CN104645184A - Traditional Chinese medicine composition for treating senile dementia - Google Patents
Traditional Chinese medicine composition for treating senile dementia Download PDFInfo
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- CN104645184A CN104645184A CN201310586017.5A CN201310586017A CN104645184A CN 104645184 A CN104645184 A CN 104645184A CN 201310586017 A CN201310586017 A CN 201310586017A CN 104645184 A CN104645184 A CN 104645184A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating senile dementia. The traditional Chinese medicine composition is prepared from following raw material mediciens, by weight: 9-15 parts of salviae miltiorrhizae, 6-12 parts of angelica sinensis, 3-10 parts of ginseng, 3-9 parts of acorus tatarinowii, 3-9 parts of fructus alpinae oxyphyllae, 3-10 parts of rhizoma chuanxiong, 10-30 parts of astragalus membranaceus and 3-9 parts of polygala tenuifolia. The eight medicines achieve the effects cooperatively and synergistically achieve the effects. The traditional Chinese medicine composition has functions of quieting spirit and boosting intelligence, resisting senile dementia and enhancing study and memory ability.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to the Chinese medicine composition for the treatment of senile dementia.
Background technology
Alzheimer (AD) is the nervous system degenerative disease of the Progressive symmetric erythrokeratodermia development of a kind of onset concealment.Show as feature with dysmnesia, aphasia, apraxia, agnosia, the infringement of visual space technical ability, n-back test obstacle and the generalized dementia such as personality and behavior change clinically, the cause of disease is not bright so far.Within 65 years old, send out patient in the past, claim presenile dementia; Within 65 years old, claim alzheimer disease with sequela person.
Slowly or concealment, patient and household are often unable to explain clearly when onset to this sick onset of clinical manifestation.Be more common in more than 70 years old (average 73 years old of male, women is 75 years old) old man, a few patients symptom after physical disease, fracture or spirit are upset is clear rapidly.Women many compared with male (female: man is 3: 1).Main manifestations is decrease of cognitive function, mental symptom and behavior disorder, the decline gradually of activity of daily living.Deterioration degree according to cognitive competence and physical function is divided into three periods.
First stage (1 ~ 3 year)
For the mild dementia phase.Show as hypomnesis, recent amnesia is given prominence to; Judgement declines, and patient can not analyze event, thinks deeply, judge, is difficult to process complicated problem; Work or housework careless, can not independently carry out doing shopping, economic affairs etc., social difficulty; Although still can do a little routine work be familiar with, show new things and be ignorantly difficult to resolve, apathy, excitation once in a while, often has suspicious; Time of occurrence disorientation, can make orientation to residing place and personage, to the directed difficulty in residing geographical position, and the visual space ability of labyrinth; Speech vocabulary is few, name difficulty.
Second stage (2 ~ 10 years)
For the moderate dementia phase.Show as far and near memory to be badly damaged, the visual space ability of simple structure declines, time, disturbance of orientation to place; Grievous injury is had in process problem, the similitude distinguishing things and discrepancy; Independently can not carry out outdoor activity, wearing the clothes, Personal hygiene and keep wanting help in personal appearance; Calculating can not; There is various nervous symptoms, visible aphasia, apraxia and agnosia; Emotion becomes irritable uneasiness from indifferent, often walks about and does not stop, visible urinary incontinence.
Phase III (8 ~ 12 years)
For the severe dementia phase.Patient relies on the person of looking after completely, and serious memory loss, only deposits the memory of fragment; Daily life can not be taken care of oneself, gatism, present keep silent, rigid limbs, visible pyramidal sign of having a medical check-up is positive, has Primitive reflexs such as holding by force, grope and suck.Final stupor, generally dies from the complication such as infection.
The traditional Chinese medical science thinks that the cause of disease of senile dementia is mainly damaged not enough by essence, gas, anemia, and brain is hollow, insufficiency of vital energy and blood, the gods owner of lost property, or gas, fire, all evil internal resistances of expectorant, above disturb clearly caused by key.Itself and position are at brain, but closely related with the internal organs such as the kidney liver heart, spleen.Chinese medicine has original advantage in treatment senile dementia, with a long history and experienced.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of senile dementia, improve senile dementia symptom.
The Chinese medicine composition for the treatment of senile dementia of the present invention, is made up of the crude drug comprising following weight portion: Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Radix Ginseng 3-10 part, Rhizoma Acori Graminei 3-9 part, Fructus Alpiniae Oxyphyllae 3-9 part, Rhizoma Chuanxiong 3-10 part, Radix Astragali 10-30 part and Radix Polygalae 3-9 part.
