CN101961437B - Anti-stress compound preparation and preparation process thereof - Google Patents
Anti-stress compound preparation and preparation process thereof Download PDFInfo
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- CN101961437B CN101961437B CN2010102909519A CN201010290951A CN101961437B CN 101961437 B CN101961437 B CN 101961437B CN 2010102909519 A CN2010102909519 A CN 2010102909519A CN 201010290951 A CN201010290951 A CN 201010290951A CN 101961437 B CN101961437 B CN 101961437B
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Abstract
The present invention discloses an anti-stress compound preparation, which consists of 30 weight parts of Chinese medicinal composition and 0.65 weight part of nutrient composition, wherein the Chinese medicinal composition comprises the following components in part by weight: 5 to 40 parts of 0.8 percent eleutheroside, 5 to 40 parts of 2 percent salisorosides rosavin, 3 to 20 parts of spina date seed, 10 to 70 parts of grassleaf sweelflag rhizome, 5 to 50 parts of tribulus terrestris L. and 5 to 40 parts of astragalus; and the nutrient composition comprises the following components in part by weight: 100 to 300 parts of tyrosine, 3 to 20 parts of vitamin C, 40 to 100 parts of vitamin B2, 100 to 220 parts of vitamin B1, 40 to 100 parts of vitamin B6, 100 to 220 parts of vitamin PP, 2 to 12 parts of folic acid, 40 to 120 parts of ferrous lactate and 200 to 800 vitamin E powder containing 30 percent of VE. Capsules of the invention are proved by clinical application to have the effects of supporting right, securing the root and enhancing the immunity of organisms, are applied to people with relatively higher life stress and work stress in the modern society, and can enhance the endurance of the organisms, reduce the stress-resisting stress levels of the organisms and improve the anti-stress capability of the organisms.
Description
Technical field
The present invention relates to a kind of anti-stress compound preparation and preparation technology thereof, belong to pharmaceutics of Chinese drugs and clinical practice field.
Background technology
The reaction of the body Fitow that stress be meant strong or deleterious stimulation to destroy the stable state of organismic internal environment and the cause opposite sex, appropriateness stress play an important role to keeping body existence, excessive or persistently stress cause a series of pathological phenomenons to produce.Chronic stress be a kind of persistent excessively stress, be to cause the particularly important cause of disease of nerve and mental sickness of many chronic diseases.Long-term chronic stress can cause the central nervous system function imbalance, show as degradation symptom under anxiety, insomnia, forgetful, absent minded, the ability of learning and memory clinical, having a strong impact on people's physical and mental health and quality of life, especially in military operation, stress disorders usually causes army's non-combat casualty, and modern medicine still lacks effective means in the face of how to prevent stress damage and improve resisting stress capability.But people's actual life and special operation and national defence then are starved of effective anti-stress medicine.
Summary of the invention
The purpose of this invention is to provide a kind of anti-stress compound preparation and preparation technology thereof, clinical efficacy is definite, and toxic and side effects is little, and is cheap and have wide range of applications.
A kind of anti-stress compound preparation, be made up of 30 parts of weight powder Chinese medicine compositions and 0.65 part of weight portion nutrient composition, wherein said Chinese medicine composition is by weight: 0.8% eleutheroside 5-40 part, 2% rhodioloside 5-40 part, Semen Ziziphi Spinosae 3-20 part, Rhizoma Acori Graminei 10-70 part, Fructus Atriplicis Sibiricae 5-50 part and Radix Astragali 5-40 part; Nutrient composition is by weight: tyrosine 100-300 part, vitamin C 3-20 part, vitamin B2 40-100 part, vitamin B1
100-220 part, vitamin B6 40-100 part, vitamin PP 100-220 part, folic acid 2-12, zinc lactate 40-120 part, ferrous lactate 40-120 part, vitamin E powder (containing VE30%) 200-800 part.
According to the prescription of compound preparation, the preparation technology of employing is: respectively Semen Ziziphi Spinosae, Rhizoma Acori Graminei, Fructus Atriplicis Sibiricae, the Radix Astragali four flavor Chinese medicines are detected impurity in 60 ℃ of drying baker dry 24 hours, be ground into fine powder and cross 100 mesh sieves, mix, and standby; With above-mentioned mixing fine powders and 0.8% eleutheroside, 2% rhodioloside mixing, obtain Chinese medicine composition then; With Chinese medicine composition and the abundant mixing of nutrient composition, the fill capsule is packed, promptly at last.
