CN1704099A - Urination disturbance eliminating drop pills and its preparation method - Google Patents

Abstract

The invention relates to a urination disturbance eliminating drop pills and its preparation method, which is prepared by using Chinese pink herb, knotgrass, clematis stem, plantain seeds (salt baked), talcum, cape jasmine, rhubarb horsetails and baked licorice root extracts as the active constituents, using gelatin glycerin as the base material, comminuting the active constituents and charging into molten base material, stirring to dissolve, keeping the temperature at 60-65 deg. C, instilling into fluid wax, condensing into drop pills, erasing fluid wax and drying.

Description

The clear drop pill and preparation method thereof that drenches

Technical field

The present invention relates to a kind of pure Chinese medicinal preparation, particularly a kind of preparation of clear pouring Chinese patent medicine improves, and is a kind of new clear pouring drop pill.The invention still further relates to the preparation method of above-mentioned drop pill.

Background technology

'Qinglin ' have up till now drench clearly electuary, clearly drench granule, drench dosage form such as capsule clearly, have clearing away heat-fire, the function of relieving stranguria by diuresis cures mainly damp-heat in the urinary bladder, the puckery pain of frequent micturition, it is not smooth to drench drop, the difficulty in urination is obstructed, little distention and fullness in the abdomen, diseases such as dry mouth and throat.

Up to the present advantages such as drop pill is the pill made from dropping preparation method, and drop pill is made with solid dispersion method as a kind of novel form, and it is short to have molten diffusing time, is beneficial to absorption, and the performance drug effect is rapid, and find no this dosage form are applied in the 'Qinglin '.

Summary of the invention

The object of the present invention is to provide a kind of clear pouring drop pill, the dosage form of 'Qinglin ' is improved, improve the bioavailability of 'Qinglin ', reduce adjuvant, reduce production costs.

Clear pouring drop pill of the present invention is that the extract of distinguishing the flavor of medical materials with Herba Dianthi, Herba Polygoni Avicularis, Caulis Akebiae, Semen Plantaginis (salt stir-fry), Talcum, Fructus Gardeniae, Radix Et Rhizoma Rhei, Radix Glycyrrhizae (processing) etc. above eight is an effective ingredient, with gelatin glycerol is substrate, effective ingredient is pulverized in the substrate that adds fusing, after the stirring and dissolving, keep under 60-65 ℃ the constant temperature, splash in the liquid paraffin, be condensed into drop pill, wipe the liquid paraffin drying and make.Wherein 1000 balls need Herba Dianthi 35g, Herba Polygoni Avicularis 35g, Caulis Akebiae 35g, Semen Plantaginis (salt stir-fry) 35g, Talcum 35g, Fructus Gardeniae 35g, Radix Et Rhizoma Rhei 35g, Radix Glycyrrhizae (processing) 35g, need gelatin 12g, glycerol 37g, purified water 16g.

The method that the present invention is used to prepare above-mentioned clear pouring drop pill may further comprise the steps:

The effective ingredient of a, the above eight flavor medical materials of extraction: above eight flavors decoct with water each 1 hour three times, collecting decoction filters, and filtrate is concentrated into 1: 1.5, adding ethanol makes and contains alcohol amount and reach 65%, fully stir, placed 4 hours, filter, merge with above-mentioned filtrate, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.28-1.30 (80 ℃), drying under reduced pressure, and it is standby to be ground into fine powder.

The preparation of b, gelatin glycerol substrate: take by weighing gelatin, glycerol, purified water in proportion, earlier with in the purified water addingization glue jar, be warmed up to 30 ℃ with glycerol adding and stirring, when temperature is raised to 40 ℃, will be heated to 70-80 ℃, mix homogeneously in the gelatin adding jar, fusion, be incubated 2 hours, make the foam come-up, defoam, filter heat preservation for standby use.

C, the eight flavor medicinal substances extract fine powders that step a is obtained join step b in the stand-by gelatin glycerol substrate of melting and heat preservation, after the stirring and dissolving, remain under 60 ℃ the condition, and the system of dripping goes in the liquid paraffin to be condensed into drop pill, wipes the liquid paraffin drying and makes.

The clear pouring drop pill of the invention described above is owing to used solid dispersion method, and drop pill substrate is little with medicine fusion post gap, has reduced medicine and air contact area, makes effective ingredient avoid air influence and reduces stability.The molten diffusing speed of this drop pill is fast, active component bioavailability height.

