CN1698869A - Mind easing oral liquor with gen-seng and lily bulb - Google Patents
Mind easing oral liquor with gen-seng and lily bulb Download PDFInfo
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Abstract
Disclosed is a mind-easing oral liquor with gen-seng and lily bulb for treating deficiency of qi and blood in the heart and spleen, wherein each 1000ml of the preparation contains the following Chinese medicinal ingredients, gen-seng 100g, polygala root 60g, astragalus root 100g, lily bulb 80g, Chinese angelica root 100g, grassleaved sweetflag rhizome 60g, root of red rooted saliva 100g, glutinous rehmannia 80g, poria cocos wolf 100g, and schisandra fruit 60g.
Description
Technical field
The invention belongs to and a kind ofly be applicable to treatment because of the cardiopalmus due to deficiency of both the heart and spleen, the deficiency of both vital energy and Yin, insomnia, dreaminess, dizzy weak, the pure Chinese medicinal preparation of diseases such as asthenia.
Background technology
Deficiency of both the heart and spleen, deficiency of both vital energy and Yin are the common diseases of tcm internal medicine, and its symptom mainly contains cardiopalmus, insomnia, and dreaminess, dizzy weak, asthenia etc.The degradation factor is relevant under internal metabolism obstacle that it lacks of proper care with rhythm of life quickening, the increase of working and learning pressure, overfatigue, prolonged illness, have a delicate constitution, Chronic consumptions causes and the resistance.The classical symptom that wherein sleep disorder is a deficiency of both the heart and spleen, deficiency of both vital energy and Yin produced, easily cause body immunity decline, emotion agitation and anxiety as untimely treatment, even cause serious consequences such as hypertension, neurasthenia, cordis and cerebral accident, psychological illness.
Before the present invention makes, treat this disease both at home and abroad, the calm class Western medicine of clinical general employing, for example stable, alprazolam etc., though these medicines have certain curative effect, side effect is bigger, common side effect has giddy, weak and drowsiness, heavy dose can cause ataxia, dyskinesia, and prolonged application can produce toleration, can cause dependency, so the patient is difficult to accept.
Along with the day by day approval of international community to natural drug, traditional Chinese medicine obtains people's attention and favor again, but it is also few in number to treat the pure tcm product of this disease in the market.Its representative kind is the ANSHEN BUNAO YE that Aodong, Jilin pharmaceutical factory produces, it is made up of Six-element medicines such as Cornu Cervi Pantotrichum, Radix Polygoni Multiflori Preparata, Herba Epimedii, Rhizoma Zingiberis, Radix Glycyrrhizae, Fructus Jujubaes, major function is that spermatogenesis is mended marrow, strengthened mentality, is used for neurasthenia, insomnia, forgetful and headache.These product are given birth to the angle that the pulp horn degree promptly increases brain nutrition from replenishing essence, reach the effect of nourishing the brain and tranquilizing the mind, and its maximum shortcoming is to produce effect when taking medicine, promptly stop to increase brain nutrition after the drug withdrawal after the state of an illness can increase the weight of again, therefore, curative effect is not consolidated, relapse rate height after the drug withdrawal.
Summary of the invention
For overcoming the above-mentioned defective of prior art, the purpose of this invention is to provide a kind of pure Chinese medicinal preparation mind easing oral liquor with gen-seng and lily bulb that is used for the treatment of deficiency of both the heart and spleen, deficiency of both vital energy and Yin card, this oral liquid has better curative effect to treatment deficiency of both the heart and spleen, deficiency of both vital energy and Yin card, has particularly that relapse rate after the drug withdrawal is low, the characteristics of efficacy consolidation.
