CN1695656A - Compsn. of Chinese traditional medicine for enhancing sexual function, physical strength and anti fatigue - Google Patents
Compsn. of Chinese traditional medicine for enhancing sexual function, physical strength and anti fatigue Download PDFInfo
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Abstract
A Chinese medicine for treating weakness, fatigue, hyposexuality, insomnia, hypomnesia, etc is proportionally prepared from 11 Chinese-medicinal materials including sea horse, pilose antler, ginseng, Chinese angelica root, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition with sexual function improving, physical strength reinforcing, antifatigue effect, raising hypoxia-bearing capability.
Background technology
Health product or medicine that many sexual function improving and kidney-tonifying and body-strengthening are arranged in the market, give birth to the fur seal ball of hall production, the NANBAO of Tianjin Lik-Sang pharmaceutical factory etc. as: Jing Dou Juan, though but these medicines of selling on the market have certain curative effect, there is the shortcoming that taking dose is big and uncertain therapeutic efficacy is cut.Therefore, market is little to taking dose, the sexual function improving of taking convenience, determined curative effect, and still there are ever-increasing demand in the medicine or the health product that improve hypoxia-bearing capability and improve muscle power.
Summary of the invention
The object of the present invention is to provide a kind of like this Chinese medicine composition, through evidence, said composition can improve male mice mating effect, alleviate hydrocortisone and cause every yang deficiency symptom of mice, improve preputial glands, seminal fluid capsule and the weight of prostate of extracing the testis mice, weight to each genitals of neuter all has tangible influence, and obviously improves the swimming endurance of mice and improve the hypoxia-bearing capability of mice.
The composition of Chinese medicine composition of the present invention comprises (by weight):
Hippocampus 1-20 Testis et Pentis Canis 1-20 Cornu Cervi Pantotrichum 1-20
Herba Epimedii 2-40 Ootheca Mantidis 1.5-30 Semen Allii Tuberosi 0-30
Fructus Psoraleae 0-30 Radix Ginseng 2-40 Cortex Cinnamomi 0-20
Radix Angelicae Sinensis 0-40 Radix Rehmanniae 0-40.
Chinese medicine composition composition of the present invention preferably includes (by weight):
Hippocampus 3-12 Testis et Pentis Canis 3-12 Cornu Cervi Pantotrichum 3-12
Herba Epimedii 6-25 Ootheca Mantidis 5-20 Semen Allii Tuberosi 0-18
Fructus Psoraleae 4-20 Radix Ginseng 7-25 Cortex Cinnamomi 3-12
Radix Angelicae Sinensis 5-20 Radix Rehmanniae Preparata 0-20.
Chinese medicine composition of the present invention is formed and is more preferably comprised (by weight):
Hippocampus 4-8 Testis et Pentis Canis 4-8 Cornu Cervi Pantotrichum 4-8
Herba Epimedii 12-18 Ootheca Mantidis 7-12 Semen Allii Tuberosi 7-12
Fructus Psoraleae 7-12 Radix Ginseng 12-18 Cortex Cinnamomi 4-8
Radix Angelicae Sinensis 7-13 Radix Rehmanniae Preparata 7-13.
Chinese medicine composition of the present invention is formed and is most preferably comprised (by weight):
Hippocampus 6 Testis et Pentis Canis 6 Cornu Cervi Pantotrichums 6
Herba Epimedii 15 Ootheca Mantidiss 9 Semen Allii Tuberosi 9
Fructus Psoraleae 9 Radix Ginsengs 15 Cortex Cinnamomis 6
Radix Angelicae Sinensis 10 Radix Rehmanniaes Preparata 10.
The present composition has the effect of kidney warming and yang invigorating, strengthening bone and muscle and replenishing QI and blood.Be used for physical weakness clinically, spirit is tired, lassitude loin and legs, deficiency of the kidney cold sperm, hyposexuality, diseases such as insomnia forgetfulness.The normal person also can be used as health product and takes, and to improve muscle power, sexual function improving improves the mental status and improves adaptive capacity to environment etc.
This compositions is common big benefit marrow, the high tonic prescriptions of forming that fill blood of four kinds of animal drugs, seven kinds of draft medicines, specially goes into kidney channel, and invigorating kidney-YANG, profit kidney are dry, transfer the human potential, thereby reach the purpose that consolidates, effects a permanent cure.Hippocampus has female, the androgen-like action of enhancing; Testis et Pentis Canis, i.e. testis of male dog and external genitalia, contained androgen etc. benefits human body; Ootheca Mantidis, i.e. Mantidis ovum has the merit of the kidney invigorating arresting seminal emission; Cornu Cervi Pantotrichum more has strong benefit effect to human body, the scalable nervous system, and the elimination that accelerates fatigue improves immunologic function, strengthens cardiac contractile force, improves cardiac function and promotes gastrointestinal function appetite strengthening etc.Four medicines are united for theory of Chinese medical science is called " product that flesh and blood is in love " and " dirty with dirty benefit ", can reach the purpose of kidney-reinforcing Yang-strengthening.
Since ancient times, the normal and plant amedica compatibility use of animal drugs, mutual reinforcement between each other.We also follow tradition, realize kidney invigorating and YANG supporting with Herba Epimedii, Fructus Psoraleae, Semen Allii Tuberosi, the gain sexual function; Reuse Radix Ginseng, Radix Angelicae Sinensis, Radix Rehmanniae Preparata benefiting vital QI and blood; At last, activate yang, assist a ruler in governing a country animal drugs performance drug effect with the Cortex Cinnamomi the kidney warming.
