CN1927334A - Garlic powder health care capsule for reducing blood lipids and method for preparing same - Google Patents

Abstract

The invention relates to a garlic powder blood fat-reduction capsule. Wherein, it comprises garlic powder, vitamin C, vitamin E, and beta-cyclodextrin, whose mass percentages are garlic powder at 40-80%, vitamin C at 4-12%, vitamin E at 4-12%, and beta-cyclodextrin at 12-36%. And the production comprises (1), preparing garlic powder that pretreating and slicing the garlic, to be emerged with 0.1-0.5%Na2SO3 and 0.05-0.15%L-aminothiopropionic acid protective solutions, drying, broking and screening to obtain the garlic powder; (2), preparing capsule compound that mixing said garlic powder at 40-80%, vitamin C at 4-12%, vitamin E at 4-12%, and beta-cyclodextrin at 12-36%; (3), disinfecting and packing 0.25g capsule compound into one capsule.

Description

Garlic powder health care capsule for reducing blood lipids and preparation method thereof

Technical field

The invention belongs to the health food category that hyperlipemia is had the assisting in preventing and treating effect, relate to a kind of garlic powder health care capsule for reducing blood lipids and preparation method thereof.

Background technology

Hyperlipemia is to cause arteriosclerotic independent hazard factor, be the arch-criminal who causes cardiovascular and cerebrovascular disease, sickness rate is high and abnormally dangerous, adds up according to World Health Organization (WHO), current cardiovascular disease is seized 1,200 ten thousand people's life every year, accounts for 25% of the total death toll in the world.Hyperlipidemia is not rare in China, and along with reasons such as China people's living standard obviously improve, dietary habit changes, the incidence rate of hyperlipidemia also has the trend that rises gradually.At present, in existing health product with blood fat reducing, the ubiquity raw material is various, shortcomings such as complicated process of preparation.The Chinese patent CN1739651A that authorized on March 1st, 2006 for example has the effect of auxiliary treatment hyperlipidemia, but it raw materials usedly has a Chinese herbal medicine above in 6, and complicated process of preparation is various.And these products are to adopt Chinese herbal medicine to be carried out decocting to boil mostly, extract some of effective ingredient, so just caused in the valuable Chinese medicinal herbs utilization limitation and waste.

Summary of the invention

The purpose of this invention is to provide a kind of is the garlic powder health care capsule for reducing blood lipids and preparation method thereof of primary raw material with Bulbus Allii.

Garlic powder health care capsule for reducing blood lipids involved in the present invention, its technical scheme is to be equipped with by Bulbus Allii powder, vitamin C, vitamin E and beta-schardinger dextrin-to mix the compositions of forming in conventional capsule for medicine, the percentage by weight of each component is in the compositions: Bulbus Allii powder 40-80%, vitamin C 4-12%, vitamin E 4-12%, beta-schardinger dextrin-12-36%.

The production technology of above-mentioned garlic powder health care capsule for reducing blood lipids may further comprise the steps:

1) preparation Bulbus Allii powder: earlier Bulbus Allii is removed base of a fruit striping ginning outturn lobe afterwash, on microtome, be cut into the thick Bulbus Allii sheet of 3-5mm, Bulbus Allii piece is soaked in adopts 0.1-0.5%Na then ₂SO ₃In 0.05-0.15%L-cysteine solution, soak 30min, take out drying subsequently, place hot air drier dry, drying condition is: early stage, baking temperature was 45 ℃ of constant temperature, and be 2h drying time; The later stage baking temperature is 55 ℃ of constant temperature, until being dried to constant weight, at last the Bulbus Allii piece of dry gained is pulverized in pulverizer, crosses 60 mesh sieves and gets Bulbus Allii powder;

2) preparation capsule composition: with the above-mentioned Bulbus Allii powder that makes and vitamin C, vitamin E and beta-schardinger dextrin-by Bulbus Allii powder 40-80%, vitamin C 4-12%, vitamin E 4-12%, the mixed of the percentage by weight of beta-schardinger dextrin-12-36% is formed capsule composition;

3) above-mentioned capsule composition is incapsulated by every 0.25 gram, promptly make garlic powder health care capsule for reducing blood lipids.

