CN1686277A - Medicine for treating child common cold and its preparation method - Google Patents
Medicine for treating child common cold and its preparation method Download PDFInfo
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Abstract
A Chinese medicine for treating infantile cold is prepared from 8 Chinese-medicinal materials including honeysuckle flower, forsythia fruit, mint, schizonepeta, etc. Its preparing process is also disclosed.
Description
One, technical field
The invention belongs to the field of Chinese medicines, being specifically related to a kind of is the medicine and preparation method thereof of the treatment infantile common cold made of raw material with the vegetable Chinese herbal medicine.
Two, background technology
Infantile common cold (upper respiratory tract infection) is one of modal children disease, World Health Organization (WHO) is thought in world's department of pediatrics meeting of holding in Geneva in April, 1979, flu ranks first in pediatric disease, the infant of upper respiratory tract infection has 39%～60% approximately, the annual ill number of times of average each child of China 200,000,000 5 thousand ten thousand children can reach more than five times, and it is wind-heat syndrome that 85% flu is arranged approximately.Therefore, the flu medication is a market of department of pediatrics medication maximum.Though, existing clinically at present many Chinese patent medicines for the treatment of infantile common colds, but the Chinese patent medicine at infantile common cold is less, particularly still less at infantile anemopyretic cold infantile common cold Chinese patent medicine, even have as SANGJU GANMAO KELI, also because bring down a fever, analgesic effect is not good, and make use clinically very restricted.This medicine is special physiology, pathological characteristic at children's, the anemopyretic cold good medicine that the treatment children's of development is common.
Three, summary of the invention
The objective of the invention is to the cause of disease at infantile anemopyretic cold, provide a kind of can effectively treat infantile anemopyretic cold Chinese medicine; The present invention also provides the preparation method of this medicine.
Solution of the present invention is based on theory of Chinese medical science to pathogenetic understanding of infantile anemopyretic cold and Therapeutic Principle, in conjunction with the clinical experience of diagnosis and treatment primary disease for many years, repeated screening, the Chinese medicine that is developed into meticulously with depressed liver-energy dispersing and QI regulating, activating blood circulation to dissipate blood stasis, hard masses softening and resolving, reducing swelling and alleviating pain.
The present invention realizes by following scheme, if drug main of the present invention is made by following weight parts proportion raw material medicine:
1～6 part of Flos Lonicerae, 1～6 part of Fructus Forsythiae, 1～6 part of Rhizoma Osmundae, 1～6 part of Radix Isatidis,
1～6 part of Rhizoma Paridis, 1～5 part of Herba Menthae, 1～5 part of Herba Schizonepetae, 1～3 part of Radix Bupleuri.
Drug main of the present invention wants preferred weight part proportioning of each crude drug to be:
2～4 parts of Flos Loniceraes, 2～4 parts of Fructus Forsythiaes, 2～4 parts of Rhizoma Osmundae, 2～4 parts of Radix Isatidis,
2～4 parts of Rhizoma Paridis, 1～3 part of Herba Menthae, 1～3 part of Herba Schizonepetae, 1～2 part of Radix Bupleuri.
Drug main of the present invention wants optimum weight part proportioning of each crude drug to be:
3.4 parts of Flos Loniceraes, 3.4 parts of Fructus Forsythiaes, 3.2 parts of Rhizoma Osmundae, 3.2 parts of Radix Isatidis, 3 parts of Rhizoma Paridis, 2 parts of Herba Menthaes, 2 parts of Herba Schizonepetae, 1.8 parts of Radix Bupleuri.
The sickness rate that children's catches a cold is up to 39%～60%, and serves as many (account for flu 85%) with the hot blast flu, and Flos Lonicerae is a monarch drug in the side.The Flos Lonicerae sweet in the mouth, cold in nature, return lung, the heart, stomach warp.The function heat-clearing and toxic substances removing, eliminating carbuncle looses swollen, eliminating pathogenic heat from blood to cure dysentery.Ministerial drug in the Fructus Forsythiae side of being.The Fructus Forsythiae bitter in the mouth, cold nature is returned lung, the heart, gallbladder meridian.The function heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Medicines such as Herba Menthae, Herba Schizonepetae, Radix Isatidis, Rhizoma Osmundae, Rhizoma Paridis, Radix Bupleuri are adjuvant, are total to the tool dispelling wind to relieve the exterior syndrome, the merit of removing summer-heat pyretic toxicity.