For achieving the above object, adopted following technical scheme: a kind of deficiency of both the heart and spleen, deficiency of both vital energy and Yin card of being used for, main treatment cardiopalmus, insomnia, dreaminess, dizzy weak, the pure Chinese medicinal preparation mind easing oral liquor with gen-seng and lily bulb of diseases such as asthenia is characterized in that: the every 1000ml of this Chinese medicine preparation contains the Chinese medicine ingredients (unit: restrain) of following weight proportion:
Radix Ginseng 100g Radix Polygalae 60g Radix Astragali 100g
Bulbus Lilii 80g Radix Angelicae Sinensis 100g Rhizoma Acori Graminei 60g
Radix Salviae Miltiorrhizae 100g Radix Rehmanniae 80g Poria 100g Fructus Schisandrae Chinensis 60g
Mind easing oral liquor with gen-seng and lily bulb ties up under traditional Chinese medicine theoretical direction, is raw material with Radix Ginseng, Radix Polygalae, the Radix Astragali, Bulbus Lilii, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Poria, Fructus Schisandrae Chinensis 10 flavor Chinese crude drugs, through the compound Chinese medicinal preparation of processing and fabricating.This product has the effect of supplementing QI and nourishing YIN, mind tranquilizing and the heart calming, is used for deficiency of both the heart and spleen, and deficiency of both vital energy and Yin cures mainly cardiopalmus, insomnia, and dreaminess, dizzy weak, diseases such as asthenia.
For developing the new drug of the above-mentioned disease of treatment, the inventor has carried out secular documentation, consulted the Sheng Nong's herbal classic, Medical Treasures of the Golden Chamber, Compendium of Materia Medica, prescriptions worth thousand gold, Taiping Royal Prescriptions, with class agent office side, Shengji Zonglu, three categories of etiologic factors side, marine celestial being side, Yan's prescriptions for succouring sick, Imperial drug institution side, hospital's great achievement, Ruizhutang Jingyan Fang, Empirical Recipes from Auspicious Bamboo Hall, class bell side forever, Shi Yi De Xiao Fang, Effective Formulae Handed Down for Generations, the precious mirror of hygiene, quiet pavilion side, through dangerous secret recipe, pocket side, health is letter side easily, god side, longevity territory, the medical science main story, the Standards of Diagnosis and Treatment, Medicine Comprehended, tens of document ancient books such as kind auspiciousness Guangxi hospital choosing view, and modern times domestic and international medical research data, at last, from traditional ancient prescription of more than 300 kinds of nourishing the brain and improving intelligence class Chinese medicines and more than 60 hypermnesia of reposing, screen, test, in view of the above, and by the monarch combination principle of traditional Chinese medicine, the inventor selects at last and has determined formula for a product of the present invention.
Pharmaceutical composition of the present invention is supplementing QI and nourishing YIN, mind tranquilizing and the heart calming key medicine in conjunction with theory of Chinese medical science with the Radix Ginseng, its main tonifying five ZANG-organs, peace spirit decide soul, spasmolytic is throbbed with fear, Fructus Alpiniae Oxyphyllae happily, forefathers' reputation be qi-supplementing, blood-engendering, help intensive culture god's good medicine.Vital qi is weak, very brief deficiency of vital energy person, available it come tonification; Unit is refreshing not enough, emptyly wins weak person, available it come reinforcing; The palpitation with fear palpitation with a distress feeling, forgetful in a trance person, available it allay excitement.Modern medicine study confirms that it can strengthen corticocerebral excitement and process of inhibition, improves the motility of neural activity process, improves mental and physical function.Radix Astragali invigorating the spleen and replenishing QI, the kind internal injury overstrain of controlling, " Mingyi Bielu " say that its main husband of benefit is deficient, and five kinds of over strain is won thin.Modern study finds that it has effects such as strong hepatoprotective.The people participates in the Radix Astragali and share, and the power of QI invigorating is very grand, and QI invigorating is a principal agent to calm the nerves altogether.
