CN1698658A - Composite propolis soft capsule - Google Patents
Composite propolis soft capsule Download PDFInfo
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- CN1698658A CN1698658A CNA2005100466178A CN200510046617A CN1698658A CN 1698658 A CN1698658 A CN 1698658A CN A2005100466178 A CNA2005100466178 A CN A2005100466178A CN 200510046617 A CN200510046617 A CN 200510046617A CN 1698658 A CN1698658 A CN 1698658A
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- propolis
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- lecithin
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Abstract
The invention provides a composite propolis soft capsule, wherein the compositions comprises (by weight ratio) bee glue 3.0-3.5kg, ginkgo leaves extract 0.2-0.4kg, phosphatidy icholine 0.2-0.5kg, organic chromium 0.01-0.02kg, polyethylene glycol 5-6kg as emulsifying agent, and glycerol 0.3-0.5kg. The invention is characterized in that the capsule contains various unsaturated fatty acids, fatty acid, microelements and vitamins that are easy to be absorbed by human body.
Description
Technical field:
The present invention relates to the functional food technical field, particularly a kind of composite propolis soft capsule and production field.
Technical background:
The basis of the propolis that existing market is sold is the fragrant complex 39%-53% of resin, Polyphenols 12%-17%, polysaccharide 2%-3%, Cera Flava 19%-35%, impurity (containing pollen) 8%-12%, and it does not have the materials such as lecithin in blood pressure lowering, blood fat, the necessary organic chromium of blood glucose, EPA, DHA, bilobanone, Semen Ginkgo lactone etc. and the phospholipid.Therefore, can not effectively reduce serum cholesterol, improve glucose tolerance, suppress the activity of Angiotensin-Converting (ACE), anti-hemostatic tube tip shrinks.Its production technology also is traditional processing, can not make the nutrition in the propolis reasonably combined, gives full play to maximum effect separately.
Summary of the invention:
The objective of the invention is provides a kind of multiple unsaturated fatty acid that contains at the deficiency that exists in the above-mentioned technology, polyenoic fatty acid, various trace elements, vitamin and the composite propolis soft capsule and the production technology that are absorbed by the body easily and utilize.Make the nutritional labeling in the propolis reasonably combined, make the balanced in nutrition of absorption of human body.
The present invention is achieved in that and comprises: propolis, Folium Ginkgo, lecithin, organic chromium etc.It is characterized in that contained composition and weight number are than being major ingredient: propolis 3.0-3.5kg, Folium Ginkgo extract 0.2-0.4kg, lecithin 0.2-0.5kg, organic chromium 0.01-0.02kg, emulsifying agent Polyethylene Glycol 5-6kg, glycerol 0.3-0.5kg.
Its technology is:
1, the purifying technique of propolis
1.1 select glue the propolis index to be measured according to the propolis industry standard, select the purity height, the propolis conduct that impurity is few processes raw material
1.2 freezing processing is freezing 5-6h under-5 ℃ of conditions
1.3 pulverize and propolis be crushed to 20 orders with ball mill
1.4 the lixiviate of propolis
1. experimental results show that propolis dissolving 60%-65% in 70% alcoholic solution.And have only the antibacterial characteristics of the propolis solution that is dissolved state in 70% alcoholic solution the strongest
2. solid-liquid ratio was controlled at 1: 5
3. temperature is controlled at below 25 ℃
Propolis and ethanol are placed the stirring extraction pot, in under 4 ℃ of conditions about lixiviate 8h, getting supernatant places storage tank to be filtered, filtering residue and sediment merge, and add 5 times of volume of ethanol again and stir and extract, isolate supernatant after leaving standstill, extract twice so repeatedly, the propolis active ingredient is all proposed.