The preparation method of medicine of the present invention, its method step is as follows:
1. each crude drug of weight portion proportioning described in will filling a prescription according to concocted specification, is made into the suitable prepared slices of Chinese crude drugs;
2. Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Radix Bupleuri with the described weight portion proportioning of the prepared slices of Chinese crude drugs adds 10 times of water gagings extraction volatile oil, and device is stored standby in addition; Medicinal residues add 6～12 times of water gaging heating extraction 1～1.5 hour with remaining each medicine, filter, and add 5～10 times of water gagings again and extract 0.5～1 hour, filter the merging filtrate, (medical material: medicinal liquid) that is concentrated into 2: 1;
3. add 95% ethanol and reach 60%～90% to containing the alcohol amount in medicinal liquid, left standstill 24～48 hours, filter, get supernatant and reclaim ethanol to there not being the alcohol flavor, continue to be concentrated into relative density 1.1～1.3, cold preservation is used to prepare various preparations.
Can add various conventional adjuvant required when preparing different dosage form in the concentrated solution that the present invention extracts, the method for Chinese medicinal with routine is prepared into peroral dosage form commonly used again, as oral liquid, granule, tablet, capsule, soft capsule etc.
The present invention has dispelling wind to relieve the exterior syndrome, and the effect of removing summer-heat pyretic toxicity is used for infantile common cold heating, headache, the nasal obstruction watery nasal discharge, sneeze, cough, hypohidrosis, general malaise, swallow red, red tongue, red tongue, thin white fur of tongue or BOHUANG, floating and rapid pulse, fingerprint is pale purple.
Experimental study shows: this medicine is to influenza virus, parainfluenza virus I type (HVJ), respiratory syncytial virus (RSV), coxsackie B bunch virus-4 type (CoxB
4), adenovirus type III (Ard
3) and rhinoviral cytopathy all alleviate wherein parainfluenza virus I type (HVJ), coxsackie B bunch virus-4 type (CoxB to some extent than the virus control group
4) there were significant differences; In the body mice influenzal pneumonia there is obvious inhibitory action, influenza is caused dead mouse obvious protective effect is arranged, external have the obvious suppression effect to staphylococcus aureus and green pus hepatopathy, death to the infection of staphylococcus aureus mice in the body has significant protective effect, can reduce by the germ rabbit body temperature of injury and raise, can obviously improve the sick threshold values of mice hot plate, suppress the reaction of mice acetic acid twisting, can suppress the mice caused by dimethylbenzene xylene auricle edema, suppress the rat paw edema that chondrus ocellatus Holmes causes, can improve the cytophagous phagocytic function of mouse monokaryon, promote the mice hemolytic antibody to generate, can suppress the cough of strong aqua ammonia induced mice; Can promote mice foot sole of the foot portion sweat secretion.Can draw this product by above test and have good antiviral, antibacterial, analgesic, analgesia, calmness, antiinflammatory, enhancing human body immunity function, also have good cough-relieving, the effect of diaphoresis, be the good medicine of a treatment infantile anemopyretic cold.
We have good curative effect through clinical practice for the anemopyretic cold of infantile common cold card, and total effective rate reaches more than 95%, clinically do not find any toxic and side effects.
Four, the specific embodiment
Embodiment 1: the medicine of treatment infantile common cold of the present invention, make by following raw materials in weight portion medicine:
3.4 parts of Flos Loniceraes, 3.4 parts of Fructus Forsythiaes, 3.2 parts of Rhizoma Osmundae, 3.2 parts of Radix Isatidis, 3 parts of Rhizoma Paridis, 2 parts of Herba Menthaes, 2 parts of Herba Schizonepetae, 1.8 parts of Radix Bupleuri.
