CN1662231A - 包括应激相关障碍在内的功能性躯体障碍的预防与治疗 - Google Patents

包括应激相关障碍在内的功能性躯体障碍的预防与治疗 Download PDF

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Publication number
CN1662231A
CN1662231A CN038148455A CN03814845A CN1662231A CN 1662231 A CN1662231 A CN 1662231A CN 038148455 A CN038148455 A CN 038148455A CN 03814845 A CN03814845 A CN 03814845A CN 1662231 A CN1662231 A CN 1662231A
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compound
stress
disorder
administered
symptoms
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Chinese (zh)
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斯利尼瓦斯·G·拉奥
杰·D·克兰兹勒
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Cypress Bioscience Inc
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Cypress Bioscience Inc
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  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN038148455A 2002-04-24 2003-04-24 包括应激相关障碍在内的功能性躯体障碍的预防与治疗 Pending CN1662231A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37506802P 2002-04-24 2002-04-24
US60/375,068 2002-04-24
US46428803P 2003-04-18 2003-04-18
US60/464,288 2003-04-18

Publications (1)

Publication Number Publication Date
CN1662231A true CN1662231A (zh) 2005-08-31

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CN038148455A Pending CN1662231A (zh) 2002-04-24 2003-04-24 包括应激相关障碍在内的功能性躯体障碍的预防与治疗

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US (2) US20030232805A1 (enExample)
EP (1) EP1499309A4 (enExample)
JP (2) JP2005523334A (enExample)
CN (1) CN1662231A (enExample)
AU (1) AU2003225206B2 (enExample)
CA (1) CA2483093A1 (enExample)
MX (1) MXPA04011529A (enExample)
WO (1) WO2003090743A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602911B2 (en) 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
TW200402289A (en) * 2002-05-17 2004-02-16 Wyeth Corp Methods of treating gastrointestinary and genitourinary pain disorders
EP1513510A1 (en) * 2002-05-30 2005-03-16 Head Explorer A/S The use of milnacipran for the treatment of tension-type headache
US20040106681A1 (en) * 2002-10-03 2004-06-03 Cypress Bioscience, Inc. Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
US7704527B2 (en) * 2002-10-25 2010-04-27 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
JP2006508978A (ja) * 2002-11-19 2006-03-16 イーライ・リリー・アンド・カンパニー デュロキセチンを用いる胃腸障害の処置
EP1908461B9 (fr) * 2003-02-14 2011-08-31 Pierre Fabre Medicament Utilisation de l'énantiomère (1S, 2R) du milnacipran pour la préparation d'un médicament
FR2851163B1 (fr) * 2003-02-14 2007-04-27 Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament
US20070065463A1 (en) * 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
WO2005023265A1 (en) * 2003-09-09 2005-03-17 Pfizer Products Inc. Combination of serotonin reuptake inhibitors and norepinephrine reuptake inhibitors
RU2006107534A (ru) * 2003-09-12 2007-09-20 Уорнер-Ламберт Компани Ллс (Us) Комбинация, включающая альфа-2-дельта-лиганд анд и ssri и/или snri, для лечения депрессии и тревожного расстройства
WO2006132307A1 (ja) * 2005-06-10 2006-12-14 Pierre Fabre Medicament S.A. 安定化されたミルナシプラン製剤
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
SG183069A1 (en) * 2007-07-23 2012-08-30 Synosia Therapeutics Treatment of post-traumatic stress disorder
US20100040680A1 (en) * 2008-08-15 2010-02-18 Felix Lai Multiparticulate selective serotonin and norepinephrine reuptake inhibitor formulation
EP2496079A4 (en) * 2009-11-06 2014-05-14 Pierre Fabre Médicament Sas NOVEL (1S, 2R) -2- (AMINOMETHYL) -N, N-DIETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE CRYSTALLINE FORMS
FR2978350B1 (fr) 2011-07-28 2013-11-08 Pf Medicament Medicament a base de levomilnacipran pour la rehabilitation fonctionnelle apres accident neurologique aigu
US11110070B2 (en) 2015-11-17 2021-09-07 The Trustees Of Columbia University In The City Of New York Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US11622948B2 (en) 2017-11-09 2023-04-11 The Trustees Of Columbia University In The City Of New York Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders
US11491120B2 (en) 2017-11-09 2022-11-08 The Trustees Of Columbia University In The City Of New York Pharmacological prophylactics against stress-induced affective disorders in females
US12433904B2 (en) 2019-04-17 2025-10-07 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
JP2023509800A (ja) * 2020-01-10 2023-03-09 コンシナンス セラピューティクス, インコーポレイテッド 薬物の治療的組み合わせ及びそれらの使用方法