The Radix Rehmanniae YIN nourishing nourishes blood, and allays excitement, and the merit of yin nourishing Fructus Alpiniae Oxyphyllae is arranged.Ming Dynasty doctor family wears first gift and says, cloudy little excess of YANG, and the phase heated is strong, takes advantage of cloudy position, day by day fries in shallow oil, endures, and the disease of hyperactivity of fire caused by deficiency of YIN should be moved back sun with YIN nourishing by Radix Rehmanniae.People's daily life work, particularly brain worker, the melancholy that having works with one's mind more takes great energy, cloudy Tianjin decocts, endogenous fire is automatic, nourishes with Radix Rehmanniae, and cloudy Tianjin must be filled, mind peace and, brains is spirit clearly, efficient improves.Chinese angelica blood supplementing is invigorated blood circulation, sensible Fructus Alpiniae Oxyphyllae, and " book on Chinese herbal medicine is just " says its energy nutrition blood, the QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, it is unsuitable not have institute.Radix Angelicae Sinensis and Radix Rehmanniae are share, nourishing YIN and benefiting blood, and mind tranquilizing and the heart calming is ministerial drug altogether.The Poria invigorating the spleen and benefiting QI, the mind tranquilizing and the heart calming Fructus Alpiniae Oxyphyllae, former worthies say its benefit five kinds of strain and seven kinds of impairment, happy Fructus Alpiniae Oxyphyllae is only forgetful.Research data shows, it contains the important substance lecithin of participating in defying age process, invigorating brain and relieving mental uneasiness in the body directly, also contain protein, glucose and the inorganic salt that can lack must be arranged in the vital movement, and the polysaccharide of energy enhancing body resistance, but right to use people's ataraxy, sleep is steady, and symptoms such as cardiopalmus, hypersomnia are improved, hypermnesia.It has assistant Radix Ginseng, the Radix Astragali effectiveness with invigorating QI and tranquilization in we.Fructus Schisandrae Chinensis lung moistening nourishing kidney, the arresting seminal emission that promotes the production of body fluid, the Fructus Alpiniae Oxyphyllae of calming the nerves has good adaptation former state effect.Clinical at all times desire to ask to allay excitement calm the nerves, whenever use it more.Bulbus Lilii, as far back as Eastern Han Dynasty last years of a dynasty or reign, curing holy Zhang Zhongjing is principal agent with it promptly, the treatment absentminded is indefinite, can receive the lung moistening mind calming, the Fructus Alpiniae Oxyphyllae effectiveness of calming the nerves.Radix Salviae Miltiorrhizae function calming heart and tranquilizing mind, the Fructus Alpiniae Oxyphyllae of invigorating blood circulation, the modern times experimental studies have found that, its energy blood vessel dilating promotes microcirculation, and tangible sedation is arranged, blood-stasis internal-depression, abnormal mind is good for and is used it, has both strengthened the agile active of full side, and the blood mind tranquilizing and the heart calming of accepting orders for repairs or processing is again very imitated.Radix Polygalae, Rhizoma Acori Graminei can be dispelled turbid by expectorant.Resolving depression is comfortable, can make the cardio cerebral function obstacle that causes because of the turbid retardance of expectorant obtain correcting, and all medicines make for assistant altogether.
Generally speaking, full side is based on Radix Ginseng, Radix Astragali QI invigorating the mind invigorating, adapted Radix Rehmanniae, Radix Angelicae Sinensis nourishing YIN and benefiting blood, Poria spleen invigorating mind calming, Fructus Schisandrae Chinensis lung moistening nourishing kidney, Bulbus Lilii lung moistening mind calming, the Radix Salviae Miltiorrhizae mind calming of invigorating blood circulation, Radix Polygalae, the Rhizoma Acori Graminei resolving depression that eliminates the phlegm, the effect of playing boosting qi and nourishing yin, mind tranquilizing and the heart calming altogether.
The tradition traditional Chinese medical science thinks, diseases such as cardiopalmus, insomnia, dreaminess, dizzy weak, asthenia are caused by deficiency of both the heart and spleen, deficiency of both vital energy and Yin.Deficiency-weakness of spleen-QI, transformation failure of spleen, the change source deficiency of blood can cause deficiency of heart-blood; And deficiency of heart-blood, blood deficiency is difficult to nourish in spleen, can cause deficiency-weakness of spleen-QI, finally causes deficiency of both the heart and spleen.Deficiency of both the heart and spleen, insufficiency of vital energy and blood, the heart, brain lose supports, and just produces above-mentioned disease or symptom.Therefore to treat above-mentioned disease, it is not enough only increasing brain nutrition, do like this and can only take stopgap measures, and can not effect a permanent cure, therefore must be from the supplementing QI and nourishing YIN angle, recover or improve the heart, spleen in the generation of blood and the function aspect the operation, the improvement by the human body self function makes the heart, brain obtain prescribing adequate nutrition, thereby fundamentally cure above-mentioned disease, avoid recurring after the drug withdrawal.
The specific embodiment
Be the effectiveness of checking product of the present invention, Zhejiang Prov. Hospital of Traditional Chinese Medicine, Hangzhou Chinese Medicinal Hospital and Hangzhou are red can associating group of hospital carry out clinical verification to product of the present invention.
