CN1111052C - 'Tongrundan' pill - Google Patents
'Tongrundan' pill Download PDFInfo
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- CN1111052C CN1111052C CN 00131122 CN00131122A CN1111052C CN 1111052 C CN1111052 C CN 1111052C CN 00131122 CN00131122 CN 00131122 CN 00131122 A CN00131122 A CN 00131122A CN 1111052 C CN1111052 C CN 1111052C
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Abstract
The present invention relates to a medicine for treating constipation, particularly to a Chinese patent medicine prepared from natural flowers which are used as main raw materials. The medicine of the present invention comprises the following components: peach flower powder, vitamin C and vitamin E. When the present invention is used, the purposes of softening excrement and discharging toxin are achieved according to the principles of moisturizing the intestine, coordinating the intestine and removing toxin. The present invention solves the problems of slow therapeutic effect, large irritation to the gastrointestinal tract and easy symptom recrudescence after medicine withdrawal of the existing medicine for treating constipation. The raw materials of the present invention can be obtained easily, and the present invention has the efficacy of nourishing the face, moisturizing the skin and protecting normal functions of organism cells.
Description
The present invention relates to a kind of medicine for the treatment of constipation, particularly a kind of is the formulated Chinese patent medicine of main material with the natural flower.
Constipation is the bowl evacuation habit disorder, and defecation frequency reduces, and stool gets rid of difficulty, and feces is dry and hard, hard, tiny, every day discharge capacity＜50g.
Constipation (chronic constipation) is a kind of common clinical symptoms, rather than independently a disease or a syndrome, sign that neither disease.Its clinical onset rate is higher, and the geratic period can have 200-300 ten thousand people often to take cathartic in the U.S. up to 30% approximately, and the year consumption of national cathartic is worth 400,000,000 dollars approximately.In China, because of factors such as socio-economic factor and nationality, weather, living habit still do not have accurate statistics to the influence of constipation incidence rate.
The incidence of constipation is comparatively complicated, mainly contains following several factor:
1. congenital factor: as congenital megacolon, family splanchnopathy, internal rectum spasm disease (proctalgafugax) etc.
2. endocrine and metabolic disease: diabetes, hypothyroidism, hypobasophilism, hypokalemia, low blood calcium, porphyria etc. cause enterokinesia and slow down the pathological changes of plexus nervorum between companion's myenteron or moisture by taken in excess.
3. drug influence: analgesics, morphine, imipramine, doxepin, aluminium hydroxide and contain bismuth preparation etc., abuse diarrhea or catharsis medicine also may cause constipation.
4. neural and other systemic diseases: parkinson disease, extrapyramidal system pathological changes, systemic sclerosis, dermatomyositis, chronic obstructive emphysema etc.
5. gut hormone and other neurotransmitteies: the content of P material, vasoactive peptide and motilin is lower than matched group in the constipation patient mucous membrane of colon, and the content of 5-hydroxy tryptamine is higher than matched group in intestinal mucosa and the circular muscle.
6. other factors such as diet, occupation, living habit: in the diet content of cellulose very little, intestinal normal flora quantity reduces, long-term lacking physical exertion or the whole body health situation is relatively poor and the long-term bed person, the occupation that some is special etc.
It is relevant with knot rectum dyskinesia that the pathogeny of constipation is thought at present, can be divided into following several situation:
1. colon is by slow type constipation: have ascending colon among this kind of patient by slowly, left hemicolon by slowly and total colectomy by slowly.Colon reduces by the compliance of slow property constipation patient sigmoid colon intestinal wall, and intestinal wall is starkly lower than the normal person to the maximum tolerated dose of intestinal contents.Because intestinal contents is by slow, the full speed of rectum slows down, and causes the reactivity of rectum to reduce, even blunt.By slow, the moisture in the intestinal contents is by taken in excess, so that feces is dry and hard, has increased the weight of the difficulty of defecation just because of intestinal contents.