Embodiment 2: medicine of the present invention is felt the preparation method of oral liquid, and its step is as follows:
1. the proportioning by following weight takes by weighing each crude drug (prepared slices of Chinese crude drugs after the middle process of preparing Chinese medicine);
3.4 parts of Flos Loniceraes, 3.4 parts of Fructus Forsythiaes, 3.2 parts of Rhizoma Osmundae, 3.2 parts of Radix Isatidis, 3 parts of Rhizoma Paridis, 2 parts of Herba Menthaes, 2 parts of Herba Schizonepetae, 1.8 parts of Radix Bupleuri.
2. Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Radix Bupleuri with the described weight portion proportioning of the prepared slices of Chinese crude drugs adds 10 times of water gagings extraction volatile oil, and device is stored standby in addition; Medicinal residues add 10 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 8 times of water gagings again and extract 1 hour, filter the merging filtrate, (medical material: medicinal liquid) that is concentrated into 2: 1;
3. in medicinal liquid, add 95% ethanol and reach 80% to containing the alcohol amount, left standstill 48 hours, and filtered, get supernatant and reclaim ethanol to there not being the alcohol flavor, continue to be concentrated into relative density 1.3, add volatile oil and an amount of distilled water and transfer to 1: 1 (medical material: medicinal liquid), add an amount of aspartame, stir evenly, filter, potting, oral liquid is promptly made in sterilization.
Embodiment 3: the granule preparation of medicine of the present invention
1. take by weighing each crude drug (prepared slices of Chinese crude drugs after the middle process of preparing Chinese medicine) by following weight portion proportioning;
3.4 parts of Flos Loniceraes, 3.4 parts of Fructus Forsythiaes, 3.2 parts of Rhizoma Osmundae, 3.2 parts of Radix Isatidis, 3 parts of Rhizoma Paridis, 2 parts of Herba Menthaes, 2 parts of Herba Schizonepetae, 1.8 parts of Radix Bupleuri.
2. Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Radix Bupleuri with the described weight portion proportioning of the prepared slices of Chinese crude drugs adds 8 times of water gagings extraction volatile oil, and it is standby to be rolled into volatile oil clathrate compound with cyclodextrin; Medicinal residues add 6 times of water gaging heating extraction 1 hour with remaining each medicine, filter, and add 5 times of water gagings again and extract 0.5 hour, filter the merging filtrate, (medical material: medicinal liquid) that is concentrated into 2: 1;
3. in medicinal liquid, add 95% ethanol and reach 60%, left standstill 24 hours, filter, get the liquid clear liquid and reclaim ethanol and do not distinguish the flavor of, continue to be concentrated into thick extractum to there being alcohol to containing the alcohol amount, drying adds dextrin, and mixing is granulated drying, add volatile oil clathrate compound, mixing, packing is promptly made granule.
Embodiment 4: the soft capsule preparation method of medicine of the present invention, and its step is as follows:
1. take by weighing each crude drug (prepared slices of Chinese crude drugs after the middle process of preparing Chinese medicine) by following weight portion proportioning;
3.4 parts of Flos Loniceraes, 3.4 parts of Fructus Forsythiaes, 3.2 parts of Rhizoma Osmundae, 3.2 parts of Radix Isatidis, 3 parts of Rhizoma Paridis, 2 parts of Herba Menthaes, 2 parts of Herba Schizonepetae, 1.8 parts of Radix Bupleuri.
2. Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Radix Bupleuri with the described weight portion proportioning of the prepared slices of Chinese crude drugs adds 10 times of water gagings extraction volatile oil, and it is standby to be rolled into volatile oil clathrate compound with cyclodextrin; Medicinal residues add 8 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 6 times of water gagings again and extract 1 hour, filter the merging filtrate, (medical material: medicinal liquid) that is concentrated into 2: 1;
3. in medicinal liquid, add 95% ethanol and reach 80%, left standstill 24 hours, filter, get supernatant and reclaim ethanol to there not being the alcohol flavor to containing the alcohol amount, continue to be concentrated into relative density 1.3, drying adds suitable glycerol, volatile oil clathrate compound, mixing drips system or is pressed into soft capsule, and soft capsule is promptly made in packing.