The present composition has controls effect deficient, that manage all kinds of diseases and ailments, preserve youthful looks and lengthen one's life.The Ming Dynasty cures tame Wang Ang and once said in " the tonic agent " of " collection of prescriptions with notes ": " benefit person, tonifying for deficiency syndrome is also; Support the person, cultivate it, will protect it, make to give birth to and satisfy bar and reach, and the trouble that is not subjected to the injure also.People's gas is reported, and rare De Qiping has relatively sun and the deficiency of YIN person, the moon is arranged relatively and YANG deficiency person, thus must counterfeit drug nourishing it, and must leisurely and carefree peace relax, the years of vacation, make QI and blood belong to peace, be that the energy body and the spirit is all luxuriant, and disease is living also." we promptly are the set tonic agent of patient to " relatively the moon and YANG deficiency ".
Compositions of the present invention has the kidney warming and yang invigorating effect, has significant tonification function for the body of insufficiency of kidney-YANG, significantly the sexual function of enhancing body and property row As; Tong Time has good resisting fatigue and adaptogen, can improve the resistivity that body resists multiple environment harmful factor, as cold, overheated, strenuous exercise, lonizing radiation, foreign serum, antibacterial, drugs, anesthesia, hormone, medicine etc.; And can recover physical ability, allaying tiredness rapidly.
Hippocampus, Testis et Pentis Canis all have female, the androgen-like action of the Strong of increasing in the prescription, can adjust, increase the hormonal readiness of Strong body and the sexual function of raising body; Cornu Cervi Pantotrichum has strong effect to human body, can improve the ability to work of body, lessens fatigue and regains one's strength, improves sleep rapidly, promotes appetite, improves malnutrition and protein metabolism disturbance, promote old person health, promote recovery after being ill; Radix Ginseng has the adaptive effect that improves body, can obviously must improve the adaptive capacity that body resists various adverse circumstances, and the function of nervous system that regulates human body, feasible disorderly Shen Jing Xi System is adjusted and is improved, the resume speed of body that also accelerates fatigue and the raising body also has adjusting body sexual function to the tolerance ， Tong Time of fatigue effect; Herba Epimedii, Fructus Psoraleae, Ootheca Mantidis, Semen Allii Tuberosi all have the effect of the body of raising sexual function; Radix Angelicae Sinensis, Radix Rehmanniae Preparata nourishing YIN and supplementing blood have the obvious propagation and the differentiation that must promote hematopoietic stem cell, CFU-GM, activate body marrow Zao Xue Xi System, improve the body hemopoietic function, and can adjust the dry strong property of other drug.
Compositions of the present invention can be used as medicine by raw material, and perhaps the extracting method with routine is used as medicine the effective ingredient that extraction obtains, and described extracting method comprises that water carries organic solvent extraction and CO
2Supercritical extraction etc.The effective ingredient that the various crude drug or the extraction of compositions can be obtained is made into any dosage form that is suitable for clinically through pretreatment and according to preparation technique, the preparation technology of routine, and described pharmaceutical dosage form includes but are not limited to honeyed pill, the watered pill, capsule, decoction pieces, powder, tablet, oral liquid, concentrated pill, granule, electuary etc.For example can be with each former abrasive lapping of the present composition, mix homogeneously becomes honeyed pill with processed with honey, perhaps with making the watered pill.Also can be with Hippocampus, Testis et Pentis Canis, Cornu Cervi Pantotrichum, that the Ootheca Mantidis oven dry is ground into fine powder is standby, Herba Epimedii, Semen Allii Tuberosi, Fructus Psoraleae, Radix Ginseng, Cortex Cinnamomi, Radix Angelicae Sinensis, Radix Rehmanniae Preparata water are decocted one or many, filter, gained filtrate is condensed into the fluid extract drying and is ground into fine powder standby; At last,, granulate, make granule, or add the excipient tabletting, make tablet two kinds of fine drug powder mix homogeneously.
A kind of preferable preparation technique may further comprise the steps:
(A) with all raw materials respectively 40 ℃-80 ℃ down dry, all raw material pulverizing that then will be except that Radix Rehmanniae;
(B) Herba Epimedii, Fructus Psoraleae, Cortex Cinnamomi, Radix Angelicae Sinensis being carried out percolation extracts;
(C) get Radix Rehmanniae and use water extraction;
(D) with the drug powder of Hippocampus, Penis et testis canitis, Cornu Cervi Pantotrichum, Radix Ginseng, Ootheca Mantidis, Semen Allii Tuberosi,, and make the watered pill behind the water extract mix homogeneously of Radix Rehmanniae with the percolate of Herba Epimedii, Fructus Psoraleae, Cortex Cinnamomi, Radix Angelicae Sinensis;
(E) optional sugar coating or film-coat.
Dosage of the present invention depends on concrete dosage form, factors such as patient's age, body weight, health status.But as instructing, consumption per day can be 5-100g crude drug gross weight/day, can be in single or divided doses.
The specific embodiment
Embodiment
Come further to set forth the present invention by the following examples; it should be understood that; these embodiment only are the preferred version in the present invention's practice; never constitute any restriction to the scope of the invention; under situation without departing from the spirit and scope of the present invention, the many variations that do not depart from essence of the present invention that those skilled in the art makes all fall into protection scope of the present invention.
The preparation of embodiment 1 watered pill
Consisting of of compositions: Hippocampus 60kg, Testis et Pentis Canis 60kg, Cornu Cervi Pantotrichum 60kg, Herba Epimedii 150kg, Ootheca Mantidis 90kg, Semen Allii Tuberosi 90kg, Fructus Psoraleae 90kg, Radix Ginseng 150kg, Cortex Cinnamomi 60kg, Radix Angelicae Sinensis 100kg, Radix Rehmanniae Preparata 100kg.
The preparation of compositions method is:
1) cleaning and crush of raw material: all raw materials are cleaned, in 50-80 ℃ hot blast, dry, with Hippocampus ， Gou Kidney, Cornu Cervi Pantotrichum, Ootheca Mantidis, Radix Ginseng, Folium Allii tuberosi seed are crushed to 120 orders with pulverizer.