Clinical data
One, physical data
Observe deficiency of both the heart and spleen altogether, deficiency of both vital energy and Yin is demonstrate,proved 52 examples, be divided into treatment at random and organize 101 examples, matched group 51 examples, wherein male 49 examples are organized in treatment, women 52 examples, age 52.27 ± 11.64 (29-80 year); Matched group man 25 examples, women 26 examples, age 51.04 ± 11.07 (21-73 year).Two groups of ages are checked P＞0.05 through t, have comparability.
Two cases are selected
Meeting traditional Chinese medical science deficiency of both the heart and spleen, deficiency of both vital energy and Yin card standard person all can be selected in.
(1) tcm diagnosis standard:
Formulate with reference to " Chinese medicine encyclopedia, Basic Theories of Chinese Medicine fascicle ", be specially:
1, syndrome of deficiency of both heart and spleen:
(1) cardiopalmus; (2) insomnia and dreamful sleep; (3) forgetful; (4) spontaneous perspiration; (5) it is few to receive decreased food intake; (6) abdominal distention after meal; (7) fatigue and weakness; (8) pale and tender tongue, tongue is white; (9) thready and weak pulse.
Except that the tongue arteries and veins, it is promptly diagnosable that all tools (1)-(4) three of a tool adds (5)-(7) person of tool.
2, deficiency of both vital energy and Yin card
(1) cardiopalmus; (2) insomnia and dreamful sleep; (3) forgetful; (4) dizziness; (5) tinnitus; (6) nocturnal emission; (7) soreness of the waist and knees; (8) red tongue; (9) thready pulse.
Except that the tongue arteries and veins, it is promptly diagnosable that all tools (1)-(4) Xiang Zhongsan item adds (5)-(7) Xiang Zhongyi item person.
(2) include the case standard of observing in
All differential diagnosis in tcm that meets belong to deficiency of both the heart and spleen, deficiency of both vital energy and Yin card standard person, all can be selected in.
(3) get rid of the case standard
1, important organ functional defect and psychotics such as severe cardiac, liver, kidney are arranged.
2, with diseases caused by exogenous pathogenic factor six evil person.
3, not medication in accordance with regulations can't be judged the not congruent factor of curative effect or data, affects the treatment or safe judgement person.
Three, Therapeutic Method:
Treatment group: obey product of the present invention, each 10ml, every day 3 times, 30 days courses of treatment.
Matched group: clothes ANSHEN BUNAO YE (production of Aodong, Jilin pharmaceutical factory), each 10ml, every day 3 times, 30 days courses of treatment.
All case 1 week and viewing duration before observation are not all taken to influence other Chinese and western drugses of assessing are imitated in this medication.
Four, observational technique
(1) clinical observation: mainly observe deficiency of both the heart and spleen, deficiency of both vital energy and Yin is demonstrate,proved each symptom variation and had or not adverse effect, and before and after treatment by the symptom weight standard of keeping the score, each record is once.(mild symptoms weight classification standard sees attached list 1)
(2) safety is observed: randomly draw treatment group some cases, detect routine blood test (Hb, WBC), liver function (ALT), renal function (Scr, BUN) respectively once before and after treatment, to observe the clinical safety in utilization of this medicine.
Subordinate list 1 mild symptoms weight classification standard
| Symptom | One-level (+) | Secondary (++) | Three grades (+++) |
| Cardiopalmus | Idol has | Often have | Continue to exist |
| Fatigue and weakness | Work back body is tired | Often body is tired | Body is tired obviously, influences work |
| Spontaneous perspiration | Idol has | Often have | Continue to exist |
| Insomnia and dreamful sleep | Idol has | Often have | Continue to exist |
| Forgetful | Idol has | Often have | Memory obviously descends |
| The decreased food intake of receiving is few | Appetite difference but appetite do not subtract | Appetite difference appetite descends 1/3 | The anorexia appetite descends 2/3 |
| Abdominal distention after meal | Food back idol has abdominal distention | The food back is abdominal distention often | Abdominal distention is obvious |
| Dizzy | Idol has | Often have | Continue to exist |
| Tinnitus | Idol has | Often have | Symptom is obvious, is difficult to stand |
| Nocturnal emission | Idol has | Often have | Nocturnal emission is obvious |
| Soreness of the waist and knees | Reflection after asking, the doctor is just arranged | Symptom irregularly occurs | The symptom long-term existence |
Five, efficacy assessment standard
By the variation evaluation curative effect of symptom integral score value before and after the treatment, divide clinical recovery, produce effects, effective, invalid level Four.
