CN1319569C - Chinese medicine preparation for treating osteoporosis and fracture and preparation process thereof - Google Patents
Chinese medicine preparation for treating osteoporosis and fracture and preparation process thereof Download PDFInfo
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- CN1319569C CN1319569C CNB2004100730778A CN200410073077A CN1319569C CN 1319569 C CN1319569 C CN 1319569C CN B2004100730778 A CNB2004100730778 A CN B2004100730778A CN 200410073077 A CN200410073077 A CN 200410073077A CN 1319569 C CN1319569 C CN 1319569C
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- olibanum
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- Medicines Containing Plant Substances (AREA)
Abstract
In the present invention, medicinal materials of himalayan teasel root, Radix Notoginseng, prepared rhizome of rehmannia rhizoma, fortune's drynaria rhizome, pyrite, frankincense, Chinese angelica, szechwan lovage rhizome, white paeony root, slenderstyle acanthopanax bark, myrrh, rhubarb root, dragon's blood, red peony root, safflower, sodium borate, etc. are preprocessed and then weighed according to raw material dosage proportion. The weighed medicinal materials are processed through respective pulverization or mixing pulverization and then ground into synthetically medicinal powder so as to obtain a traditional Chinese medicine preparation. The present invention solves the technical problems of a plurality of adverse reactions or single effects on fracture reunion and wound treatment existing in the background art. The present invention has the advantages of dialectic treatment after syndrome differentiation, comprehensive treatment, chiefly improved integral quality, good effect on kidney invigoration, bone sturdiness, stasis relief and pain alleviation, obvious effect taking and no toxic side effect according to the traditional Chinese medicine principles of kidney invigoration, essence replenishment, marrow nourishment, bone sturdiness, blood nourishment, blood circulation promotion, stasis relief, pain alleviation, etc., and the unity of the present invention in the form of principles, methods, recipes and medicines is the same as the cases and the pathogenesis of primary osteoporosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of osteoporosis and fracture and preparation method thereof.Its concrete function range of application is blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, bone and muscle strengthening, is mainly used in the fracture that osteoporosis etc. causes.
Background technology
It is more that Western medicine is treated the types of drugs of osteoporosis in recent years, but used medicine almost all is antagonism bone resorption, prevents bone loss, and have the medicine that lowers risk of bone fracture in some cases.These some medicines have the part specific action to skeleton, other medicines, and for example Hormone Replacement Therapy etc. mainly is can reduce spinal column and Hip Fracture risk.
At present, Western medicine prevention of osteoporosis disease has following a few class: 1) hormones such as estrogen etc.; 2) the diphosphonic acid salt is as complying with for phosphoric acid (ETIDRONGAACID) and Alendronic Acid salt (ALENDRONATE) etc.; 3) calcitonin; 4) vitamin D; 5) novel vitamin D analogues and metabolite thereof; 6) calcium; 7) sodium fluoride; 8) according to general pyrite (YPRIFLAVONE).Synthetic steroid thing of protein stimulatory such as nandrolone (NANDROLONE), stanozolol (STANOZOLOL) and testosterone (TESTOSTERONE) etc.The herbal species of treatment osteoporosis and fracture mainly contains: 1) according to safe; 2) health bone more; 3) cause health; 4) " three-flower " bone-knitting powder; 5) the Gold Testudinis bone looses; 6) bone is dredged spirit; 7) the bone health that heals; 8) GUSHUKANG; 9) bone is dredged treasured etc.Though the Chinese and western drugs of treatment osteoporosis and fracture respectively has characteristics, and deficiency is also arranged, and is bigger as the side effect of hormone method, the short-term untoward reaction arranged, as symptoms such as vaginal hemorrhage, tenderness of breasts and upper digestive tracts; The digestive tract discomfort may appear in diphosphate, albuminuria, heating, bone mineralising obstacle etc.Some Chinese medicines, for example Radix Notoginseng Tabellae, GUSHUKANG etc. then are partial to synthetism or traumatic injury.
Summary of the invention
The object of the invention is to provide a kind of Chinese prescription for the treatment of osteoporosis and fracture and preparation method thereof, and it has solved in the background technology should produce untoward reaction, or only is partial to the technical problem that synthetism is cured the wound.
Technical solution of the present invention is:
A kind of Chinese medicine preparation for the treatment of osteoporosis and fracture, its special character is: this Chinese medicine preparation is formed by the feedstock production that comprises following consumption proportion
Radix Dipsaci 2.0～7.5%, Radix Notoginseng 12.0～17.5%, Borax 2.5～7.5%,
Sanguis Draxonis 12.0～17.5%, Rhizoma Drynariae 2.0～7.5%, Pyritum 2.0～7.5%,
Radix Rehmanniae Preparata 2.0～7.5%, Radix Angelicae Sinensis 2.0～7.5%, Rhizoma Chuanxiong 2.0～7.5%,
Cortex Acanthopancis 2.0～7.5%, the Radix Paeoniae Alba 2.0～7.5%; Olibanum 2.0～7.5%,
Myrrha 2.0～7.5%, Flos Carthami 2.0～7.5%, Radix Paeoniae Rubra 2.0～7.5%,
Radix Et Rhizoma Rhei 2.0～7.5%.
Above-mentioned Chinese medicine preparation also can comprise the raw material of following consumption proportion
The Cortex Eucommiae 0.0～7.5%, Radix Glycyrrhizae 0.0～4.0%, Eriocheir sinensis powder 0.0～7.5%.
Above-mentioned Chinese medicine preparation is advisable with the raw material that adopts following consumption proportion
The Cortex Eucommiae 2.0～7.5%, Radix Glycyrrhizae 2.0～4.0%, Eriocheir sinensis powder 6.0～7.5%.