The medical mechanism of the raw material that is adopted in the garlic powder health care capsule for reducing blood lipids of the present invention is:

Bulbus Allii belongs to the bulb of Liliaceae allium Bulbus Allii, and acrid in the mouth, warm in nature is returned spleen, stomach, lung meridian.In China with all over the world as the history in existing thousands of years of medication among the people.Bulbus Allii contains various compositions such as aminoacid, peptide class, protein, enzyme, saccharide, glycoside, vitamin, fat, inorganic salt and sulfur-containing compound.Modern medicine study shows, Bulbus Allii not only has for a long time always by outside the effects such as the detoxifcation that people utilized, antiinflammatory, sterilization, also have multiple important health care and pharmacology's effect: 1. blood fat reducing, control cardiovascular and cerebrovascular disease, can suppress platelet aggregation, bring high blood pressure down and the formation of blood glucose, preventing thrombosis.2. defying age and Oxidation, the SOD that includes can delay Normocellular death.3. antitumor action, inhibited to the propagation of the tumor cell of multiple cancers such as gastric cancer, breast carcinoma, colon cancer, hepatocarcinoma.4. antiviral, human body immunity improving power.

Vitamin C has a series of physiological function, and the reputation of " omnipotent vitamin " was once arranged, and has reflected the importance of vitamin C in the health aspect to a certain extent.Vitamin C can be treated wound, burnt, gingival hemorrhage; Can strengthen the curative effect of medication of treatment urinary tract infection; Can quicken postoperative recovery; Can help to reduce the cholesterol in the blood; Anti-curing cold; Prevent and treat arteriosclerosis; Treatment chronic hepatitis, liver cirrhosis; Alleviate biliary colic and treatment bile duct ascariasis; Reduce venothrombotic generation; The treatment iron deficiency anemia; The auxiliary treatment that is used for many diseases that cause because of the anaphylaxis material; The auxiliary treatment that is used for many viral diseases is as measles, parotitis, herpes zoster etc.; Prevent and treat cancerous protuberance; The treatment psychosis; The auxiliary treatment of acute cerebral infarction, hypoxic ischemic encephalopathy of newborn etc.

The major physiological function of vitamin E has: as the scavenger of free radical, and antioxidant activity, immunologic function and blood fat reducing function etc.Vitamin E use clinically mainly has been that synergism and other drug are united use, and main relevant with its antioxidation.Vitamin E has very strong antioxidation, by antioxidation, reduces platelet aggregation, improves the purpose that hemorheology is learned thereby reach.

Health-caring capsule of the present invention has the assisting in preventing and treating effect to hyperlipemia: its effect can be verified and illustrate to following experiment.

1 material and the method that adopts

1.1 medicine

Garlic powder health care capsule for reducing blood lipids (this laboratory development); Cholesterol and sodium cholate (traditional Chinese medicines group reagent company limited); T-CHOL (TC), triglyceride (TG), HDL-C (HDL-C) and low-density lipoprotein cholesterol (LDL-C) test kit (Zhongsheng Beikong Biological Science ﹠ Technology Co., Ltd.).

1.2 experiment feedstuff

Normal feedstuff and high lipid food are provided by Third Military Medical University's second Affiliated Hospital's animal center.High lipid food is made up of 1% cholesterol, 0.25% sodium cholate, 8% Adeps Sus domestica (refining certainly) and 90.75% normal feedstuff.

1.3 laboratory animal and grouping

Animal origin: Healthy female SD rat is provided by Third Military Medical University's second Affiliated Hospital's animal center.

Animal grouping: 48 of Healthy female SD rats, body weight 190-210 gram, normal feedstuff adapts to feeding after one week, the tail vein is got blood, detect serum cholesterol, be divided into 6 groups at random according to body weight and serum cholesterol level: normal control group, hyperlipidemia model group, low dosage prevention group, high dose prevention group, the high fat group of low dosage and the high fat group of high dose, 8 every group.Normal control group feeding normal feedstuff, all the other respectively organize the feeding high lipid food, and every all single cage of rat is raised, ad lib drinking-water.Low, high dose prevention group is also irritated simultaneously and feed capsule powder (becoming suspension with capsule powder and water are miscible) every day, and the high fat group of low, high dose then begins after one week to irritate at the feeding high lipid food feeds the capsule powder, finishes until experiment.Normal control group, hyperlipidemia model group and test low, the high fat group of high dose in first week and irritate the drinking water of feeding every day with volume.Low, high dose is respectively 100mg/kgBW and 200mg/kgBW.Experiment is 5 weeks by a definite date, and afterbody is got blood once (experiment femoral artery in latter stage is got blood) weekly, and separation of serum is measured TC, TG, HDL-C and LDL-C in the serum.

1.4 detect index and method

Body weight and food-intake: weigh weekly and write down once.

Lipids detection: TC, TG adopt enzymic colorimetric, and HDL-C adopts phosphotungstic acid-magnesium precipitate method, and LDL-C adopts the polyvinyl sulfuric acid sedimentation method, measures on the 756MC spectrophotometer.

1.5 statistical analysis technique

Adopt SPSS 11.0 software kits to carry out one factor analysis of variance and t check.

2 experimental results

2.1 the capsule powder is to the influence of rat growth

As can be seen, the whole opisthosoma weight average that is respectively tried the thing group significantly is lower than the hyperlipidemia model group from table one; Except that the food-intake of normal control group and hyperlipidemia model group has the significant difference, all the other respectively are subjected to the food-intake of examination group and hyperlipidemia model group relatively not to have significant difference.

Table 1 capsule powder is to the influence of rat growth

Group	Initial body weight (g)	Whole opisthosoma heavy (g)	Food-intake (g)
				The high fat group of normal control group hyperlipidemia model group low dosage prevention group high dose prevention group low dosage high fat group high dose	203.7±3.8 205.7±3.2 204.1±4.5 204.5±4.5 204.3±6.4 202.6±3.9	234.7±2.8(1) 244.9±4.6 214.6±11.6(1) 217±12.9(1) 215.9±10.1(1) 219.4±6.9(1)	5003.2±19.6(1) 4636.0±32.9 4518.4±24.5 4540.0±16.1 4565.6±35.7 4600.4±27.3

Annotate: (1) compares P＜0.05 with the hyperlipidemia model group

2.2 the capsule powder is to the influence of rat fat

As can be seen, TC, TG, the LDL-C of the high fat group of hyperlipidemia model group and high and low dose are significantly higher than the normal control group from table 2, table 3, show the foundation success of the hyperlipidemia model of experimental rat.

Table 2 capsule powder is to the influence of TC, TG in the rat fat

Group	TC		TG
						0 week	5 weeks	0 week	5 weeks

The high fat group of normal control group hyperlipidemia model group high dose prevention group low dosage prevention group high dose high fat group low dosage

2.69±0.59 2.71±0.68 2.68±0.71 2.70±0.63 2.71±0.61 2.73±0.58

2.69±0.26(1) 10.92±1.63 5.19±0.73(1) 6.14±0.52(1，2) 6.02±0.34(1) 6.67±0.41(1，3)

0.61±0.23 0.59±0.23 0.65±0.27 0.62±0.25 0.60±0.24 0.61±0.18

1.12±0.14(1) 2.16±0.31 1.52±0.18(1) 1.80±0.14(2) 1.72±0.16(1) 1.93±0.16

Annotate: (1) compares P＜0.01 with the hyperlipidemia model group

(2) compare P＜0.05 with high dose prevention group

Table 3 capsule powder is to the influence of HDL-C, LDL-C in the rat fat

Group	HDL-C		LDL-C
						0 week	5 weeks	0 week	5 weeks
The high fat group of normal control group hyperlipidemia model group high dose prevention group low dosage prevention group high dose high fat group low dosage	1.25±0.13 1.26±0.12 1.26±0.10 1.27±0.14 1.26±0.11 1.26±0.09	1.25±0.16 1.24±0.13 1.29±0.08 1.29±0.12 1.30±0.08 1.29±0.09	0.23±0.03 0.22±0.05 0.21±0.08 0.23±0.03 0.22±0.09 0.24±0.06	0.23±0.04(1) 6.83±0.78 3.10±0.54(1) 3.92±0.48(1，2) 3.75±0.22(1) 4.27±0.39(1，3)

Annotate: (1) compares P＜0.01 with the hyperlipidemia model group

(2) compare with high dose prevention group, (3) compare P＜0.05 with the high fat group of high dose

3 experiment brief summaries

When experiment finishes, four are tried the thing group: TC and LDL-C level all significantly are lower than hyperlipidemia model group (P＜0.01) in the rat fat of the high fat group of high and low dose prevention group and high and low dose, and significant difference (P＜0.05) is also arranged between each high low dose group; Meanwhile, TG level in the high fat group of high dose prevention group and high dose and hyperlipidemia model group also have between significant difference and low dosage prevention group and the high dose prevention group significant difference (P＜0.05) are also arranged.Though four levels that are subjected to HDL-C in the examination group are compared to the hyperlipidemia model group and raise to some extent, all do not have evident difference.Verify thus and illustrate that garlic powder health care capsule for reducing blood lipids has the assisting in preventing and treating effect to hyperlipemia.

The specific embodiment

Below in conjunction with embodiment garlic powder health care capsule for reducing blood lipids involved in the present invention and preparation method thereof is further described:

Embodiment 1:

Garlic powder health care capsule for reducing blood lipids and preparation method thereof:

1) Bulbus Allii powder preparation:

Bulbus Allii needs to be cut into the thick Bulbus Allii sheet of 3-5mm after pretreatment, again in 0.1%Na before being dried to powder ₂SO ₃With soak 30min in the 0.05%L-cysteine solution, drying is carried out in the back in hot air drier, early stage, baking temperature was 45 ℃, be 2h drying time; The later stage baking temperature is 55 ℃, is dried to constant weight, and the Bulbus Allii piece that makes is pulverized on pulverizer, and it is standby that mistake 60 mesh sieves get Bulbus Allii powder.

