CN1692124B - 与p53结合的T细胞受体分子以及其用途 - Google Patents

与p53结合的T细胞受体分子以及其用途 Download PDF

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Publication number
CN1692124B
CN1692124B CN028153030A CN02815303A CN1692124B CN 1692124 B CN1692124 B CN 1692124B CN 028153030 A CN028153030 A CN 028153030A CN 02815303 A CN02815303 A CN 02815303A CN 1692124 B CN1692124 B CN 1692124B
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tcr
chain
amino acid
acid sequence
seq
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Expired - Lifetime
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Chinese (zh)
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CN1692124A (zh
Inventor
L·A·舍曼
K·F·卡德
J·A·韦丹兹
H·C·王
E·L·汤姆森
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Scripps Research Institute
Altor Bioscience LLC
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Scripps Research Institute
Altor Bioscience LLC
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Publication of CN1692124A publication Critical patent/CN1692124A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN028153030A 2001-06-05 2002-06-05 与p53结合的T细胞受体分子以及其用途 Expired - Lifetime CN1692124B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29632401P 2001-06-05 2001-06-05
US60/296,324 2001-06-05
PCT/US2002/017785 WO2004018619A2 (en) 2001-06-05 2002-06-05 P53 binding t cell receptor molecules and uses thereof

Publications (2)

Publication Number Publication Date
CN1692124A CN1692124A (zh) 2005-11-02
CN1692124B true CN1692124B (zh) 2012-05-30

Family

ID=31946570

Family Applications (1)

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CN028153030A Expired - Lifetime CN1692124B (zh) 2001-06-05 2002-06-05 与p53结合的T细胞受体分子以及其用途

Country Status (11)

Country Link
US (1) US7456263B2 (enExample)
EP (2) EP2009019A1 (enExample)
JP (1) JP4447456B2 (enExample)
CN (1) CN1692124B (enExample)
AT (1) ATE405582T1 (enExample)
AU (1) AU2002316190B8 (enExample)
CA (1) CA2487779C (enExample)
DE (1) DE60228504D1 (enExample)
DK (1) DK1546188T3 (enExample)
ES (1) ES2307770T3 (enExample)
WO (1) WO2004018619A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144474A1 (en) * 2000-06-05 2003-07-31 Sunol Molecular Corporation T cell receptor fusions and conjugates and methods of use thereof
US8772451B2 (en) * 2003-11-10 2014-07-08 Altor Bioscience Corporation Soluble TCR molecules and methods of use
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
US10464987B2 (en) 2009-10-06 2019-11-05 Abbvie Inc. Human single-chain T cell receptors
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
WO2013169691A1 (en) 2012-05-07 2013-11-14 Trustees Of Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
UA114108C2 (uk) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
US11939365B2 (en) * 2017-09-29 2024-03-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing mutated P53
EP3692058A1 (en) 2017-10-06 2020-08-12 Oslo Universitetssykehus HF Chimeric antigen receptors
CN108060135A (zh) * 2017-12-26 2018-05-22 东莞赛尔生物科技有限公司 一种高效表达p53抑癌蛋白的t细胞、制备方法及应用
WO2019195586A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating egfrviii expressing glioblastomas
US12090170B2 (en) 2018-04-06 2024-09-17 The Regents Of The University Of California Methods of treating glioblastomas

Family Cites Families (21)

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US4867973A (en) 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
WO1988007553A1 (fr) 1987-03-26 1988-10-06 Teijin Limited Procede de preparation d'un complexe d'anticorps
EP0515527A4 (en) 1990-02-20 1993-08-25 Coulter Corporation Improved antibody-enzyme direct conjugates and method of making same
GB9200417D0 (en) 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
US6399368B1 (en) 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
ES2139012T3 (es) * 1992-05-26 2000-02-01 Univ Leiden Peptidos de la proteina p53 humana destinados para ser utilizados en composiciones que inducen una reaccion en los linfocitos t humanos, y linfocitos t citotoxicos especificos de la proteina p53 humana.
WO1994012520A1 (en) 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
CA2196085C (en) 1994-07-29 2002-12-10 Hing C. Wong Mhc complexes and uses thereof
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
JPH10510988A (ja) * 1994-12-14 1998-10-27 ザ スクリップス リサーチ インスティテュート 腫瘍−特異的細胞毒性ｔ細胞のインビボ活性化
US5830755A (en) 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
WO1997032603A1 (en) 1996-03-05 1997-09-12 The Scripps Research Institute Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
US6127524A (en) 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
AU6685698A (en) 1997-03-07 1998-09-22 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
ATE533784T1 (de) 1997-10-02 2011-12-15 Altor Bioscience Corp Lösliche, einzelkettige proteine des t- zellrezeptors
US6534633B1 (en) 1998-10-21 2003-03-18 Altor Bioscience Corporation Polyspecific binding molecules and uses thereof
WO2001090747A2 (en) 2000-05-25 2001-11-29 Sunol Molecular Corporation Modulation of t-cell receptor interactions
US20030144474A1 (en) 2000-06-05 2003-07-31 Sunol Molecular Corporation T cell receptor fusions and conjugates and methods of use thereof
DE10109855A1 (de) * 2001-03-01 2002-09-12 Stanislawski Thomas Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THEOBALD M等.Targeting p53 as a general tumor antigen.PNAS92.1995,9211993-11997. *

Also Published As

Publication number Publication date
DK1546188T3 (da) 2008-10-27
EP1546188A4 (en) 2005-12-21
JP2005525128A (ja) 2005-08-25
DE60228504D1 (de) 2008-10-02
AU2002316190A8 (en) 2004-04-08
AU2002316190B2 (en) 2009-01-22
EP1546188A2 (en) 2005-06-29
CN1692124A (zh) 2005-11-02
AU2002316190B8 (en) 2009-01-29
CA2487779C (en) 2012-10-02
US20080269113A1 (en) 2008-10-30
EP1546188B1 (en) 2008-08-20
US7456263B2 (en) 2008-11-25
ES2307770T3 (es) 2008-12-01
CA2487779A1 (en) 2004-03-04
JP4447456B2 (ja) 2010-04-07
AU2002316190A1 (en) 2004-03-17
WO2004018619A3 (en) 2005-05-06
WO2004018619A2 (en) 2004-03-04
EP2009019A1 (en) 2008-12-31
ATE405582T1 (de) 2008-09-15

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