2) percolation: take by weighing four kinds of medical materials of Herba Epimedii, Fructus Psoraleae, Cortex Cinnamomi, Radix Angelicae Sinensis of ormal weight, be ground into coarse powder, mix homogeneously, medical material with an amount of 90% ethanol evenly moistening after, in the percolation jar of packing into, compacting adds that 90% ethanol is paramount to go out medical material.Sealing was placed 48 hours; Then with the speed of per minute 250～500ml percolation slowly, collect just filtrate 1200kg in addition device preserve; Continue percolation, till hydrochloric acid-magnesium powder reaction negative.Subsequent filtrate is made for the solvent of next percolation and uses.
The liquid of will just filtering is between 1.15～1.20 at 60 ℃ of decompression recycling ethanols to proportion.Take out standby.
3) the decocting and concentrating liquid of preparation Radix Rehmanniae Preparata:
Take by weighing the Radix Rehmanniae Preparata medical material of ormal weight, put in the extraction pot, added 8 times of water gaging dippings 1 hour.Decocted then 2 hours.Filter filtrate for later use.
Residue continues to add the deionized water of 6 times of amounts, decocts 2 hours.Filter filtrate for later use.
Extracting solution is put and is evaporated to proportion in the vacuum tank is between 1.10～1.15.Take out standby.
4) controlling the water circulation ball
Take by weighing ormal weight Hippocampus, Penis et testis canitis, Cornu Cervi Pantotrichum, Radix Ginseng, Ootheca Mantidis, Tuber Onion Seed and put mix homogeneously in the mixer; Add 2 again) the percolation concentrated solution that makes, the rearmounted baking oven of mix homogeneously with 60 ℃ of oven dry, is put the medicated powder of oven dry and is pulverized on the pulverizer and mistake 120 mesh sieves.
Play die process: a small amount of medicated powder is put into watered pill pellet processing machine, machine, the medicated powder random device rotates; With aerosol apparatus or molding brush Radix Rehmanniae Preparata decocting and concentrating liquid evenly is sprayed on the medicated powder, carries out molding then.All finish molding until whole mould powder, whole ball moulds are taken out, being sieved, it is standby to grade.
The pill operation: the ball mould is placed watered pill pellet processing machine, machine, after adding Radix Rehmanniae Preparata decocting and concentrating liquid and making the mould grain moistening, evenly add medicated powder, rotation evenly is attached on the ball mould medicated powder, and pill is evenly increased.Up to specification until piller diameter and weight.The diameter of required piller is 6.2～6.5mm; Every ball weight is 0.26g ± 10%.
Sieve ball operation: the piller that makes is sieved ball, again qualified, uniform pill is put into pellet processing machine, machine, the abundant moistening of pill is hit tightly, gradation on ball, is turned over the impalpable powder spreading in the medicated powder fast, rubbed then, and is evenly moistening, bright until pill, be taken out in the screen tray, promptly.
Baking operation: the general good watered pill put in 60 ℃ of drying rooms dry, check the moisture of pill simultaneously, the moisture of the gained watered pill must not surpass 9.0%.
Select the grain operation: the watered pill of oven dry is put selected grain on the classer, select the qualified pill of dry weight.
5) coating:
With above-mentioned pill, sugar coating or film-coat.Get final product.
The preparation of embodiment 2 watered pill
The consumption of each raw material of compositions is as follows: Hippocampus: 38.0kg ， Gou Kidney: 30.4kg, Cornu Cervi Pantotrichum: 30.0kg, Ootheca Mantidis: 42.8kg, Herba Epimedii: 85.5kg, Fructus Psoraleae: 50.6kg, Semen Allii Tuberosi: 40.8kg, Radix Ginseng: 75.3kg, Cortex Cinnamomi: 33.5kg, Radix Angelicae Sinensis: 59.5kg, and Radix Rehmanniae Preparata: 61.5kg.
Preparation method is identical with embodiment 1.
The preparation of embodiment 3 watered pill
The consumption of each raw material of compositions is as follows: Hippocampus: 26.0kg ， Gou Kidney: 39.0kg, Cornu Cervi Pantotrichum: 23.5kg, Ootheca Mantidis: 56.3kg, Herba Epimedii: 72.5kg, Fructus Psoraleae: 38.6kg, Semen Allii Tuberosi: 36.8kg, Radix Ginseng: 90.8kg, Cortex Cinnamomi: 36.5kg, Radix Angelicae Sinensis: 57.5kg, and Radix Rehmanniae Preparata: 76.4kg.
Preparation method is identical with embodiment 1.
The preparation of embodiment 4 capsules
The consumption of each raw material of compositions is as follows: Hippocampus: 33.0kg ， Gou Kidney: 32.4kg, Cornu Cervi Pantotrichum: 33.0kg, Ootheca Mantidis: 51.8kg, Herba Epimedii: 82.5kg, Fructus Psoraleae: 48.6kg, Semen Allii Tuberosi: 46.8kg, Radix Ginseng: 80.3kg, Cortex Cinnamomi: 31.5kg, Radix Angelicae Sinensis: 57.5kg and Radix Rehmanniae Preparata: 51.5kg.
Hippocampus, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Ootheca Mantidis oven dry are ground into fine powder; With Herba Epimedii, Radix Ginseng, Folium Allii tuberosi seed, Fructus Psoraleae, Cortex Cinnamomi, Radix Angelicae Sinensis with 8 times of amount 90% ethanol extractions 3 times, each 2 hours, filter and merge three filtrates, dried after filtrate is condensed into extractum, to be ground into fine powder standby; Residue mixes with Radix Rehmanniae Preparata with 8 times of water gagings again and decocts 2 times, and each 1 hour, filter, merging filtrate, concentrating under reduced pressure becomes extractum, and oven dry is ground into fine powder.With fine powder and alcohol extraction fine powder mix homogeneously such as Hippocampus, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Ootheca Mantidiss, granulate, incapsulate, promptly get the capsule that every weight is 0.5g.