Embodiment 5:(1) youngster feels the antivirus action of oral liquid
1. extracorporeal antivirus effect acts on Hep
-2With add 10 respectively on the FL cell
-1～10
-6Four kinds of viral liquid of variable concentrations (influenza FM1, Coxsackie virus 4, adenovirus type III, herpes simplex virus I-type), flush away virus liquid behind the absorption 1h, (youngster feels oral liquid 2mg/ml to add nontoxic boundary medicinal liquid, the following pair cell free of toxic effects of SANGJU GANMAO KELI 10mg/ml), each viral dilution liquid is established three multiple holes, establishes virus, cell matched group simultaneously.Put 37 ℃ of CO
2Cultivate in the incubator, every day, observation of cell pathological changes situation continuous three days, the results are shown in Table 1.
Table 1 youngster feels oral liquid to the cytopathogenic influence of virus
| Strain | Infective dose (TCID50) | Youngster feels oral liquid 2mg/ml | Sang Ju Yin granule 10mg/ml |
| Influenza FM CVB4 Adv-3 HSV-1 | ????100 ????30 ????100 ????30 | ????+ ????+ ????++ ????± | ????+ ????+ ????+ ????- |
+ inhibitory action arranged;-unrestraint effect; ± cytopathic effect of delaying arranged
The result as seen, youngster feels oral liquid 2mg/kg, sense Trane 10mg/ml is to infecting the Hep of influenza FM1, Coxsackie virus 4, adenovirus type III
-2Or FL (human amniotic cell) has significant protective effect, and is not obvious to infecting the herpes simplex virus I-type effect.And that youngster feels oral liquid is stronger than the disease-resistant mould effect of Sang Ju Yin granule.
2. 50 of interior resisting virus effect mices are divided into 5 groups at random, 24h, 48h, 72h administration totally 5 times after 24h, 1h and the infection before infecting.Collunarium influenza virus infection Mus adapted strain FM1 under the shallow degree anesthesia of ether, 10LD50 infects back 96h and dissects, and gets lung and weighs, and calculates the lung index, the results are shown in Table 2.
Table 2 youngster feels oral liquid to the influence of mice viral pneumonia (x ± s)
| Group | Mus number (only) | Dosage (mg/kg) | Lung index (mg/g) | Suppression ratio (%) | The P value |
| The sick mould contrast youngster of normal control feels oral liquid and feels oral liquid Sang Ju Yin granule | ????10 ????10 ????10 ????10 ????10 | ? ? ????225 ????112.5 ????200 | ??0.92±0.60 ??1.35±0.18 ??0.98±0.16 ??1.05±0.08 ??1.09±0.12 | ? ? ????86.05 ????69.77 ????60.47 | ? ? ????P＜0.01 ????P＜0.01 ????P＜0.05 |
The result as seen, youngster feels oral liquid 225,112.5mg/kg and Sang Ju Yin granule 200mg/kg has the obvious treatment effect to the mice viral pneumonia.
(2) youngster feels the antibacterial action of oral liquid
1. external bacteriostasis is inoculated in staphylococcus aureus in the broth medium (5ml), put 37 ℃ cultivate 12h after, survey bacterial concentration with the Maxwell opacity tube, be diluted to normal saline and contain antibacterial 9 * 10
6/ ml.Streptococcus, streptococcus pneumoniae, hemophilus influenza are directly scraped from blood plate or chocolate flat board and get lawn, are made into 9 * 10
6/ ml.Get 0.05ml bacterium liquid from various antibacterial dilution tubes respectively, dibbling is felt on oral liquid or the Sang Ju Yin granule medicament flat board in containing variable concentrations, establishes control board simultaneously.Hemophilus influenza is put 5%CO
2Observe behind 37 ℃ of cultivation 48h, other antibacterial is observed after placing 37 ℃ of incubators to cultivate 24h.With quadrat method this test is repeated once, observe and the record result.See Table 3.