The traditional Chinese medical science stress prevention and the treatment category that is classified as strengthening the body resistance, the strengthening the body resistance rule of treatment is from integral body, transfers the body intrinsic factor, improves body resistance against diseases, to reach the purpose of treatment disease.Because the important function of kidney in traditional Chinese medical science internal organs system, so " the kidney invigorating " in the strengthening the body resistance rule of treatment, occupy important position.Multiple disease progression is when suffering from a deficiency of the kidney the stage, and the method for all available the kidney invigorating, regulating YIN and YANG is treated, and fully shows the importance of the strengthening the body resistance rule of treatment.
We are analyzing on the empirical basis of forefathers, and, think from clinical practice that the pathogenesis that stress cause should the single comprehensive pathogenesis of right and wrong according to modern pharmacological research achievement clinical application gains in depth of comprehension.Prophylactic agent should increase body resisting fatigue ability, human body immunity improving power based on strengthening the body resistance.Among the present invention, Radix Et Caulis Acanthopanacis Senticosi sees the Han dynasty Shennong's Herbal the earliest, it has been classified as top grade medicine.Clothes of a specified duration can be made light of one's life by commiting suicide, the life lengthening face is harmless, its acrid in the mouth, little hardship, warm in nature, Radix Et Caulis Acanthopanacis Senticosi contains extract, and composition---eleutheroside has functions such as invigorating middle warmer, smart, the strong will of benefit, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, the diuresis of being good for the stomach, can regulate the body disorder, antifatigue effect, but Radix Et Caulis Acanthopanacis Senticosi extract shows irritation cell immunity, stimulates the T-cell to produce.Radix Rhodiolae, sweet in the mouth, hardship, flat.Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica record " Radix Rhodiolae, herbal classic is top grade, the evil gas of method is mended various symptoms and signs of deficiency " be " institute is rare in the known tonic ".Rhodioloside has the magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting, it is considered as " lucky three essentials-essence " by the successive dynasties Tibetan medicine.Semen Ziziphi Spinosae, nature and flavor are sweet, and are flat." Medical Treasures of the Golden Chamber " meaning Semen Ziziphi Spinosae cures mainly controls consumptive disease with restlessness, and insomnia has nourishing the liver, and mind calming is calmed the nerves, the effect of arresting sweating.Rhizoma Acori Graminei, acrid in the mouth, temperature.. Compendium of Material Medica meaning Rhizoma Acori Graminei temperature, the deficiency of heart-QI person use it, reinforcing the mother-organ for treating deficiency of the son-organ also, Shennong's Herbal meaning Rhizoma Acori Graminei main air cold-damp numbness, cough with dyspnea, happy hole, tonifying five ZANG-organs leads to nine orifices, improve visual and auditory acuity goes out sound sound.Clothes are made light of one's life by commiting suicide for a long time, do not forget, and do not confuse, and prolong life ".Has the calmness of calming the nerves, the effect of hypermnesis.Fructus Atriplicis Sibiricae, bitter in the mouth, suffering have the suppressing the hyperactive liver resolving depression, the effect of dispelling pathogenic wind for improving eyesight.The Radix Astragali, sweet in the mouth, tepor.Belong to QI invigorating good medicine, have benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.Being aided with various nutrients increases the body nutrition supply, reaches the effect that increases body resistance against diseases.
The present invention is principle of treatment just with the strengthening the body resistance, based on spleen invigorating regulate the flow of vital energy, invigorating QI and blood, nourishing the liver and kidney, be aided with methods such as depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, eliminating damp-heat, hard masses softening and resolving, eliminating mass removing mass respectively, innovation part of the present invention, the strong point of the traditional Chinese medical science " preventive treatment of disease " just also is the embodiment of policy of putting prevention first.Adopt Radix Et Caulis Acanthopanacis Senticosi extract, Radix Rhodiolae extract invigorating the spleen and replenishing QI, strengthening the body resistance is main, increase body resisting fatigue ability, human body immunity improving power is again with the Semen Ziziphi Spinosae QI invigorating of calming the nerves, nourishing the liver, mind calming, magical effect Rhizoma Acori Graminei expelling wind and removing dampness, Fructus Atriplicis Sibiricae suppressing the hyperactive liver resolving depression, Radix Astragali benefiting QI for strengthening the superficies, arresting sweating take off admittedly, inducing diuresis to remove edema.Be aided with various nutrients and satisfy the body nutritional need, improve resisting stress capability, improve body health, can fill up the market neutral gear, adapt to the needs of era development, thus practical, have a extensive future.
Description of drawings
Fig. 1 is the horizontal variation diagram of interleukin-6 in the acute stress serum (IL-6).
Fig. 2 is the horizontal variation diagram of interleukin-2 in the acute stress serum (IL-2).
Fig. 3 is the horizontal variation diagram of acute stress tumor necrosis factor (TNF-α).
