CN105412186A - Extracting preparation method for traditional Chinese medicinal material containing volatile oil and composition of traditional Chinese medicinal material - Google Patents
Extracting preparation method for traditional Chinese medicinal material containing volatile oil and composition of traditional Chinese medicinal material Download PDFInfo
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- CN105412186A CN105412186A CN201410445244.0A CN201410445244A CN105412186A CN 105412186 A CN105412186 A CN 105412186A CN 201410445244 A CN201410445244 A CN 201410445244A CN 105412186 A CN105412186 A CN 105412186A
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Abstract
The invention belongs to the technical field of medicines and relates to an extracting preparation method for a traditional Chinese medicinal material containing volatile oil and a composition of the traditional Chinese medicinal material. The extracting preparation method comprises the following steps of extracting, concentrating, oil-liquid separating, concentration drying and the like. The extracting preparation method has the advantages that compared with a traditional volatile oil extracting technology, a volatile oil extracting device is not needed, steps for volatile oil extracting are reduced, the method is simple, the yield of volatile components is high, the extracting time is short, energy consumption is low, cost is low, and the extracting preparation method can further be used for extracting other traditional Chinese medicine containing rich grease components. The traditional Chinese medicine extract prepared through the extracting preparation method can be used for preparing tablets, granules, capsules, soft capsules, pills and drops of other forms.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of extraction preparation method of Chinese crude drug, in particular, is a kind of containing the Chinese crude drug of volatile oil and the extraction preparation method of compositions thereof.
Background technology
Volatile oil is a class active ingredient common in Chinese crude drug.Common with ter penoids in volatile oil component, in addition, still containing micromolecule aliphatic compound and micromolecule aromatic compound, have certain physiologically active, as eliminated the phlegm, cough-relieving, wind dispelling, diaphoresis, anthelmintic, the effect such as analgesia.Volatile oil is very wide in plant kingdom's distribution, especially comparatively common in the sections such as Compositae, Rutaceae, Umbelliferae, Zingiberaceae belong to.Mostly volatile oil is contained at the diaphoretic medicine, promoting flow of QI and blood medicine, aromatic damp resolving drug etc. of Chinese medicine.Clinically except applying the prepared slices of Chinese crude drugs containing volatile oil and being used as medicine, also directly use the volatile oil extracted from medical material, as Oleum menthae is used for wind dispelling, Oleum Ocimi Gratissimi is used for dental caries, patchouli oil and is used for delivering expelling summer-heat and appetizing preventing or arresting vomiting, Oleum Cinnamomi for dispelling-wind invigorating stomach, Oleum Viticis Negundo for chronic bronchitis etc.
In traditional extracting technique of Chinese medicine, to containing volatile oil Chinese crude drug extracting method mainly: after certain hour soaked by medical material, adopt the several decimal of extraction by steam distillation volatile oil, even tens hours, oil to be evaporated is carried to the greatest extent, medicinal residues are filtered, then adds water or other constituents of ethanol continuation extraction.Man-hour is long, and energy resource consumption is large, and will add volatile oil is drawn equipment on the basis of original extraction equipment, and many pharmaceutical factories do not reach requirement, this operation of volatile oil is drawn are saved, and directly decocts and extracts medical material, make loss of volatile oil very large.Also can by volatile oil is drawn out with high concentration ethanol, but in concentrate drying process afterwards, volatile oil volatilizees in a large number, and until when making finished product preparation, volatile oil remains little.These have all had a strong impact on the drug effect of Chinese patent medicine.
Summary of the invention
The object of this invention is to provide the extraction preparation method containing volatile oil Chinese crude drug and compositions thereof that a kind of method is simple, quick, cost is low, yield is high, extract for the production containing volatile oil Chinese medicine.
The present invention is achieved through the following technical solutions:
Volatile oil is insoluble in water, can be dissolved in dehydrated alcohol completely.In the aquiferous ethanol of various variable concentrations, solubilized is a certain amount of, and concentration of alcohol is less, and the amount that volatile oil dissolves is also fewer.Characteristic accordingly, will contain Chinese crude drug and compositions high concentration ethanol, merceration or the heating and refluxing extraction of volatile oil.Oil to be evaporated and other constituents extraction completely, reclaim ethanol.Because ethyl alcohol boiling point is low, gain quick return, and in removal process, volatile oil does not almost lose.When ethanol extraction recovery is concentrated into a certain degree (density 1.0 ~ 1.35g/ml), the methods such as employing is standing or centrifugal are by oil-water separation, and volatile oil concentrates on oil reservoir, and aqueous fraction can continue drying, obtains Chinese medicine extract.Volatile oil and aqueous fraction extract are merged, can be used for preparing the various dosage forms such as tablet, granule, capsule, soft capsule, drop pill.
The described high concentration ethanol extracting concentration that adds is 60 ~ 90%; Concentration of alcohol is preferably 70 ~ 80%.
Described alcohol extraction procedure can be the methods such as room temperature immersion, room temperature diafiltration, countercurrent extraction or heating and refluxing extraction.
The described method adding ethanol can be that atmospheric evaporation is concentrated, decompression rotary evaporation is concentrated, decompression thin film evaporation is concentrated or the method such as vacuum flashing is concentrated.
Being reclaimed by ethanol extraction is concentrated into a certain degree, is concentrated into density and is preferably 1.15 ~ 1.30g/ml.
Described water layer drying means can be the methods such as drying under reduced pressure, spraying dry, boiled bed drying.
The present invention extracts volatile oil by high concentration ethanol, eliminates steam distillation and puies forward this operation of volatile oil; By oil-water separation, avoid volatile oil in concentrate drying process and lose in a large number, thus realize the present invention.