1.5 filter with silt and insoluble matter in the centrifugalize filter filtration propolis
1.6 vacuum concentration reclaims ethanol
1. propolis solution is pumped in the concentration pan
2. connect condenser cooling water
3. open the hydraulic vacuum pump, the vacuum in the concentration tank is reached
66.7Kpa(500mmHg)
4. connect steam
5. control vapour pressure and make a jar interior temperature reach 145 ℃, propolis extraction page or leaf comes to life in jar, and alcohol vapour is liquefied and flows in the storage tank
6. after ethanol is evaporated completely, stop hydraulic vacuum and steam
7. propolis cream emitted, cool off, cut apart, coarse pulverization to 50 order
1.7 50 order propolis powder are dropped in the vertical belt jet pulverizer, and the material grain that utilizes high steam that hopper is entered quickens and forms disorderly shape to rotatablely move, and causes fragmentation.Broken thing rises with air-flow, when moving to the inlet of clasfficiator, is subjected to the revolution swirling action of air-flow and the air draught effect of axial vacuum, the fine powder of 5um is by outside the clasfficiator discharge machine, then centrifugalization and away from clasfficiator, getting back in the pulverizing chamber of coarse grain is pulverized once more.
1.8 fusing, emulsifying add propolis in emulsifying agent Polyethylene Glycol and the glycerol by the formula proportion in the scheme, heating with it, and temperature is controlled at 70 ℃, and addition sequence is, will melt good propolis earlier and fully mix with emulsifying agent, adds glycerol at last, mixing 15min
2, emulsifying is good propolis, lecithin, Folium Ginkgo extract, organic chromium are put into homogenizer in proportion respectively, fully mix 15min.
3, the loading of filled capsules composite propolis soft capsule is 0.5g, ± 10mg
4, drying, screening, pressing plate, finished product warehouse-in
Pharmacology function of the present invention is:
One, regulates hyperglycemia, prevention and adjuvant therapy of diabetes
Composite propolis is blood sugar lowering significantly, reduces the consumption of insulin, can comparatively fast make the blood sugar recovery normal value.Remove symptoms such as thirsty, hunger.And can prevent and treat by the caused complication of diabetes.Composite propolis has the effect of bactericidal antiphlogistic.Diabetics blood sugar content height, hypoimmunity, easy concurrent inflammation, composite propolis is control infection effectively, and conditions of patients is progressively improved.The mechanism that the composite propolis blood sugar lowering is prevented and treated complication has following several:
1, the flavonoid in the composite propolis, terpenoid substance have the reductive effect of the glycogen of promotion, thus blood sugar lowering.And this adjusting is two-way, can not reduce normal person's blood glucose.
2, composite propolis not only can anti-inflammation, can also the activating cell restore funcitons, thus blood sugar lowering content.
3, flavone compound can blood fat reducing, improves blood circulation, thereby can the treatment of vascular intercurrent disease.
4, flavonoid, glycoside can strengthen adenosine triphosphate (ATP) enzyme in the composite propolis.ATP is the source of human body energy, and enzymatic activity is strengthened, and ATP content increases, and promotes antisecosis.
5, chromium is the ingredient of glucose tolerance factor, can cause glucose tolerance to reduce after the shortage.So-called " glucose tolerance " is meant that taking in glucose (maybe can resolve into the material of glucose) rises blood glucose, makes blood glucose recover normal rapidly after menses are taken away.It mainly acts on is to assist insulin to play a role.Chromium have effect as a cofactor to starting islets of langerhans in the carbohydrate metabolism.Its model of action may be that the glucose tolerance factor that contains chromium promotes to dredge the thin base of cell membrane and insulin molecule A chain and two two and forms a stable bridge between the keys, makes insulin can fully play effect.Chromium has effect to the serum cholesterol homeostasis, but therefore prevention of arterial sclerosis.Glucose can not be made full use of, thereby cause blood sugar increasing, growth retardation, atherosclerosis and Incidence of CHD increase and might cause the generation of type ii diabetes.
Along with the increase at age, intravital chromium reduces gradually.In the composite propolis scientifically proportionately for each person the daily intake ratio that is about 50-200mcg add the organic chromium very easily be absorbed by the body and utilize.It can with the insulin synergism, carry out the metabolism of sugar, assist to carry protein to required place.