Above-mentioned Chinese medicine preparation is advisable with the feedstock production that adopts following consumption proportion
Radix Dipsaci 2.5～7.5%, Radix Notoginseng 12.5～17.0%, Borax 2.5～7.5%,
Sanguis Draxonis 12.5～17.0%, Rhizoma Drynariae 2.5～7.5%, Pyritum 2.5～7.5%,
The Cortex Eucommiae 2.5～7.5%, Radix Glycyrrhizae 2.5～3.5%, Eriocheir sinensis powder 6.0～7.5%;
Radix Rehmanniae Preparata 2.5～7.5%, Radix Angelicae Sinensis 2.5～7.5%, Rhizoma Chuanxiong 2.5～7.5%,
Cortex Acanthopancis 2.5～7.5%, the Radix Paeoniae Alba 2.5～7.5%; Olibanum 2.5～7.5%,
Myrrha 2.5～7.5%, Flos Carthami 2.5～7.5%, Radix Paeoniae Rubra 2.5～7.5%,
Radix Et Rhizoma Rhei 2.5～7.5%.
Above-mentioned Chinese medicine preparation is preferable with the feedstock production that adopts following consumption proportion
Radix Dipsaci 3.5～6.5%, Radix Notoginseng 13.5～15.5%, Borax 3.5～6.5%,
Sanguis Draxonis 13.5～15.5%, Rhizoma Drynariae 3.5～6.5%, Pyritum 3.5～6.5%,
The Cortex Eucommiae 3.0～5.0%, Radix Glycyrrhizae 3.0～3.5%, Eriocheir sinensis powder 6.0～7.0%;
Radix Rehmanniae Preparata 3.5～6.5%, Radix Angelicae Sinensis 3.5～6.5%, Rhizoma Chuanxiong 3.5～6.5%,
Cortex Acanthopancis 3.5～6.5%, the Radix Paeoniae Alba 3.5～6.5%; Olibanum 3.5～6.5%,
Myrrha 3.5～6.5%, Flos Carthami 3.5～6.5%, Radix Paeoniae Rubra 3.5～6.5%,
Radix Et Rhizoma Rhei 3.5～6.5%.
Above-mentioned Chinese medicine preparation is the best with the feedstock production that adopts following consumption proportion
Radix Dipsaci 5.0%, Radix Notoginseng 14.5%, Borax 5.0%, Sanguis Draxonis 14.5%, Rhizoma Drynariae 4.0%,
Pyritum 4.0%, the Cortex Eucommiae 3.5%, Radix Glycyrrhizae 3.0%, Eriocheir sinensis powder 6.5%; Radix Rehmanniae Preparata 4.0%,
Radix Angelicae Sinensis 4.0%, Rhizoma Chuanxiong 4.0%, Cortex Acanthopancis 4.0%, the Radix Paeoniae Alba 4.0%; Olibanum 4.0%,
Myrrha 4.0%, Flos Carthami 4.0%, Radix Paeoniae Rubra 4.0%, Radix Et Rhizoma Rhei 4.0%.
The method of osteoporosis and fracture Chinese medicine preparation is treated in a kind of preparation as mentioned above, and its special character is: the operation of this preparation method comprises
1) medical material pretreatment
[1]. get Radix Notoginseng, select, clean 60 ℃ of dry for standby with horizontal medicine-washing machine flowing water spray;
[2]. get Flos Carthami, select, remove stem and leaf, base of a fruit head, 60 ℃ were dried by the fire 1 hour, standby;
[3]. get Olibanum, remove impurity, the stir-fry of slow fire vinegar is seen melting point slightly, is omited displaing yellow to the surface, cool standby;
[4]. get Myrrha, remove impurity, processed with vinegar is fried to surface-brightening, cools standby;
[5]. get Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Radix Dipsaci, Cortex Acanthopancis, remove impurity respectively, clean, 60 ℃ of oven drying at low temperatures are standby;
[6]. get Radix Rehmanniae Preparata, remove impurity, clean, 40～50 ℃ of vacuum dryings were extremely sent out crisp, standby in 2 hours;
[7]. get Rhizoma Drynariae, remove impurity, stir-fry is yellowish-brown to the surface, hits unhairing, cools standby;
[8]. get Pyritum, remove impurity, clean, forge to kermesinus, vinegar is quenched to interior repeatedly by golden yellow blackening brown, and gloss disappears, to crisp;
[9]. get Borax, remove impurity, standby;
[10]. get Sanguis Draxonis, the surface dirt of flipping, standby;
[11] get the Cortex Eucommiae, Radix Glycyrrhizae, dry for standby;
[12] get the Eriocheir sinensis powder and dry, standby;
2) batching
Take by weighing pretreated medical material by the raw material consumption proportion;
3) pulverize
[1] Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax, the Cortex Eucommiae, Radix Glycyrrhizae, Eriocheir sinensis powder, Radix Rehmanniae Preparata, Rhizoma Drynariae, Flos Carthami pulverize separately, cross 60 mesh sieves, get Radix Notoginseng powder, Sanguis Draxonis powder, natural copper powder, Borax powder, Cortex Eucommiae powder, Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder respectively;
[2] Olibanum, Myrrha mix pulverizing, cross 60 mesh sieves, get Olibanum, Myrrha mixed powder;
[3] Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine mix pulverizing, cross 60 mesh sieves, get the mixed powder of Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine;
4) facing-up
[1] elder generation is even with Olibanum, Myrrha mixed powder and Radix Notoginseng powder, Sanguis Draxonis powder ground and mixed, gets Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis mixed powder;
[2] nature copper powder and Borax powder ground and mixed is even, get Pyritum, Borax mixed powder;
[3], get the mixed powder of Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax Six-element medicine again with Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis mixed powder and Pyritum, Borax mixed powder mix homogeneously;
[4] with Cortex Eucommiae powder, Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder Six-element medicine ground and mixed are even, even with Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax ground and mixed again, get Cortex Eucommiae powder, the mixed powder of Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax 12 flavor medicines;
5) mix
[1] with the mixed powder and the Cortex Eucommiae powder of Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine, the mixed powder remix of Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax 12 flavor medicines is even, gets the crude drug fine powder;
[2] the crude drug fine powder is placed the V-arrangement mixer do and mixed 5 minutes, must synthesize medicated powder.