The specific embodiment

To prepare drop pill 1000 balls of the present invention is that example describes:

Take by weighing Herba Dianthi 35g, Herba Polygoni Avicularis 35g, Caulis Akebiae 35g, Semen Plantaginis (salt stir-fry) 35g, Talcum 35g, Fructus Gardeniae 35g, Radix Et Rhizoma Rhei 35g, Radix Glycyrrhizae (processing) 35g.With above eight flavors, decoct with water three times, each 1 hour, add water 2800g for the first time, second, third time respectively adds water 2240g, and collecting decoction filters, and filtrate is concentrated into 1: 1.5, add ethanol and make and contain the alcohol amount and reach 65%, fully stir, placed 24 hours, filter, it is an amount of that precipitation adds 65% ethanol again, fully stirs, placed 4 hours, and filtered, merge with above-mentioned filtrate, decompression recycling ethanol also is concentrated into the clear paste of relative density 1.28-1.30 (80 ℃), 80-90 ℃ of drying under reduced pressure, and it is standby to be ground into fine powder.

Preparation gelatin glycerol substrate takes by weighing gelatin 12g respectively, glycerol 37g, purified water 16g earlier with in the purified water addingization glue jar, is warming up to 30 ℃ with glycerol adding and stirring, in when temperature rises to 40 ℃, gelatin being added jar and be heated to 70-80 ℃, mix homogeneously, fusion is incubated 2 hours, make the foam come-up, defoam, filter heat preservation for standby use.

Above-mentioned eight flavor medicinal substances extract fine powders are joined in the gelatin glycerol substrate of 60 ℃ of insulations, after the stirring and dissolving, keep following of 60 ℃ of conditions to make in 10-17 ℃ the liquid paraffin, make it to form drop pill.Wipe the outer liquid paraffin of drop pill, just made clear pouring drop pill of the present invention in 24 hours in drying below 40 ℃ again.

Through overtesting, the molten diffusing speed of the drop pill of the invention described above is greater than granule and capsule, and bioavailability also improves a lot.And the mode of production of the present invention can not produce pollution, does not need complex apparatus, and cost is lower.

Claims (3)

1, a kind of clear pouring drop pill is characterized in that: its be with Herba Dianthi, Hold, the extracts of above eight flavor medical materials such as Caulis Akebiae, Semen Plantaginis (salt stir-fry), Talcum, Fructus Gardeniae, Radix Et Rhizoma Rhei, Radix Glycyrrhizae (processing) are effective ingredient, with gelatin glycerol is substrate, effective ingredient is pulverized in the substrate that adds fusing, after the stirring and dissolving, keep under 60-65 ℃ the constant temperature, splash in the liquid paraffin, be condensed into drop pill, wipe the liquid paraffin drying and make.

2, clear pouring drop pill according to claim 1 is characterized in that: every system 1000 balls, need Herba Dianthi 35g,

Hold 35g, Caulis Akebiae 35g, Semen Plantaginis (salt stir-fry) 35g, Talcum 35g, Fructus Gardeniae 35g, Radix Et Rhizoma Rhei 35g, Radix Glycyrrhizae (processing) 35g, need gelatin 12g, glycerol 37g, purified water 16g.

3, a kind of method for preparing the described clear pouring drop pill of claim 1 is characterized in that comprising the steps:

A, the active ingredient of extracting above eight flavor medical materials: above eight flavors decoct with water each 1 hour three times, collecting decoction filters, and filtrate was concentrated to 1: 1.5, adding ethanol makes and contains alcohol amount and reach 65%, fully stir, placed 4 hours, filter, merge with above-mentioned filtrate, decompression recycling ethanol also is concentrated into the clear paste that relative density is 1.28-1.30 (80 ℃), drying under reduced pressure, and it is standby to be ground into fine powder.

The preparation of b, gelatin glycerol substrate: take by weighing gelatin, glycerol, purified water in proportion, earlier with in the purified water addingization glue jar, be warmed up to 30 ℃ with glycerol adding and stirring, when temperature is raised to 40 ℃, will be heated to 70-80 ℃, mix homogeneously in the gelatin adding jar, fusion, be incubated 2 hours, make the foam come-up, defoam, filter heat preservation for standby use.

C, the eight flavor medicinal substances extract fine powders that step a is obtained join step b in the stand-by gelatin glycerol substrate of melting and heat preservation, after the stirring and dissolving, remain under 60 ℃ the condition, and the system of dripping goes in the liquid paraffin to be condensed into drop pill, wipes the liquid paraffin drying and makes.