CN101095711A - The extracting of chrysanthemum rice extracts and the method for making the preparations thereof - Google Patents
The extracting of chrysanthemum rice extracts and the method for making the preparations thereof Download PDFInfo
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- CN101095711A CN101095711A CNA200610028335XA CN200610028335A CN101095711A CN 101095711 A CN101095711 A CN 101095711A CN A200610028335X A CNA200610028335X A CN A200610028335XA CN 200610028335 A CN200610028335 A CN 200610028335A CN 101095711 A CN101095711 A CN 101095711A
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- chrysanthemum indicum
- resin
- hpd
- total
- purification process
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Abstract
The invention relates to a method for purifying chrysanthemum chromocor by using resin, which comprises following steps: feeding chrysanthemum extract to macroporous resin, washing, collecting washing liquid, condensing, drying and getting purified chrysanthemum chromocor. The method is simple and fast. The absorption capacity and desorption rate of macroporous resin are large. The invention takes ethanol as solvent, which is cheap and non-toxic. The chrysanthemum extract can be produced into capsule, tablet, particle, pill, drop, oral liquid and injection, and etc.
Description
Technical field
The extract that the present invention relates to a kind of extraction of plant extract and separation method and obtain with this method is the preparation that main effective ingredient is made, be specifically related to Jumi extract macroporous resin separation and purification, and separate the mixture that obtains as effective ingredient with this method, any patent medicine preparation of making according to conventional method.
Technical background
" augmentation Compendium of Materia Medica " record: Chrysanthemum indicum, Chuzhou go out Herba Dendranthematis indici in a kind of mountain, and very fragrant and clear circle Huang is bright.Cloud: the furuncle that relieves internal heat, looses, dispel the wind, relieve inflammation or internal heat that to make eye bright be the first, produce Suichang stone and practice the mountain.Find that after testing Chrysanthemum indicum contains multiple bioactive ingredients such as Chrysanthemum indicum lactone, flavonoid, volatile oil, terpenoid, soap class, protein, aminoacid, need a kind of extractive technique to prepare, be the healthy service of the mankind.
Summary of the invention
The present invention be with macroreticular resin absorbing method with the Chrysanthemum indicum extracting solution through resin upper prop, eluting, collection eluent, concentrate, dry, obtain the Chrysanthemum indicum total flavones of purification, resulting mixture is made any patent medicine preparation according to the formulation method of routine.
Chrysanthemum indicum total flavones preparation method is:
1, gets Chrysanthemum indicum alcohol extraction or water and carry extract, 0.5-20 with resin and extraction medical material total amount: the ratio upper prop of 1-10,2-30 pure water eluting doubly with Chrysanthemum indicum medical material weight discards water elution liquid, reuse Chrysanthemum indicum medical material weight 2-30 10-99% ethanol elution doubly, elution flow rate 1BV/h-4BV/h, collect ethanol elution, reclaim ethanol, drying, be ground into fine powder, standby.Adopt gained purification thing of the present invention, it is 50% described according to above-mentioned technology that the percentage composition that the total flavones percentage composition accounts for total extract is not less than, gained purification thing, formulation method according to routine can be made into any patent medicine preparation, comprise capsule, tablet, granule, pill, drop pill, oral liquid, injection or the like, have lung moistening relieve internal heat, dispel the wind diffusing furuncle, relieve inflammation or internal heat make eye bright, effect such as suppressing the hyperactive liver blood pressure lowering, tonifying YIN nourishing kidney, blood fat reducing, especially vision decline and hyperpietic are had splendid prevention and treatment function.But still do not have a kind of so far with the Chinese medicine preparation of Chrysanthemum indicum as main effective ingredient.
The specific embodiment
Below the present invention is further described
Embodiment 1
Preparation method:
(1) Chrysanthemum indicum 300g, with 3 times of amounts (mass ratio), 90% ethanol extraction 2 times, each 1.5 hours, merge extractive liquid, reclaimed ethanol, was concentrated into the extractum of density 1.20, and is standby;
(2) (1) residue that extracts is added 3 times of amounts (mass ratio) water extraction 2 times, each 1.5 hours, merge extractive liquid,, be evaporated to the extractum of relative density 1.20 below 60 ℃, add 75% ethanol alcohol and be sink to the alcohol amount of containing 60%, supernatant concentration is to the extractum of density 1.20, and is standby;
(3) with (1), (2) gained extractum mixing, with 1: 5 ratio upper prop of resin and extraction medical material total amount, 3 times pure water eluting with Chrysanthemum indicum medical material weight discards water elution liquid, 80% ethanol elution that reuse Chrysanthemum indicum medical material weight is 4 times, elution speed 2BV/h collects ethanol elution, reclaims ethanol, dry, pulverize, standby by this method gained mixture, the percentage composition that the total flavones percentage composition accounts for total extract is not less than 50%
With the gained mixture, fill is formed in the Capsules, promptly gets hard capsule.