Above-mentioned pulverizing is to cross 60 mesh sieves, and flour extraction at least 97% is good.
The operation of above-mentioned preparation method also can comprise: will synthesize medicated powder and place capsule filler, and make capsule; Maybe will synthesize medicated powder water or ethanol or other solvent, make granule, tablet, pill or oral liquid etc.
The present invention has the following advantages:
1. invigorating the kidney and strengthening the bones.Radix Rehmanniae Preparata is joined intermittently, Rhizoma Drynariae, fills up essence and blood, flat the kidney invigorating gas, and residence is moving in the pneumostatic, and it is strong to make marrow fill bone;
2. strengthening bone and muscle, symplectic bone is hindered.Select kidney-reinforcing drug,, can play the effect of strengthening bone and muscle, symplectic bone wound as Radix Dipsaci, Rhizoma Drynariae;
The assistant with the medicine of enriching blood, as Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba with bone and muscle strengthening.Blood stored in the liver, kidney storing essence, The liver and the kidney have a common source, blood essence, smart marrow, the marrow bone growth promoting of giving birth to;
4. add the blood circulation promoting and blood stasis dispelling showy reiolaena root-bark, as Rhizoma Chuanxiong, Radix Notoginseng, Radix Et Rhizoma Rhei, secondly Radix Angelicae Sinensis can be enriched blood and can be invigorated blood circulation, and Pyritum then has dissipating blood stasis synthetism, analgesic effect.Share all medicines, these act on multiplication;
5. add Borax, bitter cool expectorant is coagulated with the expectorant that removes the bone joint;
6. should side's principle-method-recipe-medicines, with the etiology and pathogenesis of primary osteoporosis bigger uniformity is arranged;
7. the present invention is according to the traditional Chinese medical science " kidney tonifying, essence replenishing give birth to marrow bone strengthening ", principles such as " nourshing blood and promoting blood circulation blood-activating analgetics ", and dialectical executing controlled, and comprehensive control improves total quality emphatically, good effect, instant effect has no side effect substantially.
The specific embodiment
The present invention is mainly formed by the feedstock production of following consumption proportion
Radix Dipsaci 2.0～7.5%, Radix Notoginseng 12.0～17.5%, Borax 2.5～7.5%,
Sanguis Draxonis 12.0～17.5%, Rhizoma Drynariae 2.0～7.5%, Pyritum 2.0～7.5%,
Radix Rehmanniae Preparata 2.0～7.5%, Radix Angelicae Sinensis 2.0～7.5%, Rhizoma Chuanxiong 2.0～7.5%,
Cortex Acanthopancis 2.0～7.5%, the Radix Paeoniae Alba 2.0～7.5%; Olibanum 2.0～7.5%,
Myrrha 2.0～7.5%, Flos Carthami 2.0～7.5%, Radix Paeoniae Rubra 2.0～7.5%,
Radix Et Rhizoma Rhei 2.0～7.5%.
The raw material that can add following consumption proportion in the Chinese medicine preparation of the present invention:
The Cortex Eucommiae 2.0～7.5%, Radix Glycyrrhizae 2.0～4.0%, Eriocheir sinensis powder 6.0～7.5%.
Prepare the embodiment 1～12 of Chinese medicine preparation raw material consumption proportion of the present invention, its proportioning unit is weight percentage:
| Material name | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 | Example 7 | Example 8 | Example 9 | Example 10 | Example 11 | Example 12 |
| Radix Dipsaci | 7.5 | 2.0 | 4.5 | 3.5 | 6.5 | 5.5 | 2.5 | 5.0 | 5.0 | 5.0 | 3.0 | 5.0 |
| Radix Notoginseng | 17.5 | 13.5 | 16.5 | 14.0 | 17.5 | 15.5 | 12.0 | 15.0 | 15.0 | 14.5 | 13.0 | 17.0 |
| Borax | 4.5 | 7.5 | 2.0 | 3.5 | 4.0 | 5.5 | 2.0 | 3.0 | 5.0 | 5.0 | 6.5 | 2.5 |
| Sanguis Draxonis | 17.5 | 12.0 | 13.5 | 16.5 | 17.0 | 14.5 | 12.0 | 16.0 | 15.0 | 14.5 | 15.5 | 14.0 |
| Rhizoma Drynariae | 5.5 | 2.0 | 3.5 | 4.5 | 6.5 | 7.5 | 2.5 | 3.0 | 5.0 | 4.0 | 6.0 | 5.0 |
| Pyritum | 3.0 | 3.5 | 4.5 | 5.5 | 7.5 | 6.5 | 2.5 | 2.0 | 5.0 | 4.0 | 2.5 | 5.0 |
| The Cortex Eucommiae | 0.0 | 3.5 | 4.5 | 6.5 | 0.0 | 2.0 | 5.5 | 2.5 | 4.0 | 3.5 | 7.5 | 5.0 |
| Radix Glycyrrhizae | 2.0 | 3.0 | 2.5 | 3.5 | 0.0 | 4.0 | 3.5 | 0.0 | 3.5 | 3.0 | 2.5 | 3.0 |
| The Eriocheir sinensis powder | 7.5 | 6.0 | 7.0 | 6.5 | 0.0 | 6.0 | 6.0 | 7.0 | 7.5 | 6.5 | 0.0 | 6.5 |
| Radix Rehmanniae Preparata | 3.5 | 5.5 | 4.5 | 2.0 | 5.0 | 7.5 | 3.0 | 6.5 | 4.0 | 4.0 | 6.0 | 2.5 |
| Radix Angelicae Sinensis | 3.5 | 4.5 | 5.5 | 2.0 | 6.5 | 2.0 | 7.5 | 3.0 | 4.0 | 4.0 | 2.5 | 5.0 |
| Rhizoma Chuanxiong | 2.0 | 3.5 | 6.5 | 4.5 | 3.0 | 2.5 | 2.5 | 7.5 | 4.0 | 4.0 | 3.0 | 5.5 |
| Cortex Acanthopancis | 4.5 | 3.5 | 2.0 | 5.5 | 7.5 | 3.0 | 6.5 | 2.0 | 4.0 | 4.0 | 2.5 | 4.0 |
| The Radix Paeoniae Alba | 2.0 | 7.5 | 3.5 | 2.0 | 4.5 | 2.0 | 6.5 | 2.5 | 4.0 | 4.0 | 5.5 | 4.0 |
| Olibanum | 2.5 | 3.5 | 5.5 | 3.5 | 4.5 | 3.0 | 7.5 | 2.5 | 3.0 | 4.0 | 6.5 | 2.0 |
| Myrrha | 3.5 | 7.5 | 2.0 | 4.5 | 2.5 | 5.5 | 2.0 | 6.5 | 3.0 | 4.0 | 2.5 | 3.0 |
| Flos Carthami | 2.5 | 3.5 | 4.5 | 5.5 | 2.0 | 2.0 | 6.5 | 7.5 | 3.0 | 4.0 | 2.5 | 3.0 |
| Radix Paeoniae Rubra | 3.5 | 4.5 | 5.5 | 2.0 | 3.0 | 2.0 | 3.0 | 6.5 | 3.0 | 4.0 | 7.5 | 2.5 |