2. get rid of the accumulation type constipation: (1) proctosigmoid junction excess shrinkage, this high pressure belt has hindered feces to enter rectum from sigmoid colon, faecal impaction at sigmoid colon with the upper part.(2) anus, rectum dyskinesia: during the anal orifice and rectal intestine inhibitory reflex, exist higher residual pressure; The threshold value of anal orifice and rectal intestine inhibitory reflex increases; The sphincter ani internus at utmost required rectal mucosa intensity of electric stimulus of diastole increases.(3) anal orifice and rectal intestine anatomic abnormalities: the position under women's quiescent condition at the bottom of the basin is lower than the male, and this also is one of women's reason of easily suffering from constipation.(4) rectum defecation sensitivity lowers: owing to the sensitivity of rectum to defecation lowers, feces deposits at rectum, can not in time get rid of, and forms constipation.(5) other: as the sacrum reflection function weaken, under the Anismus, perineum at the bottom of the degradation basin syndrome also may in the generation of getting rid of the accumulation type constipation, work.
3. colon is by the normal type constipation: it is rectum that most scholars think increases relevant to the threshold value of defecation impression.With the Hopkins paresthesia inquiry schedule constipation patient is carried out psycho analysis, find that colon passes through the patient and the normal control group of time lengthening apparently higher than colon by the total SI integration of normal constipation patient of time, wherein with body constitutionization, depressed and anxiety symptom is particularly evident, it is relevant with Nervous and Mental Factors to think that colon passes through the generation of time normal type constipation.
4. mixed type constipation: mainly be that colon passes through slowly companion's discharge retardance, the statistics of China Beijing area accounts for 50% of constipation sum.
Prolonged constipation is to the harmful effect of body:
1. digestive system: prolonged constipation can be brought out colonic diverticula, hemorrhoid, proctoptosis, melanosis coli and be taken colon 26S Proteasome Structure and Function change that cathartic causes etc.
2. urinary system: cause the urinary tract inadequate drainage and expand and easily suffer from bacterial infection.
3. mastopathy: an investigation of the U.S. shows, the hard danger that suffers from breast cancer that increases of women's prolonged constipation and feces.
Other: prolonged constipation causes feces at the intestinal overstand, increases the absorption of toxin, makes people's giddy, weak, inappetence, abdominal distention, insomnia, lethargy etc.Firmly temporary transient the rising pressed in defecation hyperamization, brings out angina pectoris, myocardial infarction, heart failure etc.
The natural history of chronic constipation is longer, even continues throughout one's life, and treatment at present has the following aspects:
1. Diet Therapy
2. behavior therapy (bihavior therapy): toilet training during appointment.
3. biofeedback therapy
4. catharsis Drug therapy: commonly used have a following several drugs.
(1) bulk-forming laxative: methylcellulose, Semen Plantaginis are according to preparation etc.
(2) excrement softening agent: many storehouses salt (docusate), many storehouses calcium, many storehouses acid sodium, many storehouses acid potassium.
(3) lubricant: paraffin oil.
(4) Epsom salts: magnesium sulfate, phosphate etc.
(5) hyperosmotic laxative: sorbitol, lactulose and glycerol.
(6) irritant purgative
Anthraquinone class: Folium Sennae, Radix Et Rhizoma Rhei, Fructus Cannabis Bolus, the suitable intestinal ball of spleen reinforcing etc.
Polyphenols: contax, phenolphthalein.
Oleum Ricini, deoxycholic acid etc.
(7) its change: as digestive tract power reinforcing medicine: cisapride, low dose of erythromycin;
Opiate receptor blocker: Allylnoroxymorphone;
Pituitrin etc.
The above Drug therapy constipation has following adverse influence to body
Take lubricant for a long time and easily cause fat-soluble avitaminosis, mineral oil is absorbed, and also may form the lipid granuloma in monokaryon-----phagocyte system, has bad physiques, and with the gastroesophageal reflux person, also may cause the lipid aspiration pneumonitis.
Take Epsom salts for a long time and may cause electrolyte disturbance,,, should avoid using with chronic renal insufficiency or cardiac and existing electrolyte imbalance person as high magnesium, high phosphorus, high potassium and hypernatremia and hypocalcemia etc.
The glycone rectally causes internal rectum discomfort or burn feeling.
Take for a long time and contain the anthraquinone medicine and may cause melanosis coli, this disease may be relevant with colon cancer.
Also have abdominal distention, diarrhoea, stomachache, drug allergy to reach the drug dependence of taking medicine and being caused for a long time in addition.