Embodiment 2
Get Chrysanthemum indicum water and carry extract, 1: 4 ratio upper prop with resin and extraction medical material total amount, 4 times pure water eluting with Chrysanthemum indicum medical material weight discards water elution liquid, 95% ethanol elution that reuse Chrysanthemum indicum medical material weight is 4 times, elution flow rate 3BV/h, collect ethanol elution, reclaim ethanol, drying, be ground into fine powder, standby.Adopt gained purification thing of the present invention, the percentage composition that the total flavones percentage composition accounts for total extract is not less than 50%
With the gained mixture, it is standby to add an amount of solvent dissolving; Gelatin, glycerol, water are changed glue in proportion prepare the soft capsule skin, standby; Back fill soft capsule, is washed ball, drying, is picked up ball and promptly get soft capsule at cold wind typing.
Claims (9)
1. Chrysanthemum indicum total flavonoid resin purification process is characterized in that: with Chrysanthemum indicum extracting solution eluting, collection eluent, concentrated, dry, obtain the Chrysanthemum indicum total flavones of purification.
2. comprise D101, DA201, DM130, ELD-3, YPR-II, X5, AB-8, HPD-100, HPD-400, HPD-600, HPD-700, Dx-5, NKA-9 as the selected macroporous resin of claim 1.Wherein preferred macroporous resin is HPD-100, HPD-400, HPD-100 the best.
3. Chrysanthemum indicum total flavonoid resin purification process as claimed in claim 1 is characterized in that: with resin with extract the 0.5-20 of medical material total amount: the ratio upper prop of 1-10, preferred 1: 4-1: 5, optimum 1: 5.
4. Chrysanthemum indicum total flavonoid resin purification process as claimed in claim 1 is characterized in that: elution flow rate 1BV/h-4BV/h, preferred 1-3BV/h, best 2BV/h.
5. Chrysanthemum indicum total flavonoid resin purification process as claimed in claim 1 is characterized in that: eluant is organic alcohol, best ethanol.
6. Chrysanthemum indicum total flavonoid resin purification process as claimed in claim 1 is characterized in that: eluant eluting concentration is 10-99%, best 70-80%.
7. Chrysanthemum indicum total flavonoid resin purification process as claimed in claim 1 is characterized in that: the eluant volume is Chrysanthemum indicum medical material weight 2-30 times.Best 2-5 doubly.
8. Chrysanthemum indicum total flavonoid resin purification process as claimed in claim 1 is characterized in that: extract obtained, the percentage composition that the total flavones percentage composition accounts for total extract is not less than 50%.
9. described, extract obtained according to the described technology of claim 1, can be made into any patent medicine preparation according to the formulation method of routine, comprise capsule, tablet, granule, pill, drop pill, oral liquid, injection or the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610028335XA CN101095711A (en) | 2006-06-29 | 2006-06-29 | The extracting of chrysanthemum rice extracts and the method for making the preparations thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610028335XA CN101095711A (en) | 2006-06-29 | 2006-06-29 | The extracting of chrysanthemum rice extracts and the method for making the preparations thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101095711A true CN101095711A (en) | 2008-01-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200610028335XA Pending CN101095711A (en) | 2006-06-29 | 2006-06-29 | The extracting of chrysanthemum rice extracts and the method for making the preparations thereof |
Country Status (1)
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| CN (1) | CN101095711A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406504B (en) * | 2008-11-24 | 2011-06-22 | 浙江大学 | Method for extracting flavone substances in jumi |
| CN103432183A (en) * | 2013-09-13 | 2013-12-11 | 沈阳药科大学 | Polyphenol extract in callistephus chinensis and preparation method as well as application thereof |
-
2006
- 2006-06-29 CN CNA200610028335XA patent/CN101095711A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406504B (en) * | 2008-11-24 | 2011-06-22 | 浙江大学 | Method for extracting flavone substances in jumi |
| CN103432183A (en) * | 2013-09-13 | 2013-12-11 | 沈阳药科大学 | Polyphenol extract in callistephus chinensis and preparation method as well as application thereof |
| CN103432183B (en) * | 2013-09-13 | 2015-06-10 | 沈阳药科大学 | Polyphenol extract in callistephus chinensis and preparation method as well as application thereof |
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