Other chemical element such as calcium can influence secretion of insulin and release, zinc can be kept the structure of insulin and can participate in the coenzyme that islet cell function is regulated, nickel is insulin with function, magnesium and become to grade.Therefore enrich chemical element in the composite propolis to activating insulin, improve carbohydrate tolerance, regulating islet cell function all has certain meaning.
Two, regulate hyperlipidemia, reduce the worry of adiposis patient
Composite propolis has obvious regulating action to hyperlipidemia, hypercholesterolemia, high blood stickiness; can pile up by the interior collagen fiber hypertrophy regulating liver-QI inner cholesterol of prevention of arterial blood vessel; atherosclerosis there is preventive and therapeutic effect; can know effectively that blood vessel accumulates thing; antithrombotic forms; the protection cardiovascular and cerebrovascular vessel are improved blood circulation state and hematopoietic function.
1, contain 51 kinds of fatty acids and fatty acid ester in the composite propolis, they can the appreciable impact lipoprotein metabolism, thereby changes the danger of cardiovascular disease.Polyunsaturated fatty acid can reduce the LDL-cholesterol, so fatty acid all can make the HDL-cholesterol concentration raise, but this effect reduces along with the increase of index of unsaturated fatty acid.In addition when fatty acid with after cholesterol in the blood combines, a high proportion of cholesterol can be taken away, to reduce serum cholesterol, suppress platelet aggregation, prevent thrombosis.Angiocardiopathy preventing and apoplexy improve immunoregulation capability.
2, ginkgetin class, Semen Ginkgo (hardship) lactone have hypolipemic function preferably in the composite propolis.Fat by in vessel softening, the elimination blood reduces serum cholesterol, improves blood circulation.Can cerebral blood flow increasing and microcirculation improvement, this has the effect of antiplatelet activity factor PAF mainly due to its contained bilobalide, can reduce blood stickiness and erythrocyte aggregation, thereby improve the rheological characteristic of blood.Eliminate free radical neuroprotective cell.Hydroxy radical, superoxide anion and the nitric oxide of elimination arranged, suppress lipid peroxidation, its effect is more lasting than vitamin E.
3, lecithin is human body vitals brain, the heart, liver, the isocellular important composition composition of lung, is the high vigor material of keeping cell life, can provide body required phosphatidylcholine.Lecithin has the reduction serum cholesterol, improves blood circulation, the function of angiocardiopathy preventing.
With advancing age, cholesterol deposits in blood vessel and causes arteriosclerosis, finally brings out the appearance of cardiovascular disease.Lecithin has the good emulsifying characteristic, can stop cholesterol to remove the part deposit in the deposition of blood vessel, improves the absorption and the utilization of fat simultaneously, therefore has the effect of angiocardiopathy preventing.Because the emulsibility of lecithin, so can reduce blood viscosity, blood circulation promoting improves the blood oxygen circulation, prolongs the erythrocyte life span and strengthens hemopoietic function.
Three, regulate hypertension, eliminate and the alleviation hypertension symptom
Cholesterol in the blood, the too high formation atherosclerosis of triglyceride make vasoconstriction and the planning function produce obstacle, at this moment just need higher blood pressure to come blood circulation promoting, cause blood pressure to increase.And composite propolis has very strong oxidation resistance, the Flavonoid substances that wherein is rich in not only can reduce or lipid oxide to the harm of blood vessel, stop sclerosis of blood vessels, and can effectively reduce content of triglyceride, reduce platelet aggregation, microcirculation improvement.The aminoacid that contains in the composite propolis can suppress the activity of Angiotensin-Converting (ACE), can prevent that the hemostatic tube tip shrinks, thereby reach the effect that brings high blood pressure down, thereby hypertension is had certain preventive and therapeutic effect.
In sum, the prescription of composite propolis meets the rationale of amynologic mechanism, its function is clear and definite, concrete, and the process scientific validation is sure, and being nontoxic, the harmless due nutritional requirement that meets, is to adjust the specific crowd of certain aspect body function and the product of development and production at needs.