2) capsule composition preparation:

Bulbus Allii powder 100g, vitamin C 30g, vitamin E 30g, beta-schardinger dextrin-90g, above-mentioned raw materials uniform mixing sterilization back is made into 1000 garlic powder health care capsule for reducing blood lipids by the tolerant 0.25g of every intragranular, be packaged in the plastic bag, it is stand-by at the place of drying in the shade to be put in the exsiccator sealed storage.

Embodiment 2:

Garlic powder health care capsule for reducing blood lipids and preparation method thereof:

1) Bulbus Allii powder preparation:

Bulbus Allii needs to be cut into the thick Bulbus Allii sheet of 3-5mm after pretreatment, again in 0.3%Na before being dried to powder ₂SO ₃With soak 30min in the 0.1%L-cysteine solution, drying is carried out in the back in hot air drier, early stage, baking temperature was 45 ℃, be 2h drying time; The later stage baking temperature is 55 ℃, is dried to constant weight, and the Bulbus Allii piece that makes is pulverized on pulverizer, and it is standby that mistake 60 mesh sieves get Bulbus Allii powder.

2) capsule composition preparation:

Bulbus Allii powder 150g, Catergen 0g, vitamin E2 0g, beta-schardinger dextrin-60g, above-mentioned raw materials uniform mixing sterilization back is made into 1000 garlic powder health care capsule for reducing blood lipids by the tolerant 0.25g of every intragranular, be packaged in the plastic bag, it is stand-by at the place of drying in the shade to be put in the exsiccator sealed storage.

Embodiment 3:

Garlic powder health care capsule for reducing blood lipids and preparation method thereof:

1) Bulbus Allii powder preparation:

Bulbus Allii needs to be cut into the thick Bulbus Allii sheet of 3-5mm after pretreatment, again in 0.5%Na before being dried to powder ₂SO ₃With soak 30min in the 0.15%L-cysteine solution, drying is carried out in the back in hot air drier, early stage, baking temperature was 45 ℃, be 2h drying time; The later stage baking temperature is 55 ℃, is dried to constant weight, and the Bulbus Allii piece that makes is pulverized on pulverizer, and it is standby that mistake 60 mesh sieves get Bulbus Allii powder.

2) capsule composition preparation:

Bulbus Allii powder 200g, vitamin C 10g, vitamin E 10g, beta-schardinger dextrin-30g, above-mentioned raw materials uniform mixing sterilization back is made into 1000 garlic powder health care capsule for reducing blood lipids by the tolerant 0.25g of every intragranular, be packaged in the plastic bag, it is stand-by at the place of drying in the shade to be put in the exsiccator sealed storage.

Claims (2)

1, a kind of garlic powder health care capsule for reducing blood lipids, it is characterized in that: capsule 's content is mixed the compositions of forming by Bulbus Allii powder, vitamin C, vitamin E and beta-schardinger dextrin-, the percentage by weight of each component is in the compositions: Bulbus Allii powder 40-80%, vitamin C 4-12%, vitamin E 4-12%, beta-schardinger dextrin-12-36%.

2, the preparation method of the described garlic powder health care capsule for reducing blood lipids of claim 1 is characterized in that production craft step is as follows:

1) preparation Bulbus Allii powder: earlier Bulbus Allii is removed base of a fruit striping ginning outturn lobe afterwash, on microtome, be cut into the thick Bulbus Allii sheet of 3-5mm, Bulbus Allii piece is soaked in adopts 0.1-0.5%Na then ₂SO ₃In 0.05-0.15%L-cysteine solution, soak 30min, take out drying subsequently, place hot air drier dry, drying condition is: early stage, baking temperature was 45 ℃ of constant temperature, and be 2h drying time; The later stage baking temperature is 55 ℃ of constant temperature, until being dried to constant weight, at last the Bulbus Allii piece of dry gained is pulverized in pulverizer, crosses 60 mesh sieves and gets Bulbus Allii powder;

2) preparation capsule composition: with the above-mentioned Bulbus Allii powder that makes and vitamin C, vitamin E and beta-schardinger dextrin-by Bulbus Allii powder 40-80%, vitamin C 4-12%, vitamin E 4-12%, the mixed of the percentage by weight of beta-schardinger dextrin-12-36% is formed capsule composition;

3) above-mentioned capsule composition is incapsulated by every 0.25 gram, promptly make garlic powder health care capsule for reducing blood lipids.