Purpose of the present invention is to provide a kind of from intestine moistening, conditioning, antidotal principle, and reach softening stool, mediate toxin, stable curative effect, effect relaxes, to the gastrointestinal tract nonirritant, no dependence, the 'Tongrundan ' pill of the treatment constipation of asymptomatic knock-on after the drug withdrawal.
Technical solution of the present invention, be based on motherland's medical science to human body constipation and pathogenetic understanding of combination of syndromes disease and Therapeutic Principle, achieve with reference to modern pharmacological research, with the natural flower is raw material, be aided with body metabolism, the necessary vitC of detoxification processes, vitE, from intestine moistening, conditioning, the antidotal principle is set out, press the theory of medicine prescription, make its performance promote human endocrine and metabolic function, improve the compliance of sigmoid colon intestinal wall and the reactivity of rectum, increase the moisture in the intestinal contents, make stool softening, reduce stool by the colon time, reach defecation and act on smoothly.
Medicine of the present invention is made (consumption is weight percentage) by following component:
Flos persicae end 65-85%
Vitamin C 8-25%
Vitamin E 5-18%
The formula optimization percentage by weight ratio range of preparation medicine of the present invention is:
Flos persicae end 70-76%
Vitamin C 12-18%
Vitamin E 10-15%
An important feature of the present invention is to contain abundant Rhizoma Kaempferiae flavonol (having another name called kaempferol Kaempferol) molecular formula C in the Flos persicae
15H
10O
6, it has the effect of relieving constipation skin care, can stimulate the peristaltic forces of intestinal, removes the internal organs distension, the hectic fever due to YIN-deficiency consumptive fever.Also contain naringenin (Naringenin) in the Flos persicae alabastrum, the effect of promoting the circulation of QI cold expelling is arranged.The coumarin that contains in the Flos persicae (Coumarin) has antiplatelet aggregative activity.Flos persicae in its prescription is a rosaceous plant, " Zhenglei Bencao " record of writing of Song's TANG Shen-Wei: the Flos persicae bitter in the mouth is flat, nontoxic.Lead and remove aqueous vapor, broken stranguria caused by urinary stone, sharp defecation, following three worms, moistening face color.March 3 adopted, and dried in the shade.
The Tao Yinju cloud: March 3 picked flowers, and also was folk prescription institute palpus." dialect ": clothes three-tree Flos persicae is most, then complexion such as Flos persicae.Tang's these notes cloud: Flos persicae, main bad odor down, detumescence is full, sharp intestine and small intestine.
Wash cloud the Meng: March 3 received Flos persicae and dries, and two money an ancient type of spoons are obeyed with water in the pestle end.Children's's half money is controlled cardiac and abdominal pain.Again, tinea alba is received and not to be bloomed, and dries in the shade, and with the red person of Fructus Mori, five equilibrium is done the end, with leaf fat and, earlier with lye flush away scab, i.e. coating.
" too clear grass flitch " cloud: wine stain Flos persicae is drunk it, removes hundred diseases, beneficial color.
Cui Yuanliang " sea side " controls skin ulcer on the face, and yellow fluid goes out, and the eye skin ulcer, collects Flos persicae on 105th, disregards what, smalls it, tool for weighing medicine in ancient China is taken after mixing with liquid with half in water in food back, and is day three, very good.
The part of relevant peach is also on the books to the medical value of Flos persicae in the Compendium of Material Medica.
Another important feature of the present invention be contain human body in the medicament can not synthetic vitamin C and vitamin E.Vitamin C has important function to many aspects of vital movement process.Human body can not synthetic vitamin C, and the organism metabolism aequum must be by food or replenished in addition, through gastrointestinal tract, mainly absorbs at jejunum.
Ascorbic basic pharmacology and clinical practice have following several aspect:
1. carbohydrate metabolism and oxidation-reduction process in the participation body;
2. participate in the generation of intercellular substance, lower capillary fragility, the solidifying of accelerate blood;
3. participate in detoxifcation, the enhancing human body immunity function: vitamin C can make lymhocyte transformation rate obviously increase, and strengthens the phagocytosis of cell, helps the generation of body interferon;
4. can promote folic acid to form tetrahydrofolic acid, increase the absorption of ferrum at intestinal;
5. antihistaminic effect is arranged;
6. vitamin C can be removed the free radical that produces in the body, shows stronger antioxidation, and the protection body tissue is avoided the destruction and the damage of free radical, and is in the free radical resisting medicine of using at present, the most outstanding with ascorbic advantage.