The effective ingredient that the various crude drug or the extraction of compositions can be obtained is made into any dosage form that is suitable for clinically through pretreatment and according to preparation technique, the preparation technology of routine, and described pharmaceutical dosage form includes but are not limited to honeyed pill, the watered pill, capsule, decoction pieces, powder, tablet, oral liquid, concentrated pill, granule, electuary etc.
The pharmacodynamic study of embodiment 5 present compositions
One, the present composition is to the influence of mice mating effect
Adopt mice with male and female with the cage feeding manner, establish the present composition medication group of normal control group, positive drug control group and various dose respectively, administration every day 1 time, successive administration 10 days, female Mus vaginal orifice is respectively organized in the every morning inspection or intravaginal has the depletion of YIN bolt, calculating cloudy bolt occurrence rate, is the influence of mating effect to mice to investigate the present composition.
1, test material
1.1 test sample is the embodiment of the invention 1 a prepared watered pill preparation.Get test sample, be ground into fine powder, add deionized water and be mixed with concentration 0.6g/ml, 0.3g/ml, the suspension of 0.1g/ml with mortar.
The NANBAO JIAONANG that 1.2 positive control drug is a Tianjin Lik-Sang pharmaceutical factory to be produced (lot number: 000631, specification: the 0.3g/ grain).Remove the capsule shells of NANBAO JIAONANG, it is mixed with the suspension that concentration is 0.6g/ml with deionized water.
1.3 laboratory animal and raising are 20～22g kunming mice in 6 ages in week, male 50, and female 250; Provided by Beijing Medical University's Experimental Animal Center, its animal quality certification number is the moving word 01-3056 of doctor, and its feed for nursing is provided by Jiujiang, Beijing mouth feed factory, animal feeding in clean Animal House, 24 ± 2 ℃ of temperature, natural lighting, ad lib and drinking-water.
2, test method
2.1 dosage setting: the present composition is established high dose group 2.53g/kg, and middle dosage group 1.27g/kg and low dose group 0.63g/kg are equivalent to 10 times, 20 times, 40 times of the clinical consumption per day of people.Positive controls dosage is 0.60g/kg, is equivalent to 40 times of the clinical consumption of people.
2.2 animal grouping: mice is divided into 5 groups at random, several 60 of every treated animal, wherein male 10, female 50.Be respectively 1. normal control group, 2. present composition high dose group, 3. dosage group in the present composition, 4. present composition low dose group, 5. positive drug control group.
2.3 route of administration: every group of equal gastric infusion, consistent with the clinical administration approach.
2.4 administration time: each dosage group of the present composition and positive drug group are irritated stomach 1 time, successive administration 10 days every day.The normal control group is irritated stomach and is given with the volume deionized water.
2.5 experimental technique and result:
By every group of 10 male Mus, 50 female Mus divide into groups at random, and every male Mus is raised with cage with 5 female Mus simultaneously.From the male and female mice from cage, the male Mus gastric infusion of each administration group, the male Mus of normal control group gives with the capacity normal saline, once a day, continuous 10 days.Every morning checks that respectively organizing female Mus has the depletion of YIN bolt to occur, and takes out the female Mus that cloudy bolt occurs from cage.The results are shown in Table 1.
The result shows: present composition high dose and middle dosage composition have the male mice of increasing mating effect, relatively have significant difference (P＜0.05 and P＜0.01) with the normal control group, positive controls and normal control group more also have significant difference (P＜0.01).Illustrate that the present invention has the male mice of raising mating effect.
Table 1 present composition is to the influence (n=60) of mice mating effect
| Medicine | Dosage | The female Mus number (only) that cloudy bolt occurs | Cloudy bolt occurrence rate (%) | ??P |
| Dosage group high dose group of the present invention among the low dose group the present invention of the present invention of normal saline NANBAO JIAONANG | ??0.60 ??0.63 ??1.27 ??2.53 | ??26 ??36 ??31 ??40 ??44 | ??52 ??72 ??62 ??86 ??88 | ??＜0.05 ? ??＜0.05 ??＜0.01 |
Two, the present composition is to the influence to the yang deficiency animal
Adopt male mice, cause the mice yang deficiency syndrome, make that mice is cold-resistant, fatigue resistance decline with heavy dose of hydrocortisone.Establish the medication group of the present invention of normal control group, positive drug control group, negative control group and various dose respectively.Model of yang asthenia group intramuscular injection every day hydrocortisone 25ml/kg (0.5%), continuous three days; Positive controls, medication group gastric infusion every day 1 time, while intramuscular injection hydrocortisone 25ml/kg (0.5%), successive administration 3 days, after administration in the 4th day 1 hour, write down each treated animal body weight, body temperature, autonomic activities number (10min) and low temperature swimming time-to-live, investigate the mitigation of the present composition, whether the kidney-replenishing effect is arranged to determine it to the male mice yang deficiency symptom of yang deficiency symptom.
1, test material
1.1 test sample is the embodiment of the invention 1 a prepared watered pill preparation.Get test sample, be ground into fine powder, add deionized water and be mixed with concentration 0.6g/ml, 0.3g/ml, the suspension of 0.1g/ml with mortar.
The NANBAO JIAONANG that 1.2 positive control drug is a Tianjin Lik-Sang pharmaceutical factory to be produced (lot number: 000631, specification: the 0.3g/ grain).Remove the capsule shells of NANBAO JIAONANG, it is mixed with the suspension that concentration is 0.6g/ml with deionized water.
1.3 the medication of modeling type is a hydrocortisone injection, specification: 10mg/2ml, source: Beijing Pharmaceutical Factory No.3, lot number: 980614.
1.4 laboratory animal and raising are 60 of 20～22g Kunming male mices in 6 ages in week, provide by Beijing Medical University's Experimental Animal Center, its animal quality certification number is the moving word 01-3056 of doctor, its feed for nursing is provided by Jiujiang, Beijing mouth feed factory, animal feeding is in clean Animal House, 24 ± 2 ℃ of temperature, natural lighting, ad lib and drinking-water.
