RU2329822C1 - Antiseptic, anti-inflammatory, analgesic - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, namely for production of medical agent for external application used for treatment of burns, trophic ulcers, dry and wet gangrene, including against diabetes, decubitus, purulent infections (carbuncle, multiple infected wounds, post-infectious abscess, post appendicostomy suppuration, incomplete chronic rectal fistula, delayed healing), psoriasis, breast mastitis and fungus disease. Antiseptic, anti-inflammatory analgesic contains natural wax, propolis, vegetable oil and yellow melilot sprout tops with leaves and blossom of humidity no more than 9%, at following component ratio, mass%: yellow melilot 1.5-2.5, propolis 2.5-4.5, beeswax 4.5-7.5, vegetable oil 85.5-91.5. Efficiency of treatment is increased due to accelerated epithelisation of superficial burns at simultaneous increase in expiration date of specified agent.

EFFECT: development of method of production of effective antiseptic, anti-inflammatory analgesic.

5 ex

Description

The invention relates to the field of medicine. The ointment contains vegetable oil 85.5-91.5 wt.%; propolis 4.5-2.5 wt.%; beeswax 7.5-4.5 wt.%; grass of melilotus officinalis (humidity not more than 9%) 2.5-1.5 wt.%.

The drug promotes the rapid regeneration of damaged tissues formed by varieties of microbial flora, and also helps to heal infected wounds and ulcers. Cleanses the skin from necrotic and purulent deposits and accelerates the healing process of wounds of scarless formations at the end of treatment.

The drug is characterized by anti-inflammatory antiseptic and analgesic effect.

The invention relates to medicine and can be used as a therapeutic agent for external use, made in the form of a therapeutic ointment, used mainly in the treatment of burns, as well as trophic ulcers, dry and wet gangrene, including diabetes, pressure sores, and purulent infections ( carbuncle, multiple infected wounds, abscess after injection, suppuration after appendectomy, incomplete chronic fistula of the rectum, slow healing of wounds), psoriasis, mastitis of the mammary gland and in the treatment of fungal diseases niy.

Closest to the technical nature of the claimed is an ointment for the treatment of burns, consisting of substances of plant and animal origin (see RF patent N2248198, class A61K 9/06, op. 2005). The composition of the known ointment includes beeswax, propolis and vegetable oil with an optimal ratio of ingredients.

However, the combination of vegetable oil and beeswax does not provide a sufficiently active regenerating effect, and the wax content of 10-15 g (according to the formula) leads to a deterioration in the necessary consistency and plasticity of the ointment, which causes inconvenience in its use.

The disadvantages of this tool are the limitation of the scope and low therapeutic effect. The use of the known ointment showed that in the treatment of approximately 10% of patients revealed a negative effect of the treatment of burn wounds.

The objective of the invention is to increase the effectiveness of treatment by accelerating the epithelization of superficial burns. The solution to this problem is provided through a new ointment for the treatment of the above diseases, consisting of substances of plant and animal origin.

A new combination of components that make up the claimed ointment, provides an increase in the healing, bactericidal and anti-inflammatory properties of the ointment due to the use of substances of exclusively natural origin. The claimed ointment has high regenerating properties and when using it there are no side effects.

As an ointment base, the claimed therapeutic preparation includes vegetable sunflower oil, natural beeswax. The composition of vegetable oil includes glycerides of palmitic, stearic and linoleic acids, up to 19% protein, 26.5% carbohydrates, about 2% phytin and 1.5% tannins. Beeswax, which is part of the claimed ointment, serves as a structure-forming and film-forming component. In addition, beeswax has healing properties due to the content of meliesil alcohol and palmitic acid in it, as well as free acids - neocerotinic, cerotinic, montanic, melies, and others. Beeswax in the presence of triglycerides contained in vegetable oil contributes to the release of burn or a purulent wound of oxidizing oxygen, which favors the bactericidal gentle action of the ointment and the active healing of tissues. In addition, the presence of carotene and vitamin A in natural wax inhibits the growth of a number of pathogens with antibiotic properties and provides high ointment plasticity and increased penetration into biological tissue.

Propolis and medicinal herb "sweet clover" are also used as the main therapeutic ingredients of the claimed ointment. Propolis is a dark gray mass with a greenish or brownish tint, a bitter taste, with a characteristic resinous smell, practically insoluble in water and alcohol. It has a bactericidal, analgesic, anti-inflammatory effect.

Melilotus officinalis is a grassy fragrant biennial with a pivotal root and an upright branched stem up to 1.5 m tall. Leaves are ternary. The flowers are small, yellow, collected in a brush. It blooms in June-September.

For therapeutic purposes, shoot tops with leaves and flowers containing coumarin (in flowers about 0.8%), coumaric acid, mellotine, glycoside, purine derivatives, essential oil, vitamin C, E, carotene are used. Fresh grass of Melilotus officinalis contains the coumarin glycoside, from which coumarin is formed upon drying. Coumarin, contained in the clover grass, has anti-inflammatory, analgesic and softening effects in boils, carbuncles, purulent wounds. The bactericidal and fungicidal properties of coumarin are also known. The plant has an expectorant, emollient, anticonvulsant, carminative, analgesic, wound healing and soothing effect.

