CN1662551A - 前列腺素e2受体亚型ep4的拮抗肽 - Google Patents

前列腺素e2受体亚型ep4的拮抗肽 Download PDF

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Publication number
CN1662551A
CN1662551A CN038146851A CN03814685A CN1662551A CN 1662551 A CN1662551 A CN 1662551A CN 038146851 A CN038146851 A CN 038146851A CN 03814685 A CN03814685 A CN 03814685A CN 1662551 A CN1662551 A CN 1662551A
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China
Prior art keywords
peptide
bip
pharmaceutical composition
seq
receptor
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Pending
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CN038146851A
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English (en)
Chinese (zh)
Inventor
K·G·佩里
S·莫菲特
D·阿布兰
A·伯杰龙
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Theratechnologies Inc
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Theratechnologies Inc
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Application filed by Theratechnologies Inc filed Critical Theratechnologies Inc
Publication of CN1662551A publication Critical patent/CN1662551A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN038146851A 2002-05-23 2003-05-23 前列腺素e2受体亚型ep4的拮抗肽 Pending CN1662551A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38233602P 2002-05-23 2002-05-23
US60/382,336 2002-05-23

Publications (1)

Publication Number Publication Date
CN1662551A true CN1662551A (zh) 2005-08-31

Family

ID=29584392

Family Applications (1)

Application Number Title Priority Date Filing Date
CN038146851A Pending CN1662551A (zh) 2002-05-23 2003-05-23 前列腺素e2受体亚型ep4的拮抗肽

Country Status (8)

Country Link
US (1) US20040023853A1 (enExample)
EP (1) EP1506220A1 (enExample)
JP (1) JP2006506327A (enExample)
CN (1) CN1662551A (enExample)
AU (1) AU2003233297A1 (enExample)
BR (1) BR0311247A (enExample)
CA (1) CA2485485A1 (enExample)
WO (1) WO2003099857A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101041687B (zh) * 2007-02-28 2010-09-29 长春博泰医药生物技术有限责任公司 Pge2特异结合的噬菌体环七肽及筛选方法和合成肽的用途

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1742662A2 (en) * 2004-05-03 2007-01-17 Astellas Pharma Inc. Combination of prostaglandin e2 receptor antagonists and renin-angiotensin system inhibitors for treating renal diseases
US20060115785A1 (en) * 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
WO2007146187A2 (en) * 2006-06-06 2007-12-21 Reika Ortho Technologies, Inc. Transduction orthodontic devices
JPWO2010087425A1 (ja) 2009-01-30 2012-08-02 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
US9175080B2 (en) 2010-09-29 2015-11-03 Nb Health Laboratory Co., Ltd. Antibody against human prostaglandin E2 receptor EP4
HUE039015T2 (hu) 2013-06-12 2018-12-28 Kaken Pharma Co Ltd 4-Alkinil-imidazol-származék és ezt hatóanyagként tartalmazó gyógyszerkészítmény
TW201623277A (zh) * 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
WO2016196400A1 (en) 2015-05-29 2016-12-08 Purdue Research Foundation Bone fracture repair by targeting of agents that promote bone healing
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
AU2018268311B2 (en) 2017-05-18 2022-02-10 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
WO2018210994A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Phenyl derivatives as pge2 receptor modulators
WO2022102731A1 (ja) 2020-11-13 2022-05-19 小野薬品工業株式会社 Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療
WO2024111404A1 (ja) * 2022-11-21 2024-05-30 協和発酵バイオ株式会社 抗がん剤により誘発される急性腎障害の予防又は治療剤
WO2025115623A1 (ja) * 2023-11-28 2025-06-05 新田ゼラチン株式会社 プロスタグランジンe2産生抑制剤、それを含む飲食品、プロスタグランジンe2産生抑制方法、およびプロスタグランジンe2産生抑制剤の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605814A (en) * 1993-08-31 1997-02-25 Merck Frosst Canada Inc. DNA encoding human prostaglandin receptor EP2
TWI247606B (en) * 1999-11-24 2006-01-21 Ono Pharmaceutical Co Treating agent for osteopenic diseases
JP2003516417A (ja) * 1999-12-06 2003-05-13 オピタル・サント−ジュスティーヌ 糸球体濾過異常、動脈管開存、および骨粗鬆症治療に用いる組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101041687B (zh) * 2007-02-28 2010-09-29 长春博泰医药生物技术有限责任公司 Pge2特异结合的噬菌体环七肽及筛选方法和合成肽的用途

Also Published As

Publication number Publication date
WO2003099857A1 (en) 2003-12-04
BR0311247A (pt) 2005-03-15
WO2003099857B1 (en) 2004-02-19
AU2003233297A2 (en) 2003-12-12
AU2003233297A1 (en) 2003-12-12
US20040023853A1 (en) 2004-02-05
JP2006506327A (ja) 2006-02-23
EP1506220A1 (en) 2005-02-16
CA2485485A1 (en) 2003-12-04

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