CN108670983A - Traditional Chinese medicine extraction method - Google Patents
Traditional Chinese medicine extraction method Download PDFInfo
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- CN108670983A CN108670983A CN201810437166.8A CN201810437166A CN108670983A CN 108670983 A CN108670983 A CN 108670983A CN 201810437166 A CN201810437166 A CN 201810437166A CN 108670983 A CN108670983 A CN 108670983A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of Traditional Chinese medicine extraction method, it includes the following steps：（1）Medicinal material pre-processes；（2）It puts into extractor and adds water；（3）Alcohol is added；（4）It is extracted using reflux extraction；（5）To extracting solution water-oil separating；（6）Concentration；（7）It is dry；Present invention process method is novel, and the recovery rate of active ingredient in medicinal material can be improved in implementations by the method for the invention, and raising production efficiency in enterprise's continuous production is played an important role.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine more particularly to a kind of Traditional Chinese medicine extraction methods.
Background technology
The discussion in relation to Traditional Chinese medicine extraction method has much in recent years, however the recovery rate of active ingredient is still domestic now
The bottleneck of pharmaceutical industry of Chinese medicine modernization.Although recent year is proposed some new processes in traditional Chinese medicine extraction production, such as super
Sound field strengthens extraction, Microwave Extraction, supercritical fluid extraction etc., but mainstream instantly is still microwave leaching technology；In face of numerous Chinese medicines
It is that a complicated problem adds because it involves many factors such as production equipment and working condition that how extracting method, which chooses,
On nowadays traditional Chinese medicine extraction it is larger, be especially considering that continuous production, even if bearing fruit in an experiment, in practical situations
Also to pass through prolonged practice test.Also aforementioned novel technology for extracting, extract are often that chemical constitution is bright
True substance is entirely two entirely different things with traditional Chinese medicine production, so the producer of production traditional Chinese medicine can not make a decision, trial is new
Technique, the producer prefers to follow the trend, to avoid risk.
Invention content
It is an object of the invention to overcome the deficiencies in the prior art, adapt to reality and need, disclose a kind of Traditional Chinese medicine extraction method.
In order to achieve the object of the present invention, the technical solution adopted in the present invention is：
A kind of Traditional Chinese medicine extraction method is disclosed, it includes the following steps：
（1）Medicinal material pre-processes；
（2）It puts into extractor and adds water；
（3）Alcohol is added；
（4）It is extracted using reflux extraction；
（5）To extracting solution water-oil separating；
（6）Concentration；
（7）It is dry.
Preferably, step（1）In, medicinal material pretreatment includes：（1）By the section shape that pulverizing medicinal materials are the length of 3-10cm;
（2）Stirring, sprays into water and alcohol when stirring, and the gross mass of water and alcohol is the 20%-30% of medicinal material gross mass, by weight, alcohol and water
Ratio be 1:3-4；（3）It is sealed in the environment of 20 DEG C of -30 DEG C of degree being protected from light and stands -2 days 1 day.
Preferably, step（2）In, by weight, medicinal material：The ratio of water is 1:12-14；
Preferably, step（3）In, by weight, medicinal material：The ratio of alcohol is 1:0.02-0.08；
Preferably, step（4）In, when being extracted using reflux extraction, a. is heated to 40-50 DEG C of holding 30- first, to extractor
Extractor is then heated to 100-150 DEG C of progress refluxing extraction by 90min, b. in 1min；When refluxing extraction into extractor
Condensed water is sprayed into atomised form；The condensed water is the distilled water of room temperature.
Preferably, step（5）It is middle to carry out water-oil separating using oil water separator.
Preferably, the concentration is concentrated using evaporation and concentration or spherical vacuum.
Preferably, the drying uses boulton process.
Preferably, the step（1）、（2）In water be distilled water and PH be 6-7.
Preferably, the alcohol is methanol.
The beneficial effects of the present invention are：
Present invention process method is novel, and the recovery rate of active ingredient in medicinal material can be improved in implementation by the method for the invention, for
Production efficiency is improved in enterprise's continuous production to play an important role.
Specific implementation mode
With reference to embodiment, the present invention is further described：
Embodiment 1：A kind of Traditional Chinese medicine extraction method.