Table 3 youngster feels the vitro inhibition effect to five kinds of antibacterials of oral liquid, Sang Ju Yin granule
| Strain | The strain number | ????MIC(mg/ml) | ???MIC 50(mg/kg) | ???????MIC 50(mg/kg) | |||
| Youngster feels liquid | The Sang Ju Yin granule | Youngster feels liquid | The Sang Ju Yin granule | Youngster feels liquid | The Sang Ju Yin granule | ||
| Staphylococcal pneumonia coccus first type Streptococcus hemolyticus beta hemolysis streptococcus hemophilus influenza | ????6 ????2 ????3 ????3 ????3 | ????240～30 ????240～40 ????240～15 ????240～15 ????240～30 | ????320～40 ????320～40 ????320～20 ????320～20 ????320～30 | ????30 ????40 ????15 ????15 ????30 | ????40 ????50 ????40 ????40 ????40 | ????60 ????70 ????30 ????30 ????30 | ????80 ????80 ????60 ????60 ????60 |
The result shows, youngster feels the effect that oral liquid and Sang Ju Yin granule all have anti-above-mentioned five kinds of antibacterials, and MIC scope, MIC50, MIC90 value are basic identical, but that youngster feels oral liquid is better than the outer bacteriostasis of Sang Ju Yin granule.
2. 100 of bacteriostasis mices are divided 5 groups at random in the body, successive administration 3 days, after the last administration one hour, every Mus lumbar injection streptococcus pneumoniae 9 * 10
12/ ml0.3ml (being minimum 100% lethal dose), record dead mouse number in one week the results are shown in Table 4.
Table 4 youngster feels the protective effect of oral liquid to pneumonia infection coccus mice
| Group | Dosage (mg/kg) | Number of animals (only) | Death toll | Dead % | Survival % | ????X 2 | ????P |
| Matched group is felt liquid and is felt liquid and feel liquid Sang Ju Yin grain | ??450 ??225 ??112.5 ??300 | ??20 ??20 ??20 ??20 ??20 | ????20 ????7 ????8 ????12 ????10 | ????100 ????35 ????40 ????60 ????50 | ????0 ????65 ????60 ????40 ????50 | ????15.4 ????14.4 ????6.2 ????10.8 | ??＜0.01 ??＜0.01 ??＜0.05 ??＜0.01 |
The result shows; youngster feels oral liquid 450mg/kg pneumonia infection coccus mice is had very significant protective effect; youngster feels oral liquid 225mg/kg and Sang Ju Yin granule 300mg/kg has obvious protective effect, illustrates that youngster feels oral liquid and has tangible bacteriostasis than Sang Ju Yin granule.
(3) youngster feels oral liquid 50 of rats is got in the influence of rat fever due to the yeast, divide equally 5 groups at random, be respectively matched group, youngster feels oral liquid 298,149,75mg/kg, five groups of Sang Ju Yin granule 133mg/kg, animal before pyrogenicity 48,24h is administered twice, every Mus back subcutaneous injection 25% dried yeast powder suspension 20ml/kg pyrogenicity, 1h is administered once again after the pyrogenicity, after the pyrogenicity 4,6,8,10h surveys the anus temperature, the results are shown in Table 5.