| Radix Et Rhizoma Rhei | 7.5 | 3.5 | 2.0 | 4.5 | 2.5 | 3.5 | 6.5 | 2.0 | 3.0 | 4.0 | 5.0 | 5.5 |
It is as follows that the raw material consumption proportion prepares the concrete preparation section of Chinese medicine preparation according to the present invention:
1. medical material pretreatment
1) gets Radix Notoginseng, select, clean 60 ℃ of dry for standby with horizontal medicine-washing machine flowing water spray;
2) get Flos Carthami, select, remove stem and leaf, base of a fruit head, 60 ℃ were dried by the fire 1 hour, standby;
3) get Olibanum, remove impurity, the stir-fry of slow fire vinegar is seen melting point slightly, is omited displaing yellow to the surface, cool standby;
4) get Myrrha, remove impurity, press 2000 editions one appendix IID stir-baking with vinegar of the Pharmacopoeia of the People's Republic of China, fry, cool standby to surface-brightening;
5) get Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Radix Dipsaci, Cortex Acanthopancis, remove impurity respectively, clean with horizontal medicine-washing machine flowing water spray, 60 ℃ of oven drying at low temperatures are standby;
6) get Radix Rehmanniae Preparata, remove impurity, clean with horizontal medicine-washing machine flowing water spray, 40～50 ℃ of vacuum dryings were extremely sent out crisp, standby in 2 hours;
7) get Rhizoma Drynariae, remove impurity, stir-fry is yellowish-brown to the surface, hits unhairing, cools standby;
8) get Pyritum, remove impurity, clean, forge to kermesinus, vinegar is quenched to interior repeatedly by golden yellow blackening brown, and gloss disappears, to crisp;
9) get Borax, remove impurity, standby;
10) get Sanguis Draxonis, the surface dirt of flipping, standby;
11) get the Cortex Eucommiae, Radix Glycyrrhizae, dry for standby;
12) get the Eriocheir sinensis powder and dry, standby.
2. prepare burden
By the pretreated medical material of raw material consumption proportion of the present invention weighing.
3. pulverize
1) Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax, the Cortex Eucommiae, Radix Glycyrrhizae, Eriocheir sinensis powder, Radix Rehmanniae Preparata, Rhizoma Drynariae, Flos Carthami pulverize separately, cross 60 mesh sieves, flour extraction should be advisable more than 97%, get Radix Notoginseng powder, Sanguis Draxonis powder, natural copper powder, Borax powder, Cortex Eucommiae powder, Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder respectively;
2) Olibanum, Myrrha mix pulverizing, cross 60 mesh sieves, and flour extraction should be advisable more than 97%, get Olibanum, Myrrha mixed powder;
3) Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine mix pulverizing, cross 60 mesh sieves, and flour extraction should be advisable more than 97%, get the mixed powder of Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine.
4. facing-up
1) elder generation is even with Olibanum, Myrrha mixed powder and Radix Notoginseng powder, Sanguis Draxonis powder ground and mixed, gets Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis mixed powder;
2) nature copper powder and Borax powder ground and mixed is even, get Pyritum, Borax mixed powder;
3), get the mixed powder of Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax Six-element medicine again with Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis mixed powder and Pyritum, Borax mixed powder mix homogeneously;
4) with Cortex Eucommiae powder, Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder Six-element medicine ground and mixed are even, even with Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax ground and mixed again, get Cortex Eucommiae powder, the mixed powder of Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax 12 flavor medicines.
5. mix
1) with the mixed powder and the Cortex Eucommiae powder of Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine, the mixed powder remix of Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax 12 flavor medicines is even, gets the crude drug fine powder;
2) the crude drug fine powder is placed the V-arrangement mixer do and mixed 5 minutes, must synthesize medicated powder.
6. make Chinese medicine preparation
To synthesize medicated powder and place capsule filler, use No. 0 capsule shells filling, make capsule; Maybe will synthesize medicated powder water or ethanol, be best with ethanol, makes granule; Synthetic medicated powder also can be made into electuary, tablet, pill or oral liquid etc.
The principles of formulating prescriptions are analyzed:
The present invention is made up of medicines such as Radix Dipsaci, Radix Notoginseng, Radix Rehmanniae Preparata, Rhizoma Drynariae, Pyritum, Olibanum, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Myrrha, Radix Et Rhizoma Rhei, Sanguis Draxonis, Radix Paeoniae Rubra, Flos Carthami, Boraxs, can add the proportioning raw material Cortex Eucommiae, Eriocheir sinensis, Radix Glycyrrhizae simultaneously.Have invigorating the kidney and strengthening the bones, the function of eliminating stasis to stop pain is with the uniformity of primary osteoporosis rational method side medicine.