Commonly used to prevent hypovitaminosis C, anti-vitamin C deficiency in clinical; In and free radical, prevent the platelet aggregation reactivity to increase, prevent endotoxin and the DIC that excites of virus effectively; Prevent and treat coronary heart disease; Improve liver function; Also can act on the beta receptor of bronchial smooth muscle, make bronchiectasis; Treatment ITP; Alleviate the biliary tract ascarid biliary colic; Prevent and treat cancerous protuberance, suppress growth of tumour cell and generation, have certain antitumor action; Vitamin C participates in collagen protein synthesis, helps the generation of intercellular substance and cell membrane, plays an important role to repairing after keeping cell, tissue, the normal structure of organ and promoting tissue injury; Vitamin C can by increase catecholamines [CAT] material secrete improve body to stress resistance; Treatment mental disorder disease, pigmentation disease and arsenic, hydrargyrum, lead, benzene acute and chronic poisoning etc.
Vitamin E is basic nutrient substance, has multiple effect:
Vitamin E has the effect of stabilizing cell membrane lipid part, can prevent the oxidation reaction of unsaturated fatty acid; Increase the utilization of vitamin A; Suppress the generation of prostaglandin; Stimulate the metabolism of steroidal class material; Also help to keep neural 26S Proteasome Structure and Function, glycogen is stored to be increased, coenzyme A in the liver; adenosine diphosphate (ADP) increases, and promotes aminoacid synthetic kernel protein process, but and anti-fatty liver and anti-hepatic necrosis effect; can protect hepatocyte, tissues such as cardiac muscle are avoided the chemical toxicant infringement.
Vitamin E is an important antioxidants, its antioxidation mechanism is that the phenolic hydroxyl group hydrogen atom offers oxygen-derived free radicals or alicyclic diradical (R. in this molecular structure, ROO., RO.), make it to be reduced into fat hydroxide (ROOH), and then resolve into nontoxic hydroxy compound by GSH-PX, self peroxidating of the polyunsaturated fatty acids on the biomembrane (PUFA) promptly is blocked.
Behind the vitamin E dehydrogenation atom, be oxidized to a kind of more stable and free radical that toxicity is lower, and under ascorbic effect, it resiled.
Usually food can be supplied with the enough vitamin Es of normal body, but when the intake of unsaturated fatty acid above every day during 20g, when absorption that will vitimin supplement E, especially unsaturated fatty acid is irregular, can produce the relative shortage of vitamin E.
Clinical drug trial result of the present invention shows that it has the following advantages:
1. improve the content of P material vasoactive peptide and motilin in the constipation patient mucous membrane of colon, reduce the content of 5-hydroxy tryptamine in intestinal mucosa and the circular muscle.
2. the moisture in the increase intestinal contents makes stool softening, improves the compliance of patient's sigmoid colon intestinal wall and the reactivity of rectum.
3. strengthen the body metabolism ability, mediate vivotoxin, the effect of intestine moistening is arranged.
4. promote that folic acid forms tetrahydrofolic acid, increase the absorption of ferrum at intestinal.
5. has skin care skin moistening effect, protection body cell normal function and skin care.
The processing technology of medicine of the present invention and instructions of taking
Gather when Flos persicae is open between annual March, dry in the shade, grind into 200 purpose powder, be equipped with vitamin C and vitamin E again, in incapsulating after mixing in proportion, 200 milligrams every, goods.
By the symptom weight, cold boiled water is swallowed when taking, and taking medicine before meal is used.
Light disease person: take the 1-2 grain at every turn, day clothes 2-3 time, two weeks is a course of treatment, can cure 1-2 the course of treatment.
Serious symptom person: take the 2-4 grain at every turn, day clothes 2-3 time, two weeks is a course of treatment, can cure 2-3 the course of treatment.
Taboo: anemia of pregnant woman and pollen hypersensitivity person avoid usefulness.
Medicine of the present invention is by observation on Clinical Application light to 100 examples, the heavy patient, and total cure rate and has the effect of skin care skin moistening concurrently up to 86.5% aspect the treatment constipation, and has no side effect.
