CN1660433A - 一种治疗和/或预防痔的组合物 - Google Patents
一种治疗和/或预防痔的组合物 Download PDFInfo
- Publication number
- CN1660433A CN1660433A CN 200510000276 CN200510000276A CN1660433A CN 1660433 A CN1660433 A CN 1660433A CN 200510000276 CN200510000276 CN 200510000276 CN 200510000276 A CN200510000276 A CN 200510000276A CN 1660433 A CN1660433 A CN 1660433A
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- Prior art keywords
- inhibitor
- pharmaceutical composition
- hemorrhoid
- arginine
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Abstract
Description
PDE-5*nNOSiNOS*eNOSMMP1*MMP3*MMP9**MMP12*VEGF* | x29.0060.2253.7760.6809.4358.7537.8518.9018.153 | P值0.0290.6350.0500.4100.0240.0360.0490.0310.004 |
成分名称 | 每粒栓剂中各成分的含量 | 功能 | |
活性成分 | 氨基胍 | 10mg | NOS抑制剂 |
防己诺林碱 | 10mg | VEGF抑制剂 | |
罗格列酮 | 1mg | MMP抑制剂 | |
其他成分 | 聚氧乙烯二醇棕榈酸硬脂酸酯 | 160mg | 自动乳化脂肪基质 |
饱和多糖甘油酯 | 120mg | 脂溶性载体 | |
二甲聚硅氧烷 | 320mg | 液溶剂 | |
疏水性羟丙基甲基纤维素 | 275mg | 保留基质 | |
丙二醇 | 200mg | 潜溶媒 | |
尼泊金甲酯 | 4mg | 防腐剂 | |
尼泊金丙酯 | 2mg | 防腐剂 | |
山梨酸钾 | 20mg | 防腐剂 | |
可可脂 | 2773mg | 脂肪族基质 |
成分名称 | 每粒栓剂中各成分的含量 | 功能 | |
活性成分 | COL-3 | 10mg | MMP抑制剂 |
N-单甲基-L-精氨酸 | 10mg | NOS抑制剂 | |
土荆皮乙酸 | 10mg | VEGF抑制剂 | |
其他成分 | 聚氧乙烯二醇棕榈酸硬脂酸酯 | 160mg | 自动乳化脂肪基质 |
饱和多糖甘油酯 | 120mg | 脂溶性载体 | |
二甲聚硅氧烷 | 320mg | 液溶剂 | |
疏水性羟丙基甲基纤维素 | 275mg | 保留基质 | |
丙二醇 | 200mg | 潜溶媒 | |
尼泊金甲酯 | 4mg | 防腐剂 | |
尼泊金丙酯 | 2mg | 防腐剂 | |
山梨酸钾 | 20mg | 防腐剂 | |
可可脂 | 2764mg | 脂肪族基质 |
栓剂类型 | 48h总有效率 | 一周总有效率 | 疼痛开始减轻的平均时间 | 出血开始减少的平均时间 |
栓剂A | 95.30% | 96.50% | 14.7h | 16.2h |
活性成分为单一的氨基胍的栓剂 | 77.20% | 84.30% | 22.6h | 28.5h |
活性成分为单一的防己诺林碱的栓剂 | 78.90% | 82.80% | 20.4h | 23.9h |
活性成分为单一的罗格列酮的栓剂 | 76.30% | 86.40% | 21.7h | 27.4h |
栓剂类型 | 48h总有效率 | 一周总有效率 | 疼痛开始减轻的平均时间 | 出血开始减少的平均时间 |
栓剂B | 94.80% | 92.80% | 15.4h | 14.9h |
活性成分为单一的N-单甲基-L-精氨酸的栓剂 | 76.80% | 83.40% | 24.2h | 30h |
活性成分为单一的土荆皮乙酸的栓剂 | 78.10% | 84.50% | 21.7h | 25.3h |
活性成分为单一的COL-3的栓剂 | 74.40% | 82.60% | 22.7h | 28.6h |
Claims (20)
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107001445A (zh) * | 2014-08-27 | 2017-08-01 | 美国安进公司 | 3型金属蛋白酶组织抑制剂(timp‑3)的变体、组合物及方法 |
CN113244225A (zh) * | 2021-06-16 | 2021-08-13 | 昆明医科大学第一附属医院 | 土槿皮乙酸在制备抗血小板药物中的应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1325684A (zh) * | 2001-06-08 | 2001-12-12 | 李恩 | 氨基胍作为治疗骨质疏松症药物的应用 |
CN1511521A (zh) * | 2002-12-31 | 2004-07-14 | 北京大学第一医院 | 土荆皮乙酸在抑制血管生成中的应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN107001445A (zh) * | 2014-08-27 | 2017-08-01 | 美国安进公司 | 3型金属蛋白酶组织抑制剂(timp‑3)的变体、组合物及方法 |
CN113244225A (zh) * | 2021-06-16 | 2021-08-13 | 昆明医科大学第一附属医院 | 土槿皮乙酸在制备抗血小板药物中的应用 |
CN113244225B (zh) * | 2021-06-16 | 2022-06-28 | 昆明医科大学第一附属医院 | 土槿皮乙酸在制备抗血小板药物中的应用 |
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