2. test method
2.1 dosage setting: the present composition is established high dose group 2.53g/kg, and middle dosage group 1.27g/kg and low dose group 0.63g/kg respectively are equivalent to 10 times, 20 times, 40 times of the clinical consumption per day of people.
2.2 the animal grouping: mice is divided into 6 groups at random, 10 every group, is respectively 1. normal control group, 2. present composition high dose group, 3. dosage group in the present composition, 4. present composition low dose group, 5. model of yang asthenia group, 6. positive drug control group.
2.3 route of administration: every group of equal gastric infusion, consistent with the clinical administration approach.
2.4 administration time: each dosage group of the present invention and positive drug group are irritated stomach 1 time every day, and the administration volume is the 0.2ml/10g body weight, successive administration 3 days, the hydrocortisone of intramuscular injection simultaneously 25ml/kg.Model of yang asthenia group intramuscular injection every day hydrocortisone 25ml/kg, for three days on end; The normal control group irritate stomach give with the volume deionized water.
2.5 experimental technique:
The normal control group: gavage deionized water 20ml/kg every day, continuous 4 days, irritate in the 4th day that stomach was weighed after 1 hour, take temperature, observe autonomic activities number of times (10min) and low temperature and swim the time-to-live; The model of yang asthenia group: gavage deionized water 20ml/kg every day, intramuscular injection hydrocortisone 25ml/kg simultaneously, continuous 4 days, in intramuscular injection in the 4th day weigh after 1 hour, take temperature, observation autonomic activities number of times (10min) and low temperature swims the time-to-live; The positive control drug group: gavage the positive control drug NANBAO every day, intramuscular injection hydrocortisone 25ml/kg simultaneously, continuous 4 days, in intramuscular injection in the 4th day weigh after 1 hour, take temperature, observation autonomic activities number of times (10min) and low temperature swims the time-to-live; The medication component is three groups of low dose group (0.63g/kg), middle dosage group (1.27g/kg) and high dose group (2.53g/kg), every day is the dosage gastric infusion in accordance with regulations, the hydrocortisone of intramuscular injection simultaneously 25ml/kg, continuous 4 days, in intramuscular injection in the 4th day weigh after 1 hour, take temperature, observation autonomic activities number of times (10min) and low temperature swimming time-to-live.The results are shown in Table 2.
2.6 interpretation of result
The result shows: little, the middle and high dosage of the present composition has the obvious prolongation mice low temperature swimming time-to-live, relatively has significant difference (P＜0.05 and P＜0.01) with the model of yang asthenia group; Simultaneously can obviously increase mice autonomic activities number of times.Illustrate: have the effect of alleviating the every yang deficiency symptom of mice.
Table 2 present composition is to the influence (n=10) of yang deficiency syndrome animal
| Numbering | Dosage (g/kg) | Body temperature | Autonomic activities number of times (10min) | Low temperature swimming time (second) | Body weight | ||
| Before the administration | After the administration | Difference | |||||
| Dosage group high dose group of the present invention among the low dose group the present invention of the present invention of normal control group model of yang asthenia group NANBAO JIAONANG | ? ? ??0.60 ??0.63 ??1.27 ??2.53 | ??36.3±0.4 ??35.6±0.6 ??36.2±0.5 ??36.2±0.4 ??36.3±0.6 ??36.3±0.3 | ??20±3 ??11±6 ??22±7 *??24±5 *??28±9 **??30±11 ** | ??233.3±34.7 ??210.6±52.3 ??326±77.2 **??287±53.4 **??323.9±3.0 **??358.5±2.4 ** | ??20.3±1.2 ??20.5±1.6 ??20.7±1.9 ??21.1±1.4 ??20.6±1.1 ??20.3±1.5 | ??22.5±1.7 ??18.9±1.9 ??20.6±1.6 ??20.7±1.7 ??21.3±1.6 ??22.1±1.3 | ??+2.2 ??-1.6 ??-0.1 ??-0.4 ??+0.7 ??+1.8 |
*：P＜0.05：
**：P＜0.01
Three, the present composition is to the influence of the animal of suffering from a deficiency of the kidney
Adopt male mice, extract its testis and cause the mice nephrasthenia syndrome, cause each weight of reproductive organs of the animal of suffering from a deficiency of the kidney (castration mouse) all to be starkly lower than the intact animal.Establish normal control group, model group, positive drug control group and various dose medication group of the present invention in the research respectively; Positive drug control group, medication group gastric infusion every day 1 time, successive administration 20 days, in the 21st day with sacrifice of animal, write down each treated animal preputial glands, seminal fluid capsule, prostate, investigate the influence of the present composition, to determine its influence to the animal of suffering from a deficiency of the kidney to each weight of reproductive organs of castration male mice.
1, test material
1.1 test sample is the embodiment of the invention 1 prepared red coating watered pill.Get test sample, be ground into fine powder, add deionized water and be mixed with concentration 0.6g/l, 0.3g/ml, the suspension of 0.1g/ml with mortar.
The NANBAO JIAONANG that 1.2 positive control drug is a Tianjin Lik-Sang pharmaceutical factory to be produced (lot number: 000631, specification: the 0.3g/ grain).Remove the capsule shells of NANBAO JIAONANG, it is mixed with the suspension that concentration is 0.6g/ml with deionized water.
1.3 laboratory animal and raising are 60 of 12 ± 1g Kunming male mices in 6 ages in week, provide by Beijing Medical University's Experimental Animal Center, its animal quality certification number is the moving word 01-3056 of doctor, its feed for nursing is provided by Jiujiang, Beijing mouth feed factory, animal feeding is in clean Animal House, 24 ± 2 ℃ of temperature, natural lighting, ad lib and drinking-water.
