CN1679643A - Aloe trauma curing gel, preparation and use thereof - Google Patents
Aloe trauma curing gel, preparation and use thereof Download PDFInfo
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- CN1679643A CN1679643A CN 200410017486 CN200410017486A CN1679643A CN 1679643 A CN1679643 A CN 1679643A CN 200410017486 CN200410017486 CN 200410017486 CN 200410017486 A CN200410017486 A CN 200410017486A CN 1679643 A CN1679643 A CN 1679643A
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- pharmaceutical composition
- aloe
- carbopol
- dry powder
- polyacrylic resin
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Abstract
A medicine in the form of ointment for treating burn, scald, ulcer, bed sore, operation incision, wound, etc is proportionally prepared from aloe gel, sulfadiazine silver powder, carbopol and excipient.
Description
Technical field
The present invention relates to Aloe, polyacrylic resin (Carbopol) and silver sulfadiazine is the gel-type Pharmaceutical composition of characteristic component, and its production and application.
Technical background
Aloe is traditional medical material of motherland's medical science, and in the world, Aloe has just had report to the therapeutical effect of skin wound from twentieth century since the eighties.The research of Rodrignez-Bigas and Visuthikosold etc. shows that all the wound surface epithelization of employing Aloe treatment early.But China mostly is limited to cosmetic field in the application facet of Aloe external, accidental Aloe is applied to the trial of wound repair, but mostly be oiliness cream or dehydration ointment form greatly, be unfavorable for wound surface cleaning and later stage administration, the Aloe Pharmaceutical composition that adopts advanced substrate is needed in the present technique field badly, to treat various surface wounds and ulcer effectively.
The present invention selects the substrate of polyacrylic resin (Carbopol) as described Pharmaceutical composition for use, carboxyl in this polymer makes it have a series of characteristics that are applicable to the preparation Wound dressing, Giroux and Sehrenzel etc. have studied Carbopol Gel Transdermal performance and human body tolerance, carried out the interior medicine dynamics test simultaneously, the result shows nontoxic, the nonirritant of this material, does not influence the physiologically active of medicine.The Carbopol gel application has series of advantages such as stable performance, permeability is strong, the human body compliance is good in the preparation of Wound dressing, and the carrying medicament molecule very easily discharges by the micelle passage in the Carbopol gel structure simultaneously.
Beneficial effect
The present invention has broken the technical monopoly of imported product in this field, filled up domestic blank, the development of product of the present invention helps the raising of the whole research and development technology of national natural plants, and can provide novel effectively product and method for clinical Wound treating.
Summary of the invention
An object of the present invention is to provide with Aloe, polyacrylic resin (Carbopol) and silver sulfadiazine is the gel-type Pharmaceutical composition of characteristic component.
A further object of the present invention provides the preparation method of described Pharmaceutical composition.
Another object of the present invention provides described Pharmaceutical composition burns various surface wound diseases such as wound, radiational injury, ulcer, decubital ulcer, operation bark fetching district, operative incision and various other traumatic wound surface in treatment medicinal application.
The objective of the invention is to implement: a kind of Pharmaceutical composition by following method, its characteristic component is the Aloe mesophyll colloid liquid of 10-60% (W/V), the silver sulfadiazine dry powder (antibacterial) of 0.1-2.0% (W/V), polyacrylic resin (Carbopol) dry powder of 0.1-5.0% (W/V) and the excipient of surplus.
Described Pharmaceutical composition is the hydrophilic gel form.PH value is 6.5-7.5.
Below in conjunction with specific embodiment the present invention is done further elaboration.
Embodiment 1:
Preparation contains 10% (W/V) Aloe mesophyll colloid liquid, 0.1% (W/V) silver sulfadiazine, the described Pharmaceutical composition of 0.1% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 1g (Carbopol), add among the sterile distilled water 900mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll colloid liquid of 100mL in this solution, the commercially available silver sulfadiazine dry powder of 1g is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.
Embodiment 2:
Preparation contains 20% (W/V) Aloe mesophyll colloid liquid, the described Pharmaceutical composition of 10% (W/V) sulfanilamide and 0.5% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 5g (Carbopol), add among the sterile distilled water 695mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll colloid liquid of 200mL in this solution, the commercially available sulfanilamide dry powder of 100g is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.