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (fr) * 1981-06-23 1982-12-24 Fabre Sa Pierre Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
US4761501A (en) * 1983-10-26 1988-08-02 American Home Products Corporation Substituted phenylacetamides
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
JP2675573B2 (ja) * 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
EP0647134A4 (en) * 1992-06-23 1997-07-30 Sepracor Inc METHOD AND COMPOSITIONS FOR TREATING DEPRESSION AND OTHER DISEASES USING OPTICALLY PURE SIBUTRAMINE.
US5352683A (en) * 1993-03-05 1994-10-04 Virginia Commonwealth University Medical College Of Virginia Method for the treatment of chronic pain
TW344661B (en) * 1993-11-24 1998-11-11 Lilly Co Eli Pharmaceutical composition for treatment of incontinence
WO1995022521A1 (en) * 1994-02-22 1995-08-24 Asahi Kasei Kogyo Kabushiki Kaisha Aminoalkylcyclopropane derivative
ZA958725B (en) * 1994-10-20 1997-04-16 Lilly Co Eli Treatment of disorders with duloxetine
AUPN605795A0 (en) * 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
EP0906104A4 (en) * 1996-03-25 2003-12-10 Lilly Co Eli PAIN TREATMENT PROCESS
WO1997035586A1 (en) * 1996-03-25 1997-10-02 Eli Lilly And Company Method for treating pain
GB9617990D0 (en) * 1996-08-29 1996-10-09 Scotia Holdings Plc Treatment of pain
US6284794B1 (en) * 1996-11-05 2001-09-04 Head Explorer Aps Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US5776969A (en) * 1997-02-27 1998-07-07 Eli Lilly And Company Treatment of sleep disorders
JP2001527554A (ja) * 1997-05-07 2001-12-25 アルゴス ファーマシューティカル コーポレーション 抗うつ薬とnmdaレセプター拮抗薬とを組み合わせる神経障害痛の治療用組成物及び治療方法
UA56257C2 (uk) * 1997-09-23 2003-05-15 Елі Ліллі Енд Компані Спосіб лікування неадекватної визивної поведінки
ZA989251B (en) * 1997-10-17 2000-04-10 Lilly Co Eli Potentiation of pharmaceuticals.
CA2337507A1 (en) * 1998-07-16 2000-01-27 Massachusetts Institute Of Technology Composition for treatment of stress
JP2002524513A (ja) * 1998-09-15 2002-08-06 イーライ・リリー・アンド・カンパニー 持続痛の治療
GB2367748A (en) * 1998-10-27 2002-04-17 Vela Pharmaceuticals Use of optically pure (R)- tofisopam for treating and preventing anxiety disorders and composition thereof
JP2002529499A (ja) * 1998-11-13 2002-09-10 イーライ・リリー・アンド・カンパニー 痛みの治療方法
US6323242B1 (en) * 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
US6489341B1 (en) * 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
EP2087892A3 (en) * 1999-07-01 2009-09-30 Pharmacia & Upjohn Company LLC (S,S) reboxetine for treating age associated learning and mental disorders
HU229295B1 (en) * 1999-08-04 2013-10-28 Astellas Pharma Inc Stable medicinal compositions for oral use
IL147778A0 (en) * 1999-08-13 2002-08-14 Vela Pharmaceuticals Inc Pharmaceutical compositions containing cyclobenzaprine
AP2002002501A0 (en) * 1999-10-07 2002-06-30 Warner Lambert Co Synergistic combinations of an NK1 receptor antagonist and a gaba structural analog.
GB2355191A (en) * 1999-10-12 2001-04-18 Laxdale Ltd Combination formulations for fatigue, head injury and strokes
US20010036943A1 (en) * 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
CA2364211A1 (en) * 2000-12-05 2002-06-05 Phillip Branch Chappell Combination treatment for depression, anxiety and psychosis
EP1353675A2 (en) * 2001-01-02 2003-10-22 PHARMACIA & UPJOHN COMPANY New drug combinations of norepinehrine reuptake inhibitors and neuroleptic agents
US20020147196A1 (en) * 2001-04-05 2002-10-10 Quessy Steven Noel Composition and method for treating neuropathic pain
EA006396B1 (ru) * 2001-04-19 2005-12-29 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си Конденсированные бициклические аминокислоты
JP2005522445A (ja) * 2002-02-12 2005-07-28 サイプレス バイオサイエンス, インコーポレイテッド 注意欠陥過活動性障害(ad/hd)の処置方法
AU2003298664A1 (en) 2002-11-20 2004-06-15 Cypress Bioscience, Inc. Treatment of cognitive dysfunctions'

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AU2003225206A1 (en) 2003-11-10
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CA2483093A1 (en) 2003-11-06
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