The specific embodiment
Embodiment 1
Production technology is the mensuration of propolis being carried out physical and chemical index and sanitary index according to propolis industry operative norm, selection purity height, the propolis that impurity is few are used raw material as processing, freezing processing 5-6h under-5 ℃ of conditions, pulverize with ball mill, lixiviate in 70% alcoholic solution is filtered propolis with the centrifugalize filter, and vacuum concentration reclaims ethanol, micronizing, emulsifying are produced propolis 3.15kg.Emulsifying agent Polyethylene Glycol 5.9kg, lecithin 0.35kg, Folium Ginkgo extract 0.29kg, organic chromium 0.01kg, glycerol 0.3kg intimate mixing, filled capsules, drying, screening, pressing plate are produced composite propolis 10kg.
Embodiment 2
Production technology is the mensuration of propolis being carried out physical and chemical index and sanitary index according to propolis industry operative norm, selection purity height, the propolis that impurity is few are used raw material as processing, freezing processing 5-6h under-5 ℃ of conditions, pulverize with ball mill, lixiviate in 70% alcoholic solution is filtered propolis with the centrifugalize filter, and vacuum concentration reclaims ethanol, ultra micron is pulverized, and propolis 3.10kg is produced in emulsifying.Emulsifying agent Polyethylene Glycol 5.9kg, lecithin 0.48kg, Folium Ginkgo extract 0.4kg, organic chromium 0.02kg, glycerol 0.4kg intimate mixing, filled capsules, drying, screening, pressing plate are produced composite propolis 10kg.
Embodiment 3
Production technology is the mensuration of propolis being carried out physical and chemical index and sanitary index according to propolis industry operative norm, selection purity height, the propolis that impurity is few are used raw material as processing, freezing processing 5-6h under-5 ℃ of conditions, pulverize with ball mill, lixiviate in 70% alcoholic solution is filtered propolis with the centrifugalize filter, and vacuum concentration reclaims ethanol, ultra micron is pulverized, and propolis 3kg is produced in emulsifying.Emulsifying agent Polyethylene Glycol 6.0kg, lecithin 0.3kg, Folium Ginkgo extract 0.335kg, organic chromium 0.015kg, glycerol 0.35kg intimate mixing, filled capsules, drying, screening, pressing plate are produced composite propolis 10kg.
Main effect: blood sugar lowering, blood fat reducing, blood pressure lowering, diabetes, cardiovascular and cerebrovascular vessel and apoplexy are had tangible curative effect.
Claims (2)
1, a kind of composite propolis soft capsule, comprise: propolis, Folium Ginkgo, lecithin, organic chromium etc., it is characterized in that, contained composition and weight number are than being major ingredient: propolis 3.0-3.5kg, Folium Ginkgo extract 0.2-0.4kg, lecithin 0.2-0.5kg, organic chromium 0.01-0.02kg, emulsifying agent Polyethylene Glycol 5-6kg, glycerol 0.3-0.5kg.
2, composite propolis soft capsule according to claim 1, it is characterized in that, the technology of composite propolis soft capsule is carried out as follows: select glue: according to the propolis industry standard propolis index is measured, selected the purity height, the propolis conduct that impurity is few processes raw material; Freezing processing: freezing 5-6h under-5 ℃ of conditions; Pulverize: propolis is crushed to 20 orders with ball mill; Solid-liquid ratio is controlled at .1: 5, temperature is controlled at below 25 ℃, propolis and ethanol are placed the stirring extraction pot, in under 4 ℃ of conditions about lixiviate 8h, to get supernatant and place storage tank to be filtered, filtering residue and sediment merge, and add 5 times of volume of ethanol again and stir and extract, isolate supernatant after leaving standstill, extract twice so repeatedly, the propolis active ingredient is all proposed; Filter: with silt and the insoluble matter in the centrifugalize filter filtration propolis; Vacuum concentration reclaims ethanol: propolis solution is pumped in the concentration pan, connect condenser cooling water, open the hydraulic vacuum pump, make the vacuum in the concentration tank reach 66.7Kpa (500mmHg), connect steam, the