2, test method
2.1 dosage setting: the present composition is established high dose group 2.53g/kg, and middle dosage group 1.27g/kg and low dose group 0.63g/kg are equivalent to 10 times, 20 times, 40 times of the clinical consumption per day of people.Positive controls dosage is 0.60g/kg, is equivalent to 40 times of the clinical consumption of people.
2.2 the animal grouping: mice is divided into 6 groups at random, 10 every group, is respectively 1. normal control group, 2. present composition high dose group, 3. dosage group in the present composition, 4. present composition low dose group, 5. castration model group, 6. positive drug control group.
2.3 route of administration: every group of equal gastric infusion, consistent with clinical plan with approach.
2.4 administration time: each dosage group of the present invention and positive drug group are irritated stomach 1 time every day, in beginning in the 3rd day administration of mice operation back, successive administration 20 days; The model group of suffering from a deficiency of the kidney and normal control group irritate stomach give with the volume deionized water.
2.5 experimental technique:
The normal control group: gavage deionized water 20ml/kg every day, continuous 20 days, after the 21st day, put to death, take by weighing preputial glands, seminal fluid capsule, weight of prostate rapidly; The model group of suffering from a deficiency of the kidney: animal under etherization, the sterilization skin of scrotum.Extract bilateral testes.Postoperative intramuscular injection scotcil 20,000 units/kg.After the castration 3 days, gavage every day and get ionized water 20ml/kg, continuous 20 days, after the 21st day, put to death, take by weighing preputial glands, seminal fluid capsule, weight of prostate rapidly; The positive control drug group: animal under etherization, the sterilization skin of scrotum.Extract bilateral testes.Postoperative intramuscular injection scotcil 20,000 units/kg.After the castration 3 days, gavage every day and get positive control drug NANBAO JIAONANG 0.6g/kg, continuous 20 days, after the 21st day, put to death, take by weighing preputial glands, seminal fluid capsule, weight of prostate rapidly; The medication group: animal under etherization, the sterilization skin of scrotum.Extract bilateral testes.Postoperative intramuscular injection scotcil 20,000 units/kg.Castration is divided into 3 groups at random after 3 days, the present invention is divided into low dose group (0.63g/kg), middle dosage group (1.27g/kg) and high dose group (2.53g/kg).Every day, dosage gavaged medicine in accordance with regulations, and continuous 20 days, after the 21st day, put to death, take by weighing preputial glands, seminal fluid capsule, weight of prostate rapidly.Experimental result sees Table 3.
2.6 interpretation of result
The result shows: the middle and high dosage group of the present composition all can make preputial glands, seminal fluid capsule, the weight of prostate that improves the castration treated animal, with the castration model group relatively have significant difference (P＜0.05 〉.Illustrate: the weight to each genitals of neuter all has tangible influence.
Pair the suffer from a deficiency of the kidney influence (n=10) of animal of table 3
| Group | Dosage (g/kg) | Preputial glands (mg) | Prostate+seminal fluid capsule (mg) |
| The normal control group dosage group high dose group of the present invention among the low dose group the present invention of the present invention of model group NANBAO group of suffering from a deficiency of the kidney | ? ? ??0.60 ??0.63 ??1.27 ??2.53 | ??15.3±1.6 ??11.3±2.1 ??15.7±3.1 *??12.1±2.3 ??15.3±4.1 *??16.4±2.7 * | ??18.7±1.3 ??13.4±4.1 ??18.3±2.5 *??14.2±1.2 ??17.1±3.6 *??18.3±2.4 * |
*：P＜0.05
Four, the antifatigue effect of the present composition
Adopt male mice, successive administration 10 days is tied up mice the swimming of heavy back then, and meter record mice fatigue sinks to the groove death time, to investigate the endurance of animal.Establish model group, positive drug control group and various dose medication group of the present invention in the research respectively; Positive controls, medication group gastric infusion every day 1 time, successive administration 10 days, after administration in the 10th day 1 hour, mice is tied up the swimming of heavy back, till sinking to bottom land death with mice, write down the time of the swimming of each treated animal in water, mice is tied up the effect of revisiting the swimming time, whether can improve tiing up of mice and revisit swimming endurance to determine it to investigate the present composition.
1. test material
1.1 test sample is the embodiment of the invention 1 a prepared watered pill preparation.Get test sample, be ground into fine powder, add deionized water and be mixed with concentration 0.6g/ml, 0.3g/ml, the suspension of 0.1g/ml with mortar.
The NANBAO JIAONANG that 1.2 positive control drug is a Tianjin Lik-Sang pharmaceutical factory to be produced (lot number: 000631, specification: the 0.3g/ grain).Remove the capsule shells of NANBAO JIAONANG, it is mixed with the suspension that concentration is 0.6g/ml with deionized water.
1.3 laboratory animal and raising are 50 of 19 ± 1g Kunming male mices in 6 ages in week, provide by Beijing Medical University's Experimental Animal Center, its animal quality certification number is the moving word 01-3056 of doctor, its feed for nursing is provided by Jiujiang, Beijing mouth feed factory, animal feeding is in clean Animal House, 24 ± 2 ℃ of temperature, natural lighting, ad lib and drinking-water.
2. test method
2.1 dosage setting: the present composition is established high dose group 2.53g/kg, and middle dosage 1.27g/kg and low dosage 0.63g/kg are equivalent to 10 times, 20 times, 40 times of the clinical consumption per day of people.Positive controls dosage is 0.60g/kg, is equivalent to 40 times of the clinical consumption of people.
2.2 animal grouping: mice is divided into 5 groups at random, 10 every group, is respectively 1. model group, 5. positive drug control group of dosage group preparation preparation 4. of the present invention low dose group in the preparation high dose group 2. of the present invention preparation 3. of the present invention.
2.3 route of administration: every group of equal gastric infusion, consistent with clinical plan with approach.