In one embodiment of the invention, the weight proportion of each crude drug of described Chinese medicine composition is: Radix Salviae Miltiorrhizae 10 grams, Radix Angelicae Sinensis 10 grams, Radix Ginseng 6 grams, Rhizoma Acori Graminei 6 grams, Fructus Alpiniae Oxyphyllae 6 grams, Rhizoma Chuanxiong 6 grams, the Radix Astragali 10 grams, Radix Polygalae 6 grams.
The Chinese medicine composition that the present invention treats senile dementia conventionally can make the various dosage forms on pharmaceutics, comprises tablet, capsule, pill, granule, oral liquid, colloid, syrup etc.
The preparation method of Chinese medicine composition of the present invention comprises the following steps:
1) take the crude drug of described weight portion, extract 2-3 time with the alcohol heating reflux of 50-90%, each ethanol extracting the 50-90% of the 5-20 times amount using crude drug weight, each extraction time is 1-3 hour, and merge extractive liquid, filters to get filtrate;
2) filtrate recycling ethanol, is concentrated into thick paste;
3) thick paste be dry, pulverize into fine powder, be then prepared into required dosage form, or thick paste is added pharmaceutic adjuvant and be prepared into various dosage form.
Treat in the Chinese medicine composition of senile dementia in the present invention, Radix Salviae Miltiorrhizae is monarch drug, has effect that nourishing blood and promoting blood circulation is calmed the nerves, and improves brain microcirculation; All the other are ministerial drug, and Radix Angelicae Sinensis has effect of blood circulation promoting and enriching, antioxidation free radical resisting; Radix Ginseng has effect of invigorating QI and tranquilization Fructus Alpiniae Oxyphyllae, strengthens ability of learning and memory; Rhizoma Acori Graminei has effect of refreshment Fructus Alpiniae Oxyphyllae, strengthens ability of learning and memory; Fructus Alpiniae Oxyphyllae has effect that the kidney warming takes the photograph expectorant; Rhizoma Chuanxiong has effect that circulation of qi promoting is dispeled the wind; The Radix Astragali has effect of invigorating the spleen and replenishing QI; Radix Polygalae has the effect of Fructus Alpiniae Oxyphyllae of calming the nerves, and can promote muscle power and intelligence, dementia and protection brain.Eight taste medical instruments have the effect of Synergistic, combined effect, have effect of Fructus Alpiniae Oxyphyllae of calming the nerves, dementia, enhancing ability of learning and memory.
Detailed description of the invention
The invention will be further described by the following examples, but this is not limitation of the present invention, those skilled in the art, according to basic thought of the present invention, can make various amendment or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
Embodiment 1: prepared by medicine
Crude drug: Radix Salviae Miltiorrhizae 10 grams, Radix Angelicae Sinensis 10 grams, Radix Ginseng 6 grams, Rhizoma Acori Graminei 6 grams, Fructus Alpiniae Oxyphyllae 6 grams, Rhizoma Chuanxiong 6 grams, the Radix Astragali 10 grams, Radix Polygalae 6 grams.
Preparation process:
1) crude drug of described weight portion is taken;
2) add the ethanol of 80% of 10 times amount by weight, heating and refluxing extraction, repeat aforementioned operation and extract 1 time again, each 2 hours, merge extractive liquid, filtered to get filtrate;
3) filtrate recycling ethanol, is concentrated into thick paste;
4) thick paste be dry, pulverize into fine powder;
5) fine powder is divided encapsulated.
Experimental example: drug effect is checked
Animal: 80 SPF level KM mices, 18-22g, male and female half and half.
Medicine: Chinese medicine composition of the present invention, by embodiment 1 thick paste fine powder adding distil water suspension.
Control drug: piracetam, fine powder processed, adding distil water suspension.
Experimental technique:
Mice is divided into 4 groups at random according to body weight: matched group, model group, Chinese medicine composition group of the present invention, piracetam group, often organizes 20.Except matched group lumbar injection normal saline and gavage equivalent distilled water, all the other are group lumbar injection D-galactose 60mg/ (kg.d) (normal saline) and gavage AlCl35mg/ (kg.d) (distilled water preparation) respectively, every day 1 time, continuous 60d.Chinese medicine composition of the present invention and piracetam group give outside D-galactose and AlCl3 the morning from modeling, and afternoon every day gives corresponding medicine, every day 1 time, and continuous 60 days, gavage volume was 0.2mL/10g.
Mice Jumping test: memory sexual disorders is tested.