Monarch drug Radix Dipsaci, Radix Notoginseng.Radix Dipsaci " pharmacopeia " (version in 2000) is put down in writing these product " bitter, hot, tepor "." continuous folding is hindered for invigorating the liver and kidney, bone and muscle strengthening." because of " main muscles and bones the wrecking of continuing is so a Radix Dipsaci " (" medicine justice "), " book on Chinese herbal medicine of looking for the truth " thinks " Radix Dipsaci, real promoting flow of QI and blood muscles and bones first medicine are also ".Radix Notoginseng " pharmacopeia " is put down in writing sweet, the little hardship of these product, temperature." dissipating blood stasis hemostasis, subduing swelling and relieving pain "." Records of Tradition Chinese and Western Medicine in Combination " think Radix Notoginseng " its kind blood stasis dispelling blood, blood stasis dispelling blood and do not hinder fresh blood ... if traumatic injury, in connect the internal organs meridians and do pain person, You Jie proves effective ".
Ministerial drug Radix Rehmanniae Preparata, Rhizoma Drynariae, Pyritum, Olibanum.Radix Rehmanniae Preparata " pharmacopeia " record " sweet in the mouth, tepor." " nourishing YIN and supplementing blood, beneficial essence is filled out marrow "." medicine justice " meaning " Radix Rehmanniae Preparata is specially gone into liver and is enriched blood, the kidney invigorating water more, nourish Kidney-Yin, packing bone marrow; Sharp blood vessels, tonification is Kidney-Yin, controls all hepatic and renal YIN deficiency, and deficient all kinds of diseases and ailments are the strengthening renal yin to inhibit predominant yang medicine." to put down in writing these product " bitter, warm for Rhizoma Drynariae " pharmacopeia "." " the kidney invigorating bone strengthening continues and hinders pain relieving ".The supplement to the Herbal record has invigorating kidney, promoting blood circulation and teeth consolidating effect." Quanzhou book on Chinese herbal medicine " record is specially controlled reunion of bone with four liang of single Rhizoma Drynariae.Pyritum is put down into liver, the blood and relieving pain that can loose, and reunion of bone knochenbruch folding, pain caused by ecchymoma is the key medicine of Shangke bone-knitting.Pyritum " pharmacopeia " is put down in writing these product " hot, flat "." dissipating blood stasis, synthetism, pain relieving ".Olibanum, the hot fragrant profit of loosing has the effect of regulating qi and activating blood analgesic therapy, is that the medicine of muscle pain relieving " dredge also " Compendium of Material Medica is thought the effect with " muscle is stretched in the analgesic therapy of invigorating blood circulation ".
Adjuvant drug Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Myrrha, Radix Et Rhizoma Rhei, Sanguis Draxonis, Radix Paeoniae Rubra, Flos Carthami.
Radix Angelicae Sinensis " pharmacopeia " is put down in writing these product " sweet, hot, temperature "." enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation ".Ancients are called " the gas medicine in the blood, also the sage in the blood also ".Rhizoma Chuanxiong " pharmacopeia " is put down in writing these product " hot, temperature "." invigorate blood circulation promoting the circulation of QI to relieve pain ".Its property is hot looses, and walks Liver Channel, and the blood medicine in the gas also.The Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong and ministerial drug Radix Rehmanniae Preparata are SIWU TANG, support QI and blood regulating with tonifying liver, positive cloudy helping, and resource biochemistry is infinite, and muscles and bones is strengthened.Cortex Acanthopancis " pharmacopeia " record " hot, bitter, temperature "." wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening "., the effect of tool bone and muscle strengthening, yang-energy that can invigorating the liver and kidney, strengthening bone and muscle be with a little less than playing flaccidity, the treating the liver deficiency of the kidney yin, muscles and bones is lost the soreness of the waist and knees of labor, the Myrrha bitter in the mouth, property is flat.Promoting blood circulation and stopping pain, detumescence and promoting granulation.Radix Et Rhizoma Rhei " pharmacopeia " record " hardship, cold "." purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation ".Can go into blood system, removing blood stasis.Not only broken blood-retention, kind again broken stagnated blood no matter traumatic injury muscles and bones blood stasis is new and old, all can be used, and the effect of promoting tissue regeneration by removing blood stasis is arranged, and blood stasis is gone and fresh blood is given birth to, and fresh blood is given birth to then bone and must be supported.Sanguis Draxonis sweet in the mouth, salty, property are flat, the dissipating blood stasis analgesic therapy, and hemostasia and promoting granulation is held back skin ulcer.The interior damage that is used to fracture, blood stasis does not disappear, the same usefulness of blood-activating analgetic medicine such as normal and Olibanum, Myrrha, Flos Carthami, Flos Carthami suffering, temperature, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Control the traumatic injury congestive edema and have a pain, often join Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Myrrha etc., can strengthen blood circulation promoting and blood stasis dispelling, the reducing swelling and alleviating pain effect.
The messenger drug Borax.Because of suffering from a deficiency of the kidney the bone marrow inanition, essence is not filled marrow, just stays the stasis of blood with fixed attention, and the stasis of blood is coagulated then backwater, wet staying just given birth to expectorant, so join sweet salty and cool Borax for making, the heat clearing away expectorant can " knot reduces phlegm ", with promoting blood circulation to remove blood stasis medicine compatibility, blood circulation promoting medicine dissipating blood stasis, Borax expectorant, with dissipation skeleton, the sluggish stasis of blood expectorant of bone marrow.In addition, coagulate the easy heat-transformation of the stasis of blood, Borax is cool in nature, and cold prevents the stasis of blood from transconversion into heat to heat, and the medicine that is beneficial to invigorating the kidney and strengthening the bones better plays a role.