Table 5 youngster feels oral liquid to the influence of rat fever due to the yeast (x ± s)
| Group | Dosage (mg/kg) | Number of animals (only) | Normal anus temperature ℃ | Different time after the pyrogenicity (h) anus temperature is with the normal anus temperature difference ℃ | |||
| ??4 | ??6 | ??8 | ??10 | ||||
| Matched group is felt liquid and is felt liquid and feel liquid Sang Ju Yin granule | ??298 ??149 ??75 ??133 | ??9 ??9 ??9 ??9 ??9 | ??37.3±0.5 ??37.3±0.4 ??37.3±0.3 ??37.3±0.3 ??37.3±0.3 | ??1.46±0.43 ??0.57±0.2 **??0.68±0.4 *??0.95±0.4 *??0.98±0.3 * | ??1.43±0.36 ??0.78±0.2 **??0.92±0.3 **??0.97±0.3 *??1.06±0.3 * | ??0.92±0.45 ??0.65±0.36 ??0.78±0.32 ??0.87±0.38 ??0.68±0.27 | ??0.74±0.38 ??0.44±0.2 ??0.46±0.24 ??0.42±0.37 ??0.49±0.46 |
Annotate: compare * P＜0.05 with matched group, * * P＜0.01 (down together)
The result shows, youngster feels oral liquid 298mg/kg, 149mg/kg, Sang Ju Yin granule 133mg/kg after pyrogenicity 4,6h has the obvious suppression effect to rat fever due to the yeast, it is approaching with Sang Ju Yin granule 133mg/kg effect that youngster feels oral liquid 149mg/kg, but be better than the Sang Ju Yin granule.
(4) 45 of the rats that influence of rat paw edema are divided equally 5 groups at random due to the on Carrageenan, Yu Zhiyan is preceding 48,24,1h administration 3 times, hungry 16h before the last administration, the right back toes aponeurosis (aponeuroses) of the every treated animal of 1h is injected 1% carrageenin 0.1ml down and is caused inflammation after the administration, cause scorching back 1,2,3,4,5h surveys rat paw edema, the result with every Mus about back toes and ankle joint circumference and difference represent, the results are shown in Table 6.
Table 6 youngster feels the influence (x ± s) of rat paw edema due to the oral liquid on Carrageenan
| Group | Dosage (mg/kg) | Number of animals (only) | Cause scorching back different time (h) foot swelling degree (mm) | ||||
| ?1 | ?2 | ?3 | ?4 | ?5 | |||
| Matched group is felt liquid and is felt liquid and feel liquid Sang Ju Yin granule | ????298 ????149 ????75 ????133 | ????9 ????9 ????9 ????9 ????9 | ?11.4±1.23 ?8.6±0.53 **?9.7±0.54 ?10.2±1.34 ?10.2±2.25 | ?16.3±2.14 ?12.3±2.4 *?12.8±2.3 *?14.1±3.6 ?14.2±2.6 | ?17.6±2.45 ?14.2±2.5 *?14.5±2.5 *?15.3±2.68 ?15.2±2.3 * | ?19.3±2.3 ?15.3±2.3 **?16.3±2.5 *?17.1±2.34 ?17.4±2.5 * | ?16.3±2.4 ?13.5±2.5 ?14.7±2.2 ?15.3±2.1 ?16.1±2.8 |
Annotate: compare * P＜0.05, * * P＜0.01 with matched group
The result shows, youngster feels oral liquid 298mg/kg in causing scorching back 1～4h, 149mg/kg is in causing scorching back 2～4h, Sang Ju Yin granule 133mg/kg is in causing scorching back 3～4, foot swelling has obvious inhibitory action to rat carrageenan, it is approaching with SANGJU GANMAO KELI 133mg/kg effect that youngster feels oral liquid 149mg/kg, illustrates that youngster feels oral liquid and has better antiinflammatory action than SANGJU GANMAO KELI.
Claims (7)
1, a kind of medicine for the treatment of infantile common cold is characterized in that it mainly is to be made by following raw materials in weight portion medicine:
1～6 part of Flos Lonicerae, 1～6 part of Fructus Forsythiae, 1～6 part of Rhizoma Osmundae, 1～6 part of Radix Isatidis,
1～6 part of Rhizoma Paridis, 1～5 part of Herba Menthae, 1～5 part of Herba Schizonepetae, 1～3 part of Radix Bupleuri.