Fig. 4 is the horizontal variation diagram of interleukin-6 in the chronic stress serum (IL-6).
Fig. 5 is the horizontal variation diagram of interleukin-2 in the chronic stress serum (IL-2).
The specific embodiment
Embodiment 1
Take off row Chinese medicine composition and nutrient composition by weight: 5 parts of 5 parts of 0.8% eleutherosides, 5 parts of 2% rhodiolosides, 3 parts of Semen Ziziphi Spinosaes, 10 parts of Rhizoma Acori Graminei, 5 parts of Fructus Atriplicis Sibiricaees and the Radixs Astragali; Nutrient composition is: 100 parts in tyrosine, 3 parts of vitamin Cs, 40 parts of vitamin Bies, 00 part of VB11,40 parts of vitamin Bies, 100 parts of vitamin Pies, 2 parts in folic acid, 40 parts of zinc lactate, 40 parts of ferrous lactates, 200 parts of vitamin E powders (containing VE30%).
Take off row Chinese medicine composition and nutrient composition by weight: 40 parts of 40 parts of 0.8% eleutherosides, 40 parts of 2% rhodiolosides, 20 parts of Semen Ziziphi Spinosaes, 70 parts of Rhizoma Acori Graminei, 50 parts of Fructus Atriplicis Sibiricaees and the Radixs Astragali; Nutrient composition is: 300 parts in tyrosine, 20 parts of vitamin Cs, 100 parts of vitamin Bies, 20 parts of vitamin B1ies, 100 parts of vitamin Bies, 220 parts of vitamin Pies, 12 parts in folic acid, 120 parts of zinc lactate, 120 parts of ferrous lactates, 800 parts of vitamin E powders (containing VE30%).
Embodiment 3
Take off row Chinese medicine composition and nutrient composition by weight: 20 parts of 20 parts of 0.8% eleutherosides, 20 parts of 2% rhodiolosides, 10 parts of Semen Ziziphi Spinosaes, 50 parts of Rhizoma Acori Graminei, 30 parts of Fructus Atriplicis Sibiricaees and the Radixs Astragali; Nutrient composition is: 200 parts in tyrosine, 10 parts of vitamin Cs, 60 parts of vitamin Bies, 50 parts of VB11s, 60 parts of vitamin Bies, 150 parts of vitamin Pies, 10 parts in folic acid, 100 parts of zinc lactate, 80 parts of ferrous lactates, 500 parts of vitamin E powders (containing VE30%).
Embodiment 4
Take off row Chinese medicine composition and nutrient composition by weight: 20 parts of 30 parts of 0.8% eleutherosides, 20 parts of 2% rhodiolosides, 10 parts of Semen Ziziphi Spinosaes, 40 parts of Rhizoma Acori Graminei, 30 parts of Fructus Atriplicis Sibiricaees and the Radixs Astragali; Nutrient composition is: 120 parts in tyrosine, 10 parts of vitamin Cs, 60 parts of vitamin Bies, 40 parts of VB11s, 60 parts of vitamin Bies, 60 parts of vitamin Pies, 8 parts in folic acid, 70 parts of zinc lactate, 80 parts of ferrous lactates, 500 parts of vitamin E powders (containing VE30%).
The preparation technology of above embodiment is: respectively Semen Ziziphi Spinosae, Rhizoma Acori Graminei, Fructus Atriplicis Sibiricae, the Radix Astragali four flavor Chinese medicines detected impurity in 60 ℃ of drying baker dry 24 hours, is ground into fine powder, cross 100 mesh sieves, mix, and standby; With above-mentioned mixing fine powders and 0.8% eleutheroside, 2% rhodioloside mixing, obtain Chinese medicine composition then; Last 30 parts Chinese medicine composition and 0.65 part the nutrient composition got by weight, abundant mixing, the fill capsule, packing, promptly.
The capsule that the present invention makes confirms to have strengthening the body resistance, enhancing human body immunity power function through clinical practice.Be applicable to life in the modern society, the crowd that operational pressure is bigger, but the stress level of enhancing body endurance, alleviation body counter pressure, the anti-stress ability of raising body.Oral; The prevention: one time 4,2 times on the one.The treatment: one time 4,3 times on the one, 4 weeks were a course of treatment.
Attached 1: clinical practice
1, clinical data: among the 56 routine patients, the oldest person 45 years old, age reckling 18 years old, 30 years old mean age, the elder of the course of disease 5 years, the shortest person 3 months.All cases Tibet of all doing for oneself is carried out special duty and is gone to a doctor.Have typical symptoms, be diagnosed as in various degree stress disorders through psychological doctor, but do not have obvious clinical symptoms, the blood pressure heart rate is all in normal range.