Embodiment 3:
Preparation contains 30% (W/V) Aloe mesophyll colloid liquid, 0.1% (W/V) nitrofural, the described Pharmaceutical composition of 3.0% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 30g (Carbopol), add among the sterile distilled water 670mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll colloid liquid of 300mL in this solution, 1g nitrofural dry powder is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.
Embodiment 4:
Preparation contains 40% (W/V) Aloe mesophyll colloid liquid, the described Pharmaceutical composition of 1.0% (W/V) neomycin and 2.0% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 20g (Carbopol), add among the sterile distilled water 570mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll colloid liquid of 400mL in this solution, 10g polygynax dry powder is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.
Embodiment 5:
Preparation contains 60% (W/V) Aloe mesophyll colloid liquid, 3.0% (W/V) gentamycin, the described Pharmaceutical composition of 0.1% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 1g (Carbopol), add among the sterile distilled water 370mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll colloid liquid of 600mL in this solution, 30mL 80,000 IU gentamicin sulfate solution are 6.8 with the triethanolamine adjust pH after the even matter, obtain the milky gelinite.
Embodiment 6:
Preparation contains 20% (W/V) Aloe mesophyll colloid liquid, 1.0% (W/V) silver sulfadiazine, 3.0% (W/V) clotrimazole (Clotrimazole), the described Pharmaceutical composition of 5.0% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 50g (Carbopol), add among the sterile distilled water 710mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.In this solution, add commercially available 1: 1 Aloe mesophyll colloid liquid of 200mL, the commercially available silver sulfadiazine dry powder of 10g, 30g clotrimazole (Clotrimazole) dry powder is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.
Claims (4)
1. Pharmaceutical composition, its characteristic component is the Aloe mesophyll colloid liquid of 10-60% (W/V), the silver sulfadiazine dry powder (antibacterial) of 0.1-2.0% (W/V), polyacrylic resin (Carbopol) dry powder of 0.1-5.0% (W/V) and the excipient of surplus.
2. Pharmaceutical composition according to claim 1 prepares like this:
Polyacrylic resin (Carbopol 930-945) with 0.1-5.0% (W/V) is water-soluble;
The Aloe mesophyll colloid liquid that adds 10-60% (W/V) stirs and makes abundant dissolving;
The silver sulfadiazine dry powder (antibacterial) that adds 0.1-2.0% (W/V) stirs and makes abundant mixing;
With gained solution acid adjustment basicity to pH 6.5-7.5.
3. Pharmaceutical composition according to claim 1 is the hydrophilic gel form.
4. burn the medicinal application of various surface wound diseases such as wound, radiational injury, ulcer, decubital ulcer, operation bark fetching district, operative incision and various other traumatic wound surface as the preparation of the described Pharmaceutical composition of the arbitrary claim of claim 1-3 and in treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410017486 CN1679643A (en) | 2004-04-06 | 2004-04-06 | Aloe trauma curing gel, preparation and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410017486 CN1679643A (en) | 2004-04-06 | 2004-04-06 | Aloe trauma curing gel, preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1679643A true CN1679643A (en) | 2005-10-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410017486 Pending CN1679643A (en) | 2004-04-06 | 2004-04-06 | Aloe trauma curing gel, preparation and use thereof |
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| CN (1) | CN1679643A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2008661A2 (en) | 2007-05-03 | 2008-12-31 | Lucia Antonia Spannagel | Formulation based on marigold aloe and centellae |
| CN108853312A (en) * | 2018-09-25 | 2018-11-23 | 陕西天宇制药有限公司 | Lauromacrogol external-use gel and preparation method thereof |
-
2004
- 2004-04-06 CN CN 200410017486 patent/CN1679643A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2008661A2 (en) | 2007-05-03 | 2008-12-31 | Lucia Antonia Spannagel | Formulation based on marigold aloe and centellae |
| CN108853312A (en) * | 2018-09-25 | 2018-11-23 | 陕西天宇制药有限公司 | Lauromacrogol external-use gel and preparation method thereof |
| CN108853312B (en) * | 2018-09-25 | 2021-04-16 | 陕西天宇制药有限公司 | Polycinnamic alcohol external gel and preparation method thereof |
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Addressee: Zhao Yingde Document name: Notification before expiration of term |
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