrochloride powder 40kg, dioxopromethazine powder 2kg, vitamin C 100kg, Folium Isatidis and Radix Isatidis (herb) extract powder 400kg, mix homogeneously, pharmaceutical technology is made tablet routinely, every 0.5g, dress box packing.
Embodiment 6, get finished product acetaminophen powder 200kg, pseudoephedrine hydrochloride powder 20kg, dioxopromethazine powder 1kg, vitamin C 50kg, Folium Isatidis and Radix Isatidis (herb) extract powder 2000kg, mix homogeneously adds adjuvants such as an amount of sugar, dextrin, and pharmaceutical technology is made electuary routinely, every bag 10g, dress box packing.
The clinical observation on the therapeutic effect data:
One, treatment target:
The flu patient that common cold, influenza multiple reasons such as (viral influenza) cause mainly shows as heating, headache, nasal obstruction, rhinorrhea, cough, laryngopharynx swelling and pain etc.
Two, Therapeutic Method:
In, patients with mild, the each 2-3 grain of tablet (or capsule), or each 1 bag of electuary, every day three times, three days is a course of treatment; Cough the patient with severe symptoms of yellow sticking expectorant, abundant expectoration, add with antibiotic and give anti-inflammatory treatment.The child, according to age and state of an illness weight, decrement is taken.
Three, curative effect determinate standard:
1, recovery from illness: various cold symptoms obviously disappear, and drug withdrawal was not recurred about three days;
2, take a turn for the better: various cold symptoms alleviate more than 1/2;
3, invalid: various diseases are not seen improvement.
Four, case is selected:
The clinical use of this prescription is treated the over thousands of people of various patients for many years, now randomly draws patient's 100 examples in the year, and the age is between 5-70 year, male's 50 examples, women's 50 examples.
Five, model case:
Case 1, open * *, the woman, 40 years old, on January 20 2002 first visit date, dizzy heavy, 38.4 ℃ of body temperature were ached all over, slight cough, no expectorant, the state of an illness is in a couple of days.Take our tablet, each 3, every day 3 times, serve on three days after further consultation, patient's spirit is very good, various cold symptoms all disappear, and accuse it after the inquiring and reduce by half and take drug withdrawal two days later, note warmingly, observe nearly Zhou Weijian flu and recur.
Case 2, in *, the woman, 12 years old, April 6 2002 first visit date, influenza, laryngopharynx swelling and pain, cough, nasal obstruction, 39 ℃ of body temperature were taken contac two days, the commentaries on classics of not getting better.Take our electuary, each 1 bag, every day 3 times, further consultation after serveing on three days, pharyngeal the swelling and ache of patient disappears substantially, do not cough, flow a little clear nasal mucus, body temperature is normal, advises it to take three days again, each 1 bag, every day 2 times, further consultation once more after the drug withdrawal, cold symptoms all disappear, and observe and a week do not see recurrence.
Case 3, in * *, man, 38 years old, April 8 2002 first visit date, influenza, distending pain in the head, nasal obstruction, general malaise, 38.7 ℃ of body temperature.Take our tablet, each 3, serve on three days every day 3 times, patient's headache disappears substantially, the BITONG snivel, body temperature is normal, took medicine again three days, further consultation, the health recovery from illness is observed and a week is not seen recurrence.
Case 4, Yao * *, the man, 43 years old, on June 30 2002 first visit date, the sleep of windowing cool evening was coveted in readme, and wind is caught a cold, headache, nasal obstruction, laryngopharynx swelling and pain is coughed sticking yellow sputum, and is uncomfortable from head to foot, takes temperature 38.8 ℃, do not eat any coldrex.Take our tablet, each 3, add antibiotic every day 3 times, serve on three days after further consultation, the various cold symptoms of patient obviously alleviate, and bring down a fever, headache disappears, watery nasal discharge, expectorant is few.Took this medicine more continuously three days, cough stops, and pharyngeal inflammation disappears, after add this medicine electuary again, every day 1, bag checked that two days later health recovers fully.
Case 5, Mrs Ding, 22 years old, October 5 2002 first visit date.Have a high fever when examining, take temperature 39.3 ℃, headache, the tonsil redness, the discomfort of one felting all fagged out is felt sick anorexia.Take our tablet, each 3, add antibiotic every day 3 times, serve on three days after, the patient feels well, body temperature is reduced to 37 ℃, brings down a fever substantially, headache alleviates, pharyngeal inflammation phenomenon take a favorable turn, but swallow thing still feel the difficulty.Continued this medicine of clothes and antibiotic three days again, pharyngeal inflammation complete obiteration during further consultation, physical rehabilitation is not seen other cold symptoms, observes and a week does not see recurrence.
Case 6, Lee * *, the man, 69 years old, 2002 first visit dates December 29 days had chronic bronchitis history and asthma 8 years, catch a cold recently, laryngopharynx swelling and pain, cough is frequent, yellow sputum is arranged, 37.8 ℃ of body temperature.Take our tablet, each 3, add antibiotic every day 3 times, to take medicine two days later, cough promptly alleviates, and takes medicine continuously two days later again, and cough stops substantially, and pharyngeal detumescence has a small amount of expectorant.Cut out antibiotic, take this medicine electuary again, each 1 bag, every day 2 times, further consultation after three days, cold symptoms does not have, observes and a week does not see recurrence.