2, the medicine of treatment infantile common cold according to claim 1 is characterized in that it mainly is to be made by following preferred raw materials in weight portion medicine:
2～4 parts of Flos Loniceraes, 2～4 parts of Fructus Forsythiaes, 2～4 parts of Rhizoma Osmundae, 2～4 parts of Radix Isatidis,
2～4 parts of Rhizoma Paridis, 1～3 part of Herba Menthae, 1～3 part of Herba Schizonepetae, 1～2 part of Radix Bupleuri.
3, the medicine of treatment infantile common cold according to claim 1 is characterized in that it mainly is to be made by following optimum weight part proportion raw material medicine:
3.4 parts of Flos Loniceraes, 3.4 parts of Fructus Forsythiaes, 3.2 parts of Rhizoma Osmundae, 3.2 parts of Radix Isatidis, 3 parts of Rhizoma Paridis, 2 parts of Herba Menthaes, 2 parts of Herba Schizonepetae, 1.8 parts of Radix Bupleuri.
4, a kind of method for preparing claim 1 or 2 or 3 described medicines is characterized in that it comprises that the following step poly-:
1. each crude drug of weight portion proportioning according to concocted specification, is made into the prepared slices of Chinese crude drugs described in will filling a prescription;
2. Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the radix bupleuri extract volatile oil of the described weight portion proportioning of the prepared slices of Chinese crude drugs is standby, the medicinal residues behind the extraction volatile oil merge with remaining each medicine, soak, heating extraction filters, extracting in water again then, filter, merging filtrate concentrates;
3. add ethanol in medicinal liquid, leave standstill the back and filter, get supernatant and reclaim ethanol to there not being the alcohol flavor, continue to concentrate, cold preservation merges with the volatile oil that extracts, and is used to prepare various oral formulations.
5, according to the preparation method of the described medicine of claim 4, it is characterized in that in step (2), adding 6-12 doubly to the water of drug weight, soaked heating extraction 1-1.5 hour 20 minutes, add 5-10 times of water gaging again and extracted 0.5-1 hour, filtrate is concentrated into medical material: medicinal liquid is 2: 1.
6, according to the preparation method of the described medicine of claim 4, it is characterized in that adding in the step (3) concentration is that 95% ethanol reaches 60%-90% to containing the alcohol amount, leaves standstill 24-48 hour, and supernatant concentration is to relative density 1.1-1.8.
7, according to the preparation method of claim 4 medicine, after it is characterized in that the volatile oil merging of 3. middle concentrated solution of step and extraction, the relevant auxiliary materials that adds different oral formulations can be made into the various oral formulations of oral liquid, granule, tablet, capsule, soft capsule.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240328A (en) * | 2011-07-01 | 2011-11-16 | 沈庆利 | Traditional Chinese medicine for treating cold and preparation method thereof |
| CN102475835A (en) * | 2010-11-25 | 2012-05-30 | 北京东方运嘉医药科技开发有限公司 | Pharmaceutical composition for treating common cold or cough caused by common cold in children and preparation method thereof |
| CN102526319A (en) * | 2011-12-31 | 2012-07-04 | 大连大学 | Traditional Chinese medicine prescription for treating epidemic febrile disease and preparation method thereof |
-
2005
- 2005-03-30 CN CN 200510038611 patent/CN1289124C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475835A (en) * | 2010-11-25 | 2012-05-30 | 北京东方运嘉医药科技开发有限公司 | Pharmaceutical composition for treating common cold or cough caused by common cold in children and preparation method thereof |
| CN102475835B (en) * | 2010-11-25 | 2013-12-11 | 北京东方运嘉科技发展有限公司 | Pharmaceutical composition for treating common cold or cough caused by common cold in children and preparation method thereof |
| CN102240328A (en) * | 2011-07-01 | 2011-11-16 | 沈庆利 | Traditional Chinese medicine for treating cold and preparation method thereof |
| CN102526319A (en) * | 2011-12-31 | 2012-07-04 | 大连大学 | Traditional Chinese medicine prescription for treating epidemic febrile disease and preparation method thereof |
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| Publication number | Publication date |
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| CN1289124C (en) | 2006-12-13 |
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