The chronic constipation diagnostic criteria that we adopt in clinical observation is as follows:
(1) the infrequent defecation time surpassed own custom more than 1 day, or twice defecation time interval is more than 3 days.
(2) constipation with dry stool.
(3) defecation effort is felt not to the utmost with defecation sense of discomfort or pain or defecation.
(4) get rid of organic constipation through whole body health check-up and physics and chemistry or special examined.
Possess in the above first three items any one and the 4th, continue more than 2 weeks.
The constipation symptom standards of grading that we adopt in clinical observation: see Table.
Name: sex: age: diagnosis: the course of disease:
Symptom score
After treating before the treatment
Just inferior
Just matter
The effort defecation
Defecation time
Just time 1 minute: defecation 1 time/3 days or surpassed automatically custom 1 day
2 minutes: stiff
3 points: dry and hard as ball or stool band blood
Effort defecation companion's discomfort or pain sensation or defecation are felt not to the utmost
1 minute: tired back took place
2 minutes: happen occasionally
3 minutes: often take place
Each defecation time
1 minute: 15-20 minute
2 minutes: 21-30 minute
3 minutes:＞＞30 minutes
Curative effect determinate standard
Recovery from illness: transference cure, integration be zero＞＞more than the 2W
Produce effects: symptom is obviously improved, the more preceding reduction of integration＞＞
2/3,＞＞more than the 2W
Effectively: symptom takes a turn for the better, integration reduction＞＞1/2
Invalid: symptom does not have improvement, and integration does not have reduction
Through with Fructus Cannabis Bolus, Folium Sennae, just be the medicine paired observation such as to lead to find that 'Tongrundan ' pill has stable curative effect aspect the treatment constipation, non-stimulated to gastrointestinal tract, no drug dependence, the cathartic colon not taking place, do not increase the weight of advantages such as constipation after the drug withdrawal, also has skin care, skin moistening, health-care effect.
The invention will be further described below by embodiment, but the present invention is not limited only to these examples.
Embodiment 1:
Take by weighing raw material by following percentage by weight
Flos persicae end 75%
Vitamin C 15%
Vitamin E 10%
Above raw material is made into finished product and packing by above-mentioned processing technology.
Embodiment 2:
Take by weighing raw material by following percentage by weight
Flos persicae end 85%
Vitamin C 10%
Vitamin E 5%
Above raw material is made into finished product and packing by above-mentioned processing technology.
Embodiment 3:
Take by weighing raw material by following percentage by weight
Flos persicae end 65%
Vitamin C 20%
Vitamin E 15%
Above raw material is made into finished product and packing by above-mentioned processing technology.
Claims (2)
1. 'Tongrundan ' pill for the treatment of constipation, it is characterized in that: it is formulated by following component and percentage by weight:
Flos persicae end 65-85%
Vitamin C 8-25%
Vitamin E 5-18%
2. the 'Tongrundan ' pill of treatment constipation according to claim 1 is characterized in that: the percentage by weight of each component is:
Flos persicae end 70-76%
Vitamin C 12-18%
Vitamin E 10-15%
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00131122 CN1111052C (en) | 2000-11-03 | 2000-11-03 | 'Tongrundan' pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00131122 CN1111052C (en) | 2000-11-03 | 2000-11-03 | 'Tongrundan' pill |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1293969A CN1293969A (en) | 2001-05-09 |
| CN1111052C true CN1111052C (en) | 2003-06-11 |
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ID=4594480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00131122 Expired - Fee Related CN1111052C (en) | 2000-11-03 | 2000-11-03 | 'Tongrundan' pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1111052C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169842A (en) * | 2013-03-05 | 2013-06-26 | 段占全 | Intelligent constipation-treating intestinal clearance capsules, and preparation method thereof |
| CN104825714A (en) * | 2015-06-05 | 2015-08-12 | 刘云杰 | Traditional Chinese medicine for treating constipation |
| CN105663752A (en) * | 2016-03-23 | 2016-06-15 | 卞毓平 | Vitamin-E soft capsule |
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2000
- 2000-11-03 CN CN 00131122 patent/CN1111052C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1293969A (en) | 2001-05-09 |
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