Six, therapeutic outcome statistical table:
| Case | The example number | Recovery from illness | Take a turn for the better | Invalid | Total effective rate |
| Common cold | ????42 | ????29 | ????12 | ????1 | ????97.6％ |
| Influenza (viral influenza) | ????58 | ????38 | ????18 | ????2 | ????96.6％ |
| Amount to | ????100 | ????67 | ????30 | ????3 | ????97％ |
Seven, contrast experiment
Use prescription of the present invention and existing medicine commonly used such as contac, paracetamol, GANKANG/KUAIKE (component is identical), compound paracetamol and zinc gluconate tablets, paracetamol etc. to carry out the clinical treatment experiment, time is selected in the winter, catches a cold prone period in two seasons of spring, the flu patient amounts to 300 people, age is at 5-70 between year, be divided into 6 groups, every group 50 people, state of an illness weight, age, sex ratio are roughly suitable, take this prescription and above-mentioned several drugs (paracetamol is once taken 1 half) by usual amounts respectively, observe the treatment situation after 72 hours:
1, recovery from illness: cold symptoms such as heating, headache, nasal obstruction, cough, laryngopharynx swelling and pain disappear, and recurrence was not seen in drug withdrawal in three days;
2, produce effects: original various flu diseases obviously alleviate:
3, invalid: various diseases are not seen improvement substantially.
By above statistical data as can be seen, take the cure rate that the experimental group effective percentage of medicament of the present invention reaches after 98%, 72 hour and reach 68%, all apparently higher than matched group.
Claims (3)
1, a kind of coldrex, it is characterized in that, it is made by the following weight proportion raw material: acetaminophen 10-1000 part, pseudoephedrine hydrochloride 1-100 part, dioxopromethazine 0.1-10 part, vitamin C 5-500 part, extract powder 20-2000 part of any one or two kinds of mixture in Radix Isatidis, the Folium Isatidis.
2, according to the described a kind of coldrex of claim 1, it is characterized in that, each set of dispense ratio content is: acetaminophen 50-500 part, pseudoephedrine hydrochloride 10-60 part, dioxopromethazine 1-5 part, Catergen 0-200 part, extract powder 100-1000 part of any one or two kinds of mixture in Radix Isatidis, the Folium Isatidis.
According to the described a kind of coldrex of claim 1, it is characterized in that 3, each set of dispense ratio content is: 400 parts of acetaminophen, 40 parts of pseudoephedrine hydrochlorides, 2 parts of dioxopromethazine, 100 parts of vitamin Cs, 400 parts of the extract powders of any one or two kinds of mixture in Radix Isatidis, the Folium Isatidis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100436948A CN1331485C (en) | 2005-05-31 | 2005-05-31 | Medicine for treating cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100436948A CN1331485C (en) | 2005-05-31 | 2005-05-31 | Medicine for treating cold |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1709390A true CN1709390A (en) | 2005-12-21 |
| CN1331485C CN1331485C (en) | 2007-08-15 |
Family
ID=35705722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100436948A Expired - Fee Related CN1331485C (en) | 2005-05-31 | 2005-05-31 | Medicine for treating cold |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1331485C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111632065A (en) * | 2020-06-19 | 2020-09-08 | 韩译萱 | Antipyretic formula |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208063C (en) * | 2002-10-25 | 2005-06-29 | 张善良 | Chemical mixture and its use |
-
2005
- 2005-05-31 CN CNB2005100436948A patent/CN1331485C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111632065A (en) * | 2020-06-19 | 2020-09-08 | 韩译萱 | Antipyretic formula |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1331485C (en) | 2007-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1843499A (en) | Traditional Chinese medicine formulation for treating bronchitis and tonsillitis | |
| CN1251763A (en) | Process for preparing Chinese medicine 'Qianjin tablets' for treating gynopathy | |
| CN103211997A (en) | Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof | |
| CN101683420B (en) | Applications of traditional Chinese medicine composition in preparation of medicament for treating acute pharyngitis | |
| CN100512850C (en) | Lung heat-cleaning throat-moistening cough-relieving syrup | |
| CN101564458B (en) | Application of Chinese medicinal composition in preparing medicament for treating bronchitis | |
| CN100333770C (en) | Medicine for preventing and curing laryngolaryngitis and its preparation method | |
| CN103211901A (en) | Lung clearing and inflammation diminishing medicament and preparation method thereof | |
| CN1374126A (en) | Medicine for clearing away heat and toxic material and its prepn | |
| CN108704058B (en) | Composition for treating pharyngitis and preparation method and application thereof | |
| CN1331485C (en) | Medicine for treating cold | |
| CN1883678A (en) | Medicine for treating infants cough and preparation method thereof | |
| CN1150927C (en) | Stomatopathy and throat disease treating health care medicine and its production process | |
| CN1748731A (en) | Compound preparation for cough and sputum and its preparing method | |
| CN1293881C (en) | Compound antitussive | |
| WO2003090749A1 (en) | Use of berberine with high solubility in preparation of medicament | |
| CN1233408C (en) | Tablet medicine for treating pharyngolaryngitis and its preparation method | |
| CN115252724B (en) | Traditional Chinese medicine composition for treating pharyngitis, product and preparation method | |
| CN1188129C (en) | Pectoral | |
| CN109568428B (en) | Yongquan plaster for children | |
| CN106491692A (en) | A kind of coldrex | |
| CN1895604A (en) | Antasthmatic | |
| WO2007059649A1 (en) | Chinese pharmaceutical compositions for treating upper respiratory tract infection and processes for preparation thereof | |
| CN1876075A (en) | A medicine for treating asthma, acute and chronic bronchitis and preparation method thereof | |
| CN104353053A (en) | Traditional Chinese medicine composition for treating swine mycoplasmal pneumonia and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |