CN1253188C - Medicine for treating hypertension and its preparing process - Google Patents
Medicine for treating hypertension and its preparing process Download PDFInfo
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- CN1253188C CN1253188C CNB2004100730180A CN200410073018A CN1253188C CN 1253188 C CN1253188 C CN 1253188C CN B2004100730180 A CNB2004100730180 A CN B2004100730180A CN 200410073018 A CN200410073018 A CN 200410073018A CN 1253188 C CN1253188 C CN 1253188C
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Abstract
The present invention relates to a drug for treating hypertension, which is characterized in that the drug is a drug preparation prepared from raw materials of the following proportion: 1 to 7.5 parts by weight of tall gastrodia tuber, 2 to 15 parts by weight of stir-baked cortex eucommiae with salt solution, 1.5 to 11.25 parts by weight of radix rehmanniae recens, 3 to 22.5 parts by weight of fried semen zizyphi spinosae, 3 to 22.5 parts by weight of red sage root, 1.5 to 11.25 parts by weight of white peony root, 1 to 7.5 parts by weight of keel, 1 to 7.5 parts by weight of oyster shell, 1.2 to 9 parts by weight of chrysanthemum, 1.5 to 11.25 parts by weight of membranous milkvetch root and 1 to 7.5 parts by weight of radices polygalae. By adopting the preparation technology that the monarch drug tall gastrodia tuber is pulverized and used as a drug, the eucommia bark, the radix rehmanniae recens, the white peony root, the red sage root, the fried semen zizyphi spinosae, the radices polygalae and the chrysanthemum are decocted with water and precipitated with alcohol, and the membranous milkvetch root and the oyster shell are decocted with water, the present invention not only has favorable treatment effects on hypertension of yin deficiency and yang hyperactivity, but also has obvious effects on the accompanying symptoms of patients with hypertension.
Description
Technical field
The present invention relates to the hypertensive medicine of a kind of treatment, specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, also relates to the preparation method of this medicine simultaneously.
Background technology
Hypertension is to cause human dead principal disease, as the main paathogenic factor of coronary heart disease, cerebrovascular, is the commonly encountered diseases and the frequently-occurring disease of harm humans health.Whole nation sample census demonstration for the third time in 1991, population hypertension standardized prevalence is 11.9% more than 15 years old, after WHO revised Evaluation of Diagnostic Criteria of Hypertension in the recent period, China's hypertension actual diseased rate is this ratio head and shoulders above.Hypertension is a commonly encountered diseases, it is again the most important risk factor that causes human dead principal disease such as coronary heart disease, cerebrovascular disease etc., it is closely related that the sickness rate of the heart, cerebrovascular disease and case fatality rate are patient's blood pressure level, therefore, control and the research to hypertension is all paid much attention in countries in the world.
Summary of the invention
The purpose of this invention is to provide a kind of pure Chinese medicinal preparation of treatment type of deficiency of YIN leading to hyper activity of YANG hypertension and preparation method of said preparation of being applicable to, medicine of the present invention not only has curative effect preferably to the type of deficiency of YIN leading to hyper activity of YANG hypertension, and hyperpietic's simultaneous phenomenon is had more significantly effect.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Rhizoma Gastrodiae 1-7.5 Cortex Eucommiae(processed with salt) 2-15 Radix Rehmanniae 1.5-11.25 Semen Ziziphi Spinosae (parched) 3-22.5
Radix Salviae Miltiorrhizae 3-22.5 Radix Paeoniae Alba 1.5-11.25 Os Draconis 1-7.5 Concha Ostreae 1-7.5
Flos Chrysanthemi 1.2-9 Radix Astragali 1.5-11.25 Radix Polygalae 1-7.5.
Above-mentioned each component is made medicine production method of the present invention is:
1, get Rhizoma Gastrodiae, clean, run through, shave, drying by the prescription weighing, is ground into fine powder, sieves;
2, get Radix Astragali decoction pieces, Os Draconis, the Concha Ostreae (the Concha Ostreae pack is decocted a drug wrapped) of clean dry, add 7 times of amounts of water, decoct 3 times, each 2 hours, close half decocting liquid, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.10～1.12 (50 ℃);
3, get the Cortex Eucommiae, clean, shredding, drying is fried to fracture of wire, surperficial coke black according to 95 editions Chinese Pharmacopoeia appendix IID saline methods of processing, by the prescription weighing;
4; get the Radix Rehmanniae of clean dry; Semen Ziziphi Spinosae (parched); Radix Salviae Miltiorrhizae; the Radix Paeoniae Alba and Radix Polygalae decoction pieces, Flos Chrysanthemi seven flavors add 9 times of amounts of water, decoct 3 times; 2 hours for the first time, second; three difference 1.5 hours, collecting decoction; filter; the dense place of filtrate decompression to relative density is the thick paste of 1.20～1.22 (50 ℃); add ethanol, make to contain the alcohol amount and reach 60%, fully stir; standing over night; filter, reclaim ethanol, with last thick paste mix homogeneously; add Rhizoma Gastrodiae fine powder and an amount of dextrin; mixing, dry below 80 ℃, be ground into fine powder; add an amount of ethanol and cross the granulation of 16 mesh sieves; dry; granulate or spray granulation, 1000 No. 1 capsules of packing into, promptly.
Elaboration side separates with Chinese medical theory
In this prescription, use Rhizoma Gastrodiae, focus on suppressing the hyperactive liver and subsiding YANG, get the Rhizoma Gastrodiae specially good effect of invigorating the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome of holding concurrently to relieve dizziness, high fever, infantile convulsions, epilepsy, etc.The Cortex Eucommiae, singly using promptly has definite curative effect to hypertension.The empty of we nourishing kidney must the Cortex Eucommiae, can doublely control diseases such as soreness of waist and knee joint simultaneously again.Last two flavors, the Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome, Cortex Eucommiae nourishing the liver and kidney, both mutually 5, the void of invigorating the liver and kidney, suppressing the hyperactive liver sun high brought into play main therapeutical effect at the basic pathogenesis of hypertension hyperactivity of YANG due to deficiency of YIN, is monarch drug in square altogether.
The Radix Rehmanniae has clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting effect, is used for the card of interior-heat caused by deficiency of YIN, and we use it, " removing heat from blood is enriched blood, the kidney invigorating water kidney-YIN being deficient "; Semen Ziziphi Spinosae tonifying liver, mind calming, arresting sweating, promote the production of body fluid, join Tianjin 5, control high, the palpitation and insomnia of cloudy kidney yang, auxiliary monarch drug nourishing YIN and clearing away heat, suppressing the hyperactive liver and subsiding YANG with the Radix Rehmanniae.The Radix Salviae Miltiorrhizae hardship, be slightly cold, GUIXIN, Liver Channel, activating blood circulation and dissipating phlegm, the relieving restlessness that clears away heart-fire, we use it, both can control the blood stasis accompanied symptoms, again can with the Radix Rehmanniae, Semen Ziziphi Spinosae compatibility to control the palpitation and insomnia of deficiency of heart-blood, disturbance of deficiency-heat inside the body, last three flavors, Radix Rehmanniae, Semen Ziziphi Spinosae nourishing YIN and clearing away heat, Radix Salviae Miltiorrhizae nourishes blood, invigorates blood circulation, auxiliary monarch drug is ministerial drug in the side altogether.
Os Draconis are sweet, puckery, be slightly cold, GUIXIN, Liver Channel, have the effect of suppressing the hyperactive liver and subsiding YANG, tranquillizing and allaying excitement; Concha Ostreae becomes, is slightly cold, returns liver, gallbladder, kidney channel, has tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN effect, both phases 5, dizzy, the palpitation with fear insomnia of the hyperactivity of YANG due to deficiency of YIN of ruling together; Radix Paeoniae Alba hardship, acid, be slightly cold, return liver, spleen channel, have suppressing the hyperactive liver, nourish blood, the effect of yin fluid astringing, be usually used in the headache, dizzy due to the excessive rising of liver-YANG; The effect that Flos Chrysanthemi is sweet, bitter, be slightly cold, return lung, Liver Channel, have diffusing wind heat clearing away, suppressing the hyperactive liver makes eye bright, it is dizzy to be used to have a headache, last four flavors mutually 5, common assistant helps monarch, the ministerial drug effect with its suppressing the hyperactive liver and subsiding YANG of further enhancing, the yin fluid astringing that nourishes blood.
The sweet temperature of the Radix Astragali, return lung, spleen channel, have invigorating QI to consolidate the body surface resistance, diuresis effect, we use it, mainly take into account pathological changes later stage deficiency of YIN affecting YANG and the card of two void occurs, the merit of getting inrigorating qi and promoting blood circulation simultaneously helps Radix Salviae Miltiorrhizae to invigorate blood circulation, Radix Polygalae hardship, suffering, temperature, GUIXIN, kidney, lung meridian, we help the Semen Ziziphi Spinosae mind tranquilizing and the heart calming in order to assistant, diseases such as Cure for insomnia, forgetful, palpitation with fear, and last Six-element is adjuvant in the side of being altogether.
Take a broad view of full side, the Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome, Cortex Eucommiae nourishing the liver and kidney, both mutual-assistances are usefulness, nourishing YIN for suppressing the hyperactive YANG is the monarch of all medicines altogether; The Radix Rehmanniae, Semen Ziziphi Spinosae nourishing YIN and clearing away heat, Os Draconis, oyster yin-nourishing YANG hyperactivity suppressing, the Radix Paeoniae Alba, Flos Chrysanthemi heat clearing away suppressing the hyperactive liver and subsiding YANG, common auxiliary, assistant principal drug assistance nourishing YIN for suppressing the hyperactive YANG; Radix Salviae Miltiorrhizae, Radix Astragali benefiting QI for activating blood circulation, treatment blood stasis accompanied symptoms; The Radix Polygalae assistant helps the Semen Ziziphi Spinosae mind tranquilizing and the heart calming.Quan Fangshi simply, monarch, minister, assistant make reasonable compatibility, gather the merit of nourishing YIN for suppressing the hyperactive YANG, nourishing blood to tranquillize the mind altogether, are applicable to treatment type of deficiency of YIN leading to hyper activity of YANG hypertension, disease sees that dizziness and headache, soreness of the waist and knees, tinnitus are forgetful, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia etc.
Modern pharmacological research shows that Rhizoma Gastrodiae has obvious hypotensive effect, but decreased heart rate also simultaneously, increase cardiac output, reduce Peripheral resistance, reduce myocardial oxygen consumption, reduce cerebrovascular and crown vascular resistance, increase coronary flow and cerebral blood flow, anticoagulant; The Cortex Eucommiae has quick and durable hypotensive effect and diuresis; The Radix Paeoniae Alba has dosage correlation hypotensive effect and resisting oxygen lack; Radix Salviae Miltiorrhizae have bring high blood pressure down, blood vessel dilating, coronary blood flow increasing, multiple effect such as resist myocardial ischemia; Semen Ziziphi Spinosae has tangible blood pressure lowering, blood fat reducing, prevents and treats the atherosclerosis effect; The Radix Astragali can obviously reduce arteriotony and vascular resistance, also has resisting myocardial ischemia simultaneously, improves effects such as cardiac function; Radix Polygalae has hypotensive effect; Flos Chrysanthemi has effects such as coronary artery dilating, coronary blood flow increasing and anoxia enduring.
Said medicine all has blood pressure lowering, vasodilative effect in various degree, compatibility should with can bring into play more significant antihypertensive effect.
In order to further specify content of the present invention, set forth from the following aspects:
One, study of pharmacy
Medicine of the present invention is made up of 11 flavor Chinese medicines, beats powder according to the physicochemical property employing monarch drug Rhizoma Gastrodiae of the principles of formulating prescriptions and the medical material of respectively distinguishing the flavor of and is used as medicine the Cortex Eucommiae, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae, Radix Polygalae, Flos Chrysanthemi seven flavor medicine water decoction-alcohol sedimentation; The preparation technology of the Radix Astragali, Os Draconis, Du oyster decocting by orthogonal test, investigates water decoction-alcohol sedimentation technology with protocatechualdehyde and content of paeoniflorin in raw material and the alcohol deposit fluid and three indexs of paste-forming rate; Investigate decocting technology with astragaloside content in raw material and the decocting liquid and fried amount binomial index, determined best manufacturing condition, and amplify production, verified the reasonability and the stability of this technology by three batches of pilot scales.
In order to ensure drug quality, provide detailed documents and materials to the physicochemical property of every flavor medical material, formulated the quality standard of quality of medicinal material standard and medicine finished product.The place of production, concocting method to medical material in the medical material standard have been done corresponding qualification, have set up thin-layer method in the finished product standard and have differentiated monarch drug Rhizoma Gastrodiae, the Cortex Eucommiae, ministerial drug Radix Salviae Miltiorrhizae, and assistant makes the method for Radix Paeoniae, the Radix Astragali; Assay selects for use the HLPC method to measure the content that mainly contains the effective constituent gastrodine in the Rhizoma Gastrodiae, stipulates that its gastrodin content limit must not be lower than 0.02%.And three batches of pilot products are carried out quality inspection, the result is all up to specification.
Investigate by trimestral preliminarily stabilised test, the every at ambient temperature index of this product all within prescribed limit, is not seen significant change.
Two, pharmacodynamic study
By three kinds of animals, three kinds of dosage, the pharmacodynamic study of six experiments proves, medicine ig of the present invention administration can significantly reduce renal hypertensive rat and spontaneous hypertensive rat blood pressure (P≤0.01), systolic pressure descend respectively 14.1%-19.9%, 12.7%-22.8%, 13.0%-21.1%, 13.1%-23.4%; The dog Hemodynamics Study shows that medicine of the present invention can reduce the blood pressure of anesthetized dog significantly, and the heart rate that do not raise during blood pressure lowering also can significantly increase dog coronary flow and blood supply of cardiac muscle, reduces coronary resistance; Medicine ig of the present invention administration can significantly reduce the spontaneous activity in mice number of times, with the pentobarbital sodium of sub-threshold dose mice sleep there is the obvious synergistic effect, and the whole blood height that can obviously reduce stasis of blood rat is cut viscosity, low viscosity and the whole blood reduced viscosity cut of whole blood, and can significantly reduce plasma viscosity, packed cell volume, shorten erythrocyte electrophoretic time, above result shows, medicine of the present invention not only has tangible hypotensive effect, do not influence the animal heart rate, simultaneously can increase dog coronary flow and blood supply of cardiac muscle, reduce coronary resistance, also have tranquilizing soporific, the effect of blood circulation promoting and blood stasis dispelling meets the Therapeutic Principle of hypertension treating both the principal and secondary aspects of a disease.
Three, toxicologic study
Acute toxicity test is by the maximum tolerated dose side of survey method, irritates stomach total amount 30g/kg in 30 mices one day secondary, observes a week and do not see overt toxicity, and no dead mouse, this dosage are equivalent to 666.7 times of people's consumption per day.
Carried out three dosage (1.0g, 2.5g, 5.0g/kg), 90 days long term toxicity test by a definite date with 83 of SD rats, during administration and in 14 days convalescent period, the general signs of animal, feces, receive food, no significant change, physiochemical indice (5), blood parameters (10), internal organs show medicine of the present invention no tangible intoxicating effect under experimental condition than also no significant difference of (12), histological examination every indexs such as (15 organs).
Four, clinicing aspect
In order to verify the preliminary curative effect of medicine of the present invention, on the basis of a large amount of clinical practices in the past, we entrust The People's Hospital that medicine of the present invention is carried out preliminary clinical research, below are research datas:
(1), physical data
1, case source: inpatient's 6 examples, outpatient's 94 examples amount to 100 routine patients, and all case all meets the case choice criteria.
2, age distribution: as shown in table 1
| Group | The example number | ＜40 | 40～ | 50～ | 60～ | Mean age |
| The treatment group | 100 | 2 | 22 | 32 | 44 | 55.9±8.89 |
3, sex distributes: women's 36 examples in 100 examples, account for 36.00%, and male's 64 examples account for 64.00%.
4, the course of disease distributes: as shown in table 2
| The example number | ＜1 year | 1 year～ | 3 years～ | 6 years～ | |
| The treatment group | 100 | 10 | 36 | 20 | 34 |
(2), case choice criteria
1, Western medicine diagnose standard: according to the WHO newest standards, systolic pressure 〉=140mmhg (18.7kpa) and/or diastolic pressure 〉=90mmhg (12kpa) are hypertension.Hypertension history was arranged for the past, long-term (more than 3 months) untreated, this checks the normotensive, does not classify hypertension as.As one to medication treatment, this checks the normotensive, still classifies hypertension as, and the person's of having a question check after drug withdrawal January remakes diagnosis.
2, differential diagnosis in tcm standard: with the syndrome of hyperactivity of yang due to yin deficiency is the object of observation.Card is seen: dizziness and headache, tinnitus are forgetful, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, red tongue, white and thin fur or few tongue, stringy and thready pulse and counting.
3, include standard in: meet the diagnosis of doctor trained in Western medicine hypertension, clinical stages, is II phase person and meets the dialectical standard person of traditional Chinese medical science hyperactivity of YANG due to deficiency of YIN, and the age was 18～70 years old person.
(3), test method:
Oral medicine of the present invention, each 4,3 times/day, 4 weeks of taking medicine continuously are a course of treatment, observation index: in blood pressure, heart rate, the symptom headache, dizzy be primary symptom, keeping the score is 0,2,4,6 minute; Tinnitus, vexed, cardiopalmus, insomnia are time disease, and keeping the score is 0,1,2,3 minute.
(4), curative effect determinate standard
1, efficacy of antihypertensive treatment evaluation criteria:
Produce effects: 1. more than the diastolic pressure decline 10mmhg (1.3kpa), and reach normal range; Though 2. diastolic pressure be not depressurized to normally descended 20mmhg (2.7kpa) or more than.Must possess wherein 1.
Effectively: 1. diastolic pressure descends not as good as 10mmhg (1.3kpa), but has reached normal range; 2. decline 10-19mmhg (1.3-2.5kpa) before diastolic pressure is treated, but do not reach normal range; 3. systolic pressure is more than the preceding decline 30mmhg (4kpa) of treatment.Must possess wherein 1.
Invalid: as not reach above standard.
2, symptom efficacy assessment standard:
Produce effects: symptom integral reduces 2/3.
Effectively: symptom integral reduces 1/3.
Invalid: as to increase the weight of even symptom integral reduces less than 1/3.
(5), result:
1, efficacy of antihypertensive treatment: as shown in table 3
Table 3 efficacy of antihypertensive treatment table
| The example number | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate | |
| The treatment group | 100 | 50.00 | 36.00 | 14.00 | 86.00 |
As seen from Table 3, treatment back obvious effective rate is 50.00%, and total effective rate is 86.00%.
2, symptom curative effect: as shown in table 4
Table 4 symptom curative effect table
| The example number | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate | |
| The treatment group | 100 | 56.00 | 34.00 | 10.00 | 90.00 |
As seen from Table 4, symptom curative effect obvious effective rate is 56.00%, and total effective rate is 90.00%
3, remission situation: as shown in table 5
Table 5 remission situation relatively
| Symptom | The example number | Do not disappear | Disappear | Disappearance rate (%) |
| The vexed palpitation and insomnia of headache vertigo and tinnitus | 88 86 52 66 70 82 | 32 30 26 26 32 30 | 56 56 26 40 38 52 | 63.64 65.12 50.00 60.61 54.29 66.41 |
As seen from Table 5, secondly doing well,improving is vexed with dizzy, headache, insomnia better, relatively poor to tinnitus, cardiopalmus.
4, the age groups efficacy of antihypertensive treatment relatively: as shown in table 6
Table 6 age groups efficacy of antihypertensive treatment relatively
| Age group | The example number | Produce effects | Effectively | Invalid |
| ＜50 50-60 ＞60 | 24 32 44 | 12 16 22 | 8 12 16 | 4 4 6 |
Riddit checks U
1=0.2835 P＞0.05 (＜50/50-60)
U
2＝0.1097 P＞0.05(＜50/＞60)
U
3＝0.4792 P＞0.05(50-60/＞60)
As seen from Table 6, through the Riddit check, relatively, even P＞0.05 shows the curative effect there was no significant difference between age groups between each group.
5, different course of disease efficacy of antihypertensive treatment relatively: as shown in table 7
The different course of disease efficacy of antihypertensive treatment of table 7 relatively
| The course of disease | The example number | Produce effects | Effectively | Invalid |
| ＜1 year 1-6＞6 year | 12 56 32 | 8 30 12 | 2 18 16 | 2 8 4 |
Riddit checks U
1=0.8664 P＞0.05 (＜1 year/1-6)
U
2=1.2016 P＞0.05 (＜1 year/＞6 years)
U
3=0.5444 P＞0.05 (1-6/＞6 year)
As seen from Table 7, through Riddit check, relatively, equal P＞0.05 shows the curative effect there was no significant difference of the different courses of disease between each group.
6, untoward reaction: have 3 routine patients to take the back and slight stomach upset occurs, feeling of repletion is arranged, continue to take the back and disappear, do not have other untoward reaction and occur.Heart rate does not also have significant change before and after the treatment.
(6), brief summary: clinical drug result of the present invention shows that following advantage is arranged:
1, Drug therapy 100 routine hypertension II phase patients of the present invention, the blood pressure lowering obvious effective rate is 50.00%, total effective rate is 86.00%; To the symptom curative effect, obvious effective rate is 56.00%, and total effective rate is 90.00%.Show that medicine of the present invention when obviously improving patient's subjective symptoms, also has more definite efficacy of antihypertensive treatment.
2, doing well,improving with dizzy, headache better, insomnia, vexed taking second place, tinnitus, cardiopalmus are relatively poor.The transference cure rate shows that substantially more than 60% medicine of the present invention has more significantly effect to hyperpietic's simultaneous phenomenon.
3, medicine of the present invention all has curative effect preferably to the patient of the age groups and the different courses of disease, not the curative effect there was no significant difference between on the same group.
4, taking medicine of the present invention does not have the obvious adverse reaction generation, and heart rate is not also had tangible influence.
Description of drawings
Fig. 1 is a pharmaceutical preparation flow chart of the present invention.
Specific embodiment
Embodiment 1
Take by weighing raw material by following proportioning: (unit: gram)
Rhizoma Gastrodiae 75 Cortex Eucommiae(processed with salt) 150 Radix Rehmanniae 112.5 Semen Ziziphi Spinosae (parched)s 225 Radix Salviae Miltiorrhizaes 225
The Radix Paeoniae Alba 112.5 Os Draconis 75 Concha Ostreaes 75 Flos Chrysanthemis 90 Radixs Astragali 112.5 Radix Polygalaes 75
Production method
More than ten simply, get Rhizoma Gastrodiae, clean, run through, shave, drying by the prescription weighing, is ground into fine powder, sieves.Get Radix Astragali decoction pieces, Os Draconis, the Concha Ostreae (the Concha Ostreae pack is decocted a drug wrapped) of clean dry, add 7 times of amounts of water, decoct 3 times, each 2 hours, close half decocting liquid, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.10～1.12 (50 ℃).Get the Cortex Eucommiae, clean shredding; drying is fried to fracture of wire according to 95 editions Chinese Pharmacopoeia appendix IID saline methods of processing; the surface coke black is by the prescription weighing; get the Radix Rehmanniae of clean dry; Semen Ziziphi Spinosae (parched); Radix Salviae Miltiorrhizae; the Radix Paeoniae Alba and Radix Polygalae decoction pieces, Flos Chrysanthemi seven flavors add 9 times of amounts of water, decoct 3 times; 2 hours for the first time, second; three difference 1.5 hours, collecting decoction; filter; the dense place of filtrate decompression to relative density is the thick paste of 1.20～1.22 (50 ℃); add ethanol, make to contain the alcohol amount and reach 60%, fully stir; standing over night; filter, reclaim ethanol, with last thick paste mix homogeneously; add Rhizoma Gastrodiae fine powder and an amount of dextrin; mixing, dry below 80 ℃, be ground into fine powder; add an amount of ethanol and cross the granulation of 16 mesh sieves; dry; granulate or spray granulation, 1000 No. 1 capsules of packing into, promptly.
Embodiment 2
Take by weighing raw material by following proportioning: (unit: gram)
Rhizoma Gastrodiae 10 Cortex Eucommiae(processed with salt) 20 Radix Rehmanniae 15 Semen Ziziphi Spinosae (parched)s 30 Radix Salviae Miltiorrhizaes 30
The Radix Paeoniae Alba 15 Os Draconis 10 Concha Ostreaes 10 Flos Chrysanthemis 12 Radixs Astragali 15 Radix Polygalaes 10
Production method: with embodiment 1.
Claims (2)
1, the hypertensive medicine of a kind of treatment is characterized in that it is the medicament of being made by the following weight proportion raw material:
Rhizoma Gastrodiae 1-7.5 Cortex Eucommiae(processed with salt) 2-15 Radix Rehmanniae 1.5-11.25 Semen Ziziphi Spinosae (parched) 3-22.5
Radix Salviae Miltiorrhizae 3-22.5 Radix Paeoniae Alba 1.5-11.25 Os Draconis 1-7.5 Concha Ostreae 1-7.5
Flos Chrysanthemi 1.2-9 Radix Astragali 1.5-11.25 Radix Polygalae 1-7.5.
2, the preparation method of medicine according to claim 1 is characterized in that getting Rhizoma Gastrodiae, cleans, runs through, and shave, drying by the prescription weighing, is ground into fine powder, sieves; Get Radix Astragali decoction pieces, Os Draconis, the Concha Ostreae pack of clean dry and decoct a drug wrapped, add 7 times of amounts of water, decoct 3 times, each 2 hours, collecting decoction filtered, and surveying relative density when the liquid filter is evaporated to 50 ℃ is the thick paste of 1.10-1.12; Get the Cortex Eucommiae, clean, shredding, drying is fried to fracture of wire, surperficial coke black with the saline method of processing, by the prescription weighing; Get the Radix Rehmanniae of clean dry; Semen Ziziphi Spinosae (parched); Radix Salviae Miltiorrhizae; the Radix Paeoniae Alba and Radix Polygalae decoction pieces, Flos Chrysanthemi seven flavors add 9 times of amounts of water, decoct 3 times; 2 hours for the first time, second; three difference 1.5 hours, collecting decoction; filter; surveying relative density when filtrate decompression is concentrated into 50 ℃ is the thick paste of 1.20-1.22, adds ethanol, makes to contain the alcohol amount and reach 60%; fully stir; standing over night filters, and reclaims ethanol; with described thick paste mix homogeneously; add Rhizoma Gastrodiae fine powder and an amount of dextrin, mixing, dry below 80 ℃; be ground into fine powder; add an amount of ethanol and cross the granulation of 16 mesh sieves, drying; granulate or spray granulation, promptly.
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| CNB2004100730180A CN1253188C (en) | 2004-08-23 | 2004-08-23 | Medicine for treating hypertension and its preparing process |
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| CNB2004100730180A CN1253188C (en) | 2004-08-23 | 2004-08-23 | Medicine for treating hypertension and its preparing process |
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| CN1253188C true CN1253188C (en) | 2006-04-26 |
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| CN103211998B (en) * | 2013-03-18 | 2014-08-20 | 赵霞 | Traditional Chinese medicine composition for treatment of yin deficiency and yang excess |
| CN106109978A (en) * | 2016-08-26 | 2016-11-16 | 新疆维吾尔自治区中医医院 | A kind of traditional Chinese compound medicine of Hypertension |
| CN108635497A (en) * | 2018-07-30 | 2018-10-12 | 佛山科学技术学院 | A kind of Chinese medicine preparation and preparation method thereof for treating hypertension |
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