2.4 administration time: each dosage group of preparation of the present invention and positive drug group are irritated stomach 1 time, successive administration 10 days every day; The normal control group irritate stomach give with the volume deionized water.
2.5 experimental technique:
The normal control group: gavage deionized water 20ml/kg every day, continuous 10 days, after administration after the 10th day 1 hour, mice tied up revisit swimming, the record mice sinks to the time of bottom land death.
The positive control drug group: gavage every day and get positive control drug NANBAO JIAONANG 0.6g/kg, continuous 10 days, after administration after the 10th day 1 hour, mice tied up revisit swimming, the record mice sinks to the time of bottom land death.
The medication group: animal is divided into 3 groups at random, and the present composition is divided into low dose group (0.63g/kg), middle dosage group (1.27g/kg) and high dose group (2.53g/kg).Every day, dosage gavaged medicine in accordance with regulations, and continuous 10 days, after administration after the 10th day 1 hour, mice tied up revisit swimming, the record mice sinks to the time of bottom land death.Experimental result sees Table 4.
2.6 interpretation of result
The result shows: little, the middle and high dosage group of the present composition all can make and improve mice and tie up swimming time after heavy, with the normal control group relatively have significant difference (P＜0.01 〉.Illustrate: each dosage group of the present invention all can obviously improve mice and tie up and revisit swimming endurance.
Table 4 present composition is to the influence (n=10) of mouse anti-reflecting fatigue
| Group | Dosage (g/kg) | Swimming time (min) | The P value |
| Dosage group high dose group of the present invention among the low dose group the present invention of the present invention of model group NANBAO JIAONANG group | ? ??0.6 ??0.67 ??1.37 ??2.53 | ??21.4±3.6 ??56.4±7.1 ??51.9±10.3 ??60.1±12.7 ??73.5±8.4 | ? ??＜0.01 ??＜0.01 ??＜0.01 ??＜0.01 |
Five, the present composition is to the influence of mice hypoxia-bearing capability
Adopt male mice, successive administration 7 days, 40min after the last administration puts into and fills 15g, in the port grinding bottle of sodica calx, the record time-to-live of mice under anaerobic condition.Establish normal control group, positive drug control group and medication group in the research respectively,, whether can improve the mice hypoxia-bearing capability to determine it to investigate the influence of the present invention to the mice hypoxia endurance time.
1, test material
1.1 test sample is the embodiment of the invention 1 a prepared watered pill preparation.Get test sample, be ground into fine powder, add deionized water and be mixed with concentration 0.6g/ml, 0.3g/ml, the suspension of 0.1g/ml with mortar.
The NANBAO JIAONANG that 1.2 positive control drug is a Tianjin Lik-Sang pharmaceutical factory to be produced (lot number: 000631, specification: the 0.3g/ grain).Remove the capsule shells of NANBAO JIAONANG, it is mixed with the suspension that concentration is 0.6g/ml with deionized water.
1.3 laboratory animal and raising are 50 of 19 ± 1g Kunming male mices in 6 ages in week, provide by Beijing Medical University's Experimental Animal Center, its animal quality certification number is the moving word 01-3056 of doctor, its feed for nursing is provided by Jiujiang, Beijing mouth feed factory, animal feeding is in clean Animal House, 24 ± 2 ℃ of temperature, natural lighting, ad lib and drinking-water.
2, test method
2.1 dosage setting: the present composition is established high dose group 2.53g/kg, and middle dosage group 1.27g/kg and low dose group 0.63g/kg are equivalent to 10 times, 20 times, 40 times of the clinical consumption per day of people.Positive controls dosage is 0.60g/kg, is equivalent to 40 times of the clinical consumption of people.
2.2 animal grouping: mice is divided into 5 groups at random, 10 every group, is respectively 1. normal control group, 2. present composition high dose group, 3. dosage group in the present composition, 4. 5. positive drug control group of present composition low dose group.
2.3 route of administration: every group of equal gastric infusion, consistent with clinical plan with approach.
2.4 administration time: each dosage group of the present invention and positive drug group are irritated stomach 1 time, successive administration 7 days every day; The normal control group irritate stomach give with the volume deionized water.
2.5 experimental technique:
Normal control group: gavage deionized water 20ml/kg every day, continuous 7 days, 40min after administration in the 7th day put into mice the port grinding bottle that fills the 15g sodica calx, port grinding bottle is coated with vaseline, record envelope bottleneck to the time that mouse breathing stops be the time-to-live of mice.
Positive control drug group: gavage every day and get positive control drug NANBAO JIAONANG 0.6g/kg, continuous 7 days, 40min after administration in the 7th day put into mice the port grinding bottle that fills the 15g sodica calx, port grinding bottle is coated with vaseline, record envelope bottleneck to the time that mouse breathing stops be the time-to-live of mice.
The medication group: animal is divided into 3 groups at random, and the present composition is divided into low dose group (0.63g/kg), middle dosage group (1.27g/kg) and high dose group (2.53g/kg).Every day, dosage gavaged medicine in accordance with regulations, and continuous 7 days, 40min after administration in the 7th day put into the port grinding bottle that fills the 15g sodica calx with mice, and port grinding bottle is coated with vaseline, record envelope bottleneck to the time that mouse breathing stops be the time-to-live of mice.Experimental result sees Table 5.
2.6 interpretation of result
The result shows: little, the middle and high dosage group of the present composition all can make and improve the time-to-live of mice under anaerobic condition, relatively has significant difference (P＜0.05 and P＜0.01) with the normal control group.Illustrate: each dosage group of the present invention all can obviously improve the mice hypoxia-bearing capability.