It includes the following steps：
（1）Medicinal material pre-processes：（1）By the section shape that pulverizing medicinal materials are the length of 3-10cm;（2）Stirring, when stirring, spray into
The gross mass of water and alcohol, water and alcohol is the 20%-30% of medicinal material gross mass, and by weight, the ratio of alcohol and water is 1:3-4；（3）It is close
It is encapsulated in the environment of 20 DEG C of -30 DEG C of degree being protected from light and stands -2 days 1 day；Medicinal material progress initial stage is soaked by water and alcohol, simultaneously
Active ingredient not soluble in water in medicinal material is extracted by alcohol, efficiently basis is provided for the later stage.
（2）It puts into extractor and adds water, by weight, medicinal material：The ratio of water is 1:12-14.
（3）Alcohol is added again；By weight, medicinal material：The ratio of alcohol is 1:0.02-0.08.
（4）It is extracted using reflux extraction；When being extracted using reflux extraction, a. is heated to 40-50 first, to extractor
DEG C keep 30-90min, to step（1）Consolidated, extractor is then heated to 100-150 DEG C in 1min and carried out by b.
Refluxing extraction sprays into condensed water when refluxing extraction into extractor with atomised form；The condensed water is the distilled water of room temperature.It is logical
The heating for spending short time in this step can avoid alcohol transition volatilization in solvent, in a short time by water, be dissolved in water and alcohol
Active ingredient carry out rapid extraction, meanwhile, improve the proportion of active ingredient in alcohol, improve the extraction efficiency in entire extraction.
（5）Water-oil separating is carried out using oil water separator, currently used water-oil separating can be used in this oily water separation technique
Device carries out.
（6）Concentration, this concentration are concentrated using currently used evaporation and concentration or spherical vacuum.
（7）Dry, the drying uses boulton process.
Further, above-described water is distilled water, and above-described alcohol is methanol.
Implementation through the above steps can extract the active ingredient in Chinese medicine, and the implementation of this method can carry
The recovery rate of active ingredient in high medicinal material.
Embodiment 2, place same as Example 1 repeat no more, the difference is that：
Step（1）In, the gross mass of water and alcohol is the 20% of medicinal material gross mass.
Step（1）In, by weight, the ratio of alcohol and water is 1:3.
Step（1）In, it is sealed in the environment for 20 DEG C of degree being protected from light and stands 1 day.
Step（2）In, by weight, medicinal material：The ratio of water is 1:12.
Step（3）In, by weight, medicinal material：The ratio of alcohol is 1:0.02.
Step（4）In, 40 DEG C of holding 30min are heated to extractor.
Step（4）In, extractor is heated to 100 DEG C in 1min.
Embodiment 3, place same as Example 1 repeat no more, the difference is that：
Step（1）In, the gross mass of water and alcohol is the 30% of medicinal material gross mass.
Step（1）In, by weight, the ratio of alcohol and water is 1:4.
Step（1）In, it is sealed in the environment for 30 DEG C of degree being protected from light and stands 2 days.
Step（2）In, by weight, medicinal material：The ratio of water is 1:14.
Step（3）In, by weight, medicinal material：The ratio of alcohol is 1:-0.08.
Step（4）In, 50 DEG C of holding 90min are heated to extractor.
Step（4）In, extractor is heated to 150 DEG C in 1min.
Embodiment 4, place same as Example 1 repeat no more, the difference is that：
Step（1）In, the gross mass of water and alcohol is the 23% of medicinal material gross mass.
Step（1）In, by weight, the ratio of alcohol and water is 1:3.3.
Step（1）In, it is sealed in the environment for 23 DEG C of degree being protected from light and stands 1.5 days.
Step（2）In, by weight, medicinal material：The ratio of water is 1:12.8.
Step（3）In, by weight, medicinal material：The ratio of alcohol is 1:0.04.
Step（4）In, 45 DEG C of holding 50min are heated to extractor.
Step（4）In, extractor is heated to 120 DEG C in 1min.
Embodiment 5, place same as Example 1 repeat no more, the difference is that：
Step（1）In, the gross mass of water and alcohol is the 28% of medicinal material gross mass.
Step（1）In, by weight, the ratio of alcohol and water is 1:3.8.
Step（1）In, it is sealed in the environment of 20 DEG C of -30 DEG C of degree being protected from light and stands 2 days.
Step（2）In, by weight, medicinal material：The ratio of water is 1:13.5.
Step（3）In, by weight, medicinal material：The ratio of alcohol is 1:0.07.
Step（4）In, 48 DEG C of holding 8min are heated to extractor.
Step（4）In, extractor is heated to 140 DEG C in 1min.
What the embodiment of the present invention was announced is preferred embodiment, and however, it is not limited to this, the ordinary skill people of this field
Member understands the spirit of the present invention easily according to above-described embodiment, and makes different amplification and variation, but as long as not departing from this
The spirit of invention, all within the scope of the present invention.
Claims (10)
1. a kind of Traditional Chinese medicine extraction method, it is characterised in that：It includes the following steps：
（1）Medicinal material pre-processes；
（2）It puts into extractor and adds water；
（3）Alcohol is added；
（4）It is extracted using reflux extraction；
（5）To extracting solution water-oil separating；
（6）Concentration；
（7）It is dry.
2. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：Step（1）In, medicinal material pretreatment includes：（1）It will
Pulverizing medicinal materials are the section shape of the length of 3-10cm;（2）Stirring, sprays into water and alcohol when stirring, and the gross mass of water and alcohol is medicinal material
The 20%-30% of gross mass, by weight, the ratio of alcohol and water is 1:3-4；（3）It is sealed in the environment of 20 DEG C of -30 DEG C of degree being protected from light
It is middle to stand -2 days 1 day.
3. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：Step（2）In, by weight, medicinal material：The ratio of water
Example is 1:12-14.
4. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：Step（3）In, by weight, medicinal material：The ratio of alcohol
Example is 1:0.02-0.08.
5. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：Step（4）In, it is extracted using reflux extraction
When, be heated to 40-50 DEG C of holding 30-90min, b. is then heated to 100- to a. in 1min by extractor first, to extractor
150 DEG C of progress refluxing extractions；Condensed water is sprayed into atomised form into extractor when refluxing extraction；The condensed water is room temperature
Distilled water.
6. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：Step（5）It is middle to carry out oil using oil water separator
Water detaches.
7. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：The concentration uses evaporation and concentration or spherical vacuum
Concentration.
8. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：The drying uses boulton process.
9. Traditional Chinese medicine extraction method as claimed in claim 2, it is characterised in that：The step（1）、（2）In water be distillation
Water and PH are 6-7.
10. Traditional Chinese medicine extraction method as described in claim 1, it is characterised in that：The alcohol is methanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810437166.8A CN108670983A (en) | 2018-05-09 | 2018-05-09 | Traditional Chinese medicine extraction method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810437166.8A CN108670983A (en) | 2018-05-09 | 2018-05-09 | Traditional Chinese medicine extraction method |
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| CN201810437166.8A Pending CN108670983A (en) | 2018-05-09 | 2018-05-09 | Traditional Chinese medicine extraction method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494983A (en) * | 2020-04-27 | 2020-08-07 | 梅州市康人保健食品有限公司 | Extraction method of traditional Chinese medicinal materials |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412186A (en) * | 2014-09-03 | 2016-03-23 | 天津药物研究院 | Extracting preparation method for traditional Chinese medicinal material containing volatile oil and composition of traditional Chinese medicinal material |
| CN105969526A (en) * | 2016-05-20 | 2016-09-28 | 中发实业集团业锐药业有限公司 | Extraction method of dalbergia odorifera volatile oil |
-
2018
- 2018-05-09 CN CN201810437166.8A patent/CN108670983A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412186A (en) * | 2014-09-03 | 2016-03-23 | 天津药物研究院 | Extracting preparation method for traditional Chinese medicinal material containing volatile oil and composition of traditional Chinese medicinal material |
| CN105969526A (en) * | 2016-05-20 | 2016-09-28 | 中发实业集团业锐药业有限公司 | Extraction method of dalbergia odorifera volatile oil |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494983A (en) * | 2020-04-27 | 2020-08-07 | 梅州市康人保健食品有限公司 | Extraction method of traditional Chinese medicinal materials |
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Application publication date: 20181019 |
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