Clinical recovery: symptom all disappears, and treatment back symptom integral is reduced to " 0 ".
Produce effects: recuperate and obviously improve, reduce more than 2/3 before the integration ratio treatment of treatment back.
Effectively: symptom takes a turn for the better, and treatment back integration reduces more than 1/3 than before treating.
Invalid: symptom does not have obvious change, and treatment back integration reduces below 1/3 than treatment is preceding.
Six, statistical procedures is checked with W square of check and t.
The result
One, efficacy result
(1) treatment group efficacy result
Treatment is organized in 101 examples, syndrome of deficiency of both heart and spleen 60 examples, clinical recovery 3 examples (5%), produce effects 31 examples (51.67%), effective 24 examples (40%), invalid 2 examples (3.33%), total effective rate 96.57%, total obvious effective rate 56.67%.Deficiency of both vital energy and Yin is demonstrate,proved 41 examples, clinical recovery 1 example (2.44%), produce effects 21 examples (51.22%), effective 16 examples (39.02%), invalid 3 examples (7.32%), total effective rate 92.68%, total obvious effective rate 53.66%.Integration relatively saw attached list 2 before and after oral liquid of the present invention was demonstrate,proved each symptom treatment to deficiency of both the heart and spleen, deficiency of both vital energy and Yin.
Relatively (x ± SD) of integration is organized before and after the treatment of each symptom treatment group syndrome of deficiency of both heart and spleen in subordinate list 2 101 routine treatments
| Symptom | The example number | Integrated value | The t value | The P value | |
| Before the treatment | After the treatment | ||||
| Cardiopalmus | ??73 | ??2.28±0.79 | ????0.76±0.66 | ????13.82 | ????＜0.001 |
| Insomnia and dreamful sleep | ??101 | ??2.72±0.52 | ????0.87±0.61 | ????13.21 | ????＜0.001 |
| Forgetful | ??64 | ??2.17±0.76 | ????0.94±0.64 | ????9.91 | ????＜0.001 |
| Spontaneous perspiration | ??27 | ??1.58±0.67 | ????0.18±0.40 | ????9.46 | ????＜0.001 |
| The decreased food intake of receiving is few | ??43 | ??1.85±1.06 | ????0.23±0.46 | ????8.97 | ????＜0.001 |
| Abdominal distention after meal | ??35 | ??2.36±0.63 | ????0.50±0.27 | ????18.90 | ????＜0.001 |
| Fatigue and weakness | ??44 | ??2.33±0.85 | ????0.71±0.64 | ????10.18 | ????＜0.001 |
| Dizzy | ??29 | ??2.40±0.51 | ????0.90±0.31 | ????13.63 | ????＜0.001 |
| Tinnitus | ??23 | ??1.90±0.99 | ????0.80±0.63 | ????4.58 | ????＜0.001 |
| Nocturnal emission | ??5 | ??1.60±0.54 | ????0.60±0.54 | ????2.94 | ????＜0.05 |
| Soreness of the waist and knees | ??27 | ??1.90±0.87 | ????0.80±0.63 | ????5.24 | ????＜0.001 |
| Average total mark value | ??101 | ??11.92±3.23 | ????4.35±2.65 | ????18.02 | ????＜0.001 |
Show that from subordinate list 2 results the present invention demonstrate,proves each symptom to deficiency of both the heart and spleen, deficiency of both vital energy and Yin all highly significant curative effect (P＜0.001), wherein especially distinguished to cardiopalmus, insomnia and dreamful sleep, forgetful, abdominal distention after meal, fatigue and weakness, dizzy symptom curative effect.
(2) matched group efficacy result
In matched group 51 examples, syndrome of deficiency of both heart and spleen 28 examples, clinical recovery 0 example (0%), produce effects 8 examples (28.57%), effective 9 examples (32.14%), invalid 11 examples (39.29%), total effective rate 60.71%, total obvious effective rate 28.57%.Deficiency of both vital energy and Yin is demonstrate,proved 23 examples, clinical recovery 0 example (0%), produce effects 5 examples (21.74%), effective 16 examples (69.57%), invalid 2 examples (8.69%), total effective rate 91.30%, total obvious effective rate 21.74%.Integration relatively saw attached list 3 before and after ANSHEN BUNAO YE was demonstrate,proved each symptom treatment to deficiency of both the heart and spleen, deficiency of both vital energy and Yin.