The Cortex Eucommiae, Eriocheir sinensis powder, Radix Glycyrrhizae make the proportioning preparation.The Cortex Eucommiae is sweet, warm.Invigorating the liver and kidney, bone and muscle strengthening.Eriocheir sinensis " Chinese voluminous dictionary " is put down in writing these product " salty, cold "." heat clearing away, the blood that looses, Radix Dipsaci are hindered.Control bones and muscles injury "." herbal classic is met the source " record: " so the special removing blood stasis of Eriocheir sinensis property is the exhausted muscles and bones of energy Radix Dipsaci ".Radix Glycyrrhizae is sweet, flat.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing.But coordinating the actions of various ingredients in a prescription, cushion toxicity.
The present invention is according to the traditional Chinese medical science " kidney tonifying, essence replenishing, give birth to marrow bone strengthening ", principles such as " nourshing blood and promoting blood circulation, blood stasis dispersing and deswelling, pain relievings ", and dialectical executing controlled, and comprehensive control improves total quality emphatically.Carry out the toxicity experiment through Xian Medical Univ by large, medium and small various dose and show, took medicine six months to rat continuously, internal organs such as laboratory animal skeleton, liver are not all had the explicitly toxic action, confirm this medicine safety.Chinese Railway is built head office Xi'an hospital, Concord Hospital of Tongji Medical Univ, Beijing Research Institute of national bone injury external fixation association, Friendship Hospital, Urumqi etc., and it is evident in efficacy that proof is observed in routine osteoporosis surplus 500 and the clinical use of all types of fracture patient.To the osteoporosis total effective rate is more than 95%, and all kinds of fracture are obviously quickened growth of spur and union of fracture, shifts to an earlier date for 3～6 weeks than matched group, and local reducing swelling and alleviating pain time ratio matched group shortens 1/2.
The final report of one of clinical trial:
Treat all kinds of fracture 132 examples altogether from year August in March, 2002 to 2003, experimental group 97 examples wherein, matched group 35 examples, result of the test: two groups of general curative effect situations are that test group clinical cure 30 examples account for 30.9%; Produce effects 56 examples account for 57.7%; Effective 8 examples account for 8.2%; Invalid 3 examples account for 3.1%; Total effective rate is 96.9%.Matched group clinical cure 6 examples account for 17.1%; Produce effects 15 examples account for 42.9%; Effective 9 examples account for 25.7%; Invalid 5 examples account for 14.3%; Total effective rate is 85.7%.Analyze through Ridit, the result shows that curative effect of the present invention obviously is better than matched group, P＜0.05.Its clinical union of bone and bony union situation after two groups of 4 weeks of medication: test group clinical union of bone 71 examples account for 73.2%; Bony union 11 examples account for 11.3%; There is disunion to be inclined to 15 examples, accounts for 15.5%; Matched group clinical union of bone 20 examples account for 57.1%; Bony union 3 examples account for 8.6%; There is disunion to be inclined to 12 examples, accounts for 34.3%; Analyze through Ridit for two groups, the result shows that test group obviously is better than matched group, P＜0.05.Traditional Chinese medical science disease curative effect is: test group produce effects 76 examples account for 78.4%; Effective 16 examples account for 16.5%; Invalid 5 examples account for 5.2%; Total effective rate is 94.8%.Matched group produce effects 22 examples account for 62.9%; Effective 10 examples account for 28.6%; Invalid 3 examples account for 8.6%; Total effective rate is 91.4%.Analyze through Ridit, the result shows that the present invention and matched group curative effect are approaching, P＞0.05.Test group is removed the slight sense of feeling sick of 2 example appearance in therapeutic process, does not process, and outside dying away after half an hour, all the other patients do not find untoward reaction and toxic and side effects, show that said preparation is safe and effective.
Above-mentioned clinical trial case diagnosis standard:
1. diagnosis basis:
Foundation " new Chinese medicine clinical research guideline " (health ministry promulgation in 1993) and four editions teaching materials of high medical college " Chinese traumatology " also ask the relevant expert that formulation is discussed.
2. Western medicine diagnose standard:
1) trauma history of direct or indirect violence is arranged.
2) General Symptoms: uncomplicated simple fracture, General Symptoms are very unobvious or not serious; Serious wound, combined injury can be suffered a shock, or merge visceral organ injury; But the open fracture concurrent infection, or and go crazy, the damage of blood vessel.
3) symptom: pain and tenderness, local swelling, dysfunction, deformity, abnormal movement, bony crepitus.
4) X ray examination: the diagnosis that can clearly fracture, can confirm classification of fracture, moving direction etc.
3. experimental technique
1) observational technique of the non-at random blind method parallel control of employing.
2) test group: capsule of the present invention.Usage and consumption: 3 times on the 1st, each 5, warm water delivery service, 4 weeks were 1 course of treatment.
3) matched group: Radix Notoginseng Tabellae.Usage and consumption: 3 times on the 1st, each 4, the course of treatment is the same.
4) auxiliary treatment:, assist and fix or small splints fixation with plaster slab according to fracture site.
4. observation index
1) safety observation: 1. general health check-up project; 2. blood, urine, just routine examination; 3. the heart, liver, kidney function test; 4. adverse events is observed.
2) curative effect-type observation: 1. related symptoms sign and picture of the tongue, pulse condition; 2. vertical percussion test and functional examination; 3. X ray examination: the mensuration of callus formation time, the speed of growth and density; 4. union of fracture; 5. bony union.
5. efficacy evaluation
1) efficacy evaluation foundation: " new Chinese medicine clinical research guideline " (Ministry of Health of the People's Republic of China's promulgation in 1993) also please be drafted in relevant expert's discussion.