The experiments performed allowed us to establish the optimal content of the components that make up the claimed ointment, ensuring its maximum effectiveness: the propolis content should be 2.5-4.5 wt.%, With a propolis content of less than 2.5 wt.%, A significant decrease in the healing efficiency of burns was observed and purulent wounds, and when the content of propolis in excess of 4.5 wt.%, ointment thickened, which led to a decrease in the uniformity of the distribution of the ointment over the surface of the wound. A decrease in the content of natural wax to values less than 4.5 wt.% Or an increase in its content above 7.5 wt.% Leads to a deterioration in the necessary consistency and plasticity of the ointment, which causes inconvenience in its use. The content of sweet clover (humidity not more than 9%) should be in the range of 1.5-2.5 wt.%. When the content of clover medicinal less than 1.5 wt.% There was a significant decrease in analgesic and wound healing effect, and when the content of clover medicinal in excess of 2.5 wt.%, A significant increase in analgesic and wound healing effect does not occur.

During all experiments, it was found that the content of vegetable oil in the ointment in the range of 85.5-91.5 wt.%, Provided the required nutritional and emollient effect. An ointment is prepared as follows. 91.5 grams of vegetable oil is poured into enameled dishes, a weighed portion of 1.5 grams of sweet clover is loaded, brought to a boil, and 3.5 grams of propolis are added with stirring; beeswax 6.5 grams. After cooling to room temperature, the ointment is packaged in glass or porcelain jars and corked.

The resulting ointment is a homogeneous composition of a light brown color with a pleasant smell characteristic of clover. The prepared ointment is plastic, has a high therapeutic quality and stability, and is also completely harmless. The biological value and quality of the ointment does not depend on its shelf life. When stored in a cool, darkened place, the shelf life is several years (at least 3 years).

The results of the application of the claimed ointment in the clinic are illustrated by the following examples (for example, the treatment of victims with burns of I, II and III degree with damage from 5% to 30% of the skin surface).

In the first three cases, an ointment of the composition was used:

Melilotus officinalis grass, humidity not more than 9% - 2.5%

Propolis - 4.5%

Beeswax - 7.5%

Sunflower oil - 85.5%,

the expiration date of which is 2 years.

In the latter cases, an ointment of the following composition was used:

Melilotus officinalis grass, humidity not more than 9% - 1.5%

Propolis - 2.5%

Beeswax - 4.5%

Sunflower oil - 91.5%,

the expiration date of which is 2 years.

The degree of grinding of raw materials "clover grass" is 5-7 mm

Example 1. Patient K., 6 years old, burn boiling water of the arm and abdominal surface of 450 square meters. see. A bandage was applied - a layer of ointment with a thickness of 1 mm was applied to the cotton cloth, while the ointment was in contact with the surface of the wound. Every 24 hours, the dressing changed: skin particles and pus were removed and a new layer of ointment was applied to the cleaned areas. After 10 days, the burn was completely epithelized without any consequences and scars, etc.

Example 2. Patient I., 35 years old, the results of an autoclave explosion. The face, neck, arms and part of the chest were affected by boiling water. The total area of damage is 830 square meters. see Burn III degree. A day after the lesion, the treatment process was started using the claimed ointment according to the technology specified in the previous example. Complete healing occurred on the 14th day, while mature connective tissue and normal full-layer epithelium were revealed.

Example 3. Patient S., 28 years old, boiling water was affected face, neck, hands of both hands. The total area of affected skin is 520 square meters. see 3 hours after the lesion, treatment was started using the claimed ointment according to the technology described in Example 1. Full recovery without any signs of burns was observed after 8 days.

Example 4. Patient A., 7 years old. Both legs were affected by boiling water. The total area affected 670 square meters. see. 2 hours after the lesion began the treatment process using the claimed ointment. Complete wound healing was observed after 10 days.

Example 5. Patient I., 49 years old. Purulent lesions of the skin of the hands with a total area of 19 square meters. see. For all affected areas, dressings were applied with a layer thickness of the claimed ointment of 1.5 mm, which was in contact with the surfaces of the wounds. Every 24 hours, dressings were changed. Bacteriologically after 7 days, all wounds were almost sterile. On day 11, the wounds were completely filled with pink granulations and fibroblast sites and marginal epithelization was noted. On the 20th day, a full recovery occurred - mature connective tissue and normal full-layer epithelium were revealed. It should be noted that intoxication was not observed during the treatment, and the dressing change was painless, since the dressing with the claimed ointment does not stick to the wound surface and is freely removed. In similar cases, when using the prototype

- epithelization occurred on days 14-18 compared with the declared ointment;

- manifestations of intoxication were noted;

- marked scarring of the tissue.

In addition, the claimed ointment has been successfully used in the treatment of the above diseases.

The claimed ointment provides accelerated epithelization of burns and purulent wounds without scarring at the end of treatment. The ointment is harmless and does not have an irritating effect, while there are no side effects when using the ointment, since it contains only components made from substances of only plant and animal origin. In the process of treatment with the use of the claimed ointment, surgery is not required. The claimed ointment has a high shelf life of at least 3 years. The composition of the ointment includes widespread non-deficient materials, and since the ointment is easy to manufacture, it can be widely used in stationary and field conditions.

Claims (1)

An antiseptic, anti-inflammatory, painkiller containing beeswax, propolis and vegetable oil, characterized in that it additionally contains the tips of the shoots with leaves and flowers of the sweet clover (humidity not more than 9%) in the following ratio, wt.%: tops of shoots with leaves and clover flowers (humidity not more than 9%) 1.5-2.5 propolis 2.5-4.5 beeswax 4,5-7,5 vegetable oil 85.5-91.5