Integration comparison before and after each symptom treatment of subordinate list 3 51 matched groups (x ± SD)
| Symptom | The example number | Integrated value | The t value | The P value | |
| Before the treatment | After the treatment | ||||
| Cardiopalmus | ????39 | ????2.03±0.31 | ????1.06±0.87 | ????3.49 | ????＜0.01 |
| Insomnia and dreamful sleep | ????51 | ????2.08±0.59 | ????1.02±0.67 | ????8.15 | ????＜0.001 |
| Forgetful | ????35 | ????1.37±0.51 | ????0.07±0.45 | ????4.16 | ????＜0.001 |
| Spontaneous perspiration | ????17 | ????1.40±0.51 | ????0.71±0.47 | ????4.05 | ????＜0.05 |
| The decreased food intake of receiving is few | ????26 | ????1.35±0.47 | ????0.96±0.69 | ????4.83 | ????＜0.001 |
| Abdominal distention after meal | ????20 | ????1.72±0.72 | ????1.07±0.57 | ????3.60 | ????＜0.01 |
| Fatigue and weakness | ????27 | ????1.90±0.69 | ????1.02±0.70 | ????4.63 | ????＜0.001 |
| Dizzy | ????19 | ????2.00±0.57 | ????0.71±0.48 | ????6.45 | ????＜0.001 |
| Tinnitus | ????17 | ????1.43±0.53 | ????0.57±0.54 | ????4.45 | ????＜0.001 |
| Nocturnal emission | ????8 | ????1.40±0.55 | ????0.81±0.57 | ????2.30 | ????＜0.05 |
| Soreness of the waist and knees | ????19 | ????2.00±0.82 | ????0.71±0.75 | ????5.16 | ????＜0.001 |
| Average total mark value | ????51 | ????10.97±3.57 | ????5.04±2.21 | ????14.12 | ????＜0.001 |
Show that from subordinate list 3 results ANSHEN BUNAO YE is demonstrate,proved most symptoms to deficiency of both the heart and spleen, deficiency of both vital energy and Yin also significant curative effect (P＜0.01-0.001), wherein insomnia and dreamful sleep, the decreased food intake of receiving are reached dizzy curative effect the best less.
(3) two groups of efficacy results relatively
1, two groups of total effective rates and obvious effective rate relatively have highly significant difference (P＜0.01), and for details see attached table 4.
4 liang of total effective rates of subordinate list and obvious effective rate are relatively
| The example number | Clinical recovery | Produce effects | Effectively | Invalid | Total effective rate * | Obvious effective rate * * | |
| The treatment group | ????101 | 4 | ????52 | ????40 | ????5 | ????95.05％ | ????55.45％ |
| Matched group | ????51 | 0 | ????13 | ????25 | ????13 | ????74.51％ | ????25.49％ |
*X
2＝12.27，P＜0.01
**X
2＝13.69，P＜0.01
2, two groups of each symptom treatment front and back integration differentials relatively see attached list 5.
Integration differential comparison before and after 5 liang of each symptom treatments of group of subordinate list (x ± SD)
| Symptom | The treatment group | Matched group | The t value | The P value | ||
| The example number | Integration differential | The example number | Integration differential | |||
| Cardiopalmus | ????73 | ??1.52±0.73 | ????39 | ?1.22±0.73 | ????1.07 | ????＞0.05 |
| Insomnia and dreamful sleep | ????101 | ??1.85±0.57 | ????51 | ?1.06±0.66 | ????7.90 | ????＜0.001 |
| Forgetful | ????64 | ??1.23±0.72 | ????35 | ?0.50±0.48 | ????4.29 | ????＜0.001 |
| Spontaneous perspiration | ????27 | ??1.40±0.68 | ????17 | ?0.68±0.49 | ????2.11 | ????＜0.05 |
| The decreased food intake of receiving is few | ????43 | ??1.57±0.70 | ????26 | ?0.89±0.61 | ????2.83 | ????＜0.01 |
| Abdominal distention after meal | ????35 | ??1.86±0.63 | ????20 | ?0.65±0.65 | ????5.26 | ????＜0.001 |
| Fatigue and weakness | ????44 | ??1.62±0.72 | ????27 | ?0.83±0.68 | ????2.31 | ????＜0.05 |
| Dizzy | ????29 | ??1.33±0.70 | ????19 | ?1.29±0.52 | ????0.28 | ????＞0.05 |
| Tinnitus | ????23 | ??1.10±0.69 | ????17 | ?0.86±0.62 | ????0.95 | ????＞0.05 |
| Nocturnal emission | ????5 | ??1.00±0.54 | ????8 | ?0.59±0.54 | ????1.05 | ????＞0.05 |
| Soreness of the waist and knees | ????27 | ??1.10±0.73 | ????19 | ?1.29±0.76 | ????0.75 | ????＞0.05 |
From subordinate list 5 as can be known, oral liquid of the present invention is better than ANSHEN BUNAO YE to the curative effect of improving syndrome of deficiency of both heart and spleen, and the two relatively has highly significant difference (equal P＜0.01-0.001) except that cardiopalmus, disease of spontaneous perspiration.
Two, treatment group safety is observed
1, treatment is organized and be there is no adverse effect after all patients take product of the present invention.
2, detect results such as routine blood test, hepatic and renal function, zero difference before and after the treatment of treatment group some cases.Show that product oral liquid of the present invention is a kind of medicine that safely, has no side effect, for details see attached table 6.
Laboratory detection result before and after the treatment of subordinate list 6 treatment group some cases (x ± SD)
| The example number | Before the treatment | After the treatment | The t value | The P value | |
| ??Hb(g/L) | ????34 | ????112.23±17.45 | ????115.50±16.33 | ????0.68 | ????＞0.05 |
| ??WBC(×10 9/L) | ????34 | ????6.01±1.30 | ????5.62±1.20 | ????0.75 | ????＞0.05 |
| ??ALT(IU/L) | ????36 | ????25.76±11.09 | ????28.08±10.98 | ????0.44 | ????＞0.05 |
| ??SCr(umol/L) | ????36 | ????78.44±17.30 | ????77.90±17.33 | ????0.45 | ????＞0.05 |
| ??BUN(mmol/L) | ????36 | ????5.41±1.45 | ????5.35±1.40 | ????0.24 | ????＞0.05 |
Associating group is thought at last: the present invention has benefiting QI and nourishing blood, invigorating brain and relieving mental uneasiness effect preferably, compare with the ANSHEN BUNAO YE that the representative kind Jilin Aodong pharmaceutical factory of Chinese medicine like product produces, the effective percentage of deficiency of both the heart and spleen obviously is better than matched group, highly significant difference is arranged, the present invention to treatment syndrome of deficiency of both heart and spleen and deficiency of both vital energy and Yin card determined curative effect, safely, have no side effect.
[model case]
Chen, man, 35 years old, business personnel.Nearly one-year age was had a sleepless night because of normal appearance that be busy with one's work, but can fall asleep after taking stable class medicine.The cause work of staying up late continuously in January, the insomnia aggravation.Only slept in one day 3-4 hour, and, only can sleep 3-4 hour after taking diazepam 5-10mg, often lie awake all night after awake with dizzy, forgetful, movable back cardiopalmus, after take product first quarter moon of the present invention, symptom obviously alleviates, January, symptom disappeared substantially, can fall asleep 7-8 hour.
The preparation method step of oral liquid of the present invention is:
The present invention is a raw material with Radix Ginseng, Radix Polygalae, the Radix Astragali, Bulbus Lilii, Radix Angelicae Sinensis, Rhizoma Acori Graminei, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Poria, Fructus Schisandrae Chinensis 10 flavor Chinese crude drugs, every 1000ml contains the Chinese medicine ingredients (unit: gram): Radix Ginseng 100g of following weight proportion, Radix Polygalae 60g, Radix Astragali 100g, Bulbus Lilii 80g, Radix Angelicae Sinensis 100g, Rhizoma Acori Graminei 60g, Radix Salviae Miltiorrhizae 100g, Radix Rehmanniae 80g, Poria 100g, Fructus Schisandrae Chinensis 60g.