2) healing standard
The clinical healing criterion of fracture: 1. local no tenderness, there is not vertical percussion pain; 2. local no abnormal activity; 3. the X skiagram shows that fracture line is fuzzy, has the seriality callus to pass through fracture line; 4. functional examination: removing under the external fixation situation, upper limb can put down and be lifted the 1Kg weight and reach 1 minute, the continuous free-hand walking of lower limb energy 3 minutes, and be no less than 30 and go on foot.
Observed for 2 weeks continuously, fracture is indeformable, is the clinical healing date in the 1st day that then observes.
Claims (8)
1. Chinese medicine preparation for the treatment of osteoporosis and fracture, wherein make the raw materials of effective components consumption and consist of:
Radix Dipsaci 2.0～7.5%, Radix Notoginseng 12.0～17.5%, Borax 2.5～7.5%,
Sanguis Draxonis 12.0～17.5%, Rhizoma Drynariae 2.0～7.5%, Pyritum 2.0～7.5%,
Radix Rehmanniae Preparata 2.0～7.5%, Radix Angelicae Sinensis 2.0～7.5%, Rhizoma Chuanxiong 2.0～7.5%,
Cortex Acanthopancis 2.0～7.5%, the Radix Paeoniae Alba 2.0～7.5%; Olibanum 2.0～7.5%,
Myrrha 2.0～7.5%, Flos Carthami 2.0～7.5%, Radix Paeoniae Rubra 2.0～7.5%,
Radix Et Rhizoma Rhei 2.0～7.5%, the Cortex Eucommiae 0.0～7.5%, Radix Glycyrrhizae 0.0～4.0%,
Eriocheir sinensis powder 0.0～7.5%.
2. the Chinese medicine preparation of treatment osteoporosis according to claim 1 and fracture, wherein make the raw materials of effective components consumption and consist of:
The Cortex Eucommiae 2.0～7.5%, Radix Glycyrrhizae 2.0～4.0%, Eriocheir sinensis powder 6.0～7.5%.
3. the Chinese medicine preparation of treatment osteoporosis according to claim 1 and 2 and fracture, wherein make the raw materials of effective components consumption and consist of:
Radix Dipsaci 2.5～7.5%, Radix Notoginseng 12.5～17.0%, Borax 2.5～7.5%,
Sanguis Draxonis 12.5～17.0%, Rhizoma Drynariae 2.5～7.5%, Pyritum 2.5～7.5%,
The Cortex Eucommiae 2.5～7.5%, Radix Glycyrrhizae 2.5～3.5%, Eriocheir sinensis powder 6.0～7.5%;
Radix Rehmanniae Preparata 2.5～7.5%, Radix Angelicae Sinensis 2.5～7.5%, Rhizoma Chuanxiong 2.5～7.5%,
Cortex Acanthopancis 2.5～7.5%, the Radix Paeoniae Alba 2.5～7.5%; Olibanum 2.5～7.5%,
Myrrha 2.5～7.5%, Flos Carthami 2.5～7.5%, Radix Paeoniae Rubra 2.5～7.5%,
Radix Et Rhizoma Rhei 2.5～7.5%.
4. the Chinese medicine preparation of treatment osteoporosis according to claim 3 and fracture, wherein make the raw materials of effective components consumption and consist of:
Radix Dipsaci 3.5～6.5%, Radix Notoginseng 13.5～15.5%, Borax 3.5～6.5%,
Sanguis Draxonis 13.5～15.5%, Rhizoma Drynariae 3.5～6.5%, Pyritum 3.5～6.5%,
The Cortex Eucommiae 3.0～5.0%, Radix Glycyrrhizae 3.0～3.5%, Eriocheir sinensis powder 6.0～7.0%;
Radix Rehmanniae Preparata 3.5～6.5%, Radix Angelicae Sinensis 3.5～6.5%, Rhizoma Chuanxiong 3.5～6.5%,
Cortex Acanthopancis 3.5～6.5%, the Radix Paeoniae Alba 3.5～6.5%; Olibanum 3.5～6.5%,
Myrrha 3.5～6.5%, Flos Carthami 3.5～6.5%, Radix Paeoniae Rubra 3.5～6.5%,
Radix Et Rhizoma Rhei 3.5～6.5%.
5. the Chinese medicine preparation of treatment osteoporosis according to claim 4 and fracture, wherein make the raw materials of effective components consumption and consist of:
Radix Dipsaci 5.0%, Radix Notoginseng 14.5%, Borax 5.0%, Sanguis Draxonis 14.5%, Rhizoma Drynariae 4.0%,
Pyritum 4.0%, the Cortex Eucommiae 3.5%, Radix Glycyrrhizae 3.0%, Eriocheir sinensis powder 6.5%; Radix Rehmanniae Preparata 4.0%,
Radix Angelicae Sinensis 4.0%, Rhizoma Chuanxiong 4.0%, Cortex Acanthopancis 4.0%, the Radix Paeoniae Alba 4.0%; Olibanum 4.0%,
Myrrha 4.0%, Flos Carthami 4.0%, Radix Paeoniae Rubra 4.0%, Radix Et Rhizoma Rhei 4.0%.