Last administration starts training after 1 hour, animal is put into reaction chamber (on platform, under platform) and conform 3 minutes, and then by the copper grid in animal placing response case, logical 36 volts of alternating currents immediately, animal is shocked by electricity, and its normal reaction is on rebound platform.After training once, animal is placed on the platform in reaction chamber, records each Mus in 5 minutes and jump off the errors number of platform and jump off the incubation period of platform for the first time, in this, as school grade.As shown in the table:
| Group | Dosage #（g/kg） | Incubation period (second) | 5 minutes errors number |
| Matched group | 305±33 | 0.3±0.2 | |
| Model group | 128±79 | 2.1±1.3 |
| Piracetam group | 0.3 | 283±26* | 0.5±1.1* |
| Chinese medicine composition group of the present invention | 0.5 | 291±61* | 0.5±1.1* |
Compare with model group,
*p < 0.05;
#dosage refers to the grams of medicated powder added by every kg body weight.
Result shows, Chinese medicine composition of the present invention has the effect improving Senlie dementia model ability of learning and memory in mice.Further, Chinese medicine composition of the present invention has the effect improving senile dementia.
Claims (3)
1. treat a Chinese medicine composition for senile dementia, be made up of the crude drug comprising following weight portion: Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Radix Ginseng 3-10 part, Rhizoma Acori Graminei 3-9 part, Fructus Alpiniae Oxyphyllae 3-9 part, Rhizoma Chuanxiong 3-10 part, Radix Astragali 10-30 part and Radix Polygalae 3-9 part.
2. Chinese medicine composition according to claim 1, is characterized in that, the weight proportion of described each crude drug is: Radix Salviae Miltiorrhizae 10 grams, Radix Angelicae Sinensis 10 grams, Radix Ginseng 6 grams, Rhizoma Acori Graminei 6 grams, Fructus Alpiniae Oxyphyllae 6 grams, Rhizoma Chuanxiong 6 grams, the Radix Astragali 10 grams and Radix Polygalae 6 grams.
3. the preparation method of Chinese medicine composition described in claim 1 or 2, comprises the following steps:
1) take the crude drug of described weight portion, extract 2-3 time with the alcohol heating reflux of 50-90%, each ethanol extracting the 50-90% of the 5-20 times amount using crude drug weight, each extraction time is 1-3 hour, and merge extractive liquid, filters to get filtrate;
2) filtrate recycling ethanol, is concentrated into thick paste;
3) thick paste be dry, pulverize into fine powder, be then prepared into required dosage form, or thick paste is added pharmaceutic adjuvant and be prepared into various dosage form.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983962A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine capsules for preventing and treating senile dementia |
| CN104984110A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine decoction for preventing and treating presenile dementia |
| CN105031325A (en) * | 2015-06-30 | 2015-11-11 | 虞志秋 | Chinese herbal capsule for preventing and curing presenile dementia |
| CN108025030A (en) * | 2015-09-14 | 2018-05-11 | 莫里艾克私人有限公司 | It is used to prepare the method for herb extracts |
| CN108743864A (en) * | 2018-08-14 | 2018-11-06 | 宁夏医科大学 | A kind of Chinese medicine preparation and preparation method thereof of the diabetes complicated senile dementia of prevention |
| CN113521178A (en) * | 2021-08-25 | 2021-10-22 | 昆明市中医医院 | Traditional Chinese medicine composition for preventing and treating senile dementia |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983962A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine capsules for preventing and treating senile dementia |
| CN104984110A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine decoction for preventing and treating presenile dementia |
| CN105031325A (en) * | 2015-06-30 | 2015-11-11 | 虞志秋 | Chinese herbal capsule for preventing and curing presenile dementia |
| CN108025030A (en) * | 2015-09-14 | 2018-05-11 | 莫里艾克私人有限公司 | It is used to prepare the method for herb extracts |
| CN113893278A (en) * | 2015-09-14 | 2022-01-07 | 莫里艾克私人有限公司 | Method for preparing herbal extracts |
| CN108025030B (en) * | 2015-09-14 | 2023-09-26 | 莫里艾克私人有限公司 | Method for preparing herbal extracts |
| CN108743864A (en) * | 2018-08-14 | 2018-11-06 | 宁夏医科大学 | A kind of Chinese medicine preparation and preparation method thereof of the diabetes complicated senile dementia of prevention |
| CN113521178A (en) * | 2021-08-25 | 2021-10-22 | 昆明市中医医院 | Traditional Chinese medicine composition for preventing and treating senile dementia |
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