2, Therapeutic Method: oral capsule, one time 4,3 times on the one; The shortest person used for 1 week (accounting for 22%), the most of use 2 weeks (58%); The longest 4 weeks of use (20%) are estimated curative effect.
3, the evaluation criteria of therapeutic effect
Cure: patient's subjective symptoms disappears, and sign is normal, does not have recurrence after the drug withdrawal in February;
Effectively: patient's subjective symptoms disappears, and sign takes a turn for the better, recurrence in February after the drug withdrawal;
Invalid: with compare symptom, sign before the medication and do not have and be clearly better.
4, therapeutic outcome: among the 56 routine patients through observing,, cure 27 examples through the treatment of a course of treatment, 23 examples that take a turn for the better, invalid 6 examples, cure rate is 48.2%, total effective rate is 89.2%.
5, this capsule is in therapeutic process, and untoward reaction such as allergy, diarrhoea, weak, poor appetite appear in no case.
Attached 2: zoopery:
1, acute stress: the acute stress beam combination is tied up cold water soak stress 30 minutes.
Adopt the SD rat, be divided into three groups: normal control group (control), stress matched group (stress), acute stress+medicine group (stress+CN);
Medication is made into 340.56mg/ml concentration with drinking water with compound nutrients, gastric infusion, and every animal 3ml/d irritates 1 week of stomach, normal control group and stress matched group give the equivalent drinking water and irritate stomach.Implement acute stress after the administration.
Result: observe interleukin-6 (IL-6) in the serum, interleukin-2 (IL-2), the variation of tumor necrosis factor (TNF-α) level, as Fig. 1, Fig. 2 and shown in Figure 3.
Behind the acute stress, IL-6, the acute rising of TNF-alpha levels in the serum, the IL-2 level descends, and gives with the pharmaceutical intervention group to occur reversing.
2, chronic stress: stress group constraint cold water soak stress 30 minutes, 2 weeks of continued stimulus.
Adopt the SD rat, be divided into three groups: normal control group (control), stress matched group (stress), chronic stress+medicine group (stress+CN);
Medication is made into 340.56mg/ml concentration with drinking water with compound nutrients, gastric infusion, every animal 3ml/d, 1 all administrations in advance, 3 weeks of medicine feed, the 2nd week beginning chronic stress.Normal control group and stress matched group give the equivalent drinking water and irritate stomach.
Result: observe interleukin-6 (IL-6) in the serum, the variation of interleukin-2 (IL-2) level, as shown in Figure 4 and Figure 5
Behind the chronic stress, the acute rising of IL-6 level in the serum, the IL-2 level descends, and gives with the pharmaceutical intervention group to occur reversing.
Claims (2)
1. anti-stress compound preparation, it is characterized in that being made up of 30 parts of weight portion Chinese medicine compositions and 0.65 part of weight portion nutrient composition, wherein said Chinese medicine composition is by weight: 0.8% eleutheroside 5-40 part, 2% rhodioloside 5-40 part, Semen Ziziphi Spinosae 3-20 part, Rhizoma Acori Graminei 10-70 part, Fructus Atriplicis Sibiricae 5-50 part and Radix Astragali 5-40 part; Nutrient composition is by weight: tyrosine 100-300 part, vitamin C 3-20 part, vitamin B2 40-100 part, vitamin B1 100-220 part, vitamin B6 40-100 part, vitamin PP 100-220 part, folic acid 2-12 part, zinc lactate 40-120 part, ferrous lactate 40-120 part, contain vitamin E powder 200-800 part of VE30%.
2. a kind of anti-stress compound preparation as claimed in claim 1, the preparation technology who it is characterized in that the anti-stress compound preparation is: respectively Semen Ziziphi Spinosae, Rhizoma Acori Graminei, Fructus Atriplicis Sibiricae, the Radix Astragali four flavor Chinese medicines are picked impurity in 60 ℃ of drying baker dry 24 hours, be ground into fine powder and cross 100 mesh sieves, mix, standby; With above-mentioned mixing fine powders and 0.8% eleutheroside, 2% rhodioloside mixing, obtain Chinese medicine composition then; With Chinese medicine composition and the abundant mixing of nutrient composition, the fill capsule is packed, promptly at last.
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| CN105831481A (en) * | 2016-03-24 | 2016-08-10 | 宁波大学 | Special anti-stress enhancer for black sea bream and application thereof |
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| 朱凤香等.植物源抗应激剂有效成分的提取及应用初报.《浙江农业科学》.2004,(第6期),第338－340页. * |
| 李丽辉等.刺五加的研究进展.《国土与自然资源研究》.2008,(第3期),第95-96页. * |
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