6. according to the preparation method of described treatment osteoporosis of claim 1 and fracture Chinese medicine preparation, it is characterized in that: the operation of this preparation method comprises
1) medical material pretreatment
[1]. get Radix Notoginseng, select, clean 60 ℃ of dry for standby with horizontal medicine-washing machine flowing water spray;
[2]. get Flos Carthami, select, remove stem and leaf, base of a fruit head, 60 ℃ were dried by the fire 1 hour, standby;
[3]. get Olibanum, remove impurity, the stir-fry of slow fire vinegar is seen melting point slightly, is omited displaing yellow to the surface, cool standby;
[4]. get Myrrha, remove impurity, processed with vinegar is fried to surface-brightening, cools standby;
[5]. get Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Radix Dipsaci, Cortex Acanthopancis, remove impurity respectively, clean, 60 ℃ of oven drying at low temperatures are standby;
[6]. get Radix Rehmanniae Preparata, remove impurity, clean, 40～50 ℃ of vacuum dryings were extremely sent out crisp, standby in 2 hours;
[7]. get Rhizoma Drynariae, remove impurity, stir-fry is yellowish-brown to the surface, hits unhairing, cools standby;
[8]. get Pyritum, remove impurity, clean, forge to kermesinus, vinegar is quenched to interior repeatedly by golden yellow blackening brown, and gloss disappears, to crisp;
[9]. get Borax, remove impurity, standby;
[10]. get Sanguis Draxonis, the surface dirt of flipping, standby;
[11] get the Cortex Eucommiae, Radix Glycyrrhizae, dry for standby;
[12] get the Eriocheir sinensis powder and dry, standby;
2) batching
Take by weighing pretreated medical material by the raw material consumption proportion;
3) pulverize
[1] Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax, the Cortex Eucommiae, Radix Glycyrrhizae, Eriocheir sinensis powder, Radix Rehmanniae Preparata, Rhizoma Drynariae, Flos Carthami pulverize separately, cross 60 mesh sieves, get Radix Notoginseng powder, Sanguis Draxonis powder, natural copper powder, Borax powder, Cortex Eucommiae powder, Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder respectively;
[2] Olibanum, Myrrha mix pulverizing, cross 60 mesh sieves, get Olibanum, Myrrha mixed powder;
[3] Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine mix pulverizing, cross 60 mesh sieves, get the mixed powder of Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine;
4) facing-up
[1] elder generation is even with Olibanum, Myrrha mixed powder and Radix Notoginseng powder, Sanguis Draxonis powder ground and mixed, gets Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis mixed powder;
[2] nature copper powder and Borax powder ground and mixed is even, get Pyritum, Borax mixed powder;
[3], get the mixed powder of Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax Six-element medicine again with Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis mixed powder and Pyritum, Borax mixed powder mix homogeneously;
[4] with Cortex Eucommiae powder, Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder Six-element medicine ground and mixed are even, even with Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax ground and mixed again, get Cortex Eucommiae powder, the mixed powder of Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax 12 flavor medicines;
5) mix
[1] with the mixed powder and the Cortex Eucommiae powder of Radix Dipsaci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra seven flavor medicine, the mixed powder remix of Radix Glycyrrhizae powder, Eriocheir sinensis powder, Radix Rehmanniae Preparata powder, Rhizoma Drynariae powder, Flos Carthami powder, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Pyritum, Borax 12 flavor medicines is even, gets the crude drug fine powder;
[2] the crude drug fine powder is placed the V-arrangement mixer do and mixed 5 minutes, must synthesize medicated powder.
7. according to the preparation method of described treatment osteoporosis of claim 6 and fracture Chinese medicine preparation, it is characterized in that: described 60 mesh sieves of pulverizing, its flour extraction is at least 97%.
8. according to the preparation method of claim 6 or 7 described treatment osteoporosises and fracture Chinese medicine preparation, it is characterized in that: the operation of this preparation method comprises
To synthesize medicated powder and place capsule filler, make capsule; Maybe will synthesize medicated powder water or ethanol or other solvent, make granule, tablet, pill or oral liquid.
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| KR100626358B1 (en) * | 2005-01-20 | 2006-09-21 | 주식회사 오스코텍 | Herbal mixture extract of Notoginseng Radix, Rehmanniae Radix Preparata and Acanthopanacis Cortex and composition comprising the same for prevention and treatment of arthritis |
| CN101129448B (en) * | 2006-08-21 | 2012-04-25 | 兰州大得利生物化学制药(厂)有限公司 | Compositions for preventing and controlling climacteric syndrome and osteoporosis, and processes for producing the same |
| CN101032614B (en) * | 2007-04-05 | 2010-05-26 | 赵子山 | Chinese traditional composition for curing slow concrescence or non-concrescence of fracture and the preparing method |
| CN101317942B (en) * | 2008-07-21 | 2010-09-22 | 刘皇琼 | Bone-setting alcohol |
| CN101991736B (en) * | 2010-11-08 | 2012-01-25 | 李景禄 | Medicament for treating osteopathy |
| CN102579734B (en) * | 2011-11-28 | 2013-04-24 | 陕西宏府怡悦制药有限公司 | Traditional Chinese medicine composition of bone healing medicine, preparing method thereof and detecting method thereof |
| CN102670805B (en) * | 2012-05-15 | 2013-06-05 | 张化 | Ointment for treating bone diseases |
| CN103830770B (en) * | 2014-03-12 | 2015-11-18 | 青岛市黄岛区中医医院 | A kind of wound site medicine antibacterial antiinflammatory dressing |
| CN104001004A (en) * | 2014-06-16 | 2014-08-27 | 徐艳 | Traditional Chinese medicine composition for curing fractures and osteoporosis and preparation method and application thereof |
| CN104147288A (en) * | 2014-08-12 | 2014-11-19 | 潘阿海 | Traditional Chinese medicine with the effects of soothing channels and invigorate blood circulation |
| CN104491114A (en) * | 2014-12-30 | 2015-04-08 | 陈满锦 | Novel application of traditional Chinese medicine composition |
| CN105796739A (en) * | 2015-08-04 | 2016-07-27 | 烟台市华文欣欣医药科技有限公司 | Method for preparing traditional Chinese medicinal composition for treating geriatric fracture |
| CN105879093A (en) * | 2016-04-07 | 2016-08-24 | 永春县达埔彬达制香厂有限公司 | Dark agilawood having functions of calming nerves and promoting sleep and preparation method of dark agilawood |
| EP3903798A1 (en) * | 2020-04-27 | 2021-11-03 | Lulin Wang | Bone-strengthening pill (bsp) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
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| CN1079152A (en) * | 1992-05-28 | 1993-12-08 | 杨应和 | Preparation method of quick-acting bone injury medicine |
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