Detailed description of the invention
Below by specific embodiment, the present invention will be further described, only for illustration of the present invention, do not limit the present invention.
embodiment 1
Rhizoma Chuanxiong power is broken into coarse powder, adds 75% ethanol room temperature immersion, reclaims ethanol, is concentrated into density 1.20g/ml, and leave standstill, profit layering, water layer drying under reduced pressure, obtains Rhizoma Chuanxiong oil and Rhizoma Chuanxiong extract.
With the principle active component ligustilide in Rhizoma Chuanxiong volatile oil for Testing index, investigate Rhizoma Chuanxiong volatile oil extraction ratio (see table 1):
Table 1 Rhizoma Chuanxiong volatile oil extraction ratio investigates result
embodiment 2
Cortex Moutan is ground into coarse powder, and add 90% alcohol heating reflux and extract, reclaim ethanol, be concentrated into density 1.25g/ml, leave standstill, profit layering, water layer drying under reduced pressure, obtains Paeonia suffruticosa haze wax and Cortex Moutan extract.
With the principle active component paeonol in Cortex Moutan volatile oil for Testing index, investigate volatile oil is drawn rate (see table 2):
Table 2 Cortex Moutan volatile oil is drawn rate investigates result
embodiment 3
Radix Angelicae Dahuricae 200g, Rhizoma Chuanxiong 200g, Herba Menthae 100g, Herba Schizonepetae 100g add 80% ethanol room temperature immersion, reclaim ethanol, are concentrated into density 1.15g/ml, and leave standstill, profit layering, water layer drying under reduced pressure, obtains oily and extract.
With the principle active component imperatorin in Essential Oil of Radix Angelicae Dahuricae for Testing index, investigate volatile oil is drawn rate (see table 3):
Table 3 Chinese crude drug mixture volatile oil is drawn rate investigates result
embodiment 4
Ramulus Cinnamomi, Semen Persicae, Cortex Moutan, each 100g of the Radix Paeoniae Alba, add 60% alcohol heating reflux and extract, be concentrated into density 1.30g/ml, leave standstill, profit layering, water layer drying under reduced pressure, obtains oily and extract.
With the principle active component cinnamic aldehyde in Ramulus Cinnamomi Volatile oil for Testing index, investigate volatile oil is drawn rate (see table 4):
Table 4 Chinese crude drug mixture volatile oil is drawn rate investigates result
Claims (8)
1. one kind contains the extraction preparation method of volatile oil Chinese crude drug and compositions thereof, it is characterized in that, comprise the steps: to be broken into coarse powder containing volatile oil Chinese crude drug and composition powder thereof, adding concentration is 60 ~ 90% ethanol extractions, filter, extracting solution reclaims ethanol, is concentrated into density 1.0 ~ 1.35g/ml, oil-water separation, obtains Chinese medicine extract.
2. method as claimed in claim 1, it is characterized in that, described concentration of alcohol is preferably 70 ~ 80%.
3. method as claimed in claim 1, it is characterized in that, described alcohol extraction procedure is selected from room temperature immersion, room temperature diafiltration, countercurrent extraction or heating and refluxing extraction.
4. method as claimed in claim 1, is characterized in that, described in add ethanol method be selected from that atmospheric evaporation is concentrated, decompression rotary evaporation is concentrated, decompression thin film evaporation is concentrated or vacuum flashing concentrates.
5. method as claimed in claim 1, it is characterized in that, described concentration densities is preferably 1.15 ~ 1.30g/ml.
6. method as claimed in claim 1, it is characterized in that, described oil-water separation method is selected from stratification method or centrifugal layering.
7. method as claimed in claim 1, it is characterized in that, described water layer drying means is selected from drying under reduced pressure, spraying dry, boiled bed drying.
8. method as claimed in claim 1, it is characterized in that, the Chinese medicine extract of described preparation is for the preparation of tablet, granule, capsule, soft capsule, drop pill.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410445244.0A CN105412186A (en) | 2014-09-03 | 2014-09-03 | Extracting preparation method for traditional Chinese medicinal material containing volatile oil and composition of traditional Chinese medicinal material |
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| CN201410445244.0A CN105412186A (en) | 2014-09-03 | 2014-09-03 | Extracting preparation method for traditional Chinese medicinal material containing volatile oil and composition of traditional Chinese medicinal material |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108077993A (en) * | 2017-12-18 | 2018-05-29 | 中科国思生物科技研究（广州）有限公司 | A kind of application of hawthorn in health care reconstituted tobacoo |
| CN108670983A (en) * | 2018-05-09 | 2018-10-19 | 江西德上制药股份有限公司 | Traditional Chinese medicine extraction method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002809A (en) * | 2007-01-19 | 2007-07-25 | 三峡大学 | Medicine preparation containing extractive of Zi-Jin-Sha, preparing method and use thereof |
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2014
- 2014-09-03 CN CN201410445244.0A patent/CN105412186A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002809A (en) * | 2007-01-19 | 2007-07-25 | 三峡大学 | Medicine preparation containing extractive of Zi-Jin-Sha, preparing method and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 谷晓慧: "艾草和薄荷挥发油提取方法及其构成成分的初步研究", 《价值工程》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108077993A (en) * | 2017-12-18 | 2018-05-29 | 中科国思生物科技研究（广州）有限公司 | A kind of application of hawthorn in health care reconstituted tobacoo |
| CN108670983A (en) * | 2018-05-09 | 2018-10-19 | 江西德上制药股份有限公司 | Traditional Chinese medicine extraction method |
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Application publication date: 20160323 |
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