control vapour pressure makes a jar interior temperature reach 145 ℃, propolis extraction page or leaf comes to life in jar, alcohol vapour is liquefied and flows in the storage tank, after ethanol is evaporated completely, stop hydraulic vacuum and steam, with propolis cream emit, cool off, cut apart, coarse pulverization to 50 order, 50 order propolis powder are dropped in the vertical belt jet pulverizer fragmentation; The fine powder of 5um is by outside the clasfficiator discharge machine, and then centrifugalization and away from clasfficiator, getting back in the pulverizing chamber of coarse grain is pulverized once more; Fusing and emulsifying: propolis is added in emulsifying agent Polyethylene Glycol and the glycerol by the formula proportion in the scheme, heating with it, temperature is controlled at 70 ℃, and addition sequence is, will melt good propolis earlier and fully mix with emulsifying agent, adds glycerol at last, mixing 15min; The propolis that emulsifying is good, lecithin, Folium Ginkgo extract, organic chromium are put into homogenizer in proportion respectively, fully mix 15min; Filled capsules: the loading of composite propolis soft capsule is 0.5g, ± 10mg; Drying, screening, pressing plate, finished product warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100466178A CN100340250C (en) | 2005-06-09 | 2005-06-09 | Composite propolis soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100466178A CN100340250C (en) | 2005-06-09 | 2005-06-09 | Composite propolis soft capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1698658A true CN1698658A (en) | 2005-11-23 |
| CN100340250C CN100340250C (en) | 2007-10-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100466178A Expired - Fee Related CN100340250C (en) | 2005-06-09 | 2005-06-09 | Composite propolis soft capsule |
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| CN (1) | CN100340250C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991034A (en) * | 2010-11-11 | 2011-03-30 | 周云川 | High-efficiency wall breaking propolis soft capsule |
| CN101731506B (en) * | 2009-12-15 | 2013-01-09 | 白万军 | Health-care food of bee glue and wood frog lecithin capsule |
| CN103190621A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Propolis soft capsule and preparation method thereof |
| CN105410921A (en) * | 2015-12-16 | 2016-03-23 | 蜂乃宝本铺（南京）保健食品有限公司 | Baccharis dracunculifolia DC. propolis and seabuckthorn soft capsule and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1092624A (en) * | 1993-03-15 | 1994-09-28 | 泰兴市银杏制品厂 | Natural ginkgo juice beverage and processing technology thereof |
| CN1244362A (en) * | 1999-06-02 | 2000-02-16 | 江西长寿长天然饮料食品发展有限公司 | Ginkgo beverage |
| CN1230191C (en) * | 2003-01-20 | 2005-12-07 | 伍震懿 | Health care combination of propolis for reducing blood sugar and fat as well as method for mfg. its capsule |
| CN1253159C (en) * | 2003-11-03 | 2006-04-26 | 河北恒利集团制药股份有限公司 | Health product of compound propolis and preparing method |
-
2005
- 2005-06-09 CN CNB2005100466178A patent/CN100340250C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731506B (en) * | 2009-12-15 | 2013-01-09 | 白万军 | Health-care food of bee glue and wood frog lecithin capsule |
| CN101991034A (en) * | 2010-11-11 | 2011-03-30 | 周云川 | High-efficiency wall breaking propolis soft capsule |
| CN101991034B (en) * | 2010-11-11 | 2012-11-14 | 周云川 | High-efficiency wall breaking propolis soft capsule |
| CN103190621A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Propolis soft capsule and preparation method thereof |
| CN105410921A (en) * | 2015-12-16 | 2016-03-23 | 蜂乃宝本铺（南京）保健食品有限公司 | Baccharis dracunculifolia DC. propolis and seabuckthorn soft capsule and preparation method thereof |
| CN105410921B (en) * | 2015-12-16 | 2018-04-24 | 蜂乃宝本铺（南京）保健食品有限公司 | A kind of water wally propolis sea-buckthorn soft capsule and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100340250C (en) | 2007-10-03 |
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Addressee: Wang Yuxin Document name: Notification of registration procedures and notice of patent for invention |
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Granted publication date: 20071003 Termination date: 20130609 |