Table 5 preparation of the present invention under normal pressure to the influence (n=10) of mice hypoxia-bearing capability
| Group | Dosage | Time-to-live | The P value |
| Dosage group high dose group of the present invention among the low dose group the present invention of the present invention of normal control group NANBAO JIAONANG group | ? ??0.60 ??0.63 ??1.37 ??2.53 | ??23.13±6.12 ??37.32±4.45 ??30.48±5.01 ??38.40±5.36 ??41.12±6.37 | ? ??＜0.01 ??＜0.05 ??＜0.01 ??＜0.01 |
List of references
1, Yuan Wenxue, etc. Shenyang Pharmacy College's journal, 1990; 7 (2): 126
2, bureau of drug policy ﹠ administration of Ministry of Health of the People's Republic of China: study of tcm new drug guide p85
3, Yang Fuxin, etc. Shenyang Pharmacy College's journal, 1992; 9 (2): 111
4, Wan Zhuochang, etc. Chinese patent medicine, 1999; 9:29
5, chief editor such as Xu Shuyun. pharmacological experiment method, Beijing: People's Health Publisher, 1991; P1286
Claims (7)
1, a kind of Chinese medicine composition that is used for sexual function improving, physical strength reinforcing, antifatigue effect or improves hypoxia-bearing capability comprises following component by weight:
Hippocampus 1-20 Testis et Pentis Canis 1-20 Cornu Cervi Pantotrichum 1-20
Herba Epimedii 2-40 Ootheca Mantidis 1.5-30 Semen Allii Tuberosi 0-30
Fructus Psoraleae 0-30 Radix Ginseng 2-40 Cortex Cinnamomi 0-20
Radix Angelicae Sinensis 0-40 Radix Rehmanniae 0-40.
2, Chinese medicine composition according to claim 1, wherein the weight portion proportioning of each raw material is:
Hippocampus 3-12 Testis et Pentis Canis 3-12 Cornu Cervi Pantotrichum 3-12
Herba Epimedii 6-25 Ootheca Mantidis 5-20 Semen Allii Tuberosi 0-18
Fructus Psoraleae 4-20 Radix Ginseng 7-25 Cortex Cinnamomi 3-12
Radix Angelicae Sinensis 5-20 Radix Rehmanniae Preparata 0-20.
3, according to the arbitrary described Chinese medicine composition of claim 1-2, wherein the weight portion proportioning of each raw material is:
Hippocampus 4-8 Testis et Pentis Canis 4-8 Cornu Cervi Pantotrichum 4-8
Herba Epimedii 12-18 Ootheca Mantidis 7-12 Semen Allii Tuberosi 7-12
Fructus Psoraleae 7-12 Radix Ginseng 12-18 Cortex Cinnamomi 4-8
Radix Angelicae Sinensis 7-13 Radix Rehmanniae Preparata 7-13.
4, according to the arbitrary described Chinese medicine composition of claim 1-3, wherein the weight portion proportioning of each raw material is:
Hippocampus 6 Testis et Pentis Canis 6 Cornu Cervi Pantotrichums 6
Herba Epimedii 15 Ootheca Mantidiss 9 Semen Allii Tuberosi 9
Fructus Psoraleae 9 Radix Ginsengs 15 Cortex Cinnamomis 6
Radix Angelicae Sinensis 10 Radix Rehmanniaes Preparata 10.
5,, it is characterized in that to make any dosage form that is suitable for clinically according to the Chinese medicine composition of claim 1-5.
6, Chinese medicine composition according to claim 5, described dosage form are honeyed pill, the watered pill, capsule, decoction pieces, powder, tablet, oral liquid, concentrated pill, granule or electuary.
7, a kind of method for preparing the described Chinese medicine composition of claim 1 may further comprise the steps:
(A) with all raw materials 40 ℃-80 ℃ down dry, all raw material pulverizing that then will be except that Radix Rehmanniae:
(B) Herba Epimedii, Fructus Psoraleae, Cortex Cinnamomi, Radix Angelicae Sinensis being carried out percolation extracts;
(C) get Radix Rehmanniae and use water extraction;
(D) with Hippocampus, Penis et testis canitis, Cornu Cervi Pantotrichum, Radix Ginseng, Ootheca Mantidis, Tuber Onion Seed, the water extract controlling the water circulation ball of the percolate of Herba Epimedii, Fructus Psoraleae, Cortex Cinnamomi, Radix Angelicae Sinensis and Radix Rehmanniae;
(E) the optional coating that carries out.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102138936A (en) * | 2011-03-29 | 2011-08-03 | 江苏省中医院 | Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof |
| CN101066294B (en) * | 2007-06-14 | 2011-11-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese medicine prepn for invigorating kidney to reduce urination and its prepn |
| CN101468071B (en) * | 2007-12-28 | 2012-02-22 | 魏贤辉 | Chinese medicine medicine for suppressing and alleviating sex urge for male and female |
| CN105920086A (en) * | 2013-10-30 | 2016-09-07 | 天津中医药大学 | Preparation method of fructus psoraleae extract and fructus psoraleae extract |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1115654A (en) * | 1994-07-19 | 1996-01-31 | 于延春 | Kidney-reinforcing oral medicine and its prepn |
| CN1128626C (en) * | 2000-03-15 | 2003-11-26 | 蒲荣 | Health-care medical wine for invigorating function of kidney and strengthening bone |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066294B (en) * | 2007-06-14 | 2011-11-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese medicine prepn for invigorating kidney to reduce urination and its prepn |
| CN101468071B (en) * | 2007-12-28 | 2012-02-22 | 魏贤辉 | Chinese medicine medicine for suppressing and alleviating sex urge for male and female |
| CN102138936A (en) * | 2011-03-29 | 2011-08-03 | 江苏省中医院 | Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof |
| CN102138936B (en) * | 2011-03-29 | 2013-03-13 | 江苏省中医院 | Yellow dog penis extractive with resistance to ovarian function progeria as well as preparation method and applications thereof |
| CN105920086A (en) * | 2013-10-30 | 2016-09-07 | 天津中医药大学 | Preparation method of fructus psoraleae extract and fructus psoraleae extract |
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