CN1660194A - Effervescence grains prepared by extracting epimedium, astragalus root etc. medicinal materials - Google Patents
Effervescence grains prepared by extracting epimedium, astragalus root etc. medicinal materials Download PDFInfo
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- CN1660194A CN1660194A CN 200410061268 CN200410061268A CN1660194A CN 1660194 A CN1660194 A CN 1660194A CN 200410061268 CN200410061268 CN 200410061268 CN 200410061268 A CN200410061268 A CN 200410061268A CN 1660194 A CN1660194 A CN 1660194A
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- effervescent granule
- granule
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- kidney
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Abstract
A Chinese medicine in the form of effervescent particles for treating defficiency of vital essence of kidney and spleen, prostatplasia, chronic prostatitis, weakness, urgency of micturition, frequency of urination, etc is prepared from 5 Chinese-medicinal materials including epimedium, astragalus root, cat-tail pollen, etc.
Description
One. technical field
The invention belongs to a kind of have tonify Qi of the kidney, the treating stranguria effect of blood stasis dispelling, it is two empty to be used for the treatment of the kidney spleen, qi depression to blood stasis, prostatic hyperplasia, chronic prostatitis; Complexion rolling is white, spiritlessness and weakness, and the waist knee joint is sluggish, sagging distention in the smaller abdomen, it is not well to urinate, and drop does not go out, or the novel formulation of diseases such as frequent micturition, urgent micturition, Urethra astringent pain.
Two. technical background
The row adenitis is young and middle-aged male's commonly encountered diseases, a frequently-occurring disease, often per urethram scorching, seminal vesiculitis or epididymis inflammation and cause.Have clinically acute and chronic, bacterial infection and non-infectious, specificity and non-specific branch.Prostatitis is adult's male commonly encountered diseases, and its sickness rate is directly proportional with the growth at age, and general 40 years old begins to occur hypertrophy, and sickness rate is to rise to person more than 75%, 80 years old in 50%, 60 years old more than 50 years old, then up to 95.5%.Most of cases are based on medicine aspect treatment, and need take medicine for a long time.
Because special dissection and the pathophysiology basis of prostate itself, its clinical manifestation seems that also more complicated is changeable, although at present more advanced detection method is arranged aspect diagnosis, with regard to the cause of disease, etiological diagnosis and treatment countermeasure aspect still make clinical scholar feel a delicacy about.
This prescription shows through pharmacodynamic study: 1, can obviously suppress cell infiltration and fibroblast hypertrophy, leukopenia and lecithin are increased, can resist H stimulates caused abdominal cavity capillary permeability to increase, and has tangible antiinflammatory action.2, the mice ear experiment shows that mice ear is had the good restraining effect, and the hot plate method test shows can obviously prolong the pain reaction time of mice, improves pain territory index.3, extracorporeal bacteria inhibitor test shows all has the obvious suppression effect to staphylococcus aureus, streptococcus faecalis, staphylococcus epidermidis, and bacillus pyocyaneus, escherichia coli are also had certain inhibitory action.4, enhancing human body immunity power: body temperature, the weight loss that can resist yang deficiency animal due to the cetacort.5, activating blood circulation to dissipate blood stasis: the moving fat external caliber of Mice Auricle microcirculation is increased, and microcirculation improvement has certain treatment and preventive effect to the prostatic hyperplasia due to the propanoic acid testis; The weight of body of prostate can be obviously alleviated, auricle edema due to the Oleum Tiglii can be suppressed.6, the male rat accessory sex organ there is effect of gain; The male mice sexual function there is potentiation.
The medicine effervescent granule that this project is developed is a Chinese medicine preparation, is mainly used in the two void of treatment kidney spleen, qi depression to blood stasis, prostatic hyperplasia, chronic prostatitis; Complexion rolling is white, spiritlessness and weakness, and the waist knee joint is sluggish, sagging distention in the smaller abdomen, it is not well to urinate, and drop does not go out, or diseases such as frequent micturition, urgent micturition, Urethra astringent pain.In order to verify the curative effect of this dosage form, we done with the drug effect of QIANLIESHU KELI relatively: 1, to the influence of rat experiment nonbacterial prostatitis: the two all has obvious inhibitory action to rat experiment nonbacterial prostatitis due to the foot fork dish glue, lecithin density all can be raised to 2.60 grades, and the easypro effervescent granule in prostatitis can drop to total white blood cells 6.1 * 109/L, and QIANLIESHU KELI can only drop to 7.6 * 109/L; 2, to the influence of rat experiment bacterial prostatitis: the two all has obvious inhibitory action to rat experiment bacterial prostatitis due to the escherichia coli, lecithin density all can be raised to 2.20 grades, and the easypro effervescent granule in prostatitis can drop to total white blood cells 39.1 * 109/L, and QIANLIESHU KELI can only drop to 41.3 * 109/L.As seen, the easypro effervescent granule in prostatitis is better than in the usefulness that reduces total white blood cells, has than salient feature.
This product is an effervescent granule, only need medicine and mixed with excipients is even, and granulating gets final product; Advantages such as it is succinct to have production process, and production cost is low have extremely strong practical value.At present, domestic still do not have a said preparation, and asking of this product can not only provide more selection to the patient, and can reduce medical expense in the city, reduces patient economy burden, improves patient's subsistence level, and the quality of making the life better has very important social meaning and economic implications.
Three. summary of the invention
It is two empty to the objective of the invention is to treat the kidney spleen, qi depression to blood stasis, prostatic hyperplasia, chronic prostatitis; Complexion rolling is white, spiritlessness and weakness, and the waist knee joint is sluggish, sagging distention in the smaller abdomen, it is not well to urinate, and drop does not go out, or the new product of Chinese medicine of diseases such as frequent micturition, urgent micturition, Urethra astringent pain.
The characteristics of this effervescent granule:
One kind have tonify Qi of the kidney, the treating stranguria effect of blood stasis dispelling, it is two empty to be used for the treatment of the kidney spleen, qi depression to blood stasis, prostatic hyperplasia, chronic prostatitis; Complexion rolling is white, spiritlessness and weakness, and the waist knee joint is sluggish, sagging distention in the smaller abdomen, it is not well to urinate, and drop does not go out, or the effervescent granule of diseases such as frequent micturition, urgent micturition, Urethra astringent pain.
2. according to the effervescent granule of claim 1, the prescription of this effervescent granule is made up of medical materials such as Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, Radix Cyathulaes, and its Chinese crude drug ratio is: Herba Epimedii: the Radix Astragali: Pollen Typhae: Herba Plantaginis: Radix Cyathulae=8: 4: 3: 4: 1.
3. the effervescent granule of making according to the requirement of claim 1 and 2, it is characterized in that: it is 20g that the effervescent granule of at every turn taking is equivalent to the raw medicinal herbs amount.
4. this effervescent granule disintegrate is fast, shortens dissolution time, and than other peroral dosage form better mouthfeel is arranged.
5. this effervescent granule adopts conventional method, medical materials such as Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, Radix Cyathulae are decocted with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, it is 1.40 (80 ℃) that filtrate is concentrated into relative density, add excipient, granulation, drying, granulate is promptly.
The excipient that this effervescent granule adopts often is: Icing Sugar, medical material fine powder, lactose, starch, dextrin, mannitol, sorbitol, xylitol etc.
The effervescent that this effervescent granule adopts with acid often is: citric acid, tartaric acid, fumaric acid etc.
The effervescent that this effervescent granule adopts with alkali often is: sodium bicarbonate etc.
Four, the specific embodiment
The present invention is described in detail below in conjunction with embodiment:
Example 1:
Medical materials such as Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, Radix Cyathulae are decocted with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into the extractum that relative density is 1.40 (80 ℃), and extractum is divided into two parts, a 3 parts of the Icing Sugar that add, 0.2 part of sodium bicarbonate, stir, make granule, the dry granule 1 that gets; Use a Icing Sugar and 0.2 part of citric acid in addition, add the water mixing and stirring, make granule, the dry granule 2 that gets.Above granule 1 mixes with 2, and granulate promptly.
Example 2:
Medical materials such as Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, Radix Cyathulae are decocted with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and filtrate is concentrated into suitable proportion, with 2 parts of Icing Sugar, 0.2 part of sodium bicarbonate, citric acid is bed material for 0.2 part, make granule through one-step palletizing, the dry granule that gets, granulate is promptly.
Claims (3)
- One kind have tonify Qi of the kidney, the treating stranguria effect of blood stasis dispelling, it is two empty to be used for the treatment of the kidney spleen, qi depression to blood stasis, prostatic hyperplasia, chronic prostatitis; Complexion rolling is white, spiritlessness and weakness, and the waist knee joint is sluggish, sagging distention in the smaller abdomen, it is not well to urinate, and drop does not go out, or the effervescent granule of diseases such as frequent micturition, urgent micturition, Urethra astringent pain.
- 2. according to the effervescent granule of claim 1, the prescription of this effervescent granule is made up of medical materials such as Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, Radix Cyathulaes, and its Chinese crude drug ratio is: Herba Epimedii: the Radix Astragali: Pollen Typhae: Herba Plantaginis: Radix Cyathulae=8: 4: 3: 4: 1.
- 3. the effervescent granule of making according to the requirement of claim 1 and 2, it is characterized in that: it is 20g that the effervescent granule of at every turn taking is equivalent to the raw medicinal herbs amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410061268 CN1660194A (en) | 2004-12-03 | 2004-12-03 | Effervescence grains prepared by extracting epimedium, astragalus root etc. medicinal materials |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410061268 CN1660194A (en) | 2004-12-03 | 2004-12-03 | Effervescence grains prepared by extracting epimedium, astragalus root etc. medicinal materials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1660194A true CN1660194A (en) | 2005-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410061268 Pending CN1660194A (en) | 2004-12-03 | 2004-12-03 | Effervescence grains prepared by extracting epimedium, astragalus root etc. medicinal materials |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397440A (en) * | 2011-12-01 | 2012-04-04 | 王敬一 | External hot-applied traditional Chinese medicine for treating prostatitis |
-
2004
- 2004-12-03 CN CN 200410061268 patent/CN1660194A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397440A (en) * | 2011-12-01 | 2012-04-04 | 王敬一 | External hot-applied traditional Chinese medicine for treating prostatitis |
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Addressee: Shen Fangxiong Document name: Notification that Application Deemed to be Withdrawn |
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| WD01 | Invention patent application deemed withdrawn after publication |