According to the pharmaceutical composition of above-mentioned prescription, follow these steps to make oral liquid of the present invention:
1, Radix Ginseng, Rhizoma Acori Graminei, Radix Angelicae Sinensis three flavor steam distillations are collected distillate 100ml, and device is preserved in addition;
2, seven flavors such as above-mentioned medicinal residues and all the other Radixs Astragali decoct with water three times, add 6.5 times of amounts of water for the first time, decocted 1.5 hours, second and third time all adds 5 times of amounts of water, and each decocted 1 hour, collecting decoction filters, and filtrate is concentrated into 500ml, put coldly, add ethanol 1400ml, stir evenly, leave standstill more than 12 hours, filter, decompression filtrate recycling ethanol is to there not being the alcohol flavor, it is an amount of to add water, stirs evenly cold preservation 72 hours, filter, add simple syrup 300ml, sorbic acid 2.5g and above-mentioned distillate, stirring and dissolving, add water to 1000ml again, stir evenly, embedding, sterilization, promptly.
The present invention also can adopt other conventional pharmaceutical methods that pharmaceutical composition of the present invention is made as pill, tablets and other formulations.
Claims (1)
1, a kind ofly is applicable to that treatment is because of the cardiopalmus due to deficiency of both the heart and spleen, the deficiency of both vital energy and Yin, insomnia, dreaminess, dizzy weak, the pure Chinese medicinal preparation mind easing oral liquor with gen-seng and lily bulb of diseases such as asthenia is characterized in that: the every 1000ml of this Chinese medicine preparation contains the Chinese medicine ingredients (unit: restrain) of following weight proportion:
Radix Ginseng 100g Radix Polygalae 60g Radix Astragali 100g
Bulbus Lilii 80g Radix Angelicae Sinensis 100g Rhizoma Acori Graminei 60g
Radix Salviae Miltiorrhizae 100g Radix Rehmanniae 80g Poria 100g Fructus Schisandrae Chinensis 60g.
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| CN102309634A (en) * | 2011-09-06 | 2012-01-11 | 上海中医药大学附属岳阳中西医结合医院 | Hypnotic Chinese medicinal preparation for external use |
| CN103110876A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine preparation for treating heart qi deficiency type bradycardia |
| CN104223297A (en) * | 2014-09-05 | 2014-12-24 | 青岛恒波仪器有限公司 | Aging-delaying health schisandra chinensis oral solution and preparation method thereof |
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| CN1513516A (en) * | 2003-07-24 | 2004-07-21 | 贵州益兴宝典生物科技股份有限公司 | Pure natural health care product for improving sleeping and its manufacturing method |
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| CN102309634A (en) * | 2011-09-06 | 2012-01-11 | 上海中医药大学附属岳阳中西医结合医院 | Hypnotic Chinese medicinal preparation for external use |
| CN103110876A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine preparation for treating heart qi deficiency type bradycardia |
| CN104645184A (en) * | 2013-11-20 | 2015-05-27 | 北大方正集团有限公司 | Traditional Chinese medicine composition for treating senile dementia |
| CN104223297A (en) * | 2014-09-05 | 2014-12-24 | 青岛恒波仪器有限公司 | Aging-delaying health schisandra chinensis oral solution and preparation method thereof |
| CN104223297B (en) * | 2014-09-05 | 2016-09-14 | 杨高林 | A kind of schisandra chinensis health-care oral liquid of slow down aging and preparation method thereof |
| CN104328016A (en) * | 2014-10-08 | 2015-02-04 | 登封市绿之源农副产品开发有限公司 | Qi-benefiting and blood-nourishing persimmon vinegar and preparation method thereof |
| CN104587184A (en) * | 2014-12-26 | 2015-05-06 | 武海波 | traditional Chinese medicine composition for treating liver-yang hyperactivity |
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| Publication number | Publication date |
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| CN1320912C (en) | 2007-06-13 |
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Address after: 324000 No. 889 Century Avenue, Quzhou Economic Development Zone, Zhejiang, China Patentee after: ZHEJIANG KANGDE PHARMACEUTICAL CO., LTD. Address before: 324000 No. 889 Century Avenue, Quzhou Economic Development Zone, Zhejiang, China Patentee before: Zhejiang Kangde